کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9880263 | 1535223 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The activation of memory CD4+ T cells and CD8+ T cells in patients with multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
To reevaluate whether an association exists between the clinical course of multiple sclerosis (MS) and the activation of memory T cells, we investigated the phenotype of T cells in peripheral blood and cerebrospinal fluid (CSF) of patients with MS using five-color flow cytometry. A cross-sectional study with 39 relapsing-remitting MS patients demonstrated that the percentage of CD25+CD45RO+CD4+CD3+ cells was significantly increased in peripheral blood as well as in CSF of active MS patients compared with inactive MS patients. A longitudinal study with 11 relapsing-remitting MS patients also showed a higher percentage of CD25+CD45RO+CD4+CD3+ cells in peripheral blood at the phase of exacerbation than during remission. On the other hand, regardless of the disease activity, the percentage of CD25+CD45RO+CD8+CD3+ cells in peripheral blood was significantly higher in patients with MS than in healthy control subjects. A lower percentage of CD25+CD45RO+CD8+CD3+ cells in CSF was observed in active MS patients compared with inactive MS patients. These results suggest that the activation of memory CD4+ T cells is associated with the exacerbation of MS and activation of memory CD8+ T cells reflects systemic immunological dysregulation in MS patients. Transient as well as continuous activation of T cells by recall antigens may be involved in the disease course of MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 235, Issues 1â2, 15 August 2005, Pages 11-17
Journal: Journal of the Neurological Sciences - Volume 235, Issues 1â2, 15 August 2005, Pages 11-17
نویسندگان
Yoshinobu Okuda, Misa Okuda, Brian R. Apatoff, David N. Posnett,