کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9880330 1535225 2005 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss
چکیده انگلیسی
This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising antineurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 233, Issues 1–2, 15 June 2005, Pages 183-198
نویسندگان
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