Keywords: CDR، منطقه تعریف کننده مکمل; TLR4, Toll-like receptor 4; PDB, Protein Data Bank; cyno, cynomolgus monkey; LPS, lipopolysaccharide; CDR, complementarity-determining region; BLI, Bio-Layer Interferometry; SPR, surface plasmon resonance; PBS, phosphate-buffered saline; BSA, bovine serum
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Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; Ig, immunoglobulin; IGLV, immunoglobulin lambda variable gene; IGLJ, immunoglobulin lambda joining gene; IGLC, immunoglobulin lambda constant chain gene; ORF, open reading frame; MLN, mesenteric lymph node; RACE, r
Keywords: CDR، منطقه تعریف کننده مکمل; APC, antigen-presenting cell; CT, cholera toxin; CDR, complementarity-determining region; CB, cord blood; DC, dendritic cell; DN, double negative; DP, double positive; ETEC, enterotoxigenic Escherichia coli; GIT, gastrointestinal tract; LT, heat-labile en
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; CV, coefficient of variation; DPP4, dipeptidyl peptidase 4; LLOD, lower limit of detection; ELISA, enzyme linked immunosorbent assay; GLP, glucagon-like peptide; Ig, immunoglobulin; LC-MS, liquid chromatography-mas
Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin
Keywords: CDR، منطقه تعریف کننده مکمل; FAK, focal adhesion kinase; FAT, focal adhesion targeting; sAB, synthetic antibody; CDR, complementarity-determining region; MBP, maltose binding protein; SPR, surface plasmon resonance; ASU, asymmetric unit; PEG, polyethylene glycol; PMP, paramagnetic pa
The analysis of VH and VL genes repertoires of Fab library built from peripheral B cells of human rabies virus vaccinated donors
Keywords: CDR، منطقه تعریف کننده مکمل; Fab, fragment antigen binding; RV, rabies virus; VH, variable heavy chain; VL, variable light chain; D, diversity; J, joining; CDR, complementarity-determining region; FR, framework regionAnti-rabies virus immune repertoire IGHV and IGLV sequencing; Somat
A Fibrin-Specific Monoclonal Antibody from a Designed Phage Display Library Inhibits Clot Formation and Localizes to Tumors In Vivo
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; SIP, small immune protein; CHO, Chinese hamster ovary; PEI, polyethyleneimine; RT, room temperaturefibrin; antibody phage display; tumor neovasculature; vascular targeting
Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation
Keywords: CDR، منطقه تعریف کننده مکمل; BFA, Brefeldin A; CB, crystalline body; CDR, complementarity-determining region; CH1, heavy chain constant domain-1; CH2, heavy chain constant domain-2; CH3, heavy chain constant domain-3; CL, light chain constant domain; CHO, Chinese hamster ovary; DIC,
CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; PDB, Protein Data Bank; TDRD3, tudor-domain-containing protein 3antibody library; phage display; protein engineering; affinity; specificity
Functional aspects of fish lymphocytes
Keywords: CDR، منطقه تعریف کننده مکمل; CMC, cell-mediated cytotoxicity; CDR, complementarity-determining region; ConA, concanavalin A; CTL, cytotoxic T lymphocytes; HEL, hen egg lysozyme; Ig, immunoglobulin; ISH, in situ hybridization; ITAM, immunoreceptor tyrosine-based activation motif; ITIM
Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab
Keywords: CDR، منطقه تعریف کننده مکمل; IL-13, interleukin 13; CDR, complementarity-determining region; ICS, inhaled corticosteroids; PBS, phosphate-buffered saline; PDB, Protein Data Bank; SPR, surface plasmon resonancechronic asthma; allergy; paratope alanine scan; IL-4Rα competition
Developmental progression of equine immunoglobulin heavy chain variable region diversity
Keywords: CDR، منطقه تعریف کننده مکمل; Ig, immunoglobulin; IGHV, immunoglobulin heavy chain variable gene; IGHD, immunoglobulin heavy chain diversity gene; IGHJ, immunoglobulin heavy chain joining gene; CDR, complementarity-determining region; RT-PCR, reverse transcription polymerase chain rea
The three complementarity-determining region-like loops in the second extracellular domain of human Fc alpha/mu receptor contribute to its binding of IgA and IgM
Keywords: CDR، منطقه تعریف کننده مکمل; C region, constant region of Ig; CDR, complementarity-determining region; D1/2, domain 1/2; EC, extracellular domain; FITC, fluorescein isothiocyanate; hFcα/μR, human Fc alpha/mu receptor; HRP, horseradish peroxidase; mFcα/μR, murine Fc alpha/mu receptor;
Analytical characterization of biosimilar antibodies and Fc-fusion proteins
Keywords: CDR، منطقه تعریف کننده مکمل; ADCC, Antibody-dependent cell-mediated cytotoxicity; Ala, Alanine; Asn, Asparagine; CDC, Complement-dependent cytotoxicity; CDR, Complementarity-determining region; CE, Capillary electrophoresis; CE-LIF, Capillary electrophoresis with laser-induced fluore
Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease
Keywords: CDR، منطقه تعریف کننده مکمل; AD, Alzheimer's disease; Aβ, β-amyloid; APP, amyloid precursor protein; CNS, central nervous system; hAPP, human APP; CSF, cerebrospinal fluid; PDB, Protein Data Bank; CDR, complementarity-determining region; PBS, phosphate-buffered saline; BSA, bovine se
Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure
Keywords: CDR، منطقه تعریف کننده مکمل; polyQ, polyglutamine; htt, huntingtin; wt, wild type; HA, hemagglutinin; IP, immunoprecipitation; PDB, Protein Data Bank; CDR, complementarity-determining region; SAXS, small-angle X-ray scattering; Cer, Cerulean fluorescent protein; MBP, maltose binding
Altered T-cell receptor signaling in the pathogenesis of allergic disease
Keywords: CDR، منطقه تعریف کننده مکمل; T-cell receptor; TH2; atopyCarma1, Caspase recruitment domain-containing membrane-associated guanylate kinase; CDR, Complementarity-determining region; ERK, Extracellular signal-regulated kinase; FOXP3, Forkhead box protein 3; LAT, Linker of activated T c
Structural and functional characterization of a human IgG monoclonal antiphospholipid antibody
Keywords: CDR، منطقه تعریف کننده مکمل; Ab, antibody; aPL, antiphospholipid antibody; aCL, anti-cardiolipin antibodyL; APS, antiphospholipid syndrome; β2GPI, β2-glycoprotein I; CDR, complementarity-determining region; CL, cardiolipin; DC, dendritic cell; LPS, lipopolysaccharide; mAb, monoclonal
Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; IGHV, immunoglobulin heavy-chain variable region; VH, variable region; DH, diversity region; JH, joining region; FR, framework region; cDNA, complementary DNA; FFPE, formalin-fixed and paraffin-embedded; MRD, myelo
Crystal Structure of Human Prostate-Specific Antigen in a Sandwich Antibody Complex
Keywords: CDR، منطقه تعریف کننده مکمل; PSA, prostate-specific antigen; PCa, prostate cancer; mAb, monoclonal antibody; KLK, human kallikrein-related peptidase; Neu5Ac, N-acetylneuraminic acid; GlcNAc, N-acetyl glucosamine; Fuc, fucose; CDR, complementarity-determining region; PDB, Protein Data
Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; cLPA, cyclic LPA; IgG, immunoglobulin G; LPA, lysophosphatidic acid; PEG, polyethylene glycol; PGE, triethylene glycol; S1P, sphingosine-1-phosphate; PBS, phosphate-buffered salineantibodies; cancer therapies; lipi
Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope
Keywords: CDR، منطقه تعریف کننده مکمل; IL, interleukin; CDR, complementarity-determining region; VH, variable heavy; VL, variable light; hIL-15, human IL-15; scFv, single-chain variable fragment; SPR, surface plasmon resonance; PDB, Protein Data Bank; RU, relative unitsprotein engineering; pha
Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism
Keywords: CDR، منطقه تعریف کننده مکمل; TCR, T-cell receptor; CDR, complementarity-determining region; MHC, major histocompatibility complex; pMHC, peptide/MHC; HLA-A2, HLA-A⁎0201; MD, molecular dynamics; TRFA, time-resolved fluorescence anisotropy; TCSPC, time-correlated single-photon counting
Synthetic Antibodies Designed on Natural Sequence Landscapes
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; TRIM, trinucleotide phosphoramidite; SF-Fab, synthetic fitness Fab; HRP, horseradish peroxidase; IMGT, ImMunoGeneTics; RT, room temperature; PBS, phosphate-buffered salineantibody repertoire; antibody diversity; sy
Structure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing Epitope
Keywords: CDR، منطقه تعریف کننده مکمل; HIV-1, human immunodeficiency virus type 1; Env, envelope; CDR, complementarity-determining region; MPER, membrane-proximal external region; WT, wild type; IL, interleukin; mAb, monoclonal antibody; bNAb, broadly neutralizing antibody; PDB, Protein Data B
HuCAL PLATINUM, a Synthetic Fab Library Optimized for Sequence Diversity and Superior Performance in Mammalian Expression Systems
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; TRIM, trinucleotide mutagenesishuman combinatorial antibody libraries; HuCAL PLATINUM; CDR-H3 design; trinucleotide mutagenesis; antibody expression
In Vitro Affinity Maturation of an Anti-PSA Antibody for Prostate Cancer Diagnostic Assay
Keywords: CDR، منطقه تعریف کننده مکمل; PSA, prostate-specific antigen; scFv, single-chain variable fragment; CDR, complementarity-determining region; BPH, benign prostatic hyperplasia; fPSA, free PSA; tPSA, total PSA; aPSA, activatable PSA; mAb, monoclonal antibody; SHM, somatic hypermutation;
A New Clustering of Antibody CDR Loop Conformations
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; VH, heavy-chain variable; VL, light-chain variable; PDB, Protein Data Bankantibody structure; canonical loop conformations; affinity propagation
A novel method for quantitative measurement of a therapeutic monoclonal antibody in the presence of its target protein using enzymatic digestion
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; ELISA, enzyme linked immunosorbent assay; mAb, monoclonal antibody; PK, pharmacokinetic; QC, quality controlELISA; Monoclonal antibody; Pharmacokinetic; Target interference; Enzymatic digestion
Investigation of degradation processes in IgG1 monoclonal antibodies by limited proteolysis coupled with weak cation-exchange HPLC
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; CE, capillary electrophoresis; CEX, cation-exchange chromatography; CEX52, cation-exchange chromatography at pH 5.2; CEX68, cation-exchange chromatography at pH 6.8; EDTA, ethylenediaminetetraacetic acid; Fab, frag
Humanization of an agonistic anti-death receptor 4 single chain variable fragment antibody and avidity-mediated enhancement of its cell death-inducing activity
Keywords: CDR، منطقه تعریف کننده مکمل; mAb, monoclonal antibody; scFv, single chain variable fragment; Fab, antigen binding fragment; CDR, complementarity-determining region; FR, framework; DISC, death-inducing signaling complexDeath receptor 4; Agonistic antibody; Humanization; Apoptotic cell
Surrobodies with Functional Tails
Keywords: CDR، منطقه تعریف کننده مکمل; Cdr, complementarity-determining region; SLC, surrogate light chain; scFv, single-chain variable fragment; SEC, size-exclusion chromatography; HA, hemagglutinin; HGF, hepatocyte growth factor; PBS, phosphate-buffered saline; HRP, horseradish peroxidase; C
Dissecting the Alternatively Folded State of the Antibody Fab Fragment
Keywords: CDR، منطقه تعریف کننده مکمل; Fab, fragment antigen binding; AFS, alternatively folded state; FUV, far-UV; CDR, complementarity-determining region; HIV-1, human immunodeficiency virus-1; TCEP, tris(2-carboxyethyl)phosphine; NUV, near-UV; ANS, 8-anilino-1-naphthalene sulfonic acidalter
Coevolution of Antibody Stability and Vκ CDR-L3 Canonical Structure
Keywords: CDR، منطقه تعریف کننده مکمل; mAB, monoclonal antibody; Fv, variable domains; Fab, antigen-binding fragment; VL, light chain variable; VH, heavy chain variable domain; CDR, complementarity-determining region; CDR-L1, CDR-L2 and CDR-L3, first, second and third hypervariable loop of VL,
A Single Mutation at the Sheet Switch Region Results in Conformational Changes Favoring λ6 Light-Chain Fibrillogenesis
Keywords: CDR، منطقه تعریف کننده مکمل; ASU, asymmetric unit; BJ, Bence–Jones; CDR, complementarity-determining region; FR, framework region; LC, light chain; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; ThT, thioflavin T; VL, variable region of the light chain; WT, wild type
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding Region
Keywords: CDR، منطقه تعریف کننده مکمل; BoNT, botulinum neurotoxin; BoNT/A, botulinum neurotoxin serotype A; BoNT/A Lc, botulinum neurotoxin serotype A light chain residues 1–448; BoNT/A Lc425, truncated BoNT/A Lc containing residues 1–425; CDR, complementarity-determining region; FACS, fluores
Structure of the Complex between HER2 and an Antibody Paratope Formed by Side Chains from Tryptophan and Serine
Keywords: CDR، منطقه تعریف کننده مکمل; Fab, antigen-binding fragment; RTK, receptor tyrosine kinase; EGFR, epidermal growth factor receptor; ECD, extracellular domain; SAXS, small-angle X-ray scattering; CDR, complementarity-determining region; NSD, normalized spatial discrepancy; HRG, heregul
Stability and CDR Composition Biases Enrich Binder Functionality Landscapes
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; EGFR, epidermal growth factor receptor; FcγR, Fcγ receptor; Fn3, tenth type III domain of human fibronectin; HA, hemagglutinin; HSA, human serum albumin; mIgG, mouse immunoglobulin G; PBSA, phosphate-buffered salin
Human Framework Adaptation of a Mouse Anti-Human IL-13 Antibody
Keywords: CDR، منطقه تعریف کننده مکمل; HFA, human framework adaptation; HFS, human framework selection; SDRO, specificity-determining residue optimization; FR, framework region; HACA, human anti-chimeric antibody; CDR, complementarity-determining region; wt, wild type; PDB, Protein Data Bank;
Vaccination with autoreactive CD4+Th1 clones in lupus-prone MRL/Mp-Faslpr/lpr mice
Keywords: CDR، منطقه تعریف کننده مکمل; T cell vaccination; anti-dsDNA antibodies; Lupus nephritisMRL/lpr, MRL/Mp-Faslpr/lpr; SLE, systemic lupus erythematosus; ICs, immune complexes; U1RNP, U1 ribonucleoprotein; APCs, antigen presenting cells; CDR, complementarity-determining region; TCV, T ce
Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous VH Genes
Keywords: CDR، منطقه تعریف کننده مکمل; TT, tetanus toxoid; VH, variable immunoglobulin heavy chain; VL, variable immunoglobulin light chain; CDR, complementarity-determining region; HCDR3, CDR3 of the H chain; RV, rabies virus; WNV, West Nile virus; SPR, surface plasmon resonance; IgG, immunog
Structural Insights into Antibody Recognition of Mycobacterial Polysaccharides
Keywords: CDR، منطقه تعریف کننده مکمل; Araf, d-arabinofuranose; CDR, complementarity-determining region; LAM, lipoarabinomannan; STD, saturation transfer difference; VH, variable region of the heavy chain; VL, variable region of the light chainlipoarabinomannan; carbohydrate–antibody complex;
Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells
Keywords: CDR، منطقه تعریف کننده مکمل; NAWM, normal appearing white matter; MS, multiple sclerosis; CNS, central nervous system; TCR, T-cell receptor; CDR, complementarity-determining region; RORC, retinoic acid-related orphan nuclear hormone receptor C; PBMC, peripheral blood mononuclear cell
Energy-Based Analysis and Prediction of the Orientation between Light- and Heavy-Chain Antibody Variable Domains
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; PDB, Protein Data Bank; MSA, multiple sequence alignment; PLOP, Protein Local Optimization Programantibody; domain orientation; molecular modeling; homology modeling
The Folding Pathway of the Antibody VL Domain
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; GdmCl, guanidinium chloride; PBS, phosphate-buffered saline; AFM, atomic force microscopy; PPIase, peptidyl prolyl cis–trans isomerase; β2m, β2-microglobulin; EDTA, ethylenediaminetetraacetic acidprotein folding; p
Remarkable selective glycosylation of the immunoglobulin variable region in follicular lymphoma
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; Cκ, constant kappa region; CLL, chronic lymphocytic leukaemia; Endo H, endoglycosidase H; FL, follicular lymphoma; GC, germinal center; GL, germline; Ig, immunoglobulin; PCNSL, primary CNS lymphoma; PNGase F, pepti
Functional Intracellular Antibody Fragments Do Not Require Invariant Intra-domain Disulfide Bonds
Keywords: CDR، منطقه تعریف کننده مکمل; IAC, intracellular antibody capture; scFv, single-chain Fv; VH, variable domain of heavy chain; VL, variable domain of light chain; Fv, variable-domain fragment; CDR, complementarity-determining region; BLI, bioluminescence imaging; PEG, polyethylene glyc
Structural Insight into the Specific Interaction between Murine SHPS-1/SIRPα and Its Ligand CD47
Keywords: CDR، منطقه تعریف کننده مکمل; SHPS-1, SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1; Ig, immunoglobulin; SIRP, signal regulatory protein; mSHPS-1, murine SHPS-1; CDR, complementarity-determining region; ITIM, immunoreceptor tyrosine-based inhibition motif;
The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies
Keywords: CDR، منطقه تعریف کننده مکمل; CDR, complementarity-determining region; CDR-Hn, heavy-chain CDR 1, 2 or 3 (where n = 1, 2, or 3); CDR-L3, light-chain CDR3; Fab, antigen-binding fragment; HER2, epidermal growth factor receptor 2; PBS, phosphate-buffered saline; VEGF, vascular endothelia
Non-canonical Binding of an Antibody Resembling a Naïve B Cell Receptor Immunoglobulin to Hepatitis B Virus Capsids
Keywords: CDR، منطقه تعریف کننده مکمل; virus-host interaction; antigen–antibody interaction; cryo-electron microscopy; B cell receptor; HBVHBV, hepatitis B virus; HBcAg, core antigen; FR1, framework region 1; CDR, complementarity-determining region; Fab, antibody fragment; mAb, monoclonal anti