Keywords: Alzheimer's disease; Tau; FTDP-17; Oligomer; AFM;
مقالات ISI (ترجمه نشده)
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Keywords: AD; Alzheimer's disease; FTDP-17; frontotemporal dementia with parkinsonism linked to chromosome 17; GVD; granulovacuolar degeneration; GSK3β; glycogen synthase kinase-3β; NFTs; neurofibrillary tangles; pSyk; spleen tyrosine kinase phosphorylated at t
Keywords: AD; Alzheimer's disease; FTDP-17; frontotemporal dementia with Parkinsonism linked to chromosome 17; NFT; neurofibrillary tangle; PFFs; preformed fibrils; Tg; transgenic; Seeding; Spreading; Tau pathology; Cell death;
Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies
Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; AMPAR; AMPA-type glutamate receptor; CNS; central nervous system; FTDP-17; frontotemporal dementia with parkinsonism linked to chromosome 17; GFP; green fluorescent protein; GSK-3β; glycogen synthase kinase-3β
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
Keywords: 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose; AD; Alzheimer's disease; CBD; Corticobasal Degeneration; CSF; Cerebrospinal Fluid; DHE; Dihydroethidium; ETC; Electron Transport Chain; FCCP; Carbonyl cyanide-4-(trifluoromethoxy)pheny
Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; FTDP-17; frontotemporal dementia and Parkinsonism linked to chromosome 17; GVD; granulovacuolar degeneration; mTOR; mammalian target of rapamycin; NFTs; neurofibrillary tangles; p70S6K; S6 kinases; PI3K;
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons
Keywords: AAV; adeno-associated virus; ACAT; acyl-CoA:cholesterol acyltransferase; AD; Alzheimer's disease; CDK; cyclin-dependent kinase; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; FTDP-17; frontotemporal dementia and Parkinson
Molecular chaperones and neuronal proteostasis
Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; 17-DMAG; 17-dimethylamino-ethylamino-17-demethoxygeldanamycin; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ARSACS; autosomal recessive spastic ataxia of Charlevoix-Saguena
Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study
Keywords: Tauopathy; Neurodegenerative disease; Alzheimer's disease; FTDP-17; rTg4510; Diffusion tensor MRI; White matter integrity; Electron microscopy; Ultrastructure;
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice
Keywords: Cdk5; cyclin-dependent kinase 5; FTDP-17; frontal temporal dementias with Parkinsonism linked to chromosome 17; GSK-3β; glycogen synthase kinase 3β; MAPK (Erk1/2); mitogen-activated protein kinase; SAPK; stress-activated protein kinase; Environmental ne
T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice
Keywords: AD; Alzheimer's disease; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; P301L mice; transgenic mice expressing FTDP-17 mutation P301L of human tau; T-817MA; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate;
SJLB mice develop tauopathy-induced parkinsonism
Keywords: Tauopathy; Parkinsonism; Transgenic mouse; FTDP-17; Behavioral analysis
In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: A PET and MRI study
Keywords: FTDP-17; Microglia; Positron emission tomography; Dopamine; Acetylcholine; Magnetic resonance imagingAChE, acetylcholinesterase; BPND, binding potential; [11C]dopa, l-[β-11C]dopa; FTDP-17, frontotemporal dementia with parkinsonism linked to chromosome 17;
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains
Keywords: Tau; Tauopathies; Alzheimer's disease; FTDP-17; Filamin-A; Myosin VI
Early behavioural markers of disease in P301S tau transgenic mice
Keywords: TAU aggregates; P301S TAU gene mutation; FTDP-17; Ultrasonic vocalizations; Motor coordination; Cognition
Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
Keywords: Patch clamp; In vitro slice; Dendrite; Dendritic spine; Tauopathy; FTDP-17; Alzheimer's disease; Transgenic model; Frontal; Pyramidal cell
Intrafamilial clinical phenotypic heterogeneity with MAPT gene splice site IVS10+16C>T mutation
Keywords: Diagnosis; FTDP-17; Heterogeneity; IVS10+16C>T mutation; MAPT gene; Tauopathy
Prominent phenotypic variability associated with mutations in Progranulin
Keywords: Frontotemporal dementia; FTDP-17; Progranulin; PGRN; MRI
Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3β
Keywords: Alzheimer's disease; FTDP-17; GSK-3; tau; transgenic miceAD, Alzheimer's disease; EtOH, ethanol; FTDP-17, frontotemporal dementia and parkinsonism linked to chromosome 17; GFAP, glial fibrillary acidic protein; GSK-3β, glycogen synthase kinase-3β; NFT, ne
Demenze frontotemporali
Keywords: Demenza frontotemporale; Afasia progressiva; Demenza semantica; Malattia di Pick; FTDP-17; Biomarcatori;
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
Keywords: Microtubule associated protein tau; Fibrillization; FTDP-17; Alzheimer’s disease; High throughput screening; Inhibitor
Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation)
Keywords: Clinical-pathologic; Biomarker; FTDP-17; Genetics; Dementia; Parkinsonism; Neuroimaging; Positron emission tomography; Neurodegeneration; TauopathyEEG, electroencephalographic, electroencephalography; FD, 6-[18F]fluoro-l-dopa; FDG, 18fluorodeoxyglucose; F
Cooexpression of FTDP-17 tau and GSK-3β in transgenic mice induce tau polymerization and neurodegeneration
Keywords: Alzheimer's disease; FTDP-17; GSK-3; Transgenic mice; Tau; Paired helical filaments
The architecture of the tau haplotype block in different ethnicities
Keywords: Tau; MAPT gene; Populations genetics; FTDP-17; Progressive supranuclear palsy; Linkage disequilibrium;
Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10
Keywords: Tau; Splicing; Stem-loop model; Linear model; FTDP-17;
Quantitative analysis of tau isoform transcripts in sporadic tauopathies
Keywords: Disorders of the nervous system; Degenerative disease: Alzheimer's-miscellaneous; Alternative splicing; Tau; Alzheimer's disease (AD); Pick's disease (PiD); FTDP-17; Tauopathies;
Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat
Keywords: AD; Alzheimer's disease; AKAP79; 79 kDa A-kinase-anchoring-protein; AP; anterior to posterior; Cβ; β catalytic subunit of PKA; CaMKII; calcium/calmodulin-dependent kinase II; cdk-5; cyclin-dependent kinase-5; CREB; cAMP-responsive element binding prot
Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation
Keywords: FTDP-17, frontotemporal dementia and parkinsonism linked to chromosome 17; Tg, transgenic; NFT, neurofibrillary tangle; PPI, prepulse inhibition; ANOVA, analysis of varianceTau; FTDP-17; Behavioral analysis; Animal models
Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death
Keywords: Tau; Microtubule dynamics; FTDP-17; Alzheimer's disease; Cytoskeleton; Loss-of-function;
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
Keywords: AD; Alzheimer's disease; Aβ; amyloid β-protein; 3R; three-repeat tau; E; exon; 4R; four-repeat tau; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; IR; inter-repeat; GSK-3β; glycogen synthase kinase-3β; MT; microtubule; MAP;