دانلود مقالات ISI درباره 3 '، 5'-cyclic adenosine monophosphate + ترجمه فارسی

تعامل دیفرانسیل از شبکه های قطبی در گیرنده پپتید 1 مانند گلوکاگون به واسطه انواع اندوژن پپتید 1 مانند گلوکاگون

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; CHO; Chinese hamster ovary; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; GLP-1; glucagon-like peptide-1; GPCR; G protein-coupled receptor; iCa2+; intracellular calcium; pERK; extracellu

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

تصویربرداری نوکلئوتیدی سیکل و بیماری قلبی عروقی

Cyclic nucleotide imaging and cardiovascular disease

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; β-AR; β-adrenergic receptor; cGMP; 3′,5′-cyclic guanosine monophosphate; FRET; Förster resonance energy transfer; IBMX; 3-isobutyl-1-methylxanthine; ISO; isoproterenol; PDE; phosphodiesterase; SICM; s

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

بررسی وضعیت بالینی بینی در مدل فیبروز کیستیک موش صحرایی

Review articleAnalysis of nasal potential in murine cystic fibrosis models

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ABCC7; ATP binding cassette subfamily C member 7; ATP; Adenosine triphosphate; BALF; Bronchoalveolar lavage fluid; CaCC; Ca2+ activated chloride channel; cAMP; 3′,5′-cyclic adenosine monophosphate; CF; Cystic fibrosis; CFTR; Cystic fibrosis transmembr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

علامت هدایت قلبی دامنه کاتالیست آدنیلیل سیکلز معکوس اختلال عملکرد قلبی ناشی از تحریک گیرنده بتا-آدرنرژیک پایدار

Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain Reverses Cardiac Dysfunction Caused by Sustained Beta-Adrenergic Receptor Stimulation

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cardiomyopathy; catecholamine; gene therapy; heart failure; AAV; adeno-associated virus; AC; adenylyl cyclase; AC6mut; AC6 mutant, contains an amino acid substitution that reduces its catalytic activity; Ad5; adenovirus-5; AKAP; A-kinase-anchoring protein

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of novel thiazolo[5,4-d]pyrimidine derivatives as human A1 and A2A adenosine receptor antagonists/inverse agonists

Keywords: 3 '، 5'-cyclic adenosine monophosphate; AR; adenosine receptor; cAMP; 3′,5′-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopentyl-1,3-dipropyl-xanthine; I-AB-MECA; 4-[((4-amino-3-iodophenyl)methyl)amino]-5′-N-methylcarboxamidoadenosine; ZM 241385; (4-(2-[7-amino

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Detection of CFTR function and modulation in primary human nasal cell spheroids

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ALI; air-liquid interface; ASL; airway surface liquid; BMI; body mass index; cAMP; 3′,5′-cyclic adenosine monophosphate; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane Conductance Regulator; CRC; conditional reprogramming culture; ENaC; epit

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ACTH; Adrenocorticotropic hormone; AgRP; Agouti-related protein; α-MSH; α-melanocyte-stimulating hormone; BSA; bovine serum albumin; cAMP; 3′,5′-cyclic adenosine monophosphate; CNS; central nervous system; DMEM; Dulbecco's Modified Eagle Medium; ECL

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled receptor 52 (GPR52) agonists

Keywords: 3 '، 5'-cyclic adenosine monophosphate; GPR52; G protein-coupled receptor 52; SAR; structure-activity relationship; cAMP; 3′,5′-cyclic adenosine monophosphate; EC50; half maximal effective concentration; MAP; methamphetamine; NMDA; N-methyl-d-aspartate; PK; pharmacokinetic; CHO; Chinese h

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart

Keywords: 3 '، 5'-cyclic adenosine monophosphate; Heat shock protein 90; Leishmania braziliensis; Protozoan parasites; X-ray crystallography; Selectivity; Nucleotides; LB; Luria Bertani; SB; Super Broth; IPTG; Isopropil-β-D-1-thiogalactopyranoside; DTT; Dithiothreitol; ATP; Adenosine triphosphate; ADP;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor

Keywords: 3 '، 5'-cyclic adenosine monophosphate; G protein coupled receptors; A2A adenosine receptors; Inverse agonists; Thiazolopyrimidine derivatives; Bicyclic heteroaromatic system; AR; adenosine receptor; cAMP; 3′,5′-cyclic adenosine monophosphate; CHO; chinese hamster ovary; DPCPX; 8-cyclopenty

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Biochemical markers of striatal desensitization in cortical-limbic hyperglutamatergic TS- & OCD-like transgenic mice

Keywords: 3 '، 5'-cyclic adenosine monophosphate; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; CaMK; calcium calmodulin kinase; cAMP; 3′,5′-cyclic adenosine monophosphate; CE; capillary electrophoresis; CRE; cAMP response element; CREB; CRE binding protein; CSTC; cortico/amygdal

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

On the G protein-coupling selectivity of the native A2B adenosine receptor

Keywords: 3 '، 5'-cyclic adenosine monophosphate; BAY60-6583; 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; cAMP; 3′,5′-cyclic adenosine monophosphate; CE3F4; 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde; CGS21680; 2-[p-(2-carboxyethy

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Tools and drugs for uracil nucleotide-activated P2Y receptors

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ADP; Adenosine 5′-diphosphate; AP4A; P1,P4-Di(adenosine-5′)-tetraphosphate; AR; Adenosine receptor; AR-C118925; 5-{[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl}-N-(1H-tetrazol-5-yl)-2-furancarbo

دانلود رایگان متن کامل مقاله ISI 193 صفحه سال انتشار : 2018 سفارش ترجمه

Cooperative regulation of Gja1 expression by members of the AP-1 family cJun and cFos in TM3 Leydig and TM4 Sertoli cells

Keywords: 3 '، 5'-cyclic adenosine monophosphate; AP-1; activating protein-1; ANOVA; analysis of variance; bp; base pair; 8Br-cAMP; 8-bromoadenosine 3′,5′-cyclic monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; cJun; Jun proto-oncogene; cFos; FBJ osteosarcoma oncogene; ChIP; chromatin i

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Nitric oxide-coupled signaling in odor elicited molecular events in the olfactory center of the terrestrial snail, Helix pomatia

Keywords: 3 '، 5'-cyclic adenosine monophosphate; 5-HT; 5-hydroxytryptamine or serotonin; ACh; acetylcholine; AGC-S-P; phosphorylated substrate of the AGC-family protein kinase; Akt; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APV; (2R)-amino-5-phosphonovaleric acid; B

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Structural and Enzymatic Characterization of a cAMP-Dependent Diguanylate Cyclase from Pathogenic Leptospira Species

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; cGMP; 3′,5′-cyclic guanosine monophosphate; c-di-GMP; bis-(3′→5′) cyclic dimeric guanosine monophosphate; DGC; diguanylate cyclase; PDE; phosphodiesterase; GAF; cGMP-specific phosphodiesterases, ad

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Back to the Future: Circuit-testing TS & OCD

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ACH; acetylcholine; AMY; amygdala; cAMP; 3′,5′-cyclic adenosine monophosphate; CSTC; cortico/amygdalo-striato-thalamo-cortical; CT; cholera toxin; CTX; cortex; D1; dopamine receptor subtype 1; D1+; D1 receptor-expressing; D1CT-7; Dopamine receptor D1

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists

Keywords: 3 '، 5'-cyclic adenosine monophosphate; SAR; structure-activity relationship; cAMP; 3′,5′-cyclic adenosine monophosphate; EC50; half maximal effective concentration; MAP; methamphetamine; NMDA; N-methyl-d-aspartate; PK; pharmacokinetic; CHO; Chinese hamster ovary; SEM; standard error of t

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of linalool and eugenol on the survival of Leishmania (L.) infantum chagasi within macrophages

Keywords: 3 '، 5'-cyclic adenosine monophosphate; AVL; American visceral leishmaniasis; BALBc; an albino, laboratory-inbred strain of the house mouse; cAMP; 3′,5′-cyclic adenosine monophosphate; DMSO; dimethylsulfoxide; EGTA; ethylene glycol tetraacetic acid; FCS; fetal calf serum; HepG2; a perpetual

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology

Keywords: 3 '، 5'-cyclic adenosine monophosphate; PKA; cyclic-AMP dependent protein kinase/protein kinase A; cAMP; 3′,5′-cyclic adenosine monophosphate; ATP; adenosine 5-triphosphate; C subunits; catalytic subunits; R subunits; regulatory subunits; AKAP; A-kinase anchoring protein; AGC group of kinas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

α-MSH modulates cell adhesion and inflammatory responses of synovial fibroblasts from osteoarthritis patients

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ACTH; adrenocorticotropin; ASIP; Agouti signalling protein; ATP; adenosine triphosphate; BSA; bovine serum albumin; cAMP; 3′,5′-cyclic adenosine monophosphate; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated protein kinas

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes

Keywords: 3 '، 5'-cyclic adenosine monophosphate; GIPR; glucose-dependent Insulinotropic Peptide Receptor; cAMP; 3′,5′-cyclic adenosine monophosphate; BRET; Bioluminescence Resonance Energy Transfer; FRET; Fluorescence Resonance Energy Transfer; Glucose-dependent-insulinotropic receptor; Internalizat

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; CHO; Chinese hamster ovary; CRF1R; corticotrophin releasing factor receptor-1; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; GCGR; glucagon receptor; GLP-1; glucagon-like peptide-1; GPCR

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics

Keywords: 3 '، 5'-cyclic adenosine monophosphate; AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; AKAP; A-kinase anchor protein; AMP; 5′ adenosine monophosphate; AMPK; AMP-activated protein kinase; Arfgap1; ADP-ribosylation factor GTPase-activating protein 1; Arhgef2; Rho guanine nucleotide ex

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus

Keywords: 3 '، 5'-cyclic adenosine monophosphate; Brucella abortus; Cyclic nucleotide binding (CNB) domain; Crystal structure; cAMP; 3′,5′-cyclic adenosine monophosphate; cGMP; 3′,5′-cyclic guanosine monophosphate; cNMP; cyclic nucleotide monophosphate; CNB; cyclic nucleotide binding; PBC; phosph

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y14 receptor

Keywords: 3 '، 5'-cyclic adenosine monophosphate; DXQJLXWZLNCEJX-VBCGWZPHSA-N; BODIPY; boron-dipyrromethene; cAMP; 3′,5′-cyclic adenosine monophosphate; CHO; Chinese hamster ovary; COMU; [[(Z)-(1-cyano-2-ethoxy-2-oxoethylidene)amino]oxy-morpholin-4-ylmethylidene]-dimethylazanium hexafluorophosphate;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2

Keywords: 3 '، 5'-cyclic adenosine monophosphate; 5-HT; 5-hydroxytryptamine; cAMP; 3′,5′-cyclic adenosine monophosphate; ERK1/2; extracellular signal-regulated kinases 1/2; GPCR; G protein-coupled receptor; LogEC50; logarithm of agonist concentration that induces half-maximal response; Emax; maximal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

Keywords: 3 '، 5'-cyclic adenosine monophosphate; 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3′,5′-cyclic adenosine monophosphate;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; PKA; protein kinase A; EPAC; Exchange Protein directly Activated by Cyclic AMP; LTCC; L-type Ca2+ channel; NCX; Na+/Ca2+ exchanger; RyR; ryanodine receptor; SR; sarcoplasmic reticulum; TRPC; Transient Recept

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

New paradigms in GPCR drug discovery

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; ADP; adenosine 5′- diphosphate; GPCR; G protein-coupled receptor; TM; transmembrane helix; ERK; extracellular signal-regulated kinase; T4L; T-4 lysozyme; BRIL; thermostabilized apocytochrome b562; StaRs; s

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Research report"Hyperglutamatergic cortico-striato-thalamo-cortical circuit" breaker drugs alleviate tics in a transgenic circuit model of Tourette׳s syndrome

Keywords: 3 '، 5'-cyclic adenosine monophosphate; 5-HT; 5-hydroxytryptamine; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMY; amygdala; ANOVA; analysis of variance; cAMP; 3′,5′-cyclic adenosine monophosphate; CGN; cortical/limbic glutamatergic neuron; CSTC; cortico/amygdalo-striato-t

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Allosteric modulators of human A2B adenosine receptor

Keywords: 3 '، 5'-cyclic adenosine monophosphate; ADA; adenosine deaminase; AR; adenosine receptor; cAMP; 3′,5′-cyclic adenosine monophosphate; BAY 60-6583; 2-[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-ylsulfanyl]acetamide; CHO; Chinese hamster ovary; DMAP; 4-dimethylaminopyridine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists

Keywords: 3 '، 5'-cyclic adenosine monophosphate; IPCYPXCGYWGJEK-UHFFFAOYSA-N; cAMP; 3′,5′-cyclic adenosine monophosphate; CB; cannabinoid; CHO; Chinese hamster ovary; CNS; central nervous system; DCM; dichloromethane; DMF; N,N-dimethylformamide; DPPA; diphenylphosphonic azide; ECL; extracellular loo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Roles of hinge region, loops 3 and 4 in the activation of Escherichia coli cyclic AMP receptor protein

Keywords: 3 '، 5'-cyclic adenosine monophosphate; cAMP; 3′,5′-cyclic adenosine monophosphate; PKA; protein kinase A; Epac; exchange protein directly activated by cAMP; CRP; cAMP receptor protein; CNGC; cyclic nucleotide-gated ion channels; WT; wild-type; TEK100; 50 mM Tris 1 mM EDTA and 100 mM KCl

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices

Keywords: 3 '، 5'-cyclic adenosine monophosphate; Striatum; PDE10A; ERK; Dopamine; Estrogen; Gender; cAMP; 3′,5′-cyclic adenosine monophosphate; cGMP; Guanosine 3′,5′-cyclic mononucleotide; MSNs; medium spiny neurons; PDE10A; phosphodiesterase 10A; p-ERK; phosphorylated extracellular-signal-regul

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Regulatory mechanism of duodenal bicarbonate secretion

Keywords: 3 '، 5'-cyclic adenosine monophosphate; AC; adenylate cyclase; cNOS; constitutive nitric oxide synthase; cAMP; 3′,5′-cyclic adenosine monophosphate; cGMP; 3′,5′-cyclic guanosine monophosphate; COX; cyclooxygenase; CFTR; cystic fibrosis transmembrane conductance regulator; dbcAMP; dibuty

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

The role of loops 3 and 4 in the interdomains and intersubunits communication of E. coli cAMP receptor protein

Keywords: 3 '، 5'-cyclic adenosine monophosphate; PKA; protein kinase A; Epac; exchange protein directly activated by cAMP; CRP; cAMP receptor protein; CNGC; cyclic nucleotide-gated ion channels; CPM; N-{4-[7-(diethylamino)-4-methylcoumarin-3-yl]-phenyl}maieimide; WT; wild type; cAMP; 3′,5′-cyclic ad

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling

Keywords: 3 '، 5'-cyclic adenosine monophosphate; Angiogenesis; Ca2+-dependent K+ channels; Cytochrome P450; Eicosanoids; Endothelium; Hyperpolarization; Membrane potential; Signal transduction; bFGF; basic fibroblast growth factor; BKCa channels; large conductance KCa+ channels; COX; cyclooxygenase; cyc

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه