Keywords: شاخص ترکیبی; ABC; ATP-binding cassette; AKT; V-Akt murine thymoma viral oncogene homolog; ALDH1; aldehyde dehydrogenase 1; AR; androgen receptor; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist killer; Bax; Bcl-2-associated X protein; Bcl-2; B-c
مقالات ISI شاخص ترکیبی (ترجمه نشده)
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Keywords: شاخص ترکیبی; c-optimal design; Combination index; Dose-response studies; Multiplicative algorithms; Nonlinear regression; Toxicology;
Keywords: شاخص ترکیبی; DCM; disulfide crosslinked-micelle; DTX; docetaxel; ESCC; Esophageal squamous cell carcinoma; IHC; immunohistochemistry; TEM; Transmission electron microscope; DLS; dynamic light scatting; CI; combination index; Fa; Fraction affected; FBS; Feutal bovine s
Keywords: شاخص ترکیبی; Urolithins; Prostate cancer; Interactions; Ellagitannins gut metabolites; ADT; androgen deprivation therapy; AR; androgen receptor; bic; bicalutamide; CI; combination index; DHT; dihydrotestosterone; GnRH; gonadotropin-releasing hormone; PSA; prostate spe
Keywords: شاخص ترکیبی; 1H NMR; Proton Nuclear Magnetic Resonance; ANOVA; analysis of variance; bwGO; base washed GO; CI; Combination Index; DLS; Dynamic Light Scattering; DMEM-F12; Dulbecco's Modified Eagle's Medium F-12; DOX; doxorubicin; DT loaded POx-GO; DOX and TOS load
Keywords: شاخص ترکیبی; HDACi; histone deacetylase inhibitor; HDAC; histone deacetylase; SCFA; short-chain fatty acids; GSTs; glutathione-S transferases; NRP-1; Neuropilin-1; P-gp; P-glycoprotein; CI; combination index; Butyrate; Colorectal cancer; Dietary fiber; Synergistic eff
Keywords: شاخص ترکیبی; Curcumin (PubChem CID: 969516); Simvastatin (PubChem CID: 54454); CI; combination index; DMSO; dimethylsulfoxide; EtOH; ethanol; H2O; water; IPA; Ingenuity Pathway Analysis; NIGMS; National Institute of General Medical Sciences; STRING; search tool for re
Keywords: شاخص ترکیبی; Akt; protein kinase B; Bcl-2; B-cell lymphoma-2; Bax; Bcl-2 associated X protein; CDK; cyclin-dependent kinase; CRC; colorectal cancer; CI; combination index; Cyto c; cytochrome c; ECAR; extracellular acidification rate; EGFR; epidermal growth factor rece
Keywords: شاخص ترکیبی; CAM; complementary and alternative medicine; CI; combination index; IBD; inflammatory bowel disease; Chamomile flower; Chemokine; Coffee charcoal; Inflammatory bowel disease; Isobologram; Macrophage; Myrrh; Synergy;
Keywords: شاخص ترکیبی; Edelfosine; Doxorubicin; Lipid nanoparticles; Osteosarcoma; Synergy; Metastases; DOX; doxorubicin; CI; Combination index; DRI; drug reduction index; ET; Edelfosine; Fa; Fraction of affected cells; IC50; inhibitory concentration 50; LN; lipid nanoparticles
Keywords: شاخص ترکیبی; Breast cancer; Paclitaxel; Clotrimazole; CompuSyn simulation; Combination index;
Keywords: شاخص ترکیبی; Combination index; Synergism; Isobologram; Modelling; Gamma model;
Keywords: شاخص ترکیبی; MRCLS; myxoid/round cell liposarcoma; UPS; undifferentiated pleomorphic sarcoma; CSC; cancer stem cell; hBMSC; human bone marrow-derived mesenchymal stromal/stem cell; CPT; campthotecin; STS; soft tissue sarcomas; NER; nucleotide excision repair; DSB; dou
Keywords: شاخص ترکیبی; SCLC; small cell lung cancer; CAM; chorioallantoic membrane; CI; combination index; STR; short tandem repeat; RPMI; Roswell Park Memorial Institute; EDTA; ethylene diamine tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; SPF; s
Keywords: شاخص ترکیبی; Antimutagenic; Isothiocyanates; Combination index; Interactive effect; Synergistic;
Keywords: شاخص ترکیبی; BEN; bendamustine; CI; combination index; CLB; chlorambucil; CLL; chronic lymphocytic leukemia; Cyclo; cyclophosphamide; dADO; deoxyadenosine; Del; deletion; DHE; dihydroethidium; DiOC6; 3,3â²-dihexyloxacarbocyanine iodide; DMSO; dimethyl sulfoxide; DR;
Keywords: شاخص ترکیبی; Insecticides; Herbicides; Heavy metal; Eisenia fetida; Acute mixture toxicity; Combination index;
Keywords: شاخص ترکیبی; 7-AAD; aminoactinomycin; ANT; adenine nucleotide translocator; CI; combination index; CREB; cyclic AMP response element binding protein; DMSO; dimethyl sulfoxide; E; epicatechin; ELISA; enzyme-linked immunosorbent assay; ER; endoplasmic reticulum; FCCP; c
Keywords: شاخص ترکیبی; ATM; ataxia telangiectasia-mutated kinase; ATR; ataxia telangiectasia and Rad3-related kinase; CI; combination index; CLL; chronic lymphocytic leukemic cells; DNA-PK; DNA-dependent protein kinase; DNA-PKcs; DNA-dependent protein kinase catalytic subunit;
Keywords: شاخص ترکیبی; CI; combination index; ED50; 50% effective dose; ELISA; enzyme linked immunosorbent assay; HMGB1; high mobility group box 1; IFN-γ; interferon-gamma; IL; interleukin; LTB4; leukotrienes B4; LPS; lipopolysaccharide; MLA; methyllycaconitine; PGE2; prostagl
Keywords: شاخص ترکیبی; BSA; bovine serum albumin; CI; combination index; DRI; dose-reduction index; DTNB; 5,5-dithio-bis (2-nitrobenzoic acid); DMSO; dimethyl sulfoxide; EAC; Ehrlich ascites carcinoma; FBS; fetal bovine serum; GIST; gastrointestinal stromal tumor; GSH; glutathi
Keywords: شاخص ترکیبی; Median-effect equation; Combination index; Dose-reduction index; Isobologram; Polygonogram; Computer synergy simulation
Keywords: شاخص ترکیبی; RA; rosmarinic acid; CA; caffeic acid; FA; ferulic acid; CI; Combination Index; CYP1A; cytochromes P4501A1 and P4501A2; CYP2B/3A; cytochromes P4502B and P4503A; Hepatotoxicity; Dietary phenolic acids; Mixtures; Interactions; Species differences;
Ecotoxicological effects of binary mixtures of siduron and Cd on mRNA expression in the earthworm Eisenia fetida
Keywords: شاخص ترکیبی; Siduron; Cadmium; Earthworm; mRNA expression; Joint effects; Combination index;
Dual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma
Keywords: شاخص ترکیبی; AURKA; aurora kinase A; BRD4; Bromodomain-containing protein 4; CI; combination index; Fa; fraction affected; p-AURKA; phosphorylated AURKA, specifically at threonine 288; LOH; loss of heterozygosity; 11q; long arm of chromosome 11;
A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors
Keywords: شاخص ترکیبی; 4HPC; 4-hydroperoxycyclophosphamide; CC3; cleaved caspase-3; CI; combination index; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFRvIII; constitutively active mutant form of the epidermal growth factor receptor; SMO; ND2:SmoA1 t
Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway
Keywords: شاخص ترکیبی; Malignant glioma; Honokiol; Temozolomide; Apoptosis; Intrinsic pathway; ANOVA; analysis of variance; Bax; Bcl-2-associated X protein; BrdU; bromodeoxyuridine; CI; combination index; DEVD; Asp-Glu-Val-Asp; DiOC6; 3,3â²-dihexyloxacarbocyanine; DAPI; 4â²-6
Indirubin, a bis-indole alkaloid binds to tubulin and exhibits antimitotic activity against HeLa cells in synergism with vinblastine
Keywords: شاخص ترکیبی; Anti-cancer; Colchicine; Combination index; Indirubin; Tubulin; Vinblastine;
Full Length ArticleAn in vitro cytotoxic approach to assess the toxicity of heavy metals and their binary mixtures on hippocampal HT-22 cell line
Keywords: شاخص ترکیبی; Ach E; acetyl cholinesterase E; ANOVA; analysis of variance; As; arsenic; CA; concentration addition; CI; combination index; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GABA; Â¥-gamma-amino butyric acid; GAD; glutamate decarboxy
In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone
Keywords: شاخص ترکیبی; Phytochemical; Pharmaceuticals; Combination index; EROD; Inhibition; Interaction;
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Keywords: شاخص ترکیبی; AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells
Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro
Keywords: شاخص ترکیبی; 95%CI; 95% confidential interval; AB; apical-to-basolateral; ABC; ATP-binding cassette; Abcb1; canine P-glycoprotein; ABCB1; human P-glycoprotein; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; BA; basolateral-t
In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)
Keywords: شاخص ترکیبی; 1,8-Cineole; 4-Allylphenyl acetate; Methyl eugenol; Computational docking; GABAA benzodiazepine-binding site; AGO; Alpinia galanga oil; BZD; Benzodiazepine; GABAA; γ-Aminobutyric acid type A; NMDA; N-methyl-d-aspartate; ÎGbind; Binding energy; Ki; Inhib
ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells
Keywords: شاخص ترکیبی; Gemcitabine; ZH-1; Apoptosis; Deoxyribonucleotides; Intrinsic apoptotic pathway; ATCC; American Type Culture Collection; ATP; adenosine-triphosphate; ATP13C15N; trioctylamine, 1,1,2-trichlorotrifluoroethane, stable isotope labeled adenosine-13C1015N5-trip
Metronomic vinorelbine is directly active on Non Small Cell Lung Cancer cells and sensitizes the EGFRL858R/T790M cells to reversible EGFR tyrosine kinase inhibitors
Keywords: شاخص ترکیبی; ABCG2; ATP-binding cassette sub-family G member 2; CI; combination index; D-VNR; deacetyl-vinorelbine; EGFR; epidermal growth factor receptor; FBS; fetal bovine serum; IC50; inhibitory concentration 50; mVNR; metronomic vinorelbine; NSCLC; Non Small Cell
Manganese(II) complexes of tolfenamic acid or naproxen in polymeric structures or encapsulated in [15-MC-5] manganese(III) metallacrowns: Structure and biological activity
Keywords: شاخص ترکیبی; 5FU; 5-fluorouracil; BSA; bovine serum albumin; CDDP; cisplatin; CI; Combination Index; CPT-11; irinotecan hydrochloride, trihydrate; CT; calf-thymus; CV; coefficient of variation; DMF; N,N-dimethylformamide; DMSO; dimethylsulfoxide; DRI; dose reduction i
Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin
Keywords: شاخص ترکیبی; Adlay testa; Doxorubicin; MES-SA; MES-SA/Dx5; HUtSMCs; Multidrug resistance; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; AHE; the ethanoic extracts of adlay hull; ABE; the ethanoic extracts of adlay bran; ATE; the ethanoic extracts
Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells
Keywords: شاخص ترکیبی; Apoptosis; Cell death; Mitochondria; HDAC; BET proteins; Rhabdomyosarcoma; JQ1; ARMS; alveolar rhabdomyosarcoma; BRD; bromodomain; BET protein; bromo- and extra-Terminal protein; CI; combination index; ERMS; embryonal rhabdomyosarcoma; EV; empty vector; F
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model
Keywords: شاخص ترکیبی; 17AAG; 17-Allylamino-17-demethoxygeldanamycin; BCG; Bacillus Calmette-Guerin; DCF; 2â²,7â²-Dichlorofluorescin-diacetate; DLS; Dynamic light scattering; CI; Combination index; CBC; Complete blood count; Fa; Fraction affected; HIF-1α; Hypoxia induced fac
Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells
Keywords: شاخص ترکیبی; P. missionis; β-caryophyllene; Aromadendrene oxide 2; Phytol; Synergy; Apoptosis; Cancer therapy; EO; essential oil; β-C; β-caryophyllene; AO-(2); aromadendrene oxide 2; P; phytol; β-caryophyllene/aromadendrene oxide 2; (β-C/AO-(2); β-caryophyllene/
A transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin
Keywords: شاخص ترکیبی; Actein; Black cohosh; Microarrays; Ranunculaceae; Simvastatin; Triterpene glycoside; CI; Combination Index; CYP; Cytochrome P450; DMSO; dimethylsulfoxide; DMEM; Dulbecco's Modified Eagle's medium; ERK; Extracellular signal related kinase; EtOH; ethanol; F
Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo
Keywords: شاخص ترکیبی; Arsenic trioxide; Cisplatin; Combination therapy; Bcr-Abl-positive leukemia; Apoptosis; APL; acute promyelocytic leukemia; ATO; arsenic trioxide; Ato-C; ATO/CDDP; CDDP; Cisplatin; CI; combination index; DRI; dose-reduction index; CML; Chronic myelogenous
Herb-drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay
Keywords: شاخص ترکیبی; CYP450; cytochrome P450; HTS; high-throughput screening; IC50; the 50% inhibitory concentration; RP-HPLC; reverse phase high-performance liquid chromatography; CYP450-CO; cytochrome P450- carbon monoxide; RLM; rat liver microsome; CI; combination index; H
Synergy between next generation EGFR tyrosine kinase inhibitors and miR-34a in the inhibition of non-small cell lung cancer
Keywords: شاخص ترکیبی; MicroRNA; miR-34a; Erlotinib; Afatinib; Osimertinib; Rociletinib; EGFR:; epidermal growth factor receptor; TKI:; tyrosine kinase inhibitor; miRNA:; microRNA; DRI:; dose reduction index; CI:; combination index; NSCLC:; non-small cell lung cancer;
Original ArticleThe HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer
Keywords: شاخص ترکیبی; NSCLC; HSP90 inhibitor; PI3K inhibitor; KRAS mutation; Combination therapy; NSCLC; non-small cell lung cancer; CI; combination index;
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
Keywords: شاخص ترکیبی; PI; Propidium iodide; PBS; Phosphate buffered saline; RPMI; Roswell Park Memorial Institute medium; SRB; Sulforhodamine B; Pd; Palladium; DMSO; Dimethyl sulfoxide; TCA; Trichloro Acetic Acid; FBS; Fetal bovine serum; 7-AAD; 7-amino actinomycin D; CI; Comb
Curcumin synergizes with the endocannabinoid reuptake inhibitor OMDM-2 in human MCF-7 breast cancer and U-87 glioblastoma cells
Keywords: شاخص ترکیبی; Î9-THC; Delta-9-tetrahydrocannabinol; 2-AG; 2-arachidonoylglycerol; AEA; Anandamide; BCL2; B-cell CLL/lymphoma 2; CB-1; Cannabinoid receptor 1; CB-2; Cannabinoid receptor 2; CI; Combination Index; CXCR4; chemokine receptor type 4; DDS; Drug delivery syst
Original ArticleHSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2
Keywords: شاخص ترکیبی; Small cell lung cancer; BCL-2 inhibitor; HSP90 inhibitor; Combination therapy; CI; combination index; SCLC; small cell lung cancer;
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
Keywords: شاخص ترکیبی; Alzheimer; Amyloid; Combination index; Lasalocid; Presenilin; Synergism;
RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems
Keywords: شاخص ترکیبی; 3-MA; 3-methyladenine; ARE; antioxidant response elements; ATG5; autophagy related 5; CI; combination index; DCF-DA; 2â²,7â²-dichlorofluorescein diacetate; GSH; glutathione; HNC; head and neck cancer; IHC; immunohistochemistry; LC3; microtubule-associat