Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; AOX1; aldehyde oxidase 1; 11β-HSD; 11β-hydroxysteroid dehydrogenase; CBR; carbonyl reductase; CYP; cytochrome P450; EDTA; ethylenediamine-N,N,N',N'-tetraacetic acid; G-6-P; glucose-6-phosphate; G-6-PDH; glucose-6-phosphate
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Keywords: آلدو کتو ردوکتاز; Androgens; Intracrinology; Steroid biosynthesis; Hormone-dependent cancer; Testosterone; 11-oxygenated androgens; 11KA4; 11-keto-androstenedione; 11KDHT; 11-keto-5α-dihydrotestosterone; 11KT; 11-keto-testosterone; 11OHA4; 11β-hydroxy-androstenedione; 11
Keywords: آلدو کتو ردوکتاز; 3-BC; 3-benzylidene camphor; 4-MBC; 4-methylbenzylidene camphor; Aβ; amyloid-β; ABAD; Aβ-binding alcohol dehydrogenase; AD; Alzheimer's disease; AI; aromatase inhibitor; AKR; aldo-keto reductase; AME; apparent mineralocorticoid excess; AR; androgen r
Keywords: آلدو کتو ردوکتاز; AA; arachidonic acid; AKR; aldo-keto reductase; AOS; allene oxide synthase; CX; carbon numbers; COX; cyclooxygenase; cPGES; cytosolic PGE synthase; cPLA2; cytosolic phospholipase A2; CYP; cytochrome P450; DGLA; dihomo-γ-linolenic acid; DP; prostaglandin
Keywords: آلدو کتو ردوکتاز; Barley; Hordeum vulgare; Poaceae; Abiotic stress tolerance; Transgenic barley; Aldose reductase; DsRed/GFP fluorescent proteins; AKR; aldo-keto reductase; cpMsALR; MsALR protein targeted to the chloroplast; DsRed; red fluorescent protein from Discosoma sp
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Cofactor-binding residues; Marivirga tractuosa; Retinal; Retinol
Keywords: آلدو کتو ردوکتاز; ALR2; aldose reductase; AKR; aldo-keto reductase; NADPH; β-nicotinamide adenine dinucleotide phosphate reduced form; ARIs; aldose reductase inhibitors; SAR; structure-activity relationship; Quinoxalinone derivatives; Aldose reductase inhibitors; Struct
Keywords: آلدو کتو ردوکتاز; Aedes aegypti; Mosquito; Juvenile hormone; Corpora allata; Aldehyde dehydrogenase 3; RNAi; Aldo-keto reductase; Farnesal;
Essential Intracrine Androgenic Action in Lung Development for Both Sexes
Keywords: آلدو کتو ردوکتاز; 5α-DH-DOC; 5α-dihydro-deoxycorticosterone; AKR; aldo-keto reductase; DHT; dihydrotestosterone; DOC; deoxycorticosterone; GD; gestation day; HSD; hydroxysteroid dehydrogenase; NMR; nuclear magnetic resonance; PND; postnatal day; androgens; bronchopulmona
An aldo-keto reductase, Bbakr1, is involved in stress response and detoxification of heavy metal chromium but not required for virulence in the insect fungal pathogen, Beauveria bassiana
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Stress response; Detoxification; Heavy metal; Insect fungal pathogen; Beauveria bassiana;
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: آلدو کتو ردوکتاز; ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1
Keywords: آلدو کتو ردوکتاز; 9,10-Phenanthrenequinone; Neuroblastoma cell; Apoptosis; Reactive oxygen species; Antioxidant property; NAD(P)H:quinone oxidoreductase 1; AKR; aldo-keto reductase; AMC; 7-amido-4-methylcoumarin; ATM; ataxia telangiectasia mutated kinase; BSO; dl-buthionin
High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; ARE; antioxidant response element; CD44; cluster of differentiation 44; CSC; cancer stem cell; GCLC; glutamate-cysteine ligase catalytic subunit; GPX; glutathione peroxidase; GSH; glutathione; HO-1; heme oxygenase-1; HA; hyaluron
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism
Keywords: آلدو کتو ردوکتاز; Nrf2 activator; CDDO-Im; Carnosic acid; Neuroblastoma; Carbonyl stress; Methylglyoxal; GSH synthesis; AGEs; advanced glycation end products; AKR; aldo-keto reductase; BSO; buthionine sulfoximine; CA; carnosic acid; CEL; Nε-(1-carboxyethyl)lysine; CDDO-Im
Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008
Keywords: آلدو کتو ردوکتاز; Cancer; Enzyme inhibitor; Psoriasis; RAR/RXR agonist; Retinoic acid; Skin disease; AR; Aldose Reductase; AKR; Aldo-Keto Reductase; AKR1B10; AKR family member 1B10; AKR1B15; AKR family member 1B15; AKR1A1; AKR family member 1A1 or aldehyde reductase; ARIs;
Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs
Keywords: آلدو کتو ردوکتاز; CBR; carbonyl reductase; SDR; short-chain dehydrogenase/reductase; CYP; cytochrome P450; AKR; aldo-keto reductase; DOX; doxorubicin; FA; fatty acid; ONE; 4-oxo-2-nonenal; 13h; 8-hydroxy-2-imino-2H-chromene-3-carboxylic acid (2-chlorophenyl)amide; DHRS4; d
4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer
Keywords: آلدو کتو ردوکتاز; ABC transporters; ATP-binding cassette transporters; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; Akt; protein kinase B; ALDH; aldehyde dehydrogenase; AOR; alkenal/one oxidoreductase; AP-1; activator Protein-1; AR; aldose reductase; ARE/EpRE;
Proteome analysis reveals an energy-dependent central process for Populus Ã canadensis seed germination
Keywords: آلدو کتو ردوکتاز; 2-D; two-dimensional; 26SP; 26S proteasome; ABA; abscisic acid; AKR; aldo-keto reductase; AlaAT; alanine aminotransferase; AspAT; aspartate aminotransferase; CBB; Coomassie brilliant blue R-250; CHX; cycloheximide; CysPI; cysteine proteinase inhibitor; DX
Characterization of AKR1B16, a novel mouse aldo-keto reductase
Keywords: آلدو کتو ردوکتاز; Aldose reductase inhibitor; Enzyme kinetics; Gene orthology; Retinaldehyde reductase; Steroid oxidoreductase; Subcellular localization; Î4-Ae; androst-4-ene-3,17-dione; AKR; aldo-keto reductase; AKR1B16; AKR family member 1B16; ARI; aldose reductase inhi
Activity improvement of a Kluyveromyces lactis aldo-keto reductase KlAKR via rational design
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Atorvastatin calcium; Rational engineering; Site-saturation mutagenesis; T-butyl 6-cyano-(3R, 5R)-dihydroxyhexanoate
Structural characterization of an aldo-keto reductase (AKR2E5) from the silkworm Bombyx mori
Keywords: آلدو کتو ردوکتاز; Protein crystal structure; Enzyme specificity; NADPH; Lepidoptera; AKR; aldo-keto reductase; DLG; DL-glyceraldehyde; PCR; polymerase chain reaction; RT-PCR; reverse transcriptase PCR; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; TI
Inhibition of aldo-keto reductase family 1 member B10 by unsaturated fatty acids
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; AKR1B10; cis-Unsaturated fatty acids; Cancer; Inhibitory selectivity; AKR; aldo-keto reductase; ALA; α-linolenic acid; ARA; arachidonic acid; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; LA; linoleic acid; ONE; 4-oxo-2-none
Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progestogens 17α,20β-di- and 17α,20β,21α-trihydroxy-4-pregnen-3-one
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; 17OH-P; 17α-hydroxyprogesterone; 17α,20αDiOH-P; 17α,20α-dihydroxy-4-pregnen-3-one; 17α,20βDiOH-P; 17α,20β-dihydroxy-4-pregnen-3-one; 20βOH-RSS; 17α,20α,21α-trihydroxy-4-pregnen-3-one; DOC; 11-deoxycorticosterone; Fab
Cloning, expression and enzymatic characterization of an aldo-keto reductase from Candida albicans XP1463
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Candida albicans; Asymmetric bioreduction; Chiral alcohol;
Cloning and characterization of a NADH-dependent aldo-keto reductase from a newly isolated Kluyveromyces lactis XP1461
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Kluyveromyces lactis; Characterization; Asymmetric bioreduction; Chiral alcohol
New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels
Keywords: آلدو کتو ردوکتاز; β Subunit; K+ channels; Inhibition; DOPAC; Aldo-keto reductase;
Transgenic barley expressing the Arabidopsis AKR4C9 aldo-keto reductase enzyme exhibits enhanced freezing tolerance and regenerative capacity
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; 4-HNE; 4-hydroxynonenal; HPLC-RID; high performance liquid chromatography with refractive index detector; MDA; malondialdehyde; ROS; reactive oxygen species; SOD; superoxide dismutase; WT; wild type; Frost tolerance; Sugar alcoho
Improved o-chlorobenzoylformate bioreduction by stabilizing aldo-keto reductase YtbE with additives
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Enzyme stability; Enzyme inactivation; Inactivation mechanism; Bioprocess enhancement
Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde
Keywords: آلدو کتو ردوکتاز; AFB1; aflatoxin B1; AFG1; aflatoxin G1; AFAR; aflatoxin B1 aldehyde reductase; AKR; aldo-keto reductase; AFBO; AFB1 exo-8,9-epoxide; 2-CBA; 2-carboxybenzaldehyde; SSA; succinic semialdehyde; WT; wide-type; IPTG; isopropyl-β-d-thiogalactoside; HPLC; high
Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds
Keywords: آلدو کتو ردوکتاز; 3HB; 3-hydroxyhexobarbital; 3OB; 3-oxohexobarbital; 3HBD; 3-hydroxyhexobarbital dehydrogenase; AKR; aldo-keto reductase; HSD; hydroxysteroid dehydrogenase; PG; prostaglandin; TBE; 6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione; 4R-TBEH; 6-tert-butyl-2,3-e
Synthesis and structure–activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Inhibitor; Crystal structure; Computer aided drug designAKR, aldo-keto reductase; COX, cyclo-oxygenase; DCM, dichloromethane; DMSO, dimethyl sulfoxide; NADPH, nicotinamide adenine dinucleotide phosphate; NSAID, non-steroidal anti-infl
2,3-Diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17β-hydroxysteroid dehydrogenase (AKR1C3)
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; AKR1C3; Selective inhibitors; 2,3-Diarylpropenoic acids; CancerDMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; ESI, electrospray ionization; HPLC, high-performance liquid chromatography; HRMS, high-resolution mass spectrometry;
Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; 7-HC; 7-hydroxycoumarin; ALDH; aldehyde dehydrogenase; ROS; reactive oxygen species; CSF; cerebrospinal fluid; HNE; 4-hydroxy-trans-2-nonenal; AD; Alzheimer's disease; DCFH/DA; dichlorodihydrofluorescein diacetate; Carbonyl toxic
Formation of a 3,4-diol-1,2-epoxide metabolite of benz[a]anthracene with cytotoxicity and genotoxicity in a human in vitro hepatocyte culture system
Keywords: آلدو کتو ردوکتاز; BA, benz[a]anthracene; BA-3,4-diol-1,2-epoxide, benz[a]anthracene-3,4-diol-1,2-epoxide; CYP, cytochrome P450; AKR, aldo-keto reductase; ROS, reactive oxygen species; B[a]P, benzo[a]pyreneBenz[a]anthracene; Cytochrome P450; Aldo-keto reductase; Benz[a]anth
Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis
Keywords: آلدو کتو ردوکتاز; Aldose reductase-like protein; Aldo-keto reductase; Coenzyme binding; AKR1B14
Vitamin C supplementation lowers urinary levels of 4-hydroperoxy-2-nonenal metabolites in humans
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; ALDH; aldehyde dehydrogenase; BMI; body mass index; DHN; 1,4-dihydroxy-2(E)-nonene; GPx; glutathione peroxidase; GSH; glutathione; GST; glutathione S-transferase; HNA; 4-hydroxy-2(E)-nonenoic acid; HNE; 4-hydroxy-2(E)-nonenal; HP
Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3
Keywords: آلدو کتو ردوکتاز; Dydrogesterone; 20α-Hydroxydydrogesterone; Progesterone; Medroxyprogesterone acetate; 20α-Hydroxyprogesterone; Aldo-keto reductase
Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
Keywords: آلدو کتو ردوکتاز; SDR; short-chain dehydrogenyse/reductase; AKR; aldo-keto reductase; 11β-HSD1; 11β-hydroxysteroid dehydrogenase 1; ANT; anthracycline; DAUN; daunorubicin; DAUNOL; daunorubicinol; ADAUN; aglycone of daunorubicin; ADAUNOL; aglycone of daunorubicinol; DOX;
Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; ALR; aldehyde reductase; AR; aldose reductase; FBS; fetal bovine serum; HNE; 4-hydroxy-2-nonenal; PHPC; (Z)-2-(phenylimino)-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamide; AKR1B10; Aldose reductase-like protein; Aldose redu
Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; 3-Bromo-5-phenylsalicylic acid; Cancer; Drug design; Human 20α-hydroxysteroid dehydrogenase; Human 3α-hydroxysteroid dehydrogenaseHSD, hydroxysteroid dehydrogenase; AKR, aldo-keto reductase; AKR1C1, human 20α-hydroxysteroid dehydrogen
Identification, cloning and characterization of an aldo-keto reductase from Trypanosoma cruzi with quinone oxido-reductase activity
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; BN-PAGE; blue native polyacrylamide gel electrophoresis; 2-DHA; 2-dihydroxyacetone; DMPO; 5,5â²-dimethyl-1-pyrroline N-oxide; ESR; electron spin resonance; 4-NBA; 4-nitrobenzaldehyde; NQ; naphthoquinone; 1,2-NQ; 1,2-naphthoquino
Effect of cytochrome P450 and aldo-keto reductase inhibitors on progesterone inactivation in primary bovine hepatic cell cultures1
Keywords: آلدو کتو ردوکتاز; cytochrome P450; aldo-keto reductase; progesterone decay; hepatic cell isolation;
Cancer biomarker AKR1B10 and carbonyl metabolism
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; AKR1B10; Cancer; Chemotherapy; Inhibitor
Inhibition of aldose reductase by dietary antioxidant curcumin: Mechanism of inhibition, specificity and significance
Keywords: آلدو کتو ردوکتاز; AKR; aldo-keto reductase; ALR1; aldehyde reductase; ALR2, AKR1B1; human aldose reductase; HSIR, AKR1B10; human small intestine reductase; ARI; aldose reductase inhibitor; RBC; red blood cells; Aldo-keto reductase; ALR2; AKR1B10; Curcumin; Sorbitol;
Tyr-51 is the proton donor–acceptor for NAD(H)-dependent interconversion of xylose and xylitol by Candida tenuis xylose reductase (AKR2B5)
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Catalytic mechanism; Brønsted catalysis; Unidirectional chemical rescue; pH study; AKR2B5; Xylose reductaseAKR, aldo-keto reductase; Y51A, mutated xylose reductase from Candida tenuis in which Tyr-51 was substituted by Ala
Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Aldehyde reductase; 20α-Hydroxysteroid dehydrogenase; 3,5-Dichlorosalicylic acid; Inhibitor selectivity; Protein structure; X-ray crystallography; Molecular modelling; Enzyme inhibition
Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Inositol auxotrophy; Oxidative stress; Heat shock sensitivity;
Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity
Keywords: آلدو کتو ردوکتاز; AA; arachidonic acid; AKR; aldo-keto reductase; ALDH; aldehyde dehydrogenase; ALEs; advanced lipoxidation end-product; ARE; antioxidant response element; CBP; CREB-binding protein; CR; caloric restriction; CREB; cAMP-responsive element-binding factor; DBI
Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family
Keywords: آلدو کتو ردوکتاز; Aldo-keto reductase; Steroidogenesis; RealTime PCR; Activity