دانلود مقالات ISI درباره 17-Aag + ترجمه فارسی

پروتئین های شوک گرم و سرطان: چگونه می توان نانومواد را مهار کرد؟

Heat shock proteins and cancer: How can nanomedicine be harnessed?

Keywords: 17-AAG; 17-allylaminogeldanamycin; ATP; Adenosine triphosphate; AUC; Area under curve; DQ; Dequalinium; EPR; Enhanced permeation and retention effect; ER; Endoplasmic reticulum; GA; Geldanamycin; HSF-1; Heat shock factor 1; Hsp; Heat shock protein; HSR; H

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

پیشرفت راهبرد های عصبی زیستی در برابر شکست پروتئازازیس: چالش های ناشی از تولید نانو

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se

دانلود رایگان متن کامل مقاله ISI 104 صفحه سال انتشار : 2017 سفارش ترجمه

القاء فارماکولوژیک پروتئین شوک حرارت 70 کادمیوم در برابر آسیب مغزی محافظت می کند

Pharmacological induction of the 70-kDa heat shock protein protects against brain injury

Keywords: 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ANOVA; analysis of variance; BBB; blood-brain barrier; CCI; controlled cortical impact; DMSO; dimethyl sulfoxide; GA; geldanamycin; GFAP; Glial fibrillary acidic protein; HSEs; heat shock elements; HSFs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

هدف قرار دادن پاسخ شوک گرما در ترکیب با پرتودرمانی: حساسیت سلول های سرطانی به مرگ سلولی ناشی از اشعه و افزایش ایمنی بدن آنها

Targeting the heat shock response in combination with radiotherapy: Sensitizing cancer cells to irradiation-induced cell death and heating up their immunogenicity

Keywords: 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

نقص و داروهای قاچاق یون قلب

Cardiac ion channel trafficking defects and drugs

Keywords: Ion channel trafficking; Drug-induced trafficking defects; Clinical relevance; QTc; Pro-arrhythmia; Pharmacological correction; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; AP; action potential; AV block; atrioventricular block; ECG; electrocardiogram;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90

Keywords: Adar; RNaseL; Lupus; Heat shock; Epigenetics; Histone deacetylase inhibitor; 17-AAG; 17-Demethoxy-17-(2-propenylamino) geldanamycin; APOBEC; Apolipoprotein B mRNA Editing Enzyme Catalytic Polypeptide-Like; ERV; Endogenous retrovirus; H3K4me3; Histone 3, l

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities

Keywords: Fungi; Depsidones; Chemistry; Biosynthesis; Spectral data; Biological activities; 17-AAG; 17-allylamino-demethoxygeldamycin; ABCA1; ATP-binding cassette transporter A1; ABCG1; ATP-binding cassette transporter G1; ABCA1; ATP-binding cassette sub-family A1;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Virtual screening and biophysical studies lead to HSP90 inhibitors

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG); ADP; adenosine diphosphate; AMPPCP; 5′-adenylylmethylenediphosphonate; ASP; Astex statistical potential; ATP; adenosine triphosphat

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4′fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells

Keywords: thiazine[6,5-b]indole; 2-(4′fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole; Hsp; heat shock protein; 17-DMAG; 17-dimethylaminoethylamino-17-demethoxygeldanamycin; 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin; A2780; human ovarian adenocarcinoma ce

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Self-assembled amphiphilic core-shell nanocarriers in line with the modern strategies for brain delivery

Keywords: Brain targeting; Core-shell nanocarriers; Micelles; Nanotechnology; 17-AAG; 17-Allylamino-17-demethoxy geldanamycin; 5-FU; 5-flourouracil; AAV; adeno-associated virus; ABC; ATP binding cassette; Ach; acetyl choline; AFM; atomic force microscopy; AmB; amph

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders

Keywords: 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin (tanespimycin); 17-DMAG; 17- dimethylaminoethylamino-17-demethoxygeldanamycin (alvespimycin); AAV; adeno-associated virus; Aβ; amyloid-β; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP;

دانلود رایگان متن کامل مقاله ISI 89 صفحه سال انتشار : 2017 سفارش ترجمه

The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice

Keywords: 17-AAG; 17-N-Allylamino-17-demethoxygeldanamycin; Col1A1; collagen-1-alpha1; GSH; reduced glutathione; HSC; hepatic stellate cells; Hsp; heat shock protein; SMA; smooth muscle actin; TIMP; tissue inhibitor metalloproteinase; Heat shock protein; 17-AAG; Ap

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Multidrug PLA-PEG filomicelles for concurrent delivery of anticancer drugs—The influence of drug-drug and drug-polymer interactions on drug loading and release properties

Keywords: Combination therapy; Multidrug micelles; PLA-PEG; Paclitaxel; 17-AAG; Rapamycin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; ALP; autophagy-lysosome pathway; AR; androgen receptor; ATXN1; ataxin-1; DMSO; dimethyl sulfoxide; DRPLA; dentatorubral pallidoluysian atrophy; HD; Huntington's disease; HSE; heat shock element; HSF1; heat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5

Keywords: PRMT5; protein arginine methyltransferase 5; EGFR; epidermal growth factor receptor; TNF; tumor necrosis factor; NF-Y; nuclear factor Y; PKC; protein kinase C; Hsp90; heat shock protein 90; UPS; ubiquitin-proteasome system; CHIP; carboxyl terminus of he

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival

Keywords: Heat shock protein; Retina; Ganglion cells; Optic nerve; Glaucoma; Neuroprotection; 17-AAG; 17-allylamino-17-demethoxygeldanamycin; AAV; adeno-associated virus; AD; Alzheimer's disease; Aβ; amyloid-β; ER; endoplasmic reticulum; GCL; ganglion cell layer;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain

Keywords: 17-AAG; 17-Allylamino-17-demethoxygeldanamycin; Cmpd; compound; CNS; central nervous system; fEPSP; evoked postsynaptic field potential; HSF1; heat-shock factor 1; HSP; heat-shock protein; Occ50; 50% occupancy; p.o.; peroral dosing; HSP70; HSP90; Occupanc

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2016 سفارش ترجمه

17AAG improves histological and functional outcomes in a rat CCI model through autophagy activation and apoptosis attenuation

Keywords: TBI; 17-AAG; Autophagy; Apoptosis; Functional recovery

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Polypeptide-based nanogels co-encapsulating a synergistic combination of doxorubicin with 17-AAG show potent anti-tumor activity in ErbB2-driven breast cancer models

Keywords: ErbB2; Her2/Neu; Breast cancer; HSP90; 17-AAG; Doxorubicin; Block copolymers; Nanogels; Drug combinations

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia

Keywords: GCI; Hsp70; 17-AAG; Inflammatory response; Autophagy; Functional recovery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular chaperones and neuronal proteostasis

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine

Keywords: HSP90 inhibitor; 17-AAG; Edelfosine; Cell cycle arrest; Apoptosis-like cell death; Leishmania spp.;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis

Keywords: CoCl2; cobalt chloride; MI; myocardial infarction; PARP; poly ADP ribose polymerase; TUNEL; terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling; RB; retinoblastoma tumor suppressor; Hsp90; heat shock protein 90; pNA; chromophore p-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG

Keywords: Hsp90; SNX-25a; 17-AAG; Apoptosis; Cell growth; Client proteins;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; CDK; cyclin dependent kinase; CHX; cycloheximide; CO; carbon monoxide; CoPP; cobalt protoporphyrin IX; FePP; ferric protoporphyrin IX; GA; geldanamycin; HO-1; heme oxygenase-1; HSP90; heat shock protein 90;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

17-AAG improves cognitive process and increases heat shock protein response in a model lesion with Aβ25–35

Keywords: 17-AAG; Heat shock protein; Memory impairment; Amyloid beta 25–35; Hippocampus; Alzheimer’s disease

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Associate editor: N. FrossardHeat shock proteins in fibrosis and wound healing: Good or evil?

Keywords: Fibrogenesis; HSP; TGF-β1 signaling; EMT; 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; AP-1; Activator protein 1; Apaf-1; Apoptotic protease-activating factor 1; CHIP; Carboxyl terminus of Hsc70-interacting protein; CsA; Cyclosporine A; ECM; Extrace

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice

Keywords: Bartter syndrome; Barttin; ClC-K; 17-AAG; Sensorineural hearing impairment;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant's cytotoxicity

Keywords: γPKC; protein kinase Cγ; SCA14; spinocerebellar ataxia type 14; Hsp70; heat-shock protein 70; Hsp40; heat-shock protein 40; Hsp90; heat-shock protein 90; GFP; green fluorescent protein; PCs; Purkinje cells; WT; wild-type; LDH; lactate dehydrogenase; CHI

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; BCS; bovine calf serum; C/EBPα; CCAAT element binding protein α; FABP4; fatty acid-binding protein 4; FACS; fluorescence-activated cell sorting; FAS; fatty acid synthase; FBS; fetal bovine serum; Hsp90; he

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Formulation and in vitro evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric mixed micelles for glioblastoma multiforme

Keywords: Mixed micelles; 17-AAG; Glioblastoma multiforme; HSP90, Pluronic® P-123; Pluronic® F-127;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-κB and disruption of mitochondria-dependent pathways

Keywords: Hsp90; heat shock protein 90; MDR; multidrug resistance; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide; 17-AAG; 17-(allylamino)-17-demethoxygeldanmycin; DMSO; dimethylsulfoxide; CML; chronic myeloid leukemia; FBS; fetal bovine serum;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores

Keywords: PR; Protease; CA-SP1; capsid-spacer peptide 1; AChE; Acetylcholinesterase; HSP90AB1; heat shock protein 90 kDa alpha (cytosolic), class B member 1; 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin; HSP90AB1; Hyperthermia; HIV; Capsid; Postentry;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Keywords: 17-AAG; 17-allylamino-17-demethoxyl-geldanamycin; co-IP; co-immunoprecipitation; GA; geldanamycin; Hsp90; heat shock protein 90; IDF; induced fit docking; Hsp90; Hsp90 inhibitor; Gastric cancer; Cancer therapy; Molecular chaperone;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition

Keywords: 17-AAG; STK38; Sp1; Radiosensitization;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?

Keywords: 17-AAG; 17-N-Allylamino-17-demethoxygeldanamycin; AMPK; AMP-activated kinase; CCCP; carbonyl cyanide 3-chlorophenylhydrazone; CsA; Cyclosporin A; CyD; Cyclophilin-D; G-G4; Gamitrinib(s), Geldanamycin (GA), mitochondrial matrix inhibitors - Gamitrinib â€

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes

Keywords: Cytokeratin 1 and 10; Involucrin; Hsp90; 17-AAG; Keratinocyte differentiation; HaCaT

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: A necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site

Keywords: eIF3c; Hsp90; HCV IRES; 17-AAG; Translation initiation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Folate receptor targeted 17-allylamino-17-demethoxygeldanamycin (17-AAG) loaded polymeric nanoparticles for breast cancer

Keywords: Nanoparticles; 17-AAG; Folic acid; Breast cancer; Polylactide-co-glycolide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Multiple Kinase Pathways Involved in the Different De Novo Sensitivity of Pancreatic Cancer Cell Lines to 17-AAG

Keywords: 17-AAG; pancreatic cancer; chemosensitivity; kinase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

SUMO-2/3 conjugates accumulating under heat shock or MG132 treatment result largely from new protein synthesis

Keywords: SUMO; SUMOylation; Protein synthesis; Heat shock; MG132; 17-AAG

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro drug treatments reduce the deleterious effects of aggregates containing polyAla expanded PHOX2B proteins

Keywords: Congenital Central Hypoventilation Syndrome; PHOX2B; Polyalanine expansions; Intracytoplasmic aggregates; Drug treatment; 17-AAG; Curcumin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein

Keywords: 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG):GABAA receptor-protein-like 1 (GABARAPL1); Glandular epithelial cell 1 (GEC1); Heat shock protein 90 (HSP90); Michigan cancer foundation-7 (MCF-7); Proteasome inhibitors; 17-AAG; 17-N-Allylamino-17-demetho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Toward understanding Machado-Joseph disease

Keywords: ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease

Keywords: Inflammatory Bowel Disease; IAP; 17-AAG; Immune Regulation; AAG; N-Allylamino-17-Demethoxygeldanamycin; CD; Crohn's disease; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HSP; heat shock protein; IBD; inflammatory bowel disease; IL; interleukin; LPT; l

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

HSP90 is crucial for regulation of LAT expression in activated T cells

Keywords: 17-AAG; 17-(allylamino)-17-demethoxygeldanamycin; HSP90; Heat Shock Protein 90; LAT; Linker for activation of T cells; LAT; HSP90; 17-AAG; T cell;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Tanespimycin as Antitumor Therapy

Keywords: 17-AAG; Heat shock protein; HSP90; Multiple myeloma; Tanespimycin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Multi-drug delivery to tumor cells via micellar nanocarriers

Keywords: Combination therapy; Polymeric micelles; Paclitaxel; 17-AAG; PEG-DSPE; PEG–PLA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin

Keywords: Tanespimycin; 17-AAG; Polymeric micelle; Prostate cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Targeting the 90 kDa heat shock protein improves photodynamic therapy

Keywords: Photodynamic therapy (PDT); Apoptosis; Hsp-90; 17-AAG; Geldanamycin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه