Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
مقالات ISI (ترجمه نشده)
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Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion
Keywords: Hyperthyroidism; Aggression; Epac1; Behavioral phenotyping; Prkar1a;
Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1
Keywords: ADCY1; adenylate cyclase type 1; ANO1; anoctamin 1; BFA; brefeldin A; CCH; carbachol; CFTR; cystic fibrosis transmembrane conductance regulator; EPAC1; exchange protein directly activated by cAMP; ER; endoplasmic reticulum; GPCR; G-protein coupled recepto
Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells
Keywords: EPAC; exchange protein directly activated by cAMP; ROCK; RhoA activated Protein Kinase; PKA; protein kinase A; HUVEC; human umbilical vein endothelial cells; GEF; guanine exchange factor; ERM; ezrin-radixin-moesin family; FERM; 4.1 ezrin-radixin-m
Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics
Keywords: 3D lrECM; three-dimensional cultures of laminin-rich extracellular matrix; ACs; adenylyl cyclases; AKAP; A-kinase anchoring protein; ATP; adenosine triphosphate; β-AR; β adrenergic receptor; β-arr2; β-arrestin 2; BnT; benzylthio group; cAB; cAMP-bindi
The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs
Keywords: Cyclic AMP; Transcription; SOCS3; EPAC1; c-Jun; AP1;
Epac contributes to cardiac hypertrophy and amyloidosis induced by radiotherapy but not fibrosis
Keywords: Radiotherapy; Epac1; Cardiomyocyte; Heart; Hypertrophy; Amyloidosis; Fibrosis;
Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways
Keywords: Rolipram; PDE; Glioblastoma; cAMP; PKA; Epac1; Rap1;
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control
Keywords: Endothelial barrier function; Adherens Junction; Rap1; Epac1; PDZ-GEF;
Novel adenosine and cAMP signalling pathways in migrating glial cells
Keywords: Satellite glial cells; Migration; Adenosine; Calcium; cAMP; Epac1;
Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors
Keywords: Rap1; Junction; Cell–cell contact; Barrier function; E-cadherin; Actin; C3G; PDZ-GEF; Epac1
Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-κB pathway in Raw 264.7 murine macrophages
Keywords: cAMP, cyclic adenine monophosphate; Epac, cAMP-responsive guanine nucleotide exchange factor; FBS, fetal bovine serum; LPS, lipopolysaccharide; ROS, reactive oxygen species; SEAP, secreted alkaline phosphataseLPS; NF-κB; cAMP; PKA; Epac1; Rap1
Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion
Keywords: Phosphodiesterase 3B; Phosphodiesterase 4D; EPAC1; PKA; cAMP;