Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese Hamster Ovary; DPBS, Dulbecco's phosphate buffered saline; HC, IgG heavy chain; HCP, host cell protein; IMAC, immobilized metal ion affinity chromatography; LC, IgG light chain; mAb, monoclonal antibody; OAA, one-armed antibodyParallelized pr
مقالات ISI CHO، تخمدان هامستر چینی (ترجمه نشده)
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Keywords: CHO، تخمدان هامستر چینی; LC–MS, liquid chromatography–mass spectrometry; CHO, Chinese hamster ovary; Fc, crystalline fragment; Fab, antigen-binding fragment; mAbs, monoclonal antibodies; PTMs, posttranslational modifications; CQAs, critical quality attributes; Lys-C, endoproteina
Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese hamster ovary; SCE, sister chromatid exchange; PARP, poly(ADP ribose) polymerase; ELISA, enzyme-linked immunosorbent assay; IC50, concentration at which 50% of activity is inhibited; ROS, reactive oxygen species; 3-AB, 3-aminobenzamide; SSB,
Keywords: CHO، تخمدان هامستر چینی; AcMNPV, autographa californica multicapsid nucleopolyhedrovirus; BEVS, Baculovirus expression vector system; CHO, Chinese hamster ovary; EGFP, enhanced green fluorescent protein; ELISA, enzyme-linked immunosorbet assay; GPCR, G-protein-coupled receptor; h
Keywords: CHO، تخمدان هامستر چینی; ATPE, aqueous two-phase extraction; ATPS, aqueous two-phase system; BP, bottom phase; BSA, bovine serum albumin; CHO, Chinese hamster ovary; CS, cell supernatant; IgG1, immunoglobulin G1; KOH, potassium hydroxide; mAB, monoclonal antibody; MP, mixing poin
Keywords: CHO، تخمدان هامستر چینی; BRET, bioluminescence resonance energy transfer; CHO, Chinese hamster ovary; Cre-Luc, cyclic AMP response element-luciferase; GPCRs, G protein-coupled receptors; HEK, human embryonic kidney; KS, Kallmann syndrome; PK2, prokineticin 2; PKR2, prokineticin r
Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese hamster ovary; DEAE, diethylamino ethanol; FVIIa, activated factor VII; FVIII, factor VIII; FIX, factor IX; FXI, factor XI; HEK, human embryonic kidney; HS, heat sterilized; NHP, natural human plasma; PCR, polymerase chain reaction; QAE, quat
Keywords: CHO، تخمدان هامستر چینی; AG, aminoguanidine hemisulfate salt; CBMN, cytokinesis-B blocked micronucleus; CHO, Chinese hamster ovary; CO, carbon monoxide; CORM, CO releasing molecule; COX-2, cyclooxygenase-2; DAF-FM, 4-amini-5-methylamino-2′,7′-difluorofluorescein diacetate; DCF, 2
Keywords: CHO، تخمدان هامستر چینی; CaMV, cauliflower mosaic virus; CHO, Chinese hamster ovary; DoE, design of experiments; DSP, downstream processing; ELP, elastin-like peptides; HCP, host cell proteins; ITC, inverse transition cycling; UTR, untranslated regionBioprocess design; Bioseparat
Keywords: CHO، تخمدان هامستر چینی; ADP, adenosine diphosphate; AMP, adenosine monophosphate; ANOVA, analysis of variance; ATP, adenosine triphosphate; CFPS, cell-free protein synthesis; CHO, Chinese hamster ovary; E.C., adenylate energy charge; eIF, eukaryotic initiation factor; HPLC, high
Keywords: CHO، تخمدان هامستر چینی; GM-CSF; TF-1 cells; CHO cells; Sialic acid; OligosaccharideACN, acetonitrile; ANOVA, analysis of variance; CHO, Chinese hamster ovary; crhGM-CSF, CHO-derived recombinant human GM-CSF; erhGM-CSF, Escherichia coli-derived recombinant human GM-CSF; FCS, feta
Keywords: CHO، تخمدان هامستر چینی; Aβ, amyloid-β; AD, Alzheimers’ disease; AICD, APP intracellular domain; APP, amyloid precursor protein; ATM/ATR, ataxia telangiectasia mutated/ataxia-telangiectasia-and Rad3-related; BCA, bicinchoninic acid; CHO, Chinese hamster ovary; CPI, complete prote
A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells
Keywords: CHO، تخمدان هامستر چینی; BFP, Blue Fluorescent Protein; BP, Bandpass; bp, Base pairs; Cas9, CRISPR-associated protein 9; CD, Chemically defined; CHO, Chinese Hamster ovary; CRISPR, Clustered regularly interspaced palindromic repeats; GFP, Green Fluorescent Protein; gRNA, Guide RN
Selective 5-HT2C receptor agonists: Design and synthesis of pyridazine-fused azepines
Keywords: CHO، تخمدان هامستر چینی; ADME, absorption, distribution, metabolism, and excretion; CHO, Chinese hamster ovary; CNS, central nervous system; ER, efflux ratio; FLIPR, fluorescence imaging plate reader; HLM, human liver microsomes; MDCK, Madin–Darby Canine Kidney cell line; MDR-1,
Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations
Keywords: CHO، تخمدان هامستر چینی; ACN, acetonitrile; Boc, tert-butyloxycarbonyl; CHO, Chinese hamster ovary; DAMGO, [D-Ala2,NMePhe4,Gly5-ol]enkephalin; DALEA, [D-Ala2, Leu5] enkephalin amide; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; HBTU, N,N,N′,N′-tetra methyl-O-(1H-benzot
Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines
Keywords: CHO، تخمدان هامستر چینی; ABS, Arthrobacter ureafaciens sialidase; ADCC, antibody-dependent cellular cytotoxicity; BTG, bovine testis galactosidase; CBG, coffee bean galactosidase; CHO, Chinese hamster ovary; DC-SIGN, dendritic cell-specific intercellular adhesion molecule-3-grabb
On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin
Keywords: CHO، تخمدان هامستر چینی; cAMP, 3′,5′-cyclic adenosine monophosphate; CGS21680, 2-[p-(2-carboxyethyl)phenyl-ethylamino]-5′-N-ethylcarboxamidoadenosine; CHO, Chinese hamster ovary; CPA, N6-cyclopentyladenosine; DMEM, Dulbecco’s modified Eagle’s medium; ERK, extracellular-signal-reg
Molecular characterization of a short neuropeptide F signaling system in the tsetse fly, Glossina morsitans morsitans
Keywords: CHO، تخمدان هامستر چینی; sNPF, short neuropeptide F; sNPFR, short neuropeptide F receptor; GPCR, G protein-coupled receptor; CHO, Chinese hamster ovary; NPF, neuropeptide FInsect; Tsetse fly; Glossina morsitans morsitans; Neuropeptide; Short neuropeptide F; G protein-coupled rece
Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers
Keywords: CHO، تخمدان هامستر چینی; rBChE, recombinant butyrylcholinesterase; MALDI TOF, matrix-assisted laser desorption–ionization time-of-flight; CHO, Chinese hamster ovary; ATCC, American Type Culture Collection; AChE, acetylcholinesterase; NCBI, National Center for Biotechnology Inform
Synthesis and structure–activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor
Keywords: CHO، تخمدان هامستر چینی; Adrenergic receptors subtypes; BPH; α1-Adrenergic antagonists; Arylpiperazinesα1-ARs, α1-adrenergic receptors; BPH, benign prostatic hyperplasia; CHO, Chinese hamster ovary; GPCRs, G protein coupled receptors; HBA, H-bond acceptor; IR, infrared; LUTS, low
Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides
Keywords: CHO، تخمدان هامستر چینی; BLI, biolayer interferometry; CD, circular dichroism; CHO, Chinese hamster ovary; CLSM, confocal laser scanning microscopy; CS, chondroitin sulfate; DAPI, 4′,6-diamidino-2-phynylindole; DMEM/F12, Dulbecco's modified Eagle's medium/nutrient F-12 Ham; FAM,
A human FSHB transgene encoding the double N-glycosylation mutant (Asn7Δ Asn24Δ) FSHβ subunit fails to rescue Fshb null mice
Keywords: CHO، تخمدان هامستر چینی; Gonadotropin; Genetic rescue; N-glycosylation; Pituitary; Ovary; TestisACTH, Adrenocorticotropin; cAMP, cyclin adenosine 5'-monophosphate; CHO, Chinese hamster ovary; FITC, Fluorescein isothiocyanate; FSH, Follicle-stimulating hormone; GH, Growth hormone;
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors
Keywords: CHO، تخمدان هامستر چینی; G protein-coupled receptor; Antagonists; Molecular modeling; Structure activity relationship; Triazolo-triazine; Adenosine receptorsAR, adenosine receptor; CCPA, 2-chloro-N6-cyclopentyladenosine; CHO, Chinese hamster ovary; IEele, per residue electrostati
KCNE1 and KCNE3: The yin and yang of voltage-gated K+ channel regulation
Keywords: CHO، تخمدان هامستر چینی; AV block, atrioventricular block; BLAST, basic local alignment search tool; cAMP, cyclic adenosine monophosphate; Cav channel, voltage-gated calcium channel; CHO, Chinese Hamster ovary; di, drug-induced; ERRγ, estrogen-related receptor γ; EST, expressed s
A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering
Keywords: CHO، تخمدان هامستر چینی; GlcNAc, N-acetylglucosamine; GalT, β-1-4-galactosyltransferase; Fut8, α-1-6-fucosyltransferase 8; GnTIV, N-acetylglucosamine-transferase IV; CHO, Chinese hamster ovary; EPO, erythropoietin; mAb, monoclonal antibody; IgG, immunoglobulinGlycosylation; Glyco
Systems Glycobiology: Integrating Glycogenomics, Glycoproteomics, Glycomics, and Other ‘Omics Data Sets to Characterize Cellular Glycosylation Processes
Keywords: CHO، تخمدان هامستر چینی; MS, mass spectrometry; CHO, Chinese hamster ovary; GlcNAc, N-acetylglucosamine; GalNAc, N-acetylgalactosamine; iTRAQ, isobaric tag for relative and absolute quantitation; TMT, tandem mass tag; LC, liquid chromatography; QUANTITY, quaternary amine-containi
Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2
Keywords: CHO، تخمدان هامستر چینی; ACAT2, acyl-coenzyme A:cholesterol acyltransferase 2; SNP, single nucleotide polymorphism; CAD, coronary artery disease; nsSNPs, non-synonymous polymorphisms; PSIC, position-specific-independent count; CHO, Chinese hamster ovary; FBS, fetal bovine serum;
Cytogenetic evaluation for the genotoxicity of bisphenol-A in Chinese hamster ovary cells
Keywords: CHO، تخمدان هامستر چینی; Bisphenol A; Endcorine disruptor; DNA damage; Micronucleus; Cytogenetic; MutagenicityEDs, endocrine disruptors; BPA, bisphenol-A; SHE, Syrian hamster embryo; SCGE, single cell gel electrophoresis; CHO, Chinese hamster ovary; LMPA, low melting point agaros
Engineering mammalian cell factories with SINEUP noncoding RNAs to improve translation of secreted proteins
Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese hamster ovary; DHFR, dihydrofolate reductase; GFP, green fluorescent protein; GS, glutamine synthetase; lncRNA, long noncoding RNA; MAb, monoclonal antibody; PBS, phosphate buffered salineCell factory; CHO cell; Serum-free; Long noncoding RNA
Phosphatidylinositol4-phosphate 5-kinase prevents the decrease in the HERG potassium current induced by Gq protein-coupled receptor stimulation
Keywords: CHO، تخمدان هامستر چینی; PI(4)P5-K; HERG channel; PI(4,5)P2; Gq protein-coupled receptors; Arrhythmiaα1R, α1-adrenergic receptors; CHO, Chinese hamster ovary; IKr, delayed rectifier K+ current; DAG, diacylglycerol; GqRs, Gq protein-coupled receptors; HERG, human ether-a-go-go-rel
Thermal stability of purified and reconstituted CFTR in a locked open channel conformation
Keywords: CHO، تخمدان هامستر چینی; CFTR, cystic fibrosis transmembrane conductance regulator; ABC, ATP-binding cassette; NBD1, N-terminal nucleotide-binding domain; CF, cystic fibrosis; CHO, Chinese hamster ovary; HEK, human embryonic kidney; BHK, baby hamster kidney; Tm, melting temperatu
The ERCC1 and ERCC4 (XPF) genes and gene products
Keywords: CHO، تخمدان هامستر چینی; AP, apurinic/apyrimidinic; ATP, adenosine triphosphate; cDNA, complementary deoxyribonucleic acid; CHO, Chinese hamster ovary; COFS, cerebro-oculo-facio-skeletal syndrome; CS, Cockayne syndrome; DSB, double strand break; FA, Fanconi anemia; GG-NER, global
Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation
Keywords: CHO، تخمدان هامستر چینی; Neutrophils; Chemokine receptor; Lung inflammation; Chemotaxis; COPD; Severe asthmaBALF, bronchoalveolar lavage fluid; BSA, bovine serum albumin; CHO, chinese hamster ovary; COPD, chronic obstructive pulmonary disease; CXCL1, chemokine (C-X-C motif) ligan
Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs
Keywords: CHO، تخمدان هامستر چینی; AcOH, acetic acid; Boc, tert-butoxycarbonyl; CHO, Chinese hamster ovary; DALEA, [d-Ala2, Leu5] enkephalin amide; DIEA, diisopropylethylamine; DMF, N,N-dimethyl formamide; hDOR, human δ-opioid receptor; DPDPE, c[d-Pen2, d-Pen5]enkephalin; DAMGO, [d-Ala2, N
Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS)
Keywords: CHO، تخمدان هامستر چینی; aHUS, Atypical haemolytic uraemic syndrome; BDC, Blood donor controls; CR1, complement receptor type 1; CHO, Chinese hamster ovary; DAF, decay accelerating factor; FH, Factor H; FHR, Factor H related; FH aAb, FH autoantibodies; Kna, Knops blood group anti
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands
Keywords: CHO، تخمدان هامستر چینی; ACN, acetonitrile; Boc, tert-butyloxycarbonyl; BH3-SMe2, Borane dimethylsulfide; CHO, Chinese hamster ovary; DALEA, [D-Ala2, Leu5] enkephalin amide; DCM, dichloromethane; DCE, dichloroethane; DOR, delta opioid receptor; DHP, dihydropyran; DIPEA, N,N-diiso
Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: Effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism
Keywords: CHO، تخمدان هامستر چینی; ALT, aminoleucine transferase; ArKO, aromatase knockout; AST, aspartate aminotransferase; AUC, area under the curve; β-CTX, c-telopeptide of type I collagen; BLAST, Basic Local Alignment Search Tools; BMI, body mass index; CHO, Chinese hamster ovary; DEXA
In vitro comparison of duration of action of melatonin agonists on melatonin MT1 receptor: Possible link between duration of action and dissociation rate from receptor
Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese hamster ovary; CHO-hMT1, CHO cells stably expressing human melatonin MT1 receptor; FBS, fetal bovine serum; mHBSS, modified Hanks׳ balanced salt solution; PTX, pertussis toxin; PBS, phosphate-buffered saline; SCN, suprachiasmatic nucleus2-Iod
Characterization of the Ala62Pro polymorphic variant of human cytochrome P450 1A1 using recombinant protein expression
Keywords: CHO، تخمدان هامستر چینی; ANF, α-naphthoflavone; BaP, benzo[a]pyrene; CHO, Chinese Hamster Ovary; CYP, cytochrome P450; dALA, δ-aminolevulinic acid; EDTA, ethylenediaminetetraacetic acid; EROD, 7-ethoxyresorufin O-dealkylation; EV, empty control vector; ME, β-mercaptoethanol; NPR,
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing
Keywords: CHO، تخمدان هامستر چینی; Aβ, β-amyloid peptide; AD, Alzheimer’s disease; APP, amyloid precursor protein; AICD, APP intracellular domain; sAPPα, soluble APPα; sAPPβ, soluble APPβ; CHO, chinese hamster ovary; CTF, C-terminal fragment; DAPT, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S
2D-DIGE screening of high-productive CHO cells under glucose limitation—Basic changes in the proteome equipment and hints for epigenetic effects
Keywords: CHO، تخمدان هامستر چینی; CHO, Chinese hamster ovary; 2D-DIGE, two-dimensional differential in-gel electrophoresis; 2DE, two-dimensional gel electrophoresis; MALDI (-ToF), matrix-assisted laser desorption/ionization (time-of-flight); MS, mass spectrometry; TCA, tricarboxylic acid
Functional neuropeptidomics in invertebrates
Keywords: CHO، تخمدان هامستر چینی; CE, Capillary electrophoresis; CHO, Chinese hamster ovary; CNS, Central nervous system; DiLeu, N,N-dimethyl leucine; dsRed, Red fluorescent protein; GFP, Green fluorescent protein; GPCRs, G-protein coupled receptors; HEK, Human embryonic kidney; IMS, Imag
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan analogues as opioid receptor ligands
Keywords: CHO، تخمدان هامستر چینی; cAMP, cyclic adenosine monophosphate; CHO, Chinese hamster ovary; DAMGO, [d-Ala2-MePhe4-Gly(ol)5]enkephalin; DFT, density functional theory; DOR, delta opioid receptor; DPN, diprenorphine; EDCI, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; GIRK, G prote
Simple size-selective separation and microscopic characterization of Phe–Phe nanotubes and study of its internalization inside CHO cells
Keywords: CHO، تخمدان هامستر چینی; Phe, phenylalanine; Phe–Phe, phenylalanine dipeptide; CHO, Chinese hamster ovary; SEM, scanning electron microscopy; TEM, transmission electron microscopy; NTs, nanotubes; SEC, size exclusion chromatography; FITC, fluorescein isothiocyanate; Fmoc, fluoren
Chloroquine impairs visual transduction via modulation of acid sensing ion channel 1a
Keywords: CHO، تخمدان هامستر چینی; Chloroquine; retinal toxicity; visual transduction; acid-sensing ion channel; ERGASICs, Acid-sensing ion channels; ERG, electroretinogram; RGNs, retinal ganglion neurons; CHO, Chinese hamster ovary; DEG/ENaC, Degenerin/epithelial sodium channel; Ops, osci
Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing
Keywords: CHO، تخمدان هامستر چینی; BSA, bovine serum albumin; CHO, Chinese hamster ovary; CRE, cAMP response elements; dhfr, dihydrofolate reductase; Compound 1, N-(5-acetamido-4-(2-thienyl)-1,3-thiazol-2-yl)-4-methylbenzamide; Compound 2, 4-methyl-N-(5-(2-(4-methylpiperazin-1-yl)-2-oxoeth
LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts
Keywords: CHO، تخمدان هامستر چینی; 4-NPP, 4-nitrophenylphosphate; AP, alkaline phosphatase; CHO, Chinese hamster ovary; CNS, central nervous system; DMEM, Dulbecco's modified Eagle's medium; EDTA, ethylenediaminetetra-acetic acid; FGF, fibroblast growth factor; HBSS, Hank's buffered salt s
In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2
Keywords: CHO، تخمدان هامستر چینی; Automated patch clamp; Azaspiracid; Cardiotoxicity; Chronic; hERG; TraffickingAZAs, azaspiracids; AZP, azaspiracid poisoning; BSA, bovine serum albumin; CHO, Chinese hamster ovary; DMSO, dimethyl sulfoxide; DPBS, Dulbecco's phosphate-buffered saline; EC,
Potentiation of insulin secretion and improvement of glucose intolerance by combining a novel G protein-coupled receptor 40 agonist DS-1558 with glucagon-like peptide-1 receptor agonists
Keywords: CHO، تخمدان هامستر چینی; ATP, adenosine triphosphate; AUC, area under the curve; BSA, bovine serum albumin; cAMP, cyclic adenosine monophosphate; CHO, Chinese hamster ovary; DHA, docosahexaenoic acid; DMSO, dimethyl sulfoxide; ELISA, enzyme-linked immunosorbent assay; ER, endopla
Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis
Keywords: CHO، تخمدان هامستر چینی; AF, atrial fibrillation; APD, action potential duration; BCL, basic cycle length; CHO, Chinese hamster ovary; ERP, effective refractory period; hpf, hours post fertilization; HRV, heart rate variability; K2P, two-pore domain K+ channels; SNP, single nucle