Keywords: Cdk5، کییناز وابسته به سیکلین 5; Cyclin-dependent kinase 5; Hippocampus; Lipopolysaccharide; Systemic inflammation; NeuroinflammationAIF, apoptosis inducing factor; Cdk5, cyclin-dependent kinase 5; COX-2, cyclooxygenase 2; cPLA2, calcium-dependent phospholipase A2; Egr-1, early growth re
مقالات ISI Cdk5، کییناز وابسته به سیکلین 5 (ترجمه نشده)
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Keywords: Cdk5، کییناز وابسته به سیکلین 5; 6-OHDA, 6-hydroxydopamine; ABP, actin binding protein; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; APP, amyloid precursor protein; Aβ, amyloid-β; Cdk5, cyclin-dependent kinase 5; CMT, Charcot-Marie-Tooth disease; CMT2, Charcot-Marie-Tooth
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AD, Alzheimer’s disease; AML, Acute myeloid leukemia; ApoE, Apolipoprotein; ARE/EpRE, Antioxidant/electrophile responsive element; COX-2, Cyclooxygenase-2; cdk5, Cyclin-dependent kinase 5; EAE, Experimental autoimmune encephalomyelitis; ER, Endoplasmic re
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Ataxin-2; Cdk5; SCA2; Phosphorylation; Proteasomal degradation; PolyQALS, amyotrophic lateral sclerosis; Cdk5, cyclin-dependent kinase 5; HD, Huntington's disease; htt, huntingtin; SCA, spinocerebellar ataxia; SDS-PAGE, sodium dodecyl sulfate polyacrylami
The untapped potential of tyrosine-based G protein signaling
Keywords: Cdk5، کییناز وابسته به سیکلین 5; BiFC, bimolecular fluorescence complementation; cAMP, cyclic adenosine monophosphate; CDK5, cyclin-dependent kinase 5; CT, carboxyl terminus; FRET, Förster resonance energy transfer; GAP, GTPase-accelerating protein; GDI, Guanosine nucleotide dissociation
Disruption of neuronal nitric oxide synthase dimerization contributes to the development of Alzheimer’s disease: Involvement of cyclin-dependent kinase 5-mediated phosphorylation of neuronal nitric oxide synthase at Ser293
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Alzheimer’s disease; Neuronal nitric oxide synthase; Dimerization; Cyclin-dependent kinase 5; p25; PhosphorylationAD, Alzheimer’s disease; CDK5, cyclin-dependent kinase 5; NO, nitric oxide; eNOS, endothelial nitric oxide synthase; nNOS, neuronal nitric ox
Clozapine induces chloride channel-4 expression through PKA activation and modulates CDK5 expression in SH-SY5Y and U87 cells
Keywords: Cdk5، کییناز وابسته به سیکلین 5; CDK5, cyclin-dependent kinase 5; CLC-4, chloride channel-4; CREB, cAMP response element-binding protein; NGF, nerve growth factor; PKA, protein kinase AChloride channel-4; Clozapine; Cyclin-dependent kinase 5; SH-SY5Y; U87
Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching
Keywords: Cdk5، کییناز وابسته به سیکلین 5; APC, adenomatous polyposis coli protein; BSA, bovine serum albumin; CDK5, cyclin-dependent kinase 5; DA, dopaminergic; DCC, deleted in colorectal cancer; DCX, doublecortin; DMEM, Dulbecco’s modified Eagle’s medium; DSCAM, Down syndrome cell adhesion molec
hnRNPA2/B1 and nELAV proteins bind to a specific U-rich element in CDK5R1 3′-UTR and oppositely regulate its expression
Keywords: Cdk5، کییناز وابسته به سیکلین 5; ARE, AU-rich element; CDK5, cyclin-dependent kinase 5; CDK5R1, cyclin-dependent kinase 5 regulatory subunit 1; CNS, central nervous system; hnRNP, heterogeneous nuclear ribonucleoprotein; IP, immunoprecipitation; miRNA, microRNA; mRNP, messenger ribonucle
Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/cdk5 pathway proteins
Keywords: Cdk5، کییناز وابسته به سیکلین 5; cdk5, cyclin-dependent kinase 5; DAT, dopamine transporter; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; H2O2, hydrogen peroxide; miRNA, microRNA; MPP, methyl phenyl pyridinium; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PBS
Differential regulation of CDK5 and c-Fos expression by morphine in the brain of Lewis and Fischer 344 rat strains
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AP-1, activator protein-1; CDK5, cyclin-dependent kinase 5; DARPP-32, dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa; DPX, distyrene plasticizer xylene; F344, Fischer 344; LC, locus coeruleus; NAC, nucleus accumbens; NTS, nucleus tractus solitariu
Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice
Keywords: Cdk5، کییناز وابسته به سیکلین 5; 6-OHDA, 6-hydroxydopamine; AIMs, abnormal involuntary movements; ANOVA, analysis of variance; cdk5, cyclin-dependent kinase 5; CS, citrate synthase; DARPP-32, dopamine and cAMP-regulated phosphoprotein 32 kDa; DA, dopamine; EDTA, ethylenediaminetetraaceti
Steroid hormones and BDNF
Keywords: Cdk5، کییناز وابسته به سیکلین 5; BDNF, brain-derived neurotrophic factor; CDK5, cyclin-dependent kinase 5; CNS, central nervous system; DEX, dexamethasone; DG, dentate gyrus; DHEA, dehydroepiandrosterone; EP, estrogen and progesterone; GABA(A), gamma-aminobutyric acid receptor A; GnRH, g
Cyclin-dependent kinase 5 is required for normal cerebellar development
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Cdk5, cyclin-dependent kinase 5; MAP2, microtubule-associated protein 2; EGL, external granule cell layer; IGL, internal granule cell layer; GC, granule cell; PCR, polymerase chain reaction; PFA, paraformaldehyde; PB, phosphate buffer; PBS, phosphate buff
Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Allosterism; Alzheimer; GSK-3 inhibition; Molecular dynamics; Drug designATP, adenosine triphosphate; CK2, casein kinase 2; CDK1, cyclin-dependent kinase 1; CDK5, cyclin-dependent kinase 5; ELISA, enzyme-linked immunosorbent assay; EDTA, ethylene-diamine-
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate
Keywords: Cdk5، کییناز وابسته به سیکلین 5; BSA, bovine serum albumin; cdk5, cyclin-dependent kinase 5; cGMP, cyclic guanosine monophosphate; Cyt c, cytochrome c; DG, dentate gyrus; LDH, lactate dehydrogenase; MCAo, middle cerebral artery occlusion; MDL28170, carbobenzoxy-valinyl-phenyl-alaninal; M
Brain-derived neurotrophic factor and glucocorticoids: Reciprocal influence on the central nervous system
Keywords: Cdk5، کییناز وابسته به سیکلین 5; ACTH, adrenocorticotropic hormone; AVP, arginin-vasopressin; BDNF, brain-derived neurotrophic factor; CDK5, cyclin-dependent kinase 5; CMS, chronic mild stress; CNS, central nervous system; CRH, corticotropin-releasing hormone; CRS, chronic restraint stre
Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AP-1, activator protein 1; BSA, bovine serum albumin; cAMP, cyclic adenosine monophosphate; CDK5, cyclin-dependent kinase 5; cGMP, cyclic guanosine monophosphate; DBD, DNA-binding domain; ERK1/2, extracellular signal-regulated kinases 1/2; GR, human gluco
The role of Cdk5 in cognition and neuropsychiatric and neurological pathology
Keywords: Cdk5، کییناز وابسته به سیکلین 5; ADBE, activity-dependent bulk endocytosis; CaMKII, Ca2+/calmodulin-dependent protein kinase; CDE, clathrin-dependent endocytosis; Cdk5, cyclin-dependent kinase 5; GSK3, glycogen synthase kinase 3; HDAC1, histone deacetylase 1; LTP, long-term potentiation;
Elevation of p-NR2AS1232 by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model
Keywords: Cdk5، کییناز وابسته به سیکلین 5; BCA, bicinchoninic acid; Bcl-2, B-cell lymphoma protein 2; Cdk5, cyclin-dependent kinase 5; Co-IP, co-immunoprecipitation; CNS, central nervous system; CTB, cholera toxin B subunit; DMSO, dimethyl sulfoxide; GCL, ganglion cell layer; Glu, glutamate; HRP,
Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AD, Alzheimer's disease; AKAP, A-kinase anchoring protein; CaMKII, calcium/calmodulin-dependent protein kinase II; CK2, casein kinase II; Cdk5, cyclin-dependent kinase 5; CREB, cyclic-AMP response element binding protein; DAPK, death-associated protein ki
An okadaic acid-induced model of tauopathy and cognitive deficiency
Keywords: Cdk5، کییناز وابسته به سیکلین 5; OA, okadaic acid; cdk5, cyclin-dependent kinase 5; GSK-3, glycogen synthase kinase-3; NFTs, neurofibrillary tangleAlzheimer's disease; Tauopathy; Cognitive deficiency; Tau phosphorylation; Neurofibrillary tangles; Oxidative stress
Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AD, Alzheimer's disease; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; ApoE, apolipoprotein E; APP, amyloid precursor protein; CA, cornu ammonis (Ammon's horn); Cdk5, cyclin-dependent kinase 5; CNR, cadherin-related neuronal receptor; C
Effects of electroconvulsive shock on the phosphorylation of DARPP-32 in rat striatum
Keywords: Cdk5، کییناز وابسته به سیکلین 5; CDK5, cyclin-dependent kinase 5; DARPP-32, Dopamine- and cAMP-regulated phosphoprotein with molecular weight 32-kDa; ECS, Electroconvulsive shock; ECT, Electroconvulsive therapy; OA, Okadaic acid; pNPP, p-nitrophenyl phosphate; PKA, protein kinase A; PP1,
Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells
Keywords: Cdk5، کییناز وابسته به سیکلین 5; cleaved caspase-3; Alzheimer's disease; apoptosis; Tet-off; hippocampal neurons; neuro-2a cell lineAD, Alzheimer disease; Aβ, β-amyloid peptide; Cdk5, cyclin-dependent kinase 5; CFP, cyan fluorescent protein; CIP, cyclin-dependent kinase 5 inhibitor pepti
Biochemical characterization of tau protein and its associated syndapin 1 and protein kinase Cɛ for their functional regulation in rat brain
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AD, Alzheimer's disease; CDK5, cyclin-dependent kinase 5; CH-3S, cholesterol-3-sulfate; CK1, casein kinase 1; DTT, dithiothreitol; GSK-3β, glycogen synthase kinase-3β; NFT, neurofibrillary tangle; nPKC, novel Ca2+-independent and diacylglycerol-dependent
FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AD, Alzheimer's disease; CM, cypermethrane; Cdk5, cyclin-dependent kinase 5; FTDP-17, frontotemporal dementia and Parkinsonism linked to chromosome 17; GSK3β, glycogen synthase kinase 3β; NFT, neurofibrillary tangle; PHF, paired helical filament; PP1, pro
CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5
Keywords: Cdk5، کییناز وابسته به سیکلین 5; CDK5, cyclin-dependent kinase 5; dn, dominant negative; PCR, polymerase chain reactionp35; E-cadherin; CDK5; Lysosomal degradation
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Mouse; Opioid; Tolerance; Dependence; NeuroadaptationAmg, amygdala; BST, bed nucleus of the stria terminalis; CPu, caudate-putamen; cdk5, cyclin-dependent kinase 5; MOR, mu opioid receptor; NAc, nucleus accumbens; PAG, periaqueductal gray; PfC, prefrontal
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
Keywords: Cdk5، کییناز وابسته به سیکلین 5; ALS, amyotrophic lateral sclerosis; BMT, bone marrow transplant; CCS, copper chaperone for SOD1; CNR1, cannabinoid receptor 1; CNS, central nervous system; COX1, cyclooxygenase 1; Cdk5, cyclin-dependent kinase 5; DS, Down syndrome; EAAT2, excitatory amino
Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
Keywords: Cdk5، کییناز وابسته به سیکلین 5; AMP, adenosine 3′:5′-monophosphate; AMPA, α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate; CDK5, cyclin-dependent kinase 5; DARPP-32, Dopamine and cyclic; AMP-regulated phosphoprotein, relative molecular mass 32,000; DLPFC, dorsolateral prefrontal corte
Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Cdk1, cyclin-dependent kinase 1; Cdk5, cyclin-dependent kinase 5; CF, cleavage furrow; CK1/2, casein kinase 1/2; ERK1/2, extracellular signal-regulated kinase 1/2; GFAP, glial fibrillary acidic protein; IFs, intermediate filaments; MAPK1/2, mitogen-activa
The making of successful axonal regeneration: Genes, molecules and signal transduction pathways
Keywords: Cdk5، کییناز وابسته به سیکلین 5; Akt, Protein kinase B; BDNF, Brain derived neurotrophic factor; cAMP, cyclic adenosine monophosphate; CAP23, Cytoskeleton-associated protein, 23 kDa; cdc42, Cell division cycle 42; cdk5, Cyclin-dependent kinase 5; CGRP, Calcitonin gene-related peptide; CN