Keywords: G پروتئین گیرنده پروتئینی (GPCR); Metabotropic glutamate receptor subtype 5 (mGlu5); Negative allosteric modulator (NAM); Central nervous system (CNS); G protein-coupled receptor (GPCR); Quinoline;
مقالات ISI G پروتئین گیرنده پروتئینی (GPCR) (ترجمه نشده)
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Keywords: G پروتئین گیرنده پروتئینی (GPCR); Neurotensin (1-13) (PubChem CID: 25077406); Neurotensin (8-13) (PubChem CID: 5311318); Neuromedin N (PubChem CID: 9940301); SR48692 (PubChem CID: 119192); G protein-coupled receptor (GPCR); G protein; β-arrestin; Neurotensin receptor 1; Neurotensin; Neur
Keywords: G پروتئین گیرنده پروتئینی (GPCR); GPCRs; G protein-coupled receptors; T2Rs; bitter taste receptors; CAMs; constitutive active mutants; TM; transmembrane; PLCβ2; phospholipase Cβ2; IP3; inositol-1,4,5-triphosphate; ECL; extracellular loop; ICL; intracellular loop; G protein-coupled recep
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Schistosome; G protein-coupled receptor (GPCR); Constitutive activity; Acetylcholine (ACh); G protein-coupled acetylcholine receptor (GAR); RNA interference (RNAi)
Keywords: G پروتئین گیرنده پروتئینی (GPCR); 2-Nal; 2-naphthylalanine; B0; radio-ligand bound in the absence of competing unlabeled ligand; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; GnRH; gonadotropin releasing hormone; GPCR; G protein-coupled receptor; IP; inositol phosphate;
Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Oxytocin; μ opioid receptor; Positive allosteric modulator; Analgesia; G protein-coupled receptor (GPCR);
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Structure-function relationship; Calcium imaging; Molecular modeling; In vitro mutagenesis; G protein-coupled receptor (GPCR); Bitter taste receptor;
Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gαi/o protein inhibitor
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Bioluminescence resonance energy transfer (BRET); Cannabinoid receptor type 1 (CB1); CB1-receptor antagonist; Inverse agonist; G protein; G protein-coupled receptor (GPCR);
CAPA periviscerokinin-mediated activation of MAPK/ERK signaling through Gq-PLC-PKC-dependent cascade and reciprocal ERK activation-dependent internalized kinetics of Bom-CAPA-PVK receptor 2
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Periviscerokinin (PVK); Bombyx mori; G protein-coupled receptor (GPCR); Extracellular signal-regulated kinase (ERK); Phosphorylation; Neuropeptide;
Functional characterization and quantitative expression analysis of two GnRH-related peptide receptors in the mosquito, Aedes aegypti
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Adipokinetic hormone receptor (AKHR); Corazonin receptor (CRZR); GnRH-related peptide; Insect; Aedes aegypti;
Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human δ-opioid receptor turnover at the plasma membrane
Keywords: G پروتئین گیرنده پروتئینی (GPCR); β1AR; β1-adrenergic receptor; DADLE; D-Ala2, D-Leu5-Enkephalin; Endo H; endo-β-N-acetylglucosaminidase H; ER; endoplasmic reticulum; FBS; fetal bovine serum; Gal; galactose; GalNAc; N-acetylgalactosamine; GalNAc-T; GalNAc-transferase; GPCR; G protein-c
The hypotensive effect of activated apelin receptor is correlated with β-arrestin recruitment
Keywords: G پروتئین گیرنده پروتئینی (GPCR); 7TMR; seven transmembrane receptor; Akt; protein kinase B; APJ; apelin receptor; βarr; β-arrestin; BRET; bioluminescence resonance energy transfer; cAMP; cyclic adenosine monophosphate; ERK1/2; extra-cellular regulated kinase 1/2; GPCR; G protein-couple
Original articleSelective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Sphingosine-1-phosphate (S1P); G protein-coupled receptor (GPCR); Ras homolog gene family member A (RhoA); Protein kinase D (PKD); Phospholipase C (PLC); Ischemia/reperfusion (I/R); Cardioprotection;
The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells
Keywords: G پروتئین گیرنده پروتئینی (GPCR); EP selectivity; G protein-coupled receptor (GPCR); Prostaglandin; Prostaglandin E1; Prostaglandin E2; Receptor regulation; AA; arachidonic acid; COX-1 and -2; cyclooxygenase-1 and -2, respectively; cPGES; cytosolic PGES; DGLA; dihomo-γ-linolenic acid; EP
Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G Protein-coupled Receptor (GPCR); Prostacyclin; Rab11; Intracellular trafficking; Prostaglandins; Human; Interaction;
A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Microglia; Migration; Impedance-based cell assay; 5-Oxo-ETE;
The N-terminus of the yeast G protein-coupled receptor Ste2p plays critical roles in surface expression, signaling, and negative regulation
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Ste2p; Yeast; Signal transduction; Saccharomyces cerevisiae;
Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Pituitary adenylate cyclase-activating peptide (PACAP); G protein-coupled receptor (GPCR); Extracellular-signal-regulated kinase (ERK); Protein kinase A (PKA); Potassium channel; Kv4.2; Ion channel modulation
The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Bitter taste receptor (T2R); Carboxyl-terminus (C-terminus); Constitutively active mutant (CAM); Membrane proximal basic residue (MPBR);
Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Fruit fly; G protein-coupled receptor (GPCR); Hormone; Insulin; Leucine-rich repeat containing GPCR (LGR); Peptide Synthesis;
Novobiocin and peptide analogs of α-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Ste2p; Yeast; Novobiocin; Allostery; DOPA;
Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); G protein; Molecular modeling; Homology modeling; Site-directed mutagenesis; Secretin-like receptor; Gastric glucose-dependent insulinotropic polypeptide receptor (GIPR);
N-glycosylation and disulfide bonding affects GPRC6A receptor expression, function, and dimerization
Keywords: G پروتئین گیرنده پروتئینی (GPCR); BSA; bovine serum albumin; CRD; cysteine-rich domain; dFBS; dialyzed fetal bovine serum; DPBS; Dulbecco's Phosphate-Buffered Saline; DTT; dithiothreitol; ECD; extracellular domain; ELISA; Enzyme-Linked Immunosorbent Assay; ER; endoplasmic reticulum; EtO
GnRH-(1-5) activates matrix metallopeptidase-9 to release epidermal growth factor and promote cellular invasion
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Matrix metalloproteinase (MMP); Epidermal growth factor receptor (EGFR); Cancer; Cell invasion; GnRH; Endometrial; Orphan receptor;
Pharmacological and signalling properties of a D2-like dopamine receptor (Dop3) in Tribolium castaneum
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Amine; Dopamine; Evolution; G protein-coupled receptor (GPCR); Insect; Pharmacology; Signalling
Agonist-induced internalisation of the glucagon-like peptide-1 receptor is mediated by the Gαq pathway
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Glucagon like peptide-1 (GLP-1); GLP-1 receptor (GLP-1R); G protein-coupled receptor (GPCR); Endocytosis; Gαq pathway.GLP-1; compound 2; compound B; 2-Aminoethoxydiphenyl borate (2-APB); BAPTA-AM; chlorpromazine; filipin; genistein; monodansylcadaverine (
G protein-coupled receptors Flop1 and Flop2 inhibit Wnt/β-catenin signaling and are essential for head formation in Xenopus
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Flop; RhoA; Wnt/β-catenin signaling; Head formation; Xenopus laevis
Conserved molecular switch interactions in modeled cardioactive RF-NH2 peptide receptors: Ligand binding and activation
Keywords: G پروتئین گیرنده پروتئینی (GPCR); FMRF-NH2; G protein-coupled receptor (GPCR); Myosuppressin (MS); Peptidergic signaling; Sulfakinin (SK);
Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Schizophrenia; Postmortem; G protein-coupled receptor kinase (GRK); G protein-coupled receptor (GPCR); Kinase; Histone deacetylase (HDAC);
Monitoring G protein-coupled receptor activation using an adenovirus-based β-arrestin bimolecular fluorescence complementation assay
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); β-Arrestin; Bimolecular fluorescence complementation (BiFC); Adenovirus; High-throughput screening
Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Serotonin 5-HT2A receptor; Metabotropic glutamate 2 (mGlu2) receptor; Lysergic acid diethylamide (LSD); LY341495; G protein-coupled receptor (GPCR); Schizophrenia;
Molecular and functional characterization of the first tick CAP2b (periviscerokinin) receptor from Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Cardioacceleratory peptide 2b (CAP2b)/periviscerokinins (PVK); Tick; qRT-PCR; Bioluminescence calcium assay; Pyrokinins (PK)
Identification, spatial expression analysis and functional characterization of a pyrokinin-1 receptor in the Chagas’ disease vector, Rhodnius prolixus
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Insect; Neurohormone; Pyrokinin (PK); Diapause hormone (DH); Pheromone biosynthesis activating neuropeptide (PBAN)
Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Cytokine; Chemokine; G protein-coupled receptor (GPCR); Uptake; MIF receptor; Endosomal signaling; Dynamin; β-Arrestin; Heteromeric receptor complex; Inflammation;
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Hallucinogenic drugs; LSD; Serotonin 5-HT2A receptor; Metabotropic glutamate mGlu2 receptor; G protein-coupled receptor (GPCR); Schizophrenia and psychosis
Glutamate-mediated signaling in Schistosoma mansoni: A novel glutamate receptor is expressed in neurons and the female reproductive tract
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Schistosoma mansoni; Metabotropic glutamate; G protein-coupled receptor (GPCR); Nervous system; Neurotransmitter; Neurons;
Nuclear β-adrenergic receptors modulate gene expression in adult rat heart
Keywords: G پروتئین گیرنده پروتئینی (GPCR); AC; adenylyl cyclase; ATP; adenosine triphosphate; βAR; β-adrenergic receptor; CAMKII; Ca2+/calmodulin-dependent protein kinase II; DNA; deoxyribonucleic acid; DTT; dithiothreitol; ET-1; endothelin 1; ERK; extracellular signal-regulated kinase; GPCR; G
9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites
Keywords: G پروتئین گیرنده پروتئینی (GPCR); 5-HT2A receptor; H1 receptor; G protein-coupled receptor (GPCR); GPCR modeling; AMDA; Phenylethylamines
Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation
Keywords: G پروتئین گیرنده پروتئینی (GPCR); C-tail, carboxyl terminal tail; ERK1/2, extracellular signal-regulated kinase 1/2; IB, immunoblotting; IP, immunoprecipitationYeast two-hybrid screening; G protein-coupled receptor (GPCR); Jun activation domain-binding protein 1 (Jab1); GPCR-interacting p
CoMFA analyses of C-2 position Salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Salvinorin A; Kappa-opioid (KOP) receptor; G protein-coupled receptor (GPCR); Structure–affinity relationship (SAFIR); Quantitative structure–activity relationship (QSAR); Comparative Molecular Field Analysis (CoMFA)
A neuromedin-pyrokinin-like neuropeptide signaling system in Caenorhabditis elegans
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Neuromedin U (NMU); Capability peptides (CAPA); Pyrokinins (PKs); Periviscerokinins (PVKs); Neuropeptides; Caenorhabditis elegans; Reverse pharmacology
Synthesis, structure–affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: Structural factors contributing to selectivity
Keywords: G پروتئین گیرنده پروتئینی (GPCR); 5-HT2A receptor; H1 receptor; Phenylethylamines; 9-Aminoalkyl-9,10-dihydroanthracene (AMDA); G Protein-coupled receptor (GPCR); Structure–activity relationship (SAR); Structure–affinity relationship (SAFIR)
Neuroanatomical mapping of juvenile rat brain regions with prominent basal signal in [35S]GTPγS autoradiography
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Functional autoradiography; Adenosine A1 receptor; LPA1 lysophosphatidic acid receptor; Orphan GPCR
Analysis of a G protein-coupled receptor for neurotensin by liquid chromatography–electrospray ionization–mass spectrometry
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Integral membrane protein; Intact protein; Detergents; Electrospray ionization–mass spectrometry (ESI–MS); G protein-coupled receptor (GPCR); Neurotensin receptor
Molecular recognition in the sphingosine 1-phosphate receptor family
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Sphingosine 1-phosphate (S1P); G protein-coupled receptor (GPCR); Endothelial differentiation gene (EDG); Computational model; Ligand recognition
Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Lutropin receptor (LH receptor); G protein-coupled receptor (GPCR); Constitutive activation; Constitutively active mutant;
Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A
Keywords: G پروتئین گیرنده پروتئینی (GPCR); G protein-coupled receptor (GPCR); Nicotinic acid (niacin); HM74A; Arachidonic acid (AA); Extracellular-signal-regulated kinases 1 and 2 (ERK1/2); Peroxisome-proliferator activated receptors (PPAR)
RGS proteins have a signalling complex: Interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins
Keywords: G پروتئین گیرنده پروتئینی (GPCR); Regulator of G protein signalling protein (RGS protein); GTPase activating protein (GAP); Heterotrimeric G protein; G protein-coupled receptor (GPCR); Effector protein; Signalling complex; Scaffolding protein
Cannabinoid receptor homo- and heterodimerization
Keywords: G پروتئین گیرنده پروتئینی (GPCR); CB1 receptor; G protein-coupled receptor (GPCR); Multimerization;