Keywords: GCGR; glucagon receptor; cAMP; cyclic-adenosine monophosphate; T2DM; type 2 diabetes mellitus; SGLT-2; sodium-glucose cotransporter-2; HGP; hepatic glucose production; GPCRs; G-protein coupled receptors; SAR; structure-activity relationship; Ser; Serine;
مقالات ISI (ترجمه نشده)
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Keywords: Gcgr; glucagon receptor; GLPâ1r; GLPâ1 receptor; Oxyntomodulin; Glucagon; GLP-1; cAMP;
Keywords: ALAS1; δ-aminolevulinate synthase 1; ANGPTL3; angiopoietin-like 3; FVII; factor VII; FXI; factor XI; GCGR; glucagon receptor; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HoFH; homozygous familial hypercholesterolemia; KSP; kinesin spindle prot
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation
Keywords: Tri-agonist; Signaling cascade; Pancreatic islets; Insulin secretion; G proteins; TRP channels; AC; Adenylyl cyclase; cAMP; Cyclic adenosine monophosphate; ECL; Extracellular loop; EPAC; Exchange protein directly activated by cAMP; FCS; Fetal calf serum;
Original ArticleLipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes
Keywords: Type 1 diabetes; Type 2 diabetes; Glucose metabolism; Lipid metabolism; Glucagon; Leptin; AUC; area under the curve; FVII; factor VII; Gcgr; glucagon receptor; HFD; high fat diet; KO; knockout; LFD; low fat diet; LNP; lipid nanoparticle; siRNA; small inte
The effects of RAMPs upon cell signalling
Keywords: Receptor activity modifying protein; G protein-coupled receptor; Signalling; Trafficking; Coupling; AM; adrenomedullin; AMY; amylin; CaSR; calcium-sensing receptor; CGRP; calcitonin gene-related peptide; CHO; chinese hamster ovary; CLR; calcitonin recepto
Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor
Keywords: cAMP; 3â²,5â²-cyclic adenosine monophosphate; CHO; Chinese hamster ovary; CRF1R; corticotrophin releasing factor receptor-1; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; GCGR; glucagon receptor; GLP-1; glucagon-like peptide-1; GPCR
Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum
Keywords: Cabp2; calcium binding protein 2; Cdkn1c; Cyclin-dependent kinase inhibitor 1c; ChIP; chromatin immunoprecipitation; CTD; C-terminal domain; G6pc; glucose-6-phosphatase; Gcgr; glucagon receptor; GCOS; GeneChip operating system; PolII; RNA polymerase II; R