3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome
Keywords: ARE، عنصر پاسخ دهنده آنتی اکسیدان است; ARE, antioxidant responsive element; BMDM, bone-marrow derived macrophages; CAC, colitis-associated colon cancer; DSRs, damage sensing receptor; DSS, dextran sulfate sodium; GSTs, glutathione S-transferases; HO-1, heme oxygenase 1; IBD, inflammatory bowel