دانلود مقالات ISI درباره Ffar1 + ترجمه فارسی

Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-γ/FFAR1 agonists

Keywords: Type-2 diabetes mellitus; PPAR-γ; FFAR1; Thiazolidindione; Biological evaluation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis and structure−activity relationship studies of GPR40 agonists containing amide linker

Keywords: GPR40; FFAR1; Insulin secretion; Type 2 diabetes mellitus; CNS;

دانلود رایگان متن کامل مقاله ISI 86 صفحه سال انتشار : 2018 سفارش ترجمه

Sunitinib specifically augments glucose-induced insulin secretion

Keywords: FFAR1; free fatty acid receptor 1; GIIS; glucose-induced insulin secretion; GLP-1R; glucagon-like peptide-1 receptor; IBMX; isobutylmethylxanthine; IGF-1R; insulin-like growth factor receptor-1; PDGFR; platelet-derived growth factor receptor; PKA; protein

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Point mutation of Ffar1 abrogates fatty acid-dependent insulin secretion, but protects against HFD-induced glucose intolerance

Keywords: FFAR1/GPR40; Free fatty acids; Insulin secretion; ENU-mutated Ffar1; FFAR1 deficient mice; High fat diet; CD; regular chow diet; ENU; N-ethyl-N-nitrosourea; FFAR1; free fatty acid receptor 1; GIIS; glucose-induced insulin secretion; GLP-1; glucagon like p

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Therapeutic journey of 2,4-thiazolidinediones as a versatile scaffold: An insight into structure activity relationship

Keywords: Thiazolidinedione; PPARγ; Antihyperglycemic; Anticancer; Antimicrobial; AI-2; Auto inducer-2; ATP; Adenosine triphosphate; ALR; Aldose reductase; COX; Cyclooxygenase; EC50; Half maximal effective concentration; ED50; Median effective dose; FFAR1; Free fa

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of the imidazole-derived GPR40 agonist AM-3189

Keywords: GPR40; FFAR1; GPCR; Agonist; Type II diabetes; Insulin secretagogue; AMG 837; AM-3189

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists

Keywords: Diabetes; PPARγ; FFAR1; Thiazolidinedione; Docking

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response

Keywords: FBS; fetal bovine serum; FFA; free fatty acids; FFAR1; free fatty acid receptor 1; GSIS; glucose-stimulated insulin secretion; SFA; saturated FFA; USFA; unsaturated FFA; OCR; oxygen consumption rate; MS; mass spectrometry; Palmitate; Oleate; Insulin secre

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism

Keywords: Cx; connexin; DCFS; divalent cation-free solution; Etd+;  ethidium; FFA; free fatty acid; GPCR; G-protein coupled receptor; GPR40; G-protein receptor 40; HC; hemichannel; LA; linoleic acid; Polyunsaturated fatty acid (PUFA); FFAR1; Connexon (hemichannel)

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2016 سفارش ترجمه

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans

Keywords: FFAR1; Free fatty acid receptor 1; G-protein coupled receptor 40; GPR40; PPARG; Insulin secretionFFAR1, free fatty acid receptor 1; GPR40, G-protein coupled receptor 40; NEFA, non-esterified fatty acids; OGTT, oral glucose tolerance test; TUEF, Tuebingen

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Homology modeling and explicit membrane molecular dynamics simulation to delineate the mode of binding of thiazolidinediones into FFAR1 and the mechanism of receptor activation

Keywords: Diabetes; FFAR1; PPARγ; Thiazolidinediones; Molecular dynamics

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1

Keywords: Beta-cell function; Beta-cell failure; TCF7L2; FFAR1; Gene×environment interaction; Pharmacogenetics; Incretin resistance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

Keywords: FFAR1; free fatty acid receptor 1; FFAs; free fatty acids; PIO; pioglitazone; PA; palmitic acid; ROS; reactive oxygen specific; PLCγ; Phospholipase C γ; ERK1/2; extracellular signal-regulated kinase 1/2; PPARγ; peroxisome proliferator activated recepto

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

Keywords: G-protein-coupled receptor; Free fatty acid; Insulin; FFAR1; FFAR2; FFAR3; GPR120;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه