کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
949135 1475911 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of depression pharmacotherapy in fertility treatment on conception, birth, and neonatal health: A systematic review
ترجمه فارسی عنوان
اثر دارو درمانی افسردگی در درمان باروری بر مفهوم، تولد و سلامت نوزادان: یک مرور سیستماتیک
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• The existing literature shows a lack of adverse impacts of antidepressant treatment on gamete quality or pregnancy outcomes.
• Currently, no studies address whether pharmacotherapy affects the health of mothers or their offspring long-term.
• Much like antidepressant use in fertile women, there are risks associated with both antidepressant use and untreated depression.
• Clinical presentations and disease severity should continue to play pivotal roles in depressive symptom management.

ObjectivesWhile antidepressant medications are currently used during conception, gestation and post-partum, considerable uncertainty exists regarding the benefits and harms conferred to mothers and their offspring. A significant body of evidence has focused on antidepressant use during pregnancy and post-partum. However, it is difficult to know if this translates to specific populations. Women receiving treatment for infertility are especially vulnerable to symptoms of depression and adverse perinatal outcomes. This systematic review aimed to determine the effects of antidepressants taken during the perinatal period by women receiving fertility treatment on conception, birth, and long-term maternal and child health outcomes.MethodsWe searched MEDLINE, EMBASE, CINAHL, the Cochrane Library, PsycINFO, ProQuest Dissertation & Theses, and Pubmed databases from January 1950 to November 2015. Articles were screened for inclusion independently by two reviewers. Studies were included if they enrolled women of reproductive age exposed to pharmacotherapy for depression and infertility at any point during the perinatal period.ResultsA total of 8587 unique citations, and 83 full-text articles were reviewed. Of these, two randomized controlled trials and two retrospective chart reviews were included in the narrative synthesis. While most studies reported on assisted reproduction processes and birth outcomes, none examined long-term impacts on maternal–child health. The few included studies did not find that antidepressant use by women receiving fertility therapy impacted gamete quality or pregnancy success.ConclusionsCurrently, no studies address whether pharmacotherapy for the treatment of depression in women undergoing assisted reproduction affects their health or that of their offspring long-term. It appears that much like antidepressant use in fertile women, there are risks associated with both antidepressant use and untreated depression. Decisions regarding the treatment of depression should be made taking into account clinical presentation and illness severity. Given the complexities of conducting research in this population, future research should attempt to leverage health registry data, to increase sample sizes and follow mothers and children longitudinally.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 84, May 2016, Pages 69–80
نویسندگان
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