Keywords: AMD; age-related macular degeneration; ATP; adenosine triphosphate; A1R; adenosine receptor type A1; A2AR; adenosine receptor type A2A; A2BR; adenosine receptor type A2B; A3R; adenosine receptor type A3; BDNF; brain-derived neurotrophic factor; CI; contin
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Keywords: SMA; styrene-maleic acid copolymer; SMALP; SMA lipid particle; MSP; membrane scaffolding protein; GPCR; G protein-coupled receptor; ABC; ATP binding cassette; hENT1; human equilibrative nucleoside transporter 1; CzcD; zinc diffusion facilitator; NMR; nucl
Keywords: A1R; adenosine receptor type 1; A2AR; adenosine receptor type 2A; Ado; adenosine; APV; d-(â)-2-amino-5-phosphonopentanoic acid; ATP; adenosine triphosphate; CGS-21680; 4-[2-[[6-amino-9-(N-ethyl-β-d-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benze
Keywords: [11C]BS-DMPX; 7-methyl-[11C]-(E)-8-(3-bromostyryl)-3,7-dimethyl-1-propargylxanthin; 2-CI-IB MECA; 2-cloro-N6-(3-iodobenzyl)-adenosine-50-N methyluronamide; A1R; ADORA 1 receptor; A2AR; ADORA 2A receptor; A2BR; ADORA 2B receptor; A3R; ADORA 3 receptor; AB-
Keywords: Guanidines; A2A receptor; Privileged structure; Iminoimidazoline; Tic-H; tetrahydroisoquinoline-hydantoin; A2AR; adenosine A2A receptor;
Early-life hyperthermic seizures upregulate adenosine A2A receptors in the cortex and promote depressive-like behavior in adult rats
Keywords: HIS; hyperthermia-induced seizures; A2AR; adenosine A2A receptor; AC; adenylate cyclase; PD; postnatal day; Febrile seizures; Adenosine A2A receptors; Cortex; Depression; Rat; Adulthood;
Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation
Keywords: Inosine; A2AR; PAM; cAMP; ERK1/2; Cytokines;
Hyaluronan in experimental injured/inflamed cartilage: In vivo studies
Keywords: ACAN; aggrecan; ADAMTS-5; A disintegrin and metalloproteinase with thrombospondin motifs 5; A2AR; adenosine type 2 receptor; Bax; BCL2 associated X protein; Bcl-2; B-cell lymphoma 2; CD44; cluster determinant 44; Col2A; collagen type II alpha; Col1a1; col
Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease
Keywords: Sandhoff disease; HexB knockout mice; Adenosine A2A receptor; Astrogliosis; Istradefylline; SD; Sandhoff disease; Hex; β-hexosaminidase; A2AR; Adenosine receptor A2A;
Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats
Keywords: A2AR; A2A type of adenosine receptors; CNS; central nervous system; COX-1 and COX-2; cyclooxygenase 1 and 2; EEG; electroencephalogram; GABAAR; GABAA type of gamma-aminobutyric acid receptors; IL-1; interleukin-1; IMP; inosine monophosphate; i.p.; intrape
Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum
Keywords: A2AR; Adenosine A2A receptor; cAMP; Cyclic adenosine monophosphate; D1R; Dopamine D1 receptor; D2R; Dopamine D2 receptor; dMSNs; Direct pathway striatal medium-sized spiny neurons; GABA; γ-Aminobutyric acid; GPCRs; G-protein coupled receptors; H2R; Hista
Hypoxia-induced miR-214 expression promotes tumour cell proliferation and migration by enhancing the Warburg effect in gastric carcinoma cells
Keywords: miR-214; PRDM16; A2AR; Hypoxia; Warburg effect; Gastric carcinoma;
A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment
Keywords: A2aR; adenosine A2a receptor; CAF; cancer-associated fibroblast; CHO; Chinese hamster ovary; IC50; concentration of compound that displaces the binding of radioligand by 50%; Kb; binding constant; Ki; inhibition constant; NECA; 5â³-N-ethylcarboxamidoaden
Altered adenosine 2A and dopamine D2 receptor availability in the 6-hydroxydopamine-treated rats with and without levodopa-induced dyskinesia
Keywords: A2AR; Adenosine 2A receptor; AIM; abnormal involuntary movement; ANOVA; analysis of variance; BPND; non-displaceable binding potential; CNS; central nervous system; D2R; dopamine type 2 receptor; L-DOPA; levodopa; LID; levodopa-induced dyskinesia; MRTM; I
Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells
Keywords: A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; A2BR; adenosine A2B receptor; A3R; adenosine A3 receptor; MAPK; mitogen activated protein kinase; NECA; 5â²-N-ethylcarboxamidoadenosine; PI3K; phosphatidylinositol-3â²-kinase; Macrophage; Chemota
Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation
Keywords: Caffeine; Cannabinoid receptor 1; Adenosine A2A receptor; Istradefylline; Novel object recognition; Memory; AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; A1R; adenosine A1 receptor; A2AR; adenosine A
Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity
Keywords: A2aR; adenosine A2a receptor; Th; T helper; NASH; nonalcoholic steatohepatitis; MCD; methionine-choline deficient; IL; interleukin; WT; wild type; NAFLD; nonalcoholic fatty liver disease; Treg; T regulatory; IFN; interferon; TNF; tumor necrosis factor; TG
Chronic oral administration of MPEP, an antagonist of mGlu5 receptor, during gestation and lactation alters mGlu5 and A2A receptors in maternal and neonatal brain
Keywords: ADA; adenosine deaminase; AMPA; (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; A2AR; adenosine A2A receptor; a.u.; arbitrary units; DHPG; (S)-3,5-dihydroxyphenylglycine; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic
Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats
Keywords: A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; Ado; adenosine; ADP; Ado diphosphate; AMP; Ado monophosphate; ATPA; do triphosphate; CNS; central nervous system; COX; cyclooxygenase; DMSO; dimethyl sulfoxide; EEG; electroencephalogram; FFT; Fast
Research PaperAberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy
Keywords: α-Syn; α-synuclein; A2AR; adenosine A2A receptor; AD; Alzheimer's disease; DG; dentate gyrus; DLB; dementia with Lewy bodies; HD; Huntington's disease; KO; knockout; LBs; Lewy bodies; LNs; Lewy neurites; MSA; multiple system atrophy; PD; Parkinson's dis
Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels
Keywords: A2AR; adenosine A2A receptor; CFA; complete Freund's adjuvant; CGS; CGS21680; CRAC; Ca2+ release-activated calcium; EAE; experimental autoimmune encephalomyelitis; FITC; fluorescein isothiocyanate; MS; multiple sclerosis; PBS; phosphate-buffered saline;
Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury
Keywords: Hippocampal neurotoxicity; Cerebral ischemia; Adenosine A1 receptor; AMPAR trafficking; Serine/threonine protein phosphatase; Adenosine-induced persistent synaptic depression; CPA; N6-cyclopentyl adenosine; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; APSD;
Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1
Keywords: A2AR; adenosine A2A receptor; AP-1; activator protein 1; BLC; B-lymphocyte chemoattractant; BMDM; bone marrow derived macrophage; CREB; cAMP response element-binding protein; DUSP1; dual specific phosphatase; Epac; exchange protein activated by cAMP; ERK;
Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury
Keywords: A2AR; adenosine A2A receptor; CNS; central nervous system; CTCF; corrected total cell fluorescence; EDTA; ethylenediamine tetraacetic acid; EGTA; ethylene glycol tetraacetic acid; EHP; elevated hydrostatic pressure; FBS; fetal bovine serum; GCL; ganglion
Research ArticleMouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia/reperfusion damage and protection by A2aR stimulation
Keywords: HP; hepatocytes; LSEC; liver sinusoidal endothelial cells; A2aR; adenosine 2a receptor; IR; ischemia-reperfusion; CGS21680; 2p-(2-carboxyethyl)-phenyl-amino-50-N-ethylcarboxyamido-adenosine; ROS; reactive oxygen species; 2-DE; two-dimensional gel electrop
Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis
Keywords: A2AR; A2A adenosine receptor; AD; Alzheimer's disease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; AREs; adenylate- and uridylate-rich elements; ELAV; embryonic lethal abn
Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor
Keywords: Adenosine; A2AR; Caffeine; 3-MCA; Anti-tumor immunity
The mutual regulation between miR-214 and A2AR signaling plays an important role in inflammatory response
Keywords: A2AR; miR-214; Expression regulation; Inflammation;
Conserved disulfide bond is not essential for the adenosine A2A receptor: Extracellular cysteines influence receptor distribution within the cell and ligand-binding recognition
Keywords: GPCRs; G protein-coupled receptors; ARs; adenosine receptors; ECL; extracellular loop; DTT; dithiothreitol; CFP; cyan fluorescent protein; A2AR; A2A receptor; WT; wild type; ER; endoplasmic reticulum; M; plasma membrane; HR; Hausdorff ratio; HEK cells; hu
Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia
Keywords: Adenosine; Astrocytes; A2AR; GLT-I; NMDA-R; Schizophrenia
Modulatory effects of inosine, guanosine and uridine on lipopolysaccharide-evoked increase in spike-wave discharge activity in Wistar Albino Glaxo/Rijswijk rats
Keywords: NF-κB; nuclear factor kappa B; A2AR; adenosine A2A receptor; Ado; adenosine; AP5; 2-amino-5-phosphonopentanoic acid; CNS; central nervous system; COX-2; cyclooxygenase-2; EEG; electroencephalogram; GABAA receptors; GABAA type of gamma-aminobutyric acid r
Salidroside attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2a receptor related mitochondria-dependent apoptosis pathway
Keywords: PAH; pulmonary arterial hypertension; PASMCs; pulmonary arterial smooth muscle cells; A2aR; adenosine A2a receptor; COPD; chronic obstructive pulmonary disease; HUVECs; human umbilical vein endothelial cells; MYH11; smooth muscle myosin heavy chain 11; RV
Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32
Keywords: Striatum; Dopamine; Orphan nuclear receptors; Antipsychotics; A2AR; adenosine 2A receptor; CDK5; cyclin-dependent kinase 5; DAPI; 4â²,6â²-Diamidino-2-phenylindole; DARPP-32; dopamine- and cAMP-regulated phosphoprotein of 32Â kDa; D1R, D2R, and D3R; dopa
Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation
Keywords: A2AR; adenosine A2A receptor; A3R; adenosine A3 receptor; KC; cytokine-induced neutrophil-attracting chemokine; l-NAME; l-(G)-nitro-l-arginine methyl ester; MIP; macrophage inflammatory protein; Adenosine; Apoptosis; Macrophages; Phagocytosis; Inflammatio
Adenosine A2A receptor activation supports an atheroprotective cholesterol balance in human macrophages and endothelial cells
Keywords: A2AR; adenosine 2A receptor; ABC transporters; ATP-binding cassette transporters; CD36; cluster of differentiation 36; FCF; foam cell formation; LDL; low-density lipoprotein; LOX-1; the lectin-like oxidized low-density lipoprotein receptor; PMA; Phorbol 1
How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance
Keywords: AC; adenylate cyclase; A2AR; Adenosine A2A receptor; cAMP; cyclic adenosine monophosphate; CK; casein kinase; D1R; Dopamine D1 receptor; D2R; Dopamine D2 receptor; D4R; Dopamine D4 receptor; GPCR; G-protein coupled receptors; LMs; linear motifs; MoREs; mo
A feedback loop in PPARγ-adenosine A2A receptor signaling inhibits inflammation and attenuates lung damages in a mouse model of LPS-induced acute lung injury
Keywords: A2AR; PPARγ; Inflammation; ALI;
Adenosine A1 receptor stimulation enhances osteogenic differentiation of human dental pulp-derived mesenchymal stem cells via WNT signaling
Keywords: ADA; adenosine deaminase; A1R; adenosine A1 receptors; A2AR; adenosine A2A receptors; A2BR; adenosine A2B receptors; A3R; adenosine A3 receptors; ALP; alkaline phosphatase; ARS; Alizarin Red S staining; CCPA; 2-chloro-N6-cyclopentyladenosine; CGS21680; 2-
Dopamine D2 receptor-mediated modulation of adenosine A2A receptor agonist binding within the A2AR/D2R oligomer framework
Keywords: A2AR; D2R; Parkinson’s disease; Receptor–receptor allosterism; Antiparkinsonian drugs
Short CommunicationTranscriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A2A and metabotropic glutamate type 5 receptors: Focus on beta-synuclein expression
Keywords: GPCR; G protein-coupled receptor; CNS; central nervous system; GABA; gamma-aminobutyric acid; A2AR; adenosine A2A receptor; D2R; dopamine D2 receptor; mGlu5R; metabotropic glutamate type 5 receptor; RET; resonance energy transfer; PKA; protein kinase A; M
G protein-coupled receptor oligomerization and brain integration: Focus on adenosinergic transmission
Keywords: A2AR; D2R; mGlu5R; Oligomerization; Brain integration;
Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands
Keywords: 7-TM; seven transmembrane; A2AR; adenosine A2A receptor; A3R; adenosine A3 receptor; BSA; bovine serum albumin; cAMP; cyclic adenosine-5â²-monophosphate; CHO; Chinese Hamster Ovary; CHOhLHr_luc; human LH receptor and luciferase reporter gene transfected
Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons
Keywords: caffeine; methylxanthines; aging; memory; neuroprotection; dendritic growth; AD; Alzheimer's disease; A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; Aβ; amyloid-β; DG; dentate gyrus; EPM; elevated plus maze; LTP; long-term potentiation; OF; o
Working memory and the homeostatic control of brain adenosine by adenosine kinase
Keywords: A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; ADK; adenosine kinase; Adk-tg; Adktm1â/â:Tg(UbiAdk); ANOVA; analysis of variance; AR; adenosine receptor; fb-Adk-tg; Adktm1â/â:tg(UbiAdk):Emx1-Cre-tg3; ITI; inter-trial interval; LTP; long-
Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function
Keywords: GPCR; G protein-coupled receptor; A2AR; A2A adenosine receptor; P2Y1R; P2Y1 receptor; P2Y12R; P2Y12 receptor; HEK; human embryonic kidney; 2MeSADP; 2-methylthiol-ADP; ZM241385; 4-(2-[7-amino-2-(2-furyl)[1,2,4]-triazolo[2,3-α][1,3,5]triazin-5-yl amino]eth
Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling
Keywords: AC; adenylyl cyclase; AR; adrenoceptor; A2AR; adenosine 2A receptor; BiFC; bimolecular fluorescence complementation; BiLC; bimolecular luminescence complementation; BRET; bioluminescence resonance energy transfer; CB1R; cannabinoid 1 receptor; CNS; centra
Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development
Keywords: alpha-2 adrenergic receptors; DSP4; methylazoxymethanol; norepinephrine transporter; high affinity receptor; G protein linkage; A2AR; alpha-2 adrenergic receptor; DBH; dopamine-β-hydroxylase; DSP4; N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochlori
Synthesis of novel 7-imino-2-thioxo-3,7-dihydro-2H-thiazolo [4,5-d] pyrimidine derivatives as adenosine A2A receptor antagonists
Keywords: Adenosine; A2AR; Combinatorial chemistry; GPCR; Radioligand binding; Parkinson’s disease; Thiazolopyrimidines
Synergism of theophylline and anticholinergics to inhibit haloperidol-induced catalepsy: A potential treatment for extrapyramidal syndromes
Keywords: AC; adenylyl cyclase; ACh; acetylcholine; A1R; adenosine A1 receptor; A2AR; adenosine A2A receptor; ANOVA; analysis of variance; BENZ; benztropine; CDT; cumulative descent time; CNS; central nervous system; DMSO; dimethylsulphoxyde; DPCPX; 8-cyclopentyl-1
Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A2A receptor antagonists
Keywords: A2AR; Antagonist; cAMP assay; Haloperidol; Radioligand-binding assay; Thiazolotriazolopyrimidines;