کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9435101 | 1298535 | 2005 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intrinsic membrane properties of vertebrate vestibular neurons: Function, development and plasticity
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کلمات کلیدی
ATDLTSmedial longitudinal fascicleRMPDVNMVNN-methyl-d-aspartateNMDATTX4-APdescending vestibular nucleusCaMKIIintTANMLFFtnSVNLVNinferior rectusHTS4-aminopyridine - 4-آمینوپیریدینUnilateral labyrinthectomy - labyrinthectomy یک طرفهlong-term depression - افسردگی طولانی مدتElectrophysiology - الکتروفیزیولوژیTetraethylammonium - تترا اتیل آمونیومtetrodotoxin - تترو دوتوکسین abducens nucleus - تحریک هستهlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Vestibular compensation - جبران Vestibulargaze - خیره شدنDevelopment - رشدVestibulo-ocular reflex - رفلکس Vestibulo-چشمlateral rectus - رکتوس جانبیNucleus prepositus hypoglossi - ریو هسته عصب زیر زبانیCoefficient of Variation - ضریب تغییرAHP - فرایند تحلیل سلسلهمراتبیinferior oblique - مایع ناقصLTD - محدودSecond-order - مرتبه دومsuperior oblique - مگس فوق العادهConductance - هدایتoculomotor nucleus - هسته oculomotorSuperior vestibular nucleus - هسته برتر وستبولارtrochlear nucleus - هسته ترچلرLateral vestibular nucleus - هسته جانبی ویستیبولارmedial vestibular nucleus - هسته داخلی وادیPosture - وضعیت یا حالت(بدن)resting membrane potential - پتانسیل غشای استراحتcalcium/calmodulin-dependent protein kinase II - پروتئین کیناز II وابسته به کلسیم / کالودولینafter-hyperpolarization - پس از hyperpolarizationPlasticity - پلاستیکTEA - چایconnexin - کنسکسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Central vestibular neurons play an important role in the processing of body motion-related multisensory signals and their transformation into motor commands for gaze and posture control. Over recent years, medial vestibular nucleus (MVN) neurons and to a lesser extent other vestibular neurons have been extensively studied in vivo and in vitro, in a range of species. These studies have begun to reveal how their intrinsic electrophysiological properties may relate to their response patterns, discharge dynamics and computational capabilities. In vitro studies indicate that MVN neurons are of two major subtypes (A and B), which differ in their spike shape and after-hyperpolarizations. This reflects differences in particular K+ conductances present in the two subtypes, which also affect their response dynamics with type A cells having relatively low-frequency dynamics (resembling “tonic” MVN cells in vivo) and type B cells having relatively high-frequency dynamics (resembling “kinetic” cells in vivo). The presence of more than one functional subtype of vestibular neuron seems to be a ubiquitous feature since vestibular neurons in the chick and frog also subdivide into populations with different, analogous electrophysiological properties. The ratio of type A to type B neurons appears to be plastic, and may be determined by the signal processing requirements of the vestibular system, which are species-variant. The membrane properties and discharge pattern of type A and type B MVN neurons develop largely post-natally, through the expression of the underlying ion channel conductances. The membrane properties of MVN neurons show rapid and long-lasting plastic changes after deafferentation (unilateral labyrinthectomy), which may serve to maintain their level of activity and excitability after the loss of afferent inputs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 76, Issue 6, August 2005, Pages 349-392
Journal: Progress in Neurobiology - Volume 76, Issue 6, August 2005, Pages 349-392
نویسندگان
H. Straka, N. Vibert, P.P. Vidal, L.E. Moore, M.B. Dutia,