Combination of Platelet-rich Plasma and Cyclooxygenase-2 Inhibitor Potently Stimulates Bone Marrow Stromal Cell Proliferation in Vitro

Conclusions: Platelet-rich plasma may directly induce bone formation by stimulating the proliferation of bone marrow stromal cells. Because cyclooxygenase-2 induction by platelet-rich plasma blunts its mitogenic activity, combination with a cyclooxygenase-2 inhibitor may enhance the osteogenic activity of platelet-rich plasma.