Keywords: Desensitization; Food allergy; Guardians; Oral immunotherapy; Quality of life; CRTH2; chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; DBPCFC; double-blind, placebo-controlled food challenge; EWP; egg white powder; FAQL-PB; the F
مقالات ISI (ترجمه نشده)
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Keywords: Urticaria; Biomarkers; CRP; IL-6; MPV; D-dimer; F1+2; Biologics; Omalizumab; ASCENT-I; ASCENT-II; GLACIAL; IL-1 antagonists; TNF-α inhibitors; Intravenous immunoglobulin; Rituximab; Ligelizumab; Quilizumab; ASST; Autologous serum skin test; ATA; Antithyr
Keywords: Allergy; immunotherapy; immune tolerance; allergen desensitization; TH2 cells; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; FAB; Facilitated allergen binding; GRASS; Gauging Response in Allergic Rhinitis to Sublingua
Keywords: atopic dermatitis; eicosanoids; leukotrienes; montelukast; pharmacology; prostaglandins; timapiprant; zileuton; COX; cyclooxygenase; CPLA2; cytosolic phospholipase A2; CRTH2; chemoattractant receptor homologous molecule expressed on T helper type 2; LT; l
Keywords: Aspirin-exacerbated respiratory disease (AERD); Asthma; Aspirin (acetylsalicylic acid, ASA); Chronic rhinosinusitis with nasal polyps; Nonsteroidal antiinflammatory drugs (NSAID); Hypersensitivity; Intolerance; AERD; aspirin-exacerbated respiratory diseas
Keywords: Anaphylaxis; basophil activation test; diagnosis; food allergy; mast cells; mast cell activation test; peanut allergy; AUC; Area under the curve; BAT; Basophil activation test; CD-sens; Threshold sensitivity; CRTH2; Chemoattractant receptor-homologous m
Keywords: Allergy; immunology; innate; inflammation; food allergy; asthma; mast cell; eosinophil; ozone; IL-33; extracellular vesicles; AERD; Aspirin-exacerbated respiratory disease; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; DP1;
Keywords: Group 2 innate lymphoid cells; aspirin-exacerbated respiratory disease; AERD; Aspirin-exacerbated respiratory disease; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; CysLT; Cysteinyl leukotriene; ILC2; Group 2 innate lymphoid
Keywords: Biologics; small molecule inhibitors; topical therapy; cytokines; mAbs; precision medicine; AD; Atopic dermatitis; AhR; Aryl hydrocarbon receptor; CRTH2; Chemoattractant receptor homologous molecules expressed on TH2 lymphocytes; EASI; Eczema Area and Sev
Keywords: Atopic dermatitis; eczema; keratinocyte; immune; TÂ helper cell; skin immune map; targeted therapy; AD; Atopic dermatitis; AMP; Antimicrobial peptide; CRTH2; Prostaglandin DP2 receptor; EASI; Eczema Area and Severity Index; FLG; Filaggrin; JAK; Janus kina
Keywords: Immunotherapy; mechanisms; allergic rhinitis; allergic asthma; long-term tolerance; T cells; B cells; type 2 innate lymphoid cells; IgE-FAB; biomarkers; Breg; Regulatory B; C1Q; Component 1Q; CRTH2; Chemoattractant receptor-homologous molecule expressed
Keywords: Biologics; Asthma; Anti-IL-5; Anti-IL-13; Anti-IL-4; Th2; CRTH2; Anti-IgE;
Keywords: AP1; Activator protein 1; cAMP; Cyclic adenosine monophoshate; CXCR; Cytokine receptors; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; DAMPs; Damage-associated molecular pattern; EtBr; Ethidium Bromide; IgE; Immunoglobulin E;
Keywords: Innate lymphoid cells; mucosal immunity; inflammatory bowel disease; allergy; asthma; psoriasis; tumor immunity; graft-versus-host disease; AD; Atopic dermatitis; ART; Antiretroviral therapy; γc; Common γ chain; CLP; Common lymphoid progenitor; cNK; Con
Keywords: Gene polymorphisms; AERD; B2ADR; IL-13; IL-17A; CYP2C19; TBXA2R; CRTH2; HSP70;
Keywords: Type 1 immunity; type 2 immunity; type 3 immunity; innate lymphoid cells; TH1; TC1; TH2; TC2; TH17/TH22; TC17/TC22; APC; Antigen-presenting cell; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; DC; Dendritic cell; Eomes; Eomeso
Keywords: Corticosteroids; bronchodilator; cytokine; chemokine; IgE; kinase; p38 mitogen-activated protein kinase; bronchial thermoplasty; corticosteroid resistance; macrolide; ACOS; Asthma-chronic obstructive pulmonary disease overlap syndrome; COPD; Chronic obs
Keywords: Diamine oxidase; basophils; allergen immunotherapy; sublingual immunotherapy; subcutaneous immunotherapy; histamine; basophil activation assay; CRTh2; Chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; DAO; Diamine oxidase; NAC; No
Keywords: Asthma; adults; inhaled corticosteroids; asthma management; ACQ; Asthma Control Questionnaire; CalvNO; Alveolar fraction of exhaled nitric oxide; COPD; Chronic obstructive pulmonary disease; CRTH2; Chemoattractant receptor homologous molecule expressed on
Keywords: Dendritic cells; cytokines; immunotherapy; mast cell; basophil; eosinophil; T cells; regulatory T cells; AHR; Airway hyperresponsiveness; CIITA; MHC class II transactivator; CRTH2; Chemoattractant receptor homologous molecule expressed on TH2 cells (also
Antiapoptotic serine protease inhibitors contribute to survival of allergenic TH2 cells
Keywords: TH2 cells; apoptosis; memory; grass pollen allergy; AICD; Activation-induced cell death; APC; Allophycocyanin; BAL; Bronchoalveolar lavage; CRTH2; Prostaglandin D2 receptor; FACS; Fluorescence-activated cell sorting; ICS; Intracellular staining; ILC1; Inn
The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation
Keywords: Asthma; TH2; voltage-gated calcium channel 1; calcium; cytokines; BAL; Bronchoalveolar lavage; [Ca2+]i; Intracellular Ca2+ concentration; Cav; Voltage-gated calcium channel; CavβAS; Cavβ antisense; CavβS; Cavβ scrambled; CRTH2; Chemoattractant recepto
Prostaglandin E2 suppresses human group 2 innate lymphoid cell function
Keywords: ILC2; allergy; prostaglandin E2; E-type prostanoid receptor 2; E-type prostanoid receptor 4; cAMP; Cyclic AMP; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; EP; E-type prostanoid receptor; ILC; Innate lymphoid cell; ILC2; Gro
New Anti-Eosinophil Drugs for Asthma and COPD
Keywords: airway inflammation; asthma; COPD; eosinophils; pharmacotherapy; CRTH2; chemoattractant receptor-homologous molecules expressed on Th2 cells; FeNO; fraction of exhaled nitric oxide; ILC2; type 2 innate lymphoid cells; Rα; receptor alpha; Th2; T helper 2;
Tyrosine kinase inhibition is an important factor for gene expression of CRTH2 in human eosinophils and lymphocytes: A novel mechanism for explaining eosinophils recruitment by the neuro-immune axis in allergic rhinitis
Keywords: Allergic rhinitis; CRTH2; Late phase reaction; Tyrosine kinase inhibitors; Leukocytes;
15-Deoxy-Î12,14-prostaglandin J2 induced neurotoxicity via suppressing phosphoinositide 3-kinase
Keywords: 15-Deoxy-Î12,14-prostaglandin J2; Phosphoinositide 3-kinase; Neurotoxicity; Cerebral cortex; Hippocampus; Memory retrieval; 15d-PGJ2; 15-Deoxy-Î12,14-prostaglandin J2; CRTH2; Chemoattractant receptor-homologous molecule expressed on T-helper type 2 ce
Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases
Keywords: VIP; Vasoactive Intestinal Peptide; VPAC-1; Vasoactive Intestinal Peptide Receptor Type 1; VPAC-2; Vasoactive Intestinal Peptide Receptor Type 2; CRTH2; Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells; PAC1; Pituitary adenylate cyclase
Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines
Keywords: Group 2 innate lymphoid cell; leukotriene E4; prostaglandin D2; IL-25; IL-33; IL-2; thymic stromal lymphopoietin; atopic dermatitis; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; CSF1; Macrophage colony-stimulating factor; cy
Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis
Keywords: Anaphylaxis; basophils; CD63 activation; FcεRI expression; CCL2; serum tryptase; CPA3; Carboxypeptidase A3; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; DBPCFC; Double-blind, placebo-controlled food challenge; ED; E
Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production
Keywords: Group 2 innate lymphoid cell; TH2; IL-4; IL-13; IL-5; CD154; IgE; Toll-like receptor; APRIL; A proliferation-inducing ligand; BAFF; BÂ cell-activating factor of the TNF family; CRS; Chronic rhinosinusitis; CRTH2; Chemoattractant receptor expressed on TH
Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts
Keywords: CRTH2; DP; Nasal polyp fibroblast; PGD2; VEGF; CRSwNP; chronic rhinosinusitis with nasal polyps; CRTH2; chemoattractant receptor-homologous molecule expressed on Th2 cells; DP; D-prostanoid; PG; prostaglandin; NPDF; nasal polyp-derived fibroblasts; VEGF;
Food, drug, insect sting allergy, and anaphylaxisHighly increased levels of IgE antibodies to vaccine components in children with influenza vaccine-associated anaphylaxis
Keywords: Anaphylaxis; influenza vaccine; hemagglutinin; IgE; basophil activation; CRTH2; Chemoattractant receptor-homologous molecule express on TH2 lymphocytes; EA group; Egg allergy group; IVA; Influenza vaccine-associated anaphylaxis; N group; No egg allergy
IL-25/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa
Keywords: Chronic rhinosinusitis with nasal polyps; nasal mucosa; IL-25; IL-33; IL-17RB; ST2; T-cell phenotype; TH2 cells; TH17 cells; T-cell receptor Vβ repertoire; microarray; AIM2; Absent in melanoma 2; CDR3; Complementarity-determining region 3; CRSwNP; Chron
Rhinitis, sinusitis, and upper airway diseaseShort-term subcutaneous grass pollen immunotherapy under the umbrella of anti-IL-4: AÂ randomized controlled trial
Keywords: Allergic rhinitis; subcutaneous allergen immunotherapy; anti-IL-4; FluoroSpot; intradermal late-phase response; AE; Adverse event; AIT; Allergen immunotherapy; Cmax; Maximum drug plasma concentration; CRTH2; Chemoattractant receptor-homologous molecule
Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function
Keywords: Atopic dermatitis; eosinophilic inflammation; eosinophilic gastrointestinal disease; IL-5; hematopoietic prostaglandin D synthase; chemoattractant receptor-homologous molecule expressed on TH2 cells; TH2; CD4; CD161; CD294; AD; Atopic dermatitis; CD62L;
Pharmacological characterization of CRTh2 antagonist LAS191859: Long receptor residence time translates into long-lasting in vivo efficacy
Keywords: cAMP; cyclic adenosine monophosphate; CHO; chinese hamster ovary cell line; CRTh2; chemoattractant receptor-homologous molecule expressed on T-helper cells; DK-PGD2; 13-14-dihydro-15-keto-PGD2; GDP; guanosine diphosphate; GPCR; G protein-coupled receptor;
Human EP2 prostanoid receptors exhibit more constraints to mutations than human DP prostanoid receptors
Keywords: DP; D-type prostanoid; EP; E-type prostanoid; PGE2; prostaglandin E2; PGD2; prostaglandin D2; FP; F-type prostanoid; PGF2α; prostaglandin F2α; IP; I-type prostanoid; PGI2; prostaglandin I2; TP; T-type prostanoid; TXA2; thromboxane A2; CRTH2; chemo-attra
Research reportCRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice
Keywords: Depression; Prostaglandin D2; CRTH2; Noradrenaline; Depression-related behavior;
Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
Keywords: CRTH2 antagonist; Asthma; Inhaled corticosteroid; ACQ; Asthma Control Questionnaire; AQLQ; Asthma Quality of Life Questionnaire; AUC; area under the curve; bid; twice daily; CI; confidence interval; CRTH2; chemoattractant receptor homologous molecule on T
Development of a decision-making biomarker for CRTH2 antagonism in clinical studies
Keywords: Decision-making biomarker; Receptor internalization; CRTH2; GPR44; PTGDR2; ACT-453859; Setipiprant; Flow cytometry;
Polarization diversity of human CD4+ stem cell memory T cells
Keywords: Tn; naïve T; Tcm; central memory T; Tem; effector memory T; Tscm; stem cell memory T; IL-2Rβ; the β chain of the IL-2 and IL-15 receptors; LFA-1; lymphocyte function-associated antigen 1; CRTH2; chemoattractant receptor-homologous molecule on Th2 cells
Computational Analysis of CRTh2 receptor antagonist: A Ligand-based CoMFA and CoMSIA approach
Keywords: CRTh2; 3D-QSAR; CoMFA; CoMSIA
Food, drug, insect sting allergy, and anaphylaxisJug r 2-reactive CD4+ T cells have a dominant immune role in walnut allergy
Keywords: Food allergy; walnut; Jug r 2; T cells; MHC class II tetramers; epitopes; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; ICS; Intracellular cytokine staining; PE; Phycoerythrin; RORC; RAR-related orphan receptor C; TCC; T-ce
Identification of leads through in silico approaches utilizing benzylthio-1H-benzo[d]imidazol-1-yl acetic acid derivatives: A potent CRTh2 antagonist
Keywords: CRTh2; Pharmacophore; Virtual screening; Molecular docking; CoMFA;
Asthma and lower airway diseaseD prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cells
Keywords: Expression; asthma; immunohistochemistry; prostaglandin D2; biopsy; ALI; Air-liquid interface; COPD; Chronic obstructive pulmonary disease; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; DK-PGD2; 13, 14-Dihydro-15-keto prost
Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk
Keywords: Prostaglandin D2; leukotriene E4; chemoattractant receptor-homologous molecule expressed on TH2 cells; TH2 cells; neutrophils; CAIA; Cell activation-induced aggregation; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; cysLT;
Mechanisms of allergy and clinical immunologyChronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization
Keywords: Cat allergy; Fel d 1; Fel d 4; TH2 cells; allergen tolerance; asthma; class II tetramer; CD154; IgG4; allergen exposure; APC; Allophycocyanin; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; PE; Phycoerythrin; sTH2; Specific
Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33
Keywords: Type 2 innate lymphoid cells; IL-33; T cells; feedback circuit; chronic asthma; BAL; Bronchoalveolar lavage; γc; Common γc chain of the IL-2 receptor; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; DRA; Dust mite, ragw
Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma
Keywords: AHR; airway hyper-responsiveness; AUC; area under the curve; BALF; bronchoalveolar lavage fluid; cAMP; cyclic adenosine monophosphate; CRTH2; chemoattractant receptor homologous molecule expressed on Th2 cells; Cmax; maximum concentration achieved after d
Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD2 receptors CRTH2 and DP
Keywords: CRTH2; DP; CYP3A4; Indole; Phenylacetic acid;