Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors
Keywords: cGMP; Vasorelaxation; Heart failure; Desensitization; Phosphorylation;
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Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels
Keywords: cGMP; Nitric oxide; Cardiac tissue; Ion channels; cAMP; Cyclic nucleotide phosphodiesterases; cGMP-dependent protein kinase; L-type calcium current;
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase
Keywords: Soluble guanylate cyclase; Heme; Nitric oxide; cGMP; BAY 58-2667; BAY 41-2272; YC-1;
Strategies in the oral pharmacotherapy of male erectile dysfunction viewed from bench and bedside (Part II)
Keywords: ED; erectile dysfunction; sGC; guanylyl cyclase; cGMP; cyclic guanosine monophosphate; NO; nitric oxide; EFS; electrical field stimulation; PDE; phosphodiesterase; α-MSH; melanocyte-stimulating hormone; ACTH; adrenocorticotropin (adrenocorticotropic horm
The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5
Keywords: cAMP; cyclic adenosine-3â²,5â²-monophosphate; cGMP; cyclic guanosine-3â²,5â²-monophosphate; NO; nitric oxide; PDE; phosphodiesterase; PDP; 9-(6-phenyl-2-oxohex-3-yl)-2-(3,4-dimethoxybenzyl)purin-6-one; Cyclic nucleotides; Sildenafil; Phosphodiesterase
C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction
Keywords: ANP; atrial natriuretic peptide; BNP; brain natriuretic peptide; CNP; C-type natriuretic peptide; cGMP; cyclic guanosine monophosphate; GC; guanylyl cyclase; LV; left ventricle/ventricular; MHC; myosin heavy chain; MI; myocardial infarction; PKG; cyclic g
Bile duct ligation plus hyperammonemia in rats reproduces the alterations in the modulation of soluble guanylate cyclase by nitric oxide in brain of cirrhotic patients
Keywords: cirrhosis; hepatic encephalopathy; cyclic GMP; BDL; bile duct ligation; BDLA; bile duct ligation with hyperammonemia; cGMP; cyclic guanosine 3â²-5â²-monophosphate; EDTA; ethylene diamine tetraacetic acid; EGTA; ethylene glycol-bis (β-aminoethyl ether)
Correlations between neuronal nitric oxide synthase and muscarinic M3/M1 receptors in the rat retina
Keywords: NOS; NO; mAChR; M3 mAChR; M1 mAChR; cGMP; nNOS mRNA;
A cell-based cGMP assay useful for ultra-high-throughput screening and identification of modulators of the nitric oxide/cGMP pathway
Keywords: Soluble guanylate cyclase; cGMP; Nitric oxide; CNG channel; BAY 41-2272; BAY 58-2667; HTS;
Signal transduction by erythrocytes on specific binding of doxorubicin immobilized on nanodispersed magnetite
Keywords: Doxorubicin; Drug-conjugate; Erythrocytes; Plasma membrane; Signal transduction; SANS; Nitric oxides (NO); cAMP; cGMP; Hemolysis; Nanodispersed magnetite; Hydroxyethylstarch; O-(2-Aminoethyl)polyethylene glycol;
Diuretic factors and second messengers stimulate secretion of the organic cation TEA by the Malpighian tubules of Drosophila melanogaster
Keywords: Organic cation transport; Malpighian tubule; Midgut; cAMP; cGMP; Tyramine; Leucokinin-T2; Tetraethylammonium;
cGMP-dependent phosphorylation and degradation of myristoylated alanine-rich C-kinase substrate
Keywords: NO; cGMP; PKG; MARCKS; Phosphorylation; NIH3T3; Degradation;
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets
Keywords: Adenosine; Calcium; cAMP; cGMP; GEA 3175; Milrinone; Nitric oxide; Phosphodiesterases; Platelets;
Role of cGMP signals in tetramethylpyrazine induced relaxation of the isolated rat aortic strip
Keywords: Aortic rings; cGMP; Guanylyl cyclase; Phosphodiestrase; PKG; TMP;
An attempt to integrate Western and Chinese medicine: rationale for applying Chinese medicine as chronotherapy against cancer
Keywords: Chinese medicine; Yin; Yang; cAMP; cGMP; Chronotherapy;
Differential CB1 and CB2 cannabinoid receptor-inotropic response of rat isolated atria: Endogenous signal transduction pathways
Keywords: Cannabinoid receptors; Atria contractility; NOS; cGMP; Camp;
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries
Keywords: Dephostatin; cGMP; GEA 3175; Nitric oxide; Protein phosphorylation; Relaxation; SNAP;
Heme oxygenase-1 (HO-1), a protective gene that prevents chronic graft dysfunction
Keywords: cGMP; cyclic 3â²:5â²-guanosine monophosphate; CO; carbon monoxide; COX; cyclooxygenase; EC; endothelial cells; ET-1; endothelin-1; HO-1; heme oxygenase-1; IL-1β; interleukin 1beta; iNOS; inducible nitric oxide synthase; IRI; ischemia and reperfusion in
Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: A mechanism by which angiotensin II antagonizes cGMP signaling
Keywords: Cyclic nucleotide phosphodiesterase; Vascular smooth muscle cell; Angiotensin II; cGMP; Cell growth;
Roles of the intracellular regions of angiotensin II receptor AT2 in mediating reduction of intracellular cGMP levels
Keywords: Angiotensin II receptor AT2; Xenopus oocytes; cGMP; 3rd Intracellular loop;
A study of signal transduction for the two diuretic peptides of Diploptera punctata
Keywords: Diuretic hormones; Diploptera punctata; Signal transduction; Camp; cGMP;
Nitric oxide donors induce calcium-mobilisation from internal stores but do not stimulate catecholamine secretion by bovine chromaffin cells in resting conditions
Keywords: cADPR; cyclic adenosine diphosphate-ribose; Ï-Aga; Ï-agatoxin; BSA; bovine serum albumine; Caf; caffeine; [Ca2+]i; intracellular free calcium concentration; Ca2+; calcium; CA; catecholamine; Ï-Ctx; Ï-conotoxine GVIA; dONOOâ; deactivated peroxynitrit
Nitric Oxide Is Released Into Circulation With Whole-Body, Periodic Acceleration*
Keywords: dicrotic notch; endothelial nitric oxide synthase; nitric oxide; a/b ratio; amplitude of pulse wave divided by height of dicrotic notch above the end-diastolic level; cGMP; cyclic guanosine monophosphate; eNOS; endothelial nitric oxide synthase; NO; nitri
Phosphodiesterases 1 and 2 regulate cellular cGMP level in rabbit submandibular gland cells
Keywords: cGMP; Phosphodiesterase; Submandibular gland; Cholinergic agonist; Ca2+;
Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells
Keywords: VASP; cGMP; VEGF; Akt; Pak; Rac;
C-type natriuretic peptide and guanylyl cyclase B receptor
Keywords: Guanylyl cyclase; cGMP; C-type natriuretic peptide;
NO and transcriptional regulation: from signaling to death
Keywords: ATM; ataxia telangiectasia-mutated; ATR; ATM- and Rad3-related; AhR; aryl hydrocarbon receptor; ARNT; AhR nuclear translocator; cGMP; cyclic guanosine monophosphate; CTAD; C-terminal transactivation domain; GSNO; S-nitrosoglutathione; HIF-1; hypoxia induc
Hydralazine decreases sodium nitroprusside-induced rat aortic ring relaxation and increased cGMP production by rat aortic myocytes
Keywords: Hydralazine; Sodium nitroprusside; Vasodilation; cGMP; NADH oxidase
Neurons exposed to ammonia reproduce the differential alteration in nitric oxide modulation of guanylate cyclase in the cerebellum and cortex of patients with liver cirrhosis
Keywords: Hyperammonemia; cGMP; Nitric oxide; Hepatic encephalopathy; Soluble guanylate cyclase;
Increased superoxide anion in rostral ventrolateral medulla contributes to hypertension in spontaneously hypertensive rats via interactions with nitric oxide
Keywords: aCSF; artificial cerebrospinal fluid; AdGFP; adenovirus encoding green fluorescence protein; AdeNOS; adenovirus encoding endothelial nitric oxide synthase; cGMP; guanosine 3â²,5â²-cyclic monophosphate; Cu/ZnSOD; cupper/zinc superoxide dismutase; HEt; hy
Effect of Cardioplegic and Organ Preservation Solutions and Their Components on Coronary Endothelium-Derived Relaxing Factors
Keywords: Ca2+; calcium; cAMP; cyclic 3â²5â²-adenosine monophosphate; cGMP; cyclic 3â²5â²-guanosine monophosphate; COX; cyclooxygenase; EDHF; endothelium-derived hyperpolarizing factor; EDRF; endothelium-derived relaxing factor; EET; epoxyeicosatrienoic acid; 5
Nitric oxide: An inhibitory retrograde modulator in the crustacean heart
Keywords: Crustacean; Heart; Neuromodulation; Central pattern generator; Negative inotropy; Negative chronotropy; Nitric oxide; cGMP;
ORIGINAL RESEARCH-BASIC SCIENCE: Cyclic Nucleotide Signaling in Cavernous Smooth Muscle
Keywords: Cavernous Smooth Muscle; Penis; cAMP; cGMP; Cyclases; PKG; PKA; Phosphodiesterase; Nitric Oxide Synthase; PDE5 Inhibitors; Molecular Biologic Studies of Sexual Function; Male Erectile Disorder;
Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications
Keywords: Phosphodiesterase inhibitors; Myocardial preconditioning; Ischemia/reperfusion injury; Vasodilatation; Pulmonary hypertension; Endothelial dysfunction; Nitric oxide; cGMP; Potassium channel; Protein kinase;
Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
Keywords: soluble guanylate cyclase; cGMP; Bay 41-2272; TGF-β1; fibrosis; progression;
Imaging of nitric oxide in the retina
Keywords: Retina; Nitric oxide; Imaging; cGMP; Signal transduction
Cardiac nitric oxide: Emerging role for nNOS in regulating physiological function
Keywords: Neuronal NO-synthase; Contraction; Catecholamines; Autonomic nervous system; cGMP; cyclic gyanosine monophoshpate; ChAT; choline acetyltransferase; eNOS; endothelial NO synthase; HSP; heat shock protein; IR; immunoreactivity; l-NMMA; l-nitro-monomethylarg
Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction
Keywords: ACE; angiotensin converting enzyme; AM; adrenomedullin; ANP; atrial natriuretic peptide; AT-II; angiotensin-II; BNP; brain natriuretic peptide; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CGPP; calcitonin gene-related pepti
Free radicals as triggers of brain edema formation after stroke
Keywords: ADC; apparent diffusion coefficient; AJ; adherens junction; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AQP; aquaporin; ATP; adenosine triphosphate; BBB; blood-brain barrier; CBF; cerebral blood flow; cGMP; cyclic guanosine monophosphat
The chemistry of nitroxyl (HNO) and implications in biology
Keywords: Nitroxyl; Nitric oxide; Chemical biology; Donor compounds; Detection; Angeli's salt; BH4; tetrahydrobiopterin; cGMP; guanosine cyclic 3â², 5â²-monophosphate; CGRP; calcitonin gene related product; cyt c; cytochrome c; deoxyMb; deoxymyoglobin; DETC; diet
Heme oxygenase and the cardiovascular-renal system
Keywords: AA; arachidonic acid; Ang II; angiotensin II; ARF; acute renal failure; β-AR; β-adrenergic receptor; BP; blood pressure; cdk; cyclin-dependent kinases; CEC; circulating endothelial cell; cGMP; cyclic guanosine monophosphate; CKI; cyclin kinase inhibitor
Plasticity of synaptic transmission in autonomic ganglia
Keywords: ACh; acetylcholine; ACTH; adrenocorticotropic hormone; CaMKII; calcium calmodulin kinase II; CAP; compound action potential; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CO; carbon monoxide; CNS; central nervous system; EPSC
The physiology and pathophysiology of nitric oxide in the brain
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Aβ; amyloid β-peptide; BBB; blood-brain barrier; BH4; tetrahydrobiopterin; C/EBP; CCAAT/enhancer-binding protein; cGMP; cyclic guanosine-3â²,5â²-monophosphate; CNS; central nervous system;
Pyridine nucleotides and calcium signalling in arterial smooth muscle: From cell physiology to pharmacology
Keywords: NAADP; cADPR; ADP-ribosyl cyclase; Ryanodine receptor; Sarcoplasmic reticulum; Lysosomes; Artery; Smooth muscle; 8-bromo-cADPR; 8-bromo-cyclic adenosine diphosphate-ribose; ACh; acetylcholine; β-NAD+; β-nicotinamide adenine dinucleotide (oxidized form);
PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
Keywords: BAL; bronchoalveolar lavage; CAM; cell adhesion molecule; cAMP; cylic adenosine monophosphate (AMP); cGMP; cyclic guanosine 5C-monophosphate (GMP); CINC/KC; cytokine-induced neutrophil chemoattractant/keratinocyte-derived chemokine; COPD; chronic obstruct
Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis
Keywords: ADMA; asymmetric dimethylarginine; ATP; adenosine triphosphate; BH4; tetrahydrobiopterin; CAT-1; cation arginine transporter 1; cGMP; guanosine-3â²5â²-cyclic monophosphate; DDAH; dimethylarginine dimethylaminohydrolase; GTP; guanosine triphosphate; Hsp9