کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9426733 | 1295932 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GABAB receptors in the medial septum/diagonal band slice from 16-25 day rat
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PSPaCSFθ rhythmMS/DBTTXIPSCmIPSCmEPSCNBQXMPSCsEPSC6-Cyano-7-nitroquinoxaline-2,3-dione - 6-Cyano-7-nitroquinoxaline-2،3-dioneD(−)-2-amino-5-phosphonopentanoic acid - D (-) - 2-amino-5-phosphonopentanoic acidd-AP5 - D-AP5sIPSC - ŞipscaAcetylcholine - استیل کولینtetrodotoxin - تترو دوتوکسین spontaneous excitatory postsynaptic current - جریان Post-synaptic جبری خودبخودیminiature inhibitory postsynaptic current - جریان ممانعت کننده پستانیپتیک مینیاتوریMiniature postsynaptic current - جریان مینیکاتور پسینات پاتیکinhibitory postsynaptic current - جریان پستانیپتیک مهارکنندهSpontaneous inhibitory postsynaptic current - جریان پستانیپتیک مهارکننده خود به خودیminiature excitatory postsynaptic current - جریان پستیینپتیک مضر تحریک آمیزCNQX - سیانکیوایکسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیPresynaptic inhibition - مهار پیش بینی شدهpostsynaptic potential - پتانسیل پتانسیپتیکbasal forebrain - پیشانی پایه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: GABAB receptors in the medial septum/diagonal band slice from 16-25 day rat GABAB receptors in the medial septum/diagonal band slice from 16-25 day rat](/preview/png/9426733.png)
چکیده انگلیسی
GABAB receptors are believed to play a role in rhythmic activity in the mammalian brain. The aim of our study was to examine the presynaptic and postsynaptic locations of these receptors in the medial septal diagonal band area (MS/DB), an area known to pace the hippocampus θ rhythm. Whole-cell patch recordings were made from parasagittal MS/DB slices obtained from the 16-25 day rat. Neurons were classified into GABAergic and cholinergic subtypes according to previous electrophysiological criteria. Bath application of the GABAB receptor agonist baclofen in the presence of tetrodotoxin, and brief tetanic fiber stimulation in the presence of ionotropic receptor antagonists, provided evidence for the presence of postsynaptic GABAB receptor transmission to GABAergic but not cholinergic neurons. Bath application of baclofen, at concentrations too low to elicit postsynaptic activity in MS/DB neurons, significantly reduced the amplitudes of stimulus-evoked ionotropic receptor inhibitory postsynaptic potentials (IPSPs) and excitatory postsynaptic potentials (EPSPs) and the paired pulse depression of these evoked potentials. Baclofen also significantly reduced the frequencies but not the amplitudes of miniature inhibitory postsynaptic currents (IPSCs) and excitatory postsynaptic currents (EPSCs), indicating the presence of presynaptic GABAB receptors on GABAergic and glutamatergic terminals in the MS/DB. Baclofen, also at a concentration too low to elicit postsynaptic activity, reduced the frequencies and amplitudes of spontaneous IPSCs and EPSCs recorded in the presence of 200-400 nM kainate. Rhythmic compound IPSCs at θ frequencies were recorded under these conditions in some neurons, and these rhythmic compound IPSCs were disrupted by the activation but not by the inhibition of GABAB receptors. These results suggest that GABAB receptors modulate rather than generate rhythmic activity in the MS/DB, and that this modulatory effect occurs via receptors located on presynaptic terminals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 132, Issue 3, 2005, Pages 789-800
Journal: Neuroscience - Volume 132, Issue 3, 2005, Pages 789-800
نویسندگان
Z. Henderson, G.A. Jones,