دانلود مقالات ISI درباره Fkbp12 + ترجمه فارسی

بی ثباتی آلوستریک انتخابی هیپوکسیا از کیناز های گیرنده مانند فعال: یک مسیر درمان بالقوه برای پیشگیری از پوکی استخوان هتروتوبیک

Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification

Keywords: ALKs; activin receptor-like (type I) kinases; BMP; bone morphogenetic protein; BMPRII; BMP type II receptor; FKBP12; FK506-binding protein 12 kDa; FOP; Fibrodysplasia Ossificans Progressiva; AMPK; AMP-activated protein kinase; SMKI; small molecule kinas

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

تجزیه و تحلیل نقش هدف سیگنالینگ رپامایسین در متابولیسم اسپینگولایپید

Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

Keywords: AbA; Aureobasidin A; ABC; ATP-binding cassette; AMPK; AMP-activated protein kinase; ATG; Autophagy-related; ATP; Adenosine triphosphate; C1P; Ceramide-1-phosphate; CERS; Ceramide synthase; CK2; Casein kinase II; CLS; Chronological lifespan; CMA; Chaperone

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

eIF4E Phosphorylation in Prostate Cancer

Keywords: eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy induced by cardamonin is associated with mTORC1 inhibition in SKOV3 cells

Keywords: FKBP12; FK506 binding protein 12 kDa; FRB domain; FKBP12-rapamycin binding domain; mTOR; mammalian target of rapamycin; mTORC1/2; mTOR complex 1/2; NF-κB; nuclear factor-κB; Raptor; regulatory associated protein of mTOR; Rictor; rapamycin-insensitive

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of FKBP12 and type II BMP receptors on signal transduction by ALK2 activating mutations associated with genetic disorders

Keywords: Activin receptor-like kinase 2 (ALK2); Bone morphogenetic proteins (BMPs); Fibrodysplasia ossificans progressiva (FOP); Diffuse intrinsic pontine glioma (DIPG); FKBP12; Signal transduction; Heterotopic ossification;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

A miniaturized peptidyl-prolyl isomerase enzyme assay

Keywords: High throughput; Assay development; Fluorescence; Peptide; Inhibitor; FKBP12; Cyclophilin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Functional consequences of chemically-induced β-arrestin binding to chemokine receptors CXCR4 and CCR5 in the absence of ligand stimulation

Keywords: βArr; β-arrestin; AP2; adaptor protein 2; Dmr A/C; dimer A/C; FKBP12; 12 kDa FK506-binding protein; FRB; FKBP12-rapamycin-binding; GPCR; G protein-coupled receptor; MCF; mean channel fluorescence; mTOR; mechanistic target of rapamycin; p38; p38 mitogen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation

Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506

Keywords: Affinity resins; PEG; Target identification; Carbonic anhydrase II; FKBP12; Benzenesulfonamide; FK506; Calcineurin; Target complex

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Molecular docking study of macrocycles as Fk506-binding protein inhibitors

Keywords: Molecular docking; Fk506-binding protein; FKBP35; FKBP12; Malaria; Peptidyl-prolyl cis/trans isomerases

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis

Keywords: AAR; Area at risk; ADP; adenosine diphosphate; AKT; Protein kinase B; ANOVA; Analysis of variance; cTnI; Cardiac troponin I; dP/dT Max; left ventricular maximum contractility; dV/dT max; Left ventricular maximum filling; ECL; Enhanced chemiluminescense; E

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion

Keywords: cardamonin (PubChem CID: 641785)Cardamonin; mTOR; Rapamycin; Proliferation; Apoptosis; FKBP12

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Statistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain

Keywords: PDB; protein data bank; FKBP; FK506 binding protein; NOESY; nuclear Overhauser enhancement spectroscopy; FKBP12; NMR; Allostery; Molecular simulation; Statistical coupling; Concerted transition;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Classical force field parameters for two high-affinity ligands of FKBP12

Keywords: CHARMM force field; Parametrization; High-affinity ligand; FKBP12; Molecular mechanics

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase

Keywords: Lentivirus; FLP recombinase; Knockdown; Inducible; FKBP12; ERT2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line

Keywords: sIBM; sporadic inclusion body myositis; APP; amyloid precursor protein; 3MA; 3-methyladenine; CQ; chloroquine; FKBP12; FK-binding protein 12; mTORC1; mammalian target of rapamycin complex1; BACE1; β-site APP-cleaving enzyme 1; AD; Alzheimer's dementia; M

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Expression of budding yeast FKBP12 confers rapamycin susceptibility to the unicellular red alga Cyanidioschyzon merolae

Keywords: Cyanidioschyzon merolae; FKBP12; Rapamycin; Red alga; TOR kinase; DMSO; dimethyl sulfoxide; His-tag; histidine-tag; kDa; kilodalton;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Structural dynamic and thermodynamic analysis of calcineurin B subunit induced by calcium/magnesium binding

Keywords: CN; calcineurin; CNB; calcineurin B subunit; CNA; calcineurin A; NFAT; nuclear factor of activated T cells; FKBP12; the FK506-binding protein; CaBPs; calcium binding proteins; IPTG; isopropyl thiogalactopyranoside; CD; circular dichroism; GdnHCl; guanidin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The Fusarium Graminearum virulence factor FGL targets an FKBP12 immunophilin of wheat

Keywords: BiFC; Biomolecular fluorescence complementation; DON; Deoxynivalenol; ERG; Elicitor-responsive gene; ETI; Effector-triggered immunity; ETS; Effector-triggered susceptibility; FHB; Fusarium head blight; FKBP; FK506-binding protein; FKBP12; 12-kDa FK506-bin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels

Keywords: FKBP12; Inositol 1,4,5-trisphosphate receptor; Ryanodine receptor; NMR;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Neuroimmunophilin GPI-1046 reduces ethanol consumption in part through activation of GLT1 in alcohol-preferring rats

Keywords: ANOVA; analysis of variance; DMSO; dimethylsulfoxide; ER; endoplasmic reticulum; FKBP12; FK506 binding protein 12; GDNF; glial cell line-derived neurotrophic factor; GLAST; glutamate aspartate transporter; GLT1; glutamate transporter 1; GPI-1046; 3-(3-pyr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs

Keywords: Erythrocytes; Drug delivery; FKBP12; Cyclophilin A; Tacrolimus; Cyclosporine A

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

Keywords: 4E-BP1; 4E binding protein 1; 5′UTR; 5′ untranslated region; AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5′-AMP-activated protein kinase; AMPK α1−/−; AMPK α1 subunit knockout; AMPKα1−/−α2−/−; A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Selective elution of target protein from affinity resins by a simple reductant with a thiol group

Keywords: Affinity resins; Target identification; Carbonic anhydrase II; FKBP12; Benzenesulfonamide; FK506; 2-Mercaptethanol (2ME); AquaFirmus

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Estimating the affinity of protein-ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry

Keywords: Ligand affinity; Electrospray ionization mass spectrometry; FKBP12; Immunophilin;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles

Keywords: FKBP12; Peptidyl–prolyl isomerase; Tau; Neurofibrillary tangles; Intermediate filament; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Myocardial release of FKBP12 and increased production of FKBP12.6 in ischemia and reperfusion experimental models

Keywords: Ischemia; Reperfusion; Pigs; HL-1 cells; FKBP12; FKBP12.6

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Role of the Botrytis cinerea FKBP12 ortholog in pathogenic development and in sulfur regulation

Keywords: FKBP12, FK506 binding protein of 12 kDa; TOR, Target of rapamycine; NCR, Nitrogen catabolite repressionBotrytis cinerea; FKBP12; Prolyl isomerase; Nutrient regulation; Sulfur regulation; Ascomycete; Pathogenicity; Serine protease

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Ligand- and substrate-based 19F NMR screening: Principles and applications to drug discovery

Keywords: ALARM; a La assay to detect reactive molecules; BEI; binding efficiency index; CPMG; Carr-Purcell-Meiboom-Gill; CSA; chemical shift anisotropy; ERETIC; electronic reference to access in vivo concentrations; FA; fluorescence anisotropy; FABS; fluorin

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2007 سفارش ترجمه

Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins

Keywords: Nonspecific binding proteins; Affinity chromatography; Poly(methacrylate); FK506; FKBP12; FKBP52;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface

Keywords: Nonspecific binding proteins; Surface plasmon resonance; FK506; FKBP12

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

A versatile method of identifying specific binding proteins on affinity resins

Keywords: Affinity resins; Competition method; Target identification; Nonspecific binding proteins; FKBP12; Carbonic anhydrase II; Dihydrofolate reductase; FK506; Benzenesulfonamide; Methotrexate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Structural Characterization of the RyR1–FKBP12 Interaction

Keywords: cryo-electron microscopy; FK506; FKBP12; ryanodine receptorCn, calcineurin; EM, electron microscopy; FKBP12, FK506-binding protein 12 kDa; FKBP12.6, FK506-binding protein 12.6 kDa; FRAP, FKBP12-rapamycin-associated protein; GFP, green fluorescent protein;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Depletion of FKBP does not affect the interaction between isolated ryanodine receptors

Keywords: Ryanodine receptor/calcium release channel; RyR array; Coupled gating; Intermolecular interaction; FKBP12; Modulation; Photon correlation spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Mechanism of osteogenic induction by FK506 via BMP/Smad pathways

Keywords: FK506; BMP; Smad; FKBP12; Osteogenic differentiation; Osteoblast;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه