Keywords: ADA; anti-drug antibodies; AMPK; 5â² adenosine monophosphate-activated protein kinase; aHUS; atypical hemolytic uremic syndrome; AMD; age-related macular degeneration; APC; antigen presenting cells; AT; anaphylatoxin; BTK; Bruton's tyrosine kinase; C1q
مقالات ISI (ترجمه نشده)
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Keywords: 5-FU; 5-fluoro-uracil; AAV; adeno-associated virus; ADAM; ADAM metallopeptidase domain; ADCC; antibody-dependent cell-mediated cytotoxicity; CCL; chemokine (C-C motif) ligand; CD; cluster of differentiation; CTLA-4; cytotoxic T-lymphocyte-associated ant
Keywords: APC; antigen presenting cell; CGD; chronic granulomatous disease; DC; dendritic cell; FcγR; Fc gamma receptor; GILT; γ-interferon-inducible lysosomal thiol reductase; GPI; glucose-6-phosphate isomerase; HEL; hen egg lysozyme; IFN-γ; interferon-gamma; I
Keywords: ADP; adenosine diphosphate; AID; autoimmune diseases; AML; acute myeloid leukemia; APRIL; a proliferation inducing ligand; BAFF; B cell activating factor; Breg; regulatory B cells; CMV; cytomegalovirus; DC; dendritic cells; EBV; Epstein Barr virus; FcγR;
Keywords: 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge
Keywords: ADA; anti-drug antibody; ADCC; antibody-dependent cell cytotoxicity; ADCP; antibody-dependent cell phagocytosis; BiTE; bi-specific T cell engagers; CDC; complement-dependent cytotoxicity; CRA; cytokine release assays; CRS; cytokine release syndrome; DC; d
Keywords: APC; antigen-presenting cells; BcR; B cell receptor; EMA; European Medicines Agency; Fc; crystallizable fragment; FcγR; receptor for IgG Fc portion; FcRn; neonatal Fc receptor; FVIIa; activated factor VII; FVIII; factor VIII; GLP-1; glucagon-like peptide
Keywords: Antibodies; Immunoconjugates; Immunotoxins; Ab; antibody; Ag; antigen; ADCC; antibody-dependent cell mediated cytotoxicity; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AKT; protein kinase B; APC; antigen-presenting cell; Apo2L/TRAIL; t
Keywords: ADCC; antibody-dependent cellular cytotoxicity; AQP4; aquaporin-4; BSA; bovine serum albumin; CDC; complement-dependent cytotoxicity; CNS; central nervous system; dSTORM; direct stochastic reconstruction microscopy; EDSS; expanded disability status scale;
Keywords: Mycobacterium tuberculosis; Tuberculosis; B cells; Antibodies; FcγR;
Keywords: AbX; antibody with mostly fucosylated glycans; AbX-AF; antibody with completely afucosylated glycans; ADCC; antibody-dependent cell-mediated cytotoxicity; AICC; antibody-independent cell-mediated cytotoxicity; CV; coefficient of variation; EC50; half maxi
Keywords: ADP; adenosine diphosphate; AE2; anion exchanger 2; Ala; alanine; AMP; adenosine monophosphate; AP; alkaline phosphatase; Arg; arginine; ATP; adenosine triphosphate; ASGP-R; asialoglycoprotein receptor; Asn; asparagine; ASOR; asialoorosomucoid; BDL; bile
Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling
Keywords: BAC; bacteria artificial chromosome; BMDC; bone marrow-derived dendritic cell; CYLD; cylindromatosis; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; FcγR; Fcγ receptor; FcR; Fc receptor; GM-CSF; Granulocyte macrophage colony-stimulating fact
Effects of amino acid substitutions on the biological activity of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori)
Keywords: Monoclonal antibody; Transgenic silkworm; Amino acid substitution; N-glycosylation; Fc-mediated effector function; ADCC; antibody-dependent cellular cytotoxicity; ADCP; antibody-dependent cellular phagocytosis; CBB; Coomassie Brilliant Blue; CDC; compleme
Conserved FcγR- glycan discriminates between fucosylated and afucosylated IgG in humans and mice
Keywords: Asn; asparagine; Bisection; bisecting GlcNAc; Fc; fragment crystallizable; FcγR; Fc gamma receptor; GlcNAc; N-acetylglucosamine; HEK; human embryonic kidney; hFcγR; human FcγR; hIgG; human IgG; IgG; immunoglobulin G; mFcγR; -mouse FcγR; mIgG; mouse
A simple method for measuring immune complex-mediated, Fc gamma receptor dependent antigen-specific activation of primary human T cells
Keywords: IVIg; Intravenous Immunoglobulin; IC; immune complex; TT; tetanus toxoid; FcγR; Fc gamma receptor; APC; antigen presenting cell; PBMC; peripheral blood mononuclear cells; DC; dendritic cell; MOA; mode of action; CTV; CellTrace Violet; IFN-γ; Interferon-
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport
Keywords: FcγR; Fc-gamma receptor; FcRn; neonatal Fc-receptor; FMAIT; fetomaternal alloimmune thrombocytopenia; HPA; human platelet antigens; IVIG; intravenous immunoglobulin; HuVEC; human umbilical vein endothelial cells; JAR; human choriocarcinoma cells; IgG; Ne
Exacerbated Immune Complex-Mediated Vascular Injury in Mice with Heterozygous Deficiency of Aryl Hydrocarbon Receptor through Upregulation of Fcγ Receptor III Expression on Macrophages
Keywords: AhR; Aryl hydrocarbon receptor; CXCL1; CXC chemokine ligand 1; DC; dendritic cell; FcγR; Fcγ receptor; FICZ; 6-formylindolo [3,2-b] carbazole; IC; immune complex; PNC; polyarteritis nodosa cutis; RA; rheumatoid arthritis; TCDD; 2,3,7,8-tetrachlorodibenz
Anti-FcγRIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of FcγRIII
Keywords: Fc receptors; anaphylaxis; mouse; signaling; IgG; IgE; EW; Chicken egg white; FcγR; Fcγ receptor; FcRγ; Fc receptor γ chain; FSC; Forward scatter; ITAM; Immunoreceptor tyrosine-based activation domain; ITIM; Immunoreceptor tyrosine-based inhibitory do
The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3â²,4â²-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a
Keywords: ABAH; 4-aminobenzoic acid hydrazide; ANOVA; analysis of variance; CL-luc; lucigenin-enhanced chemiluminescence; CL-lum; luminol-enhanced chemiluminescence; CR; complement receptor; DAPI; 4',6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfox
Quantification and simultaneous evaluation of the bioactivity of antibody produced in CHO cell culture-The use of the ectodomain of FcγRI and surface plasmon resonance-based biosensor
Keywords: FcγR; Monoclonal antibody; Surface plasmon resonance (SPR); Bioprocess monitoring;
Selective depletion of basophils ameliorates immunoglobulin E-mediated anaphylaxis
Keywords: BMMCs; bone marrow-derived mast cells; CD200R; CD200 receptor; DNP; 2,4-dinitrophenol; DNP-BSA; DNP-conjugated bovine serum albumin; FcεR; Fcε receptor; FcγR; Fcγ receptor; GFP; green fluorescent protein; Ig; Immunoglobulin; IL; Interleukin; IRES; int
Alteration in Leukocyte Subsets and Expressions of FcγR and Complement Receptors among Female Ragpickers in Eastern India
Keywords: complement receptors; FcγR; lymphocyte; monocyte; ragpicker;
Monocyte-lymphocyte fusion induced by the HIV-1 envelope generates functional heterokaryons with an activated monocyte-like phenotype
Keywords: HIV-1; human immunodeficiency virus type 1; MFI; mean fluorescence intensity; FcγR; receptor for the Fc portion of IgG; Env; HIV-1 envelope protein; SIV; simian immunodeficiency virus; PMA; phorbol 12-myristate 13-acetate; DiI; 1,1'-dioctadecyl-3, 3,3â
IgG subclasses determine pathways of anaphylaxis in mice
Keywords: Anaphylaxis; IgG; mouse model; basophil; neutrophil; monocyte; macrophage; IgG Fc receptor; platelet-activating factor; histamine; FcγR; IgG Fc receptor; FcRn; Neonatal IgG receptor; FITC; Fluorescein isothiocyanate; Gfi1; Growth factor independence 1; K
Alginate enhances Toll-like receptor 4-mediated phagocytosis by murine RAW264.7 macrophages
Keywords: FBS; foetal bovine serum; AuNPs; gold nanoparticles; FITC; fluorescein isothiocyanate; TLR; Toll-like receptor; Akt; protein kinase B; NF-κB; nuclear factor-κB; ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; MAPK; mitogen-acti
Anti-Tumor Necrosis Factor With a Glyco-Engineered Fc-Region Has Increased Efficacy in Mice With Colitis
Keywords: Crohn's Disease; Fcγ Receptor; Drug Modification; Mouse Model; ADA; adalimumab; ADAâÎF; hypo-fucosylated ADA; ADCC; antibody-dependent cellular cytotoxicity; FcγR; Fcγ-receptors; IBD; inflammatory bowel disease; IFNγ; interferon γ; Ig; immunoglo
Reviews and feature articleHuman IgE-independent systemic anaphylaxis
Keywords: Anaphylatoxin; complement; FcεR; FcγR; IgE; IgG; mast cell; basophil; mouse; NSAID; Nonsteroidal anti-inflammatory drug; PAF; Platelet-activating factor; TNP; Trinitrophenyl;
ReviewThe double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy
Keywords: DC; dendritic cell; NK; natural killer cell; BCR; B-cell receptor; TNF; tumor necrosis factor; MHC; major histocompatibility complex; LMP; liver-metastatic pancreatic; FcγR; Fc gamma receptor; TRAMP; the transgenic adenocarcinoma of the mouse prostate mo
Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice
Keywords: Ptaquiloside; Human papillomavirus; Cancer; Bracken; CD8+ T cells; BPV; Bovine Papillomavirus; CTL; Cytotoxic T Lymphocytes; FASL; FAS Ligand; FcγR; Fragment crystallisable gamma Receptor; H&E; Haematoxylin & Eosin; HPV; Human Papillomavirus; HSQC; Heter
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
Optimization of a flow cytometric assay to evaluate the human neutrophil ability to phagocytose immune complexes via Fcγ and complement receptors
Keywords: ANOVA; analysis of variance; BSA; bovine serum albumin; CD; cytochalasin D; CR; complement receptor; DCFH; 2â²,7â²-dichlorodihydrofluorescein; DMSO; dimethyl sulfoxide; FcγR; receptor for the Fc portion of IgG; FITC; fluorescein isothiocyanate; HBSS; H
PerspectiveAntibody modulation: Limiting the efficacy of therapeutic antibodies
Keywords: FcγR; Fc gamma receptor; mAb; monoclonal antibody; Antibodies; Fc gamma receptor; FcγRIIB; Modulation; Shaving; Immunotherapy; CD20; Tumour resistance;
FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells
Keywords: APC; antigen-presenting cell; c-IgG; complexed IgG; DC; dendritic cell; FcγR; Fc gamma receptor; HAGG; heat aggregated IgG; IFNγR; interferon gamma receptor; IL-1R; interleukin-1 receptor; PRR; pattern-recognition receptor; SNP; single nucleotide polymo
Structural consequences of aglycosylated IgG Fc variants evolved for FcγRI binding
Keywords: Fc; fragment crystallizable; IgG; immunoglobulin G; Fab; fragment antigen binding; FcγR; Fc gamma receptor; ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cell-mediated phagocytosis; CDC; complement-dependent cytotoxicity;
Insights into the effector functions of human IgG3 in the context of an antibody targeting transferrin receptor 1
Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cell-mediated phagocytosis; AP; alkaline phosphatase; CDC; complement-mediated cytotoxicity; CH2; constant domain 2; DNP; 2,4-dinitrophenyl; EDTA; ethylenediaminetetraacetic aci
Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge
Keywords: Ab; antibody; mAb; monoclonal antibody; nmAb; neutralizing monoclonal antibody; ADCC; antibody-dependent cellular cytotoxic activity; AID50; 50% animal infectious doses; C1; first conserved region; CTL; cytotoxic T lymphocyte; dIgA; dimeric IgA; Env; enve
Detection of drug specific circulating immune complexes from in vivo cynomolgus monkey serum samples
Keywords: ADA; anti-drug antibody; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSA; bovine serum albumin; BUN; blood urea nitrogen; CP; cut point; CREA; creatinine; FcγR; Fc-gamma receptor; HQC; high quality control sample; HPLC; high pressure
Impact of Detachment Methods on M2 Macrophage Phenotype and Function
Keywords: MDM; monocyte differentiated macrophage; IFNγ; interferon gamma; LPS; lipopolysaccharide; MHC; major histocompatibility complex; PBMC; Peripheral blood mononuclear cells; M-CSF; macrophage colony-stimulating factor; 7-AAD; 7-amino-actinomycin D; FcγR; F
IGKC and FcγR genotypes and humoral immunity to HER2 in breast cancer
Keywords: Antibody response; FcγR; GM; HER2; IGKC; KM;
Ex vivo-expanded natural killer cells kill cancer cells more effectively than ex vivo-expanded γδ T cells or αβ T cells
Keywords: ADCC; antibody-dependent cellular cytotoxicity; E/T ratio; effector-to-target ratio; FcγR; Fcγ receptor; mAb; monoclonal antibody; MHC; major histocompatibility complex; NCR; natural cytotoxicity receptor; NK cell; natural killer cell; PBMCs; peripheral
Crystal structure of a novel asymmetrically engineered Fc variant with improved affinity for FcγRs
Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cell-mediated phagocytosis; A/I ratio; activating FcγR binding to inhibitory FcγR binding; asym-mAb23; a novel asymmetrically engineered Fc; FcγR; Fcγ receptor; mAb; monoclo
Association of serum IgG N-glycome and transforming growth factor-β1 with hepatitis B virus e antigen seroconversion during entecavir therapy
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; CHB; chronic hepatitis B; CID; collision-induced dissociation; Fc; crystallizable fragment; FcγR; Fc gamma receptor; G0; galactose-deficient; G1; partially galactosylated; G2; fully galactos
Fc receptor-targeting of immunogen as a strategy for enhanced antigen loading, vaccination, and protection using intranasally administered antigen-pulsed dendritic cells
Keywords: Dendritic cell vaccine; Fcγ receptor-targeted vaccine; Intranasal vaccine; Vaccine platform; Chronic infection; Cancer; DCs; dendritic cells; BMDCs; bone marrow-derived dendritic cells; mAb; monoclonal antibody; Ft; F. tularensis; iFt; inactivated Ft; IC
A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling
Keywords: FcγR; Fc gamma receptor; CVID; common variable immunodeficiency; ITAM; immunoreceptor tyrosine-based activation motif; BCR; B cell receptor; DC; dendritic cells; MAPK; mitogen-activated protein kinase; PBMC; peripheral blood mononuclear cells; ADCC; anti
Crosstalk between Mycobacterium tuberculosis and the host cell
Keywords: AC; adenylyl cyclase; AKAP7; A-kinase anchor protein 7 isoform gamma; AM; alveolar macrophage; ATP; adenosine triphosphate; BCG; Bacille Calmette-Guérin; cAMP; cyclic adenosine monophosphate; CD1; cluster of differentiation 1; c-di-AMP; cyclic-di-adeno
An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ADCP; antibody-dependent cellular phagocytosis; BSA; bovine serum albumin; CDC; complement dependent cytotoxicity; D-PBS; Dulbecco's phosphate-buffered saline; ECD; extracellular domain; FACS; fluorescence
Dendritic cell immunoreceptor: AÂ novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells
Keywords: Intravenous immunoglobulin; dendritic cells; regulatory T cells; immune modulation; asthma; AAD; Allergic airways disease; AHR; Airway hyperresponsiveness; BMDDC; Bone marrow-derived dendritic cell; DC; Dendritic cell; DCIR; Dendritic cell immunorecepto
Cleavage of the interchain disulfide bonds in rituximab increases its affinity for FcγRIIIA
Keywords: RTX; rituximab; S-RTX; S-sulfonated rituximab; A-RTX; reduced and then alkylated rituximab; mAb; monoclonal antibody; ADCC; antibody-dependent cellular cytotoxicity; FcγR; Fcγ receptor; KHYG-1/FcγRIIIA; KHYG-1 cells stably expressing FcγRIIIA; SDS-P
A novel assay for detecting virus-specific antibodies triggering activation of Fcγ receptors
Keywords: ADCC; antibody-dependent cellular cytotoxicity; EBV; Epstein-Barr virus; ELISA; enzyme-linked immunosorbent assay; FcγR; Fcγ receptor; Fab-g; IgG Fab fragment; Fc-g; IgG Fc fragment; GAM; goat anti mouse antibody; HCMV; human cytomegalovirus; HSV; her