Keywords: Biotherapeutics; Gene and cell therapy; Pharmacokinetics; Non-clinical safety; Immunogenicity; Cross-reactive species; ATMP; advanced therapy medicinal products; CAR; chimeric antigen receptor; CD; cluster of differentiation; CMC; chemistry manufacturing
مقالات ISI (ترجمه نشده)
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Keywords: ALB; serum albumin (protein); ALB; albumin gene; FcRn; neonatal Fc receptor; Human serum albumin; Analbuminemia; Heteroduplex analysis; Hypercholesterolemia; Single-strand conformation polymorphism; DNA sequence;
Keywords: Nanotopography; Drug delivery; Epithelial permeability; Calcium switch; Tight junctions; Transcytosis; FcRn;
Keywords: Therapeutic antibody; Prediction; Allometric scaling; Two-compartment model; FcRn;
Keywords: FcRn; neonatal Fc receptor; TfR; transferrin receptor; TGN; trans-Golgi network; M6P-R; mannose-6-phosphatemannose-6-phosphate receptor; GFP; green fluorescent protein; Endosomal sorting; Receptor recycling; Recycling endosomes; Neonatal Fc receptor; Late
Comparability study of Rituximab originator and follow-on biopharmaceutical
Keywords: AA; amino acid; ABC; ammonium bicarbonate; ACN; acetonitrile; ADCC; antibody-dependent cellular cytotoxicity; CD; circular dichroism; CDC; complement-dependent cytotoxicity; CDRs; complementarity determining regions; CH; constant region of heavy chain; CH
Keywords: APC; antigen-presenting cells; BcR; B cell receptor; EMA; European Medicines Agency; Fc; crystallizable fragment; FcγR; receptor for IgG Fc portion; FcRn; neonatal Fc receptor; FVIIa; activated factor VII; FVIII; factor VIII; GLP-1; glucagon-like peptide
Keywords: BBB; bloodâbrain barrier; Col-IV; collagen IV; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; EB; evans blue; FcRn; neonatal Fc receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; H/I; hypoxic/ischemic; LRP1; low-density lipoprotein recep
Keywords: ABD; albumin-binding domain; B28; BMAP28 (amino acids 1-18); BB28; the conjugate of bombesin and B28; ABB28; the conjugate of ABD and BB28; HSA; human serum albumin; FcRn; the neonatal Fc receptor; GRPR; gastrin-releasing peptide receptor; Tumor-homing
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; AP; alkaline phosphatase; ASGP-R; asialoglycoprotein receptor; ATP; adenosine 5â²-triphosphate; BBB; blood-brain barrier; CABG; coronary artery bypass graft; DAMP; damage-associated molecular pattern; FcRn; n
Keywords: Albumin; Half-life; FcRn; Cubilin; Megalin; Therapeutics; Engineering;
Keywords: APD-FM; avalanche photodiode fluorescence microscopy; AFM; atomic force microscopy; CDR; complementarity determining regions; Chol; cholesterol; D; diffusion constant; di-8-ANEPPS; 4-[2-[6-(dioctylamino)-2-naphthalenyl]ethenyl]-1-(3-sulfopropyl)-pyridiniu
Keywords: Pulmonary delivery; Monoclonal antibodies; Pharmacokinetics; FcRn;
Keywords: Albumin; FcRn; Half-life; Protein drug; Pharmacokinetics; Animal models;
Keywords: ADP; adenosine diphosphate; AE2; anion exchanger 2; Ala; alanine; AMP; adenosine monophosphate; AP; alkaline phosphatase; Arg; arginine; ATP; adenosine triphosphate; ASGP-R; asialoglycoprotein receptor; Asn; asparagine; ASOR; asialoorosomucoid; BDL; bile
Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins
Keywords: mAb; monoclonal antibody; IgG; immunoglobulin G; FcRn; neonatal Fc receptor; MHC; major histocompatibility complex; B2M; β2 microglobulin; TEER; trans-epithelial electrical resistance; MDCK; Madin-Darby Canine Kidney; FACS; florescence-activated cell sor
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport
Keywords: FcγR; Fc-gamma receptor; FcRn; neonatal Fc-receptor; FMAIT; fetomaternal alloimmune thrombocytopenia; HPA; human platelet antigens; IVIG; intravenous immunoglobulin; HuVEC; human umbilical vein endothelial cells; JAR; human choriocarcinoma cells; IgG; Ne
Certolizumab pegol for the treatment of chronic plaque psoriasis: Results through 48Â weeks from 2 phase 3, multicenter, randomized, double-blinded, placebo-controlled studies (CIMPASI-1 and CIMPASI-2)
Keywords: anti-TNF; anti-tumor necrosis factor; certolizumab pegol; chronic plaque psoriasis; CIMPASI-1; CIMPASI-2; phase 3 trial; CZP; certolizumab pegol; DLQI; Dermatology Life Quality Index; FcRn; neonatal Fc receptor; PASI; Psoriasis Area and Severity Index;
Unidirectional transport of IgG by neonatal Fc receptor in human thyrocytes varies across different IgG subclasses
Keywords: FcRn; Thyrocytes; IgG transport; IgG subclasses;
Certolizumab pegol for the treatment of chronic plaque psoriasis: Results through 48Â weeks of a phase 3, multicenter, randomized, double-blind, etanercept- and placebo-controlled study (CIMPACT)
Keywords: anti-TNF; anti-tumor necrosis factor; certolizumab pegol; chronic plaque psoriasis; CIMPACT; etanercept; phase 3 trial; CZP; certolizumab pegol; FcRn; neonatal Fc receptor; PASI; Psoriasis Area and Severity Index; PASI 50; â¥50% reduction in PASI from
Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells
Keywords: Retinal endothelial cells; Aflibercept; Fc fusion protein; IgG; Neonatal Fc receptor; Internalization; Transport; Transcytosis; DMSO; dimethyl sulfoxide; EEA1; early endosome antigen 1; Fc; fragment crystalisable; FcRn; neonatal Fc receptor; FBS; fetal bo
Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease
Keywords: Immunoglobulin; IgE; half-life; metabolism; omalizumab; FcRn; Neonatal Fc receptor; Gal; Galectin; PK; Prausnitz-Küstner;
Medical BiotechnologyAlbumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins
Keywords: ABD; albumin binding domain; AUC; area under the curve; FcRn; neonatal Fc receptor; HSA; human serum albumin; IgG; immunoglobulin G; PEG; polyethylene glycol; MSA; mouse serum albumin; RSA; rat serum albumin; TNFα; necrosis factor; sdAb; single-domain an
Phase I Trial of Anti-Vascular Endothelial Growth Factor/Anti-angiopoietin 2 Bispecific Antibody RG7716 for Neovascular Age-Related Macular Degeneration
Keywords: AE; adverse event; AMD; age-related macular degeneration; BCVA; best-corrected visual acuity; CNV; choroidal neovascularization; CST; central subfield thickness; FcRn; neonatal Fc receptor; IgG; immunoglobulin G; IOP; intraocular pressure; MD; multiple do
IgG subclasses determine pathways of anaphylaxis in mice
Keywords: Anaphylaxis; IgG; mouse model; basophil; neutrophil; monocyte; macrophage; IgG Fc receptor; platelet-activating factor; histamine; FcγR; IgG Fc receptor; FcRn; Neonatal IgG receptor; FITC; Fluorescein isothiocyanate; Gfi1; Growth factor independence 1; K
Characterization of serum antibodies from women immunized with Gardasil: A study of HPV-18 infection of primary human keratinocytes
Keywords: HPV vaccine; HPV antibodies; HPV-18 neutralization; Primary human keratinocytes; FcRn;
PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody-antigen binding model
Keywords: Monoclonal antibody; pH-dependent antigen-binding; FcRn; TMDD; PK/PD;
Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice
Keywords: FVIII; factor VIII; rFVIIIFc; recombinant human factor VIII Fc; BDD; B-domain deleted; FL-rFVIII; full length recombinant factor VIII; Treg; regulatory T-cells; TNF-α; tumor necrosis factor-α; IFN-γ; Interferon-γ; Hemophilia A; Immune tolerance; Regul
Single chain antibody fragments with pH dependent binding to FcRn enabled prolonged circulation of therapeutic peptide in vivo
Keywords: FcRn; scFv; Phage display; pH-dependent; Half-life extension;
Oral delivery of anti-MDM2 inhibitor SP141-loaded FcRn-targeted nanoparticles to treat breast cancer and metastasis
Keywords: FcRn; SP141; MDM2 inhibitor; Oral nano-delivery; Breast cancer; Metastasis;
Human IgGs induce synthesis and secretion of IgGs and neonatal Fc receptor in human umbilical vein endothelial cells
Keywords: HUVECs; human umbilical vein endothelial cells; HSP; heat shock protein; MMP; matrix metalloprotease; FcRn; neonatal Fc receptor; Ab; antibody; EBM; endothelial basal medium; GADPH; glyceraldehyde-3-phosphate dehydrogenase; AP; alcaline phosphatase; MTT;
Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection
Keywords: ADCC; Antibody-dependent cell-mediated cytotoxicity; ARV; Anti-retroviral; AZT; Zidovudine; bnAb; Broadly neutralizing antibody; CD4bs; CD4 binding site; dIgA; Dimeric IgA; FcRn; Neonatal Fc receptor; GalCer; Galactosyl ceramide; GI; Gastrointestinal; GU;
Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization
Keywords: FcRn; pH-dependent binding; IgG; Fc-fusion; Transcytosis; Epithelial; Mucosal barrier;
Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein
Keywords: rFVIIIFc; Human cell line; HEK 293H; Hemophilia A; Manufacturing; Recombinant; aPTT; activated partial thromboplastin time; α-Gal; galactose-α-1,3-galactose; BDD; B domain-deleted; FcRn; neonatal Fc receptor; FVIII; factor VIII; HC; heavy chain; HCP; ho
The intracellular localization and association of porcine Ia-associated invariant chain with the MHC class I-related porcine neonatal Fc receptor for IgG
Keywords: FcRn, the neonatal Fc receptor; Ii, Ia-associated invariant chain; CLIP, the class II-associated Ii peptide; GFP, green fluorescent protein; RFP, red fluorescent proteinPig; Intracellular localization; FcRn; IgG; Ia-associated invariant chain
Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics
Keywords: BLI; biolayer interferometry; CH2-CH3; constant regions of heavy chains IgG; ELISA; enzyme-linked immunosorbent assay; FcRn; neonatal Fc receptor; FRET; fluorescence resonance energy transfer; HMW; high molecular weight aggregates; HPLC; high-pressure l
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge
Keywords: Ab; antibody; mAb; monoclonal antibody; nmAb; neutralizing monoclonal antibody; ADCC; antibody-dependent cellular cytotoxic activity; AID50; 50% animal infectious doses; C1; first conserved region; CTL; cytotoxic T lymphocyte; dIgA; dimeric IgA; Env; enve
The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy
Keywords: Albumin; Immunoglobulin G; FcRn; Nanoparticle; Protein engineering;
Targeting FcRn for therapy: From live cell imaging to in vivo studies in mice
Keywords: FcRn; Antibody engineering; Immunoglobulin G; Live-imaging microscopy; Autoimmunity; Antibody pharmacokinetics
Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey
Keywords: Pharmacokinetic and pharmacodynamic modeling; Therapeutic monoclonal IgG antibody; FcRn; Tumor necrosis factor-alpha; Anti-therapeutic antibody; Immunogenicity
A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis
Keywords: RA; rheumatoid arthritis; CIA; collagen-induced arthritis; HSA; human serum albumin; HRP; horseradish peroxidase; TNF; tumor necrosis factor; TNF-scFv; anti-TNF-α scFv; CD3-scFv; anti-CD3 scFv; IMAC; immobilized-metal affinity chromatography; MTT; 3-(4,5
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus species
Keywords: C1q; multivalent complex and immunoglobulin binding component of the complement activation cascade; CDR; complementarity determining region; CH1 CH2 & CH3; first, second and third heavy chain constant region domains; FcRn; neonatal Fc receptor; Cκ; kappa
Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction
Keywords: Neonatal Fc receptor; Protein-protein interactions; FcRn; Small molecule; Inhibitor;
Research ReportEfflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn
Keywords: FcRn; neonatal Fc receptor; IgG; immunoglobulin G; WT; wild type; Blood-brain-barrier; IgG; FcRn; Efflux; Intracranial; Intranasal;
ReviewAre endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?
Keywords: IgG; immunoglobulin G; FcRn; neonatal Fc receptor; Fc; fragment crystallisable (antibody constant region); Fab; fragment with antigen binding (antibody variable region); F(ab')2; covalently bound Fab portions of an antibody; PBPK; physiologically based
Placental transfer of 125Iodinated humanized immunoglobulin G2Δa in the Sprague Dawley rat
Keywords: Placental transfer; Whole body autoradiography; FcRn; Biopharmaceuticals; Immunoglobulin (IgG); Pregnancy
Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics
Keywords: Immunoglobulin; FcRn; Bioassay; Assay qualification; Fc; Flow cytometry
Receptor fusion proteins for the inhibition of cytokines
Keywords: Akt; a serine-threonine protein kinase; Bcr-Abl; fusion of the breakpoint cluster region (bcr) gene and a cellular Abelson murine leukemia viral oncogene homolog; CAPS; cryopyrin-associated periodic syndromes; CBM; cytokine binding module; CLC; cardiotr
Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast
Keywords: IgG1; immunoglobulin G class 1; Fcab; antigen binding Fc protein; Fc-wt; recombinant wild-type Fc protein; scTCR; single-chain T-cell receptor; MHC; major histocompatibility complex; CDC; complement dependent cytotoxicity; ADCC; antibody dependent cell-me
Isotype and glycoform selection for antibody therapeutics
Keywords: IgG subclasses; Glycosylation; Fc receptors; Complement; FcRn; Effector functions;