Keywords: hAECs; human aortic endothelial cells; oxLDL; oxidized low-density lipoprotein; nLDL; native low-density lipoprotein; GPX; glutathione peroxidase; IGF-1; insulin-like growth factor 1; Apoe; apolipoprotein e; ROS; reactive oxygen species; l-NAME; NG-nitro-
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Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells
Keywords: Spirostanol saponin; Autophagy; Apoptosis; Rohdea chinensis; Human acute promyelocytic leukemia; Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate-activated protein kinase; Baf-A1; bafilomycin A1; FBS; fetal bovine serum; JC-1; 5,5´,6,6´-tetrach
Research reportInhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: Interference with mTOR and autophagy
Keywords: AMPK; AMP-activated protein kinase; Atg; autophagy related gene; DAP1; death associated protein 1; 4EBP1; eukaryotic initiation factor 4E binding protein 1; FGF; fibroblast growth factor; HIF-1; hypoxia-inducible factor-1; FIP; FAK family kinase-interacti
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; AMP-activated protein kinase; Atg13; autophagy-related 13; FIP200; 200Â kilodalton focal adhesion kinase family kinase-interacting protein; GAP; GTPase activator protein; GATOR; GAP activity
RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; caRags; constitutively active Rags B and C; caRheb; constitutively active Rheb; caRhoA; constitutively active RhoA; mTOR; mechanistic target of rapamycin; mTORC; mechanistic target of rapamycin co
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; 6-OHDA; 6-hydroxydopamine; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; AMPK; AMP-dependent/activated protein kinase; DAB; 3,3â²-diaminobenzidine tetrachloride; DAPI; 4â²,6-diamidino-2-
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ATF4; activating transcription factor 4; ca; constitutively active; dn; dominant negative; ERK; extracellular signal-related protein kinase; FBS; fetal bovine serum; GCN2; general control non-dere
hsBAFF promotes proliferation and survival in cultured B lymphocytes via calcium signaling activation of mTOR pathway
Keywords: 2-APB; 2-aminoethoxydiphenyl borate; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; Akt; protein kinase B (PKB); BAFF; B-cell activating factor of the TNF family; BAPTA/AM; 1,2-bis(o-aminophenoxy) ethane-N,N,Nâ²,Nâ²-tetraacetic acid tetra(ac
Improved Clearance during Treatment of HPV-Positive Head and Neck Cancer through mTOR Inhibition
Keywords: Ad5 E6/E7; adenovirus 5 expressing HPV-16 E6 and E7; CMI; cell-mediated immunity; CRT; cisplatin/radiation therapy; HNSCC; head and neck squamous cell carcinoma; HPV; human papillomavirus; HPV-; HPV-negative; HPV+; HPV type 16 positive; HTEs; human tonsil
Molecular Mechanisms of Pancreatic Dysfunction Induced by Protein Malnutrition
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; CCK; cholecystokinin; IP; intraperitoneal; mTOR; mammalian target of rapamycin; S6; ribosomal protein S6;