Keywords: Ï â 3 FAs; omega-3 fatty acids; TBI; traumatic brain injury; CCI; controlled cortical impact; IL-1β; interleukin-1β; GPR40; G protein-coupled receptor 40; ARRB2; β-arrestin-2; NLRP3; nucleotide-binding domain and leucine-rich repeat containing pro
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GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space
Keywords: GPR40; G protein-coupled receptor 40; FFA1; free fatty acid receptor 1; PK; pharmacokinetic; GSIS; glucose-stimulated insulin secretion; T2DM; type 2 diabetes mellitus; IDF; International Diabetes Federation; GLP-1; glucagon-like peptide1; GIP; gastric in
PPARγ signaling and emerging opportunities for improved therapeutics
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; TZD; thiazolidinedione; T2DM; type 2 diabetes mellitus; RGZ; rosiglitazone; 15d-PGJ2; 15-deoxy-D12,14-prostanglandin J2; PGC-1α; PPARγ co-activator-1α; RXR; retinoid X receptor; PPRE; peroxisome
Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models
Keywords: Yhhu4488; GPR40; Type 2 diabetes mellitus; Glucagon-like peptide-1; Insulin; DPP IV; dipeptidyl peptidase IV; FRIC; fetal rat intestinal cells; GLP-1; glucagon-like peptide-1; GPR40; G protein-coupled receptor 40; GSIS; glucose-stimulated insulin secretio
Dual effects of the non-esterified fatty acid receptor 'GPR40' for human health
Keywords: AA; arachidonic acids; ABCD; ABC transporters; BDNF; brain-derived neurotrophic factor; BKCa channels; Ca2+-activated K+ channels; cAMP; cyclic AMP; CO; carbon monoxide; CLA; conjugated linoleic acids; CNS; central nervous system; CoA; coenzyme A; CREB; c
The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells
Keywords: FFAR1; free fatty acid receptor 1; FFAs; free fatty acids; PIO; pioglitazone; PA; palmitic acid; ROS; reactive oxygen specific; PLCγ; Phospholipase C γ; ERK1/2; extracellular signal-regulated kinase 1/2; PPARγ; peroxisome proliferator activated recepto
Evaluating insulin secretagogues in a humanized mouse model with functional human islets
Keywords: GLP-1; glucagon-like peptide-1; GPR40; G protein-coupled receptor 40; STZ; streptozotocin; OGTT; oral glucose tolerance test; Islet; Diabetes; Human islet grafts; Mice; Insulin;
'PUFA-GPR40-CREB signaling' hypothesis for the adult primate neurogenesis
Keywords: AC; adenylyl cyclase; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ARA; arachidonic acid; BDNF; brain-derived neurotrophic factor; BrdU; bromodeoxyuridine; [Ca2+]i; intracellular Ca2+ concentration; CaMK; calmodulin-dependent kinase; cAMP;