Keywords: Ceramide; C6-ceramide; Colorectal cancer; Integrin; Sphingolipids; Cell migrationCRC, colorectal cancer; C6-ceramide, N-hexanoyl-d-erythro-sphingosine; DH-C6-ceramide, dihydro-C6-ceramide; ATCC, American Type Culture Collection; FBS, fetal bovine serum; D
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Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer
Keywords: C6-ceramide; N-hexanoyl-d-erythrosphingosine; GC; glucosylceramide; GCS; glucosylceramide synthase; SK; sphingosine kinase; S1-P; sphingosine 1-phosphate; PPMP; d-threo-1-phenyl-2-decanoylamino-3-morpholino-propanol; PPPP; 1-phenyl-2-palmitoylamino-3-pyrr
Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics
Keywords: DMT; N-desmethyltamoxifen; AC; acid ceramidase; AML; acute myelogenous leukemia; SphK1; sphingosine kinase 1; S1-P; sphingosine 1-phosphate; GC; glucosylceramide; 4-HPR; fenretinide; GCS; glucosylceramide synthase; P-gp; P-glycoprotein; ATCC; American Typ
Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination
Keywords: Combinatorial ratiometric drug design; C6-ceramide; Nanoparticles; Nucleolin; F3-targeted delivery;
Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53
Keywords: Colorectal cancer; Ceramide; C6-ceramide; Tamoxifen; P-glycoprotein; p53CRC, colorectal cancer; P-gp, P-glycoprotein; GCS, glucosylceramide synthase; GC, glucosylceramide; PARP, poly ADP ribose polymerase; MMP, mitochondrial membrane permeabilization; FBS
P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells
Keywords: Ceramide; C6-ceramide; P-glycoprotein; P-glycoprotein antagonists; Drug resistance; Ovarian cancer
Cytotoxicity and Apoptosis Enhancement in Brain Tumor Cells Upon Coadministration of Paclitaxel and Ceramide in Nanoemulsion Formulations
Keywords: nanoemulsions; paclitaxel; C6-ceramide; U-118 human glioblastoma cells; combination therapy;
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations
Keywords: Mitochondria; Apoptosis; Pore; Sphingolipid; Ceramide; Channel; AIF; apoptosis-inducing factor; C2-ceramide; N-acetyl-d-erythro-sphingosine; C6-ceramide; N-hexanoyl-d-erythro-sphingosine; C16-ceramide; N-hexadecyl-d-erythro-sphingosine; DNP; 2,4-dinitroph