Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells
Keywords: سیگنالینگ سلولی; β-catenin; Cell signaling; Glioma stem cell; Tumorigenicity; Wnt
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Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis
Keywords: سیگنالینگ سلولی; cell signaling; distal convoluted tubule; mineral metabolism; potassium channels; thiazide-sensitive NaCl cotransporter;
In vivo veritas, the next frontier for functionally selective GPCR ligands
Keywords: سیگنالینگ سلولی; GPCR, G protein coupled receptors; βArr1, beta-arrestin 1; βArr2, beta arrestin 2; D2R, D2 dopamine receptor; GSK3, glycogen synthase kinase 3G protein coupled receptor; Functional selectivity; Animal models; Beta-arrestin; Cell signaling
MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM–integrin–Notch signaling axis
Keywords: سیگنالینگ سلولی; MAGP2, Microfibril associated glycoprotein 2; N1ICD, Notch1 intracellular domain; ECM, Extracellular matrix; HMEC, Human microvascular endothelial cells.Extracellular matrix; Cell signaling; Notch; Integrin
The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells
Keywords: سیگنالینگ سلولی; Protein kinase B; PDPK1; AKT inhibitor; Cancer treatment; Cell signaling;
MicroRNA let-7d is a target of cannabinoid CB1 receptor and controls cannabinoid signaling
Keywords: سیگنالینگ سلولی; Cannabinoid; CB1 receptor; microRNA; Cell signaling; Synaptic transmission;
Kinetics characterization of c-Src binding to lipid membranes: Switching from labile to persistent binding
Keywords: سیگنالینگ سلولی; c-Src; Surface plasmon resonance; Myristoylated proteins; Intrinsically disordered proteins (IDP); Protein dimerization on membranes; Antibody capture; SH4 domains; Cell signaling; c-Src trafficking
Resveratrol improves the anticancer effects of doxorubicin in vitro and in vivo models: A mechanistic insight
Keywords: سیگنالینگ سلولی; Breast cancer; Resveratrol; Cell signaling; Doxorubicin; Cytotoxicity; Ehrlich ascitic carcinoma; BCL-2; (B-cell lymphoma-2); COX-2; cyclooxygenase-2; DCFDA; 2',7'-dichlorofluorescin diacetate; DOX; doxorubicin; EAC; Ehrlich ascites carcinoma; IC50; h
The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains
Keywords: سیگنالینگ سلولی; LDL Receptor-related Protein-1 (LRP1); Lipid rafts; Cell signaling; Neurite outgrowth; Plasma membrane; Tissue plasminogen activator (tPA); Endocytosis;
Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1–7)
Keywords: سیگنالینگ سلولی; Angiotensin-(1-7); Antibody microarray; Cell signaling; Endothelium; Renin-angiotensin system
Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia
Keywords: سیگنالینگ سلولی; l-DOPA; Dyskinesia; Striatum; Cholinergic interneurons (TANs); Acetylcholine; Glutamate; Vesicular acetylcholine transporter (VAChT); Vesicular glutamate transporter type 3 (VGLUT3); Cell signaling;
Controversies and research agenda in nephropathic cystinosis: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference
Keywords: سیگنالینگ سلولی; biomarker; cell signaling; chronic kidney disease; cystinosin; end-stage kidney disease; rare kidney diseases;
Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract
Keywords: سیگنالینگ سلولی; cell signaling; diabetes; pyelonephritis; urology;
A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart
Keywords: سیگنالینگ سلولی; alpha-1-adrenergic; cell signaling; human modelsAb, antibody; AR, adrenergic receptor; ATP, adenosine triphosphate; BDM, 2,3-butanedione monoxime; β-MyHC, beta-myosin heavy chain; EC50, half-maximal effective concentration; GFP, green fluorescent protein;
The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion
Keywords: سیگنالینگ سلولی; Mammalian cells; Gene expression; Cell signaling; Breast cancer; RNA role; DMEM; Dulbecco's modified eagle media; EGF; epidermal growth factor; ECL; enhanced chemiluminescence; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transit
Repression of CMIP transcription by WT1 is relevant to podocyte health
Keywords: سیگنالینگ سلولی; cell signaling; gene expression; kidney development; nephrotic syndrome; podocyte; transcription regulation;
The chloride intracellular channel 5A stimulates podocyte Rac1, protecting against hypertension-induced glomerular injury
Keywords: سیگنالینگ سلولی; albuminuria; cell signaling; chronic kidney disease; glomerulus; hyperfiltration; podocyte;
Context-dependent roles for lymphotoxin-β receptor signaling in cancer development
Keywords: سیگنالینگ سلولی; Lymphotoxin-β receptor; Cell signaling; Lymphotoxin; LIGHT; Oncogenesis; Tumor microenvironment;
Inflammatory intracellular pathways activated by electronegative LDL in monocytes
Keywords: سیگنالینگ سلولی; AP-1; activator protein 1; CREB; cAMP response element-binding; ERK; extracellular signal-regulated kinase; FPLC; fast protein liquid chromatography; IL; interleukin; JNK; c-jun N-terminal kinase; LDL(+); electropositive LDL; LDL(â); electronegative LDL
Uroguanylin modulates (Na+Â +Â K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways
Keywords: سیگنالینگ سلولی; UGN; uroguanylin; PT; proximal tubule; GFR; glomerular flow rate; NHE3; Na+/H+ exchanger isoform 3; PKA; protein kinase A; PKG; protein kinase G; Gi; inhibitory G protein; PKB; protein kinase B; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1;
Calcium-sensing-receptor (CaSR) controls IL-6 secretion in metastatic breast cancer MDA-MB-231Â cells by a dual mechanism revealed by agonist and inverse-agonist modulators
Keywords: سیگنالینگ سلولی; CaSR; IL-6-secretion; GPCR; Cell signaling; Breast cancer; Traffic;
Insights into the regulation of the MXR response in haemocytes of the Mediterranean mussel (Mytilus galloprovincialis)
Keywords: سیگنالینگ سلولی; Haemocyte physiology; ABC transporter; Cell signaling; Serotonergic signaling; Adrenergic signaling; ABCB transcription; ABCC transcription; P-glycoprotein; Multidrug resistance-related protein; Marine mussels;
Quinolinic acid neurotoxicity: Differential roles of astrocytes and microglia via FGF-2-mediated signaling in redox-linked cytoskeletal changes
Keywords: سیگنالینگ سلولی; Cell signaling; Cytoskeleton; FGF-2; Gap junction; Glial cell; Quinolinic acid;
Nrf2 mediates redox adaptations to exercise
Keywords: سیگنالینگ سلولی; Acute exercise; Regular exercise; Phase II enzymes; Reactive oxygen species; Cell signaling; NFE2L2; HO-1; SOD;
Microglia in Alzheimer's disease: A multifaceted relationship
Keywords: سیگنالینگ سلولی; Microglia; Innate immunity; Alzheimer's disease; Phagocytosis; Neuroinflammation; Cell signaling;
Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning
Keywords: سیگنالینگ سلولی; Learning; Memory; Cell signaling; Fear conditioning; Hippocampus;
SILAC-based quantification of changes in protein tyrosine phosphorylation induced by Interleukin-2 (IL-2) and IL-15 in T-lymphocytes
Keywords: سیگنالینگ سلولی; SILAC; Interleukin; Cell signaling; Phosphotyrosine; T-lymphocytes
Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death
Keywords: سیگنالینگ سلولی; Insulin; Cell signaling; Ischemia; Heart; Cell death;
Sirtuin and metabolic kidney disease
Keywords: سیگنالینگ سلولی; cell signaling; chronic kidney disease; diabetic nephropathy; mitochondria; podocyte; proximal tubule;
3D surface topology guides stem cell adhesion and differentiation
Keywords: سیگنالینگ سلولی; Surface topology; Osteogenesis; Stem cell; Cell signaling;
Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid
Keywords: سیگنالینگ سلولی; Apolipoproteins; Cell signaling; Dyslipidemias; Sterol regulatory element binding proteins; Triglyceride metabolism; Very low density lipoprotein
HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression
Keywords: سیگنالینگ سلولی; HTLV; Tax; IKKε; TBK1; IFN; IRF3; Cell signaling;
Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent
Keywords: سیگنالینگ سلولی; PI-3 kinase; Chondrocyte; Cell signaling; Matrix metalloproteinase-13;
Functional roles of HIV-1 Vpu and CD74: Details and implications of the Vpu-CD74 interaction
Keywords: سیگنالینگ سلولی; AGTR1; angiotensin II type 1 receptor; β-TrCP; β-transducin repeat-containing protein; CD74-ICD; CD74 intracellular domain; CLIP; class-II-associated Ii-chain peptide; ER; endoplasmic reticulum; ERK-1/2; p44/p42 extracellular-signal-regulated kinase fam
Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors
Keywords: سیگنالینگ سلولی; Cell signaling; Transmembrane receptors; Signal to noise; FGFR; MET receptor;
Activation of signal transducer and activator of transcription 5 (STAT5) is linked to β1-integrin protein abundance in unilaterally milked bovine mammary glands
Keywords: سیگنالینگ سلولی; milking frequency; mammary; milk synthesis; cell signaling;
The roles of Wnt signaling modulators Dickkopf-1 (Dkk1) and Dickkopf-2 (Dkk2) and cell maturation state in osteogenesis on microstructured titanium surfaces
Keywords: سیگنالینگ سلولی; Osseointegration; Titanium; Osteoblast; Mesenchymal stem cell; Surface roughness; Cell signaling
Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine
Keywords: سیگنالینگ سلولی; Cocaine; mTOR; Cell signaling; Nucleus accumbens; Dopamine; Raptor;
Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation
Keywords: سیگنالینگ سلولی; Selenium; Seleno-organic compound; Antioxidants; Thiols; Glutathione peroxidase; Ebselen; Diphenyl diselenide; PhSeZnCl; Glutathione S-transferase Pi; Peroxiredoxins; Cell signaling;
Association of p75NTR and α9β1 integrin modulates NGF-dependent cellular responses
Keywords: سیگنالینگ سلولی; Integrin α9β1; p75NTR; Receptor complex; Cell adhesion; Cell signaling;
Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease
Keywords: سیگنالینگ سلولی; Keywords; ADPKD; vasopressin; chronic kidney disease; cell signaling;
Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growth
Keywords: سیگنالینگ سلولی; Spiral ganglion neuron; Surface topography; Micropatterning; Photopolymerization; Nerve guide; Cell signaling;
Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
Keywords: سیگنالینگ سلولی; cell signaling; fibroblast; fibrosis;
Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ
Keywords: سیگنالینگ سلولی; cell signaling; hypoxia; inflammation; proximal tubule;
EGF stimulates the activation of EGF receptors and the selective activation of major signaling pathways during mitosis
Keywords: سیگنالینگ سلولی; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; PLC-γ1; phospholipase C-γ1; PI3K; phosphoinositide 3-kinase; GAP; GTPase-activating protein; ERKs; extracellular signal-regulated kinases; MEK; mitogen-activated protein kinase kinase
Multiple pro-apoptotic targets of abietane diterpenoids from Salvia species
Keywords: سیگنالینگ سلولی; Tanshinone IIA; Salvinorin A; Carnosol; Cell signaling; NF-κB
Gestational marginal zinc deficiency impaired fetal neural progenitor cell proliferation by disrupting the ERK1/2 signaling pathway
Keywords: سیگنالینگ سلولی; ERK1/2; extracellular signal-regulated kinases 1/2; NPC; neural progenitor cell; E; embryonic day; MEK1/2; mitogen-activated ERK1/2 kinases 1/2; PP2A; protein phosphatase 2A; NGF; nerve growth factor; BDNF; brain-derived neurotrophic factor; BrdU; bromode
G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization
Keywords: سیگنالینگ سلولی; AcNPV; Autographa californica nuclear polyhedrosis virus; AMF; 30 μM AlCl3, 50 mM MgCl2 and 10 mM NaF; Biotin-HPDP; N-[6-(biotinamido)hexyl]-3â²-(2â²-pyridyldithio) propionamide; C12E10; polyoxyethylene 10-lauryl ether; CHO; cholesterol; GPCR; G pro
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
Keywords: سیگنالینگ سلولی; Nrf2; GSK-3; β-TrCP; Cell signaling; Oxidative stress;
Role of HIPK2 in kidney fibrosis
Keywords: سیگنالینگ سلولی; cell signaling; HIPK2; kidney fibrosis; tubular epithelial cell