A UHPLC-MS/MS method coupled with liquid-liquid extraction for the quantitation of phenacetin, omeprazole, metoprolol, midazolam and their metabolites in rat plasma and its application to the study of four CYP450 activities
Keywords: ACE; acetaminophen; PHE; phenacetin; OHOME; 5â²-hydroxy omeprazole; OME; omeprazole; OHMET; α-hydroxy metoprolol; MET; metoprolol; OHMDZ; 1â²-hydroxy midazolam; MDZ; midazolam; CYP450; Probe drug; Metabolite; UHPLC-MS/MS; DDI; 3-n-butylphthalide;