کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9429559 1297049 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
چکیده انگلیسی
Cognitive deficits in neuropsychiatric disorders, such as Alzheimer's disease (AD), have been closely related to cholinergic deficits. We have compared different markers of cholinergic function to assess the best biomarker of cognitive deficits associated to cholinergic hypoactivity. In post-mortem frontal cortex from AD patients, acetylcholine (ACh) levels, cholinacetyltransferase (ChAT) and acetylcholinesterase (AChE) activity were all reduced compared to controls. Both ChAT and AChE activity showed a significant correlation with cognitive deficits. In the frontal cortex of rats with a selective cholinergic lesion, all cholinergic parameters measured (ACh levels, ChAT and AChE activities, “in vitro” and “in vivo” basal ACh release) were significantly reduced. AChE activity was associated to ChAT activity, and even more, to “in vivo” and “in vitro” basal ACh release. Quantification of AChE activity is performed by an easy and cheap method and therefore, these results suggest that determination of AChE activity may be used as an effective first step method to evaluate cholinergic deficits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 375, Issue 1, 25 February 2005, Pages 37-41
نویسندگان
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