Keywords: ABC, accelerated blood clearance; EPR, enhanced permeability and retention; MPS, mononuclear phagocyte system; NP, nanoparticles; PACA, poly(alkyl cyanoacrylate); PEG, poly(ethylene glycol); PLA, poly(lactide); PLGA, poly(lactide-co-glycolide); PPG, poly(
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B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice
Keywords: ABC, accelerated blood clearance; BCR, B cell receptor; CHOL, cholesterol; DC, dendritic cells; DC-6-14, O,O′-ditetradecanoyl-N-(α-trimethyl ammonio acetyl) diethanolamine chloride; DOPE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; ELISA, enzyme-linked
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon
Keywords: ABC, accelerated blood clearance; Chol, cholesterol; CPA, cyclophosphamide; DiI, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate; DiO, 3,3′-dioctadecyloxacarbocyanine perchlorate; FO, follicle; HEPC, hydrogenated egg phosphatidylcholine
The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats
Keywords: ABC, accelerated blood clearance; CHOL, cholesterol; HEPC, hydrogenated egg phosphatidylcholine; mPEG2000-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000]; PEG, polyethylene glycolAccelerated blood clearance (ABC
PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner
Keywords: Ab, antibody; ABC, accelerated blood clearance; CHOL, cholesterol; HEPC, hydrogenated egg phosphatidylcholine; HRP, horseradish peroxidase; LPS, Lipopolysaccharide; MZ, marginal zone; mPEG2000-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[metho
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes
Keywords: AUC, the area under the blood concentration–time curve; ABC, accelerated blood clearance; CHOL, cholesterol; 3H-CHE, 3H-cholesterylhexadecyl ether; DGVB2+, VBS containing 0.15 mM CaCl2, 1 mM MgCl2, 5%; D-glucose and 0.1%; gelatin; DHPE, dihexadecanoylglyc
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes
Keywords: Ab, antibody; ABC, accelerated blood clearance; CHE, cholesterylhexadecyl ether; CHOL, cholesterol; 3H-CHE, 3H-cholesterylhexadecyl ether; DHPE, dihexadecanoylglycerophosphoethanolamine; DXR, doxorubicin; HEPC, hydrogenated egg phosphatidylcholine; HRP, h
Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection
Keywords: ABC, accelerated blood clearance; [3H]-CHE, [3H]-cholesterylhexadecyl ether; CHOL, cholesterol; DGVB2+, veronal buffered saline containing 0.15 mM CaCl2, 1 mM MgCl2, 5% d-glucose and 0.1% gelatin; DHPH, dihexadecanoylglycero-phosphoethanolamine; DXR, doxo
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
Keywords: ABC, accelerated blood clearance; CHOL, cholesterol; 3H-CHE, 3H-cholesterylhexadecyl ether; CLh, hepatic clearance; C, complement; HEPC, hydrogenated egg phosphatidylcholine; mPEG2000-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy(polyet