دانلود مقالات ISI درباره Gcn2 + ترجمه فارسی

محدودیت پروتئین و سرطان

Protein restriction and cancer

Keywords: PI3K; phosphoinositide 3-kinase; MAPK; mitogen activated protein kinase; mTORC1; mTOR complex 1; GCN2; general control nonderepressible 2; ULK; UNC-5 like autophagy activating kinase; ATG; autophagy related gene; GPCR; G protein coupled receptor; UCPs; un

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

تنظیم سلامت متابولیک و پیری با مسیرهای سیگنالینگ حساس به مواد مغذی

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways

Keywords: Protein restriction; Aging; Branched-chain amino acids; mTOR; Calorie restriction; GCN2; Protein quality;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

ریشه های متابولیک نارسایی قلب

Metabolic Origins of Heart Failure

Keywords: amino acids; fatty acids; glucose; heart failure; ketone bodies; AA; amino acid; BCAA; branched-chain amino acids; FA; fatty acid; FAO; fatty acid oxidation; GCN2; general control nonderepressible 2; GLOX; glucose oxidation; HBP; hexosamine biosynthesis p

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

پاسخهای پیلئوتروپیک به محدودیت متیونین

Pleiotropic responses to methionine restriction

Keywords: SAM; S-adenosylmethionine; Hcy; homocysteine; tHcy; total homocysteine; Bhmt; betaine-Hcy methyltansferase; Mthf; 5-methyltetrahydrofolate-Hcy methyltransferase; Cbs; cystathionine β-synthase; SAH; S-adenosylhomocysteine; DMG; dimethylglycine; HFD; high-

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

سنجش تغذیه، انتقال سیگنال و پاسخ ایمنی

Nutrient sensing, signal transduction and immune responses

Keywords: Immunometabolism; Nutrient sensing; Glucose; Glutamine; Amino acids; SCFA; LCFA; Cholesterol; Oxysterols; Srebp; mTORC1; c-Myc; GCN2; Slc7a5; CD36; LXR; Glycolysis; OxPhos; Lymphocyte; Macrophage;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

استرس تناسلی اندوپلاسمی در چاقی و اختلالات مرتبط با چاقی: یک دیدگاه گسترده

Endoplasmic reticulum stress in obesity and obesity-related disorders: An expanded view

Keywords: ATF4; activating transcription factor-4; ATF6α; activating transcription factor-6α; EB1; end binding protein-1; EDEM; ER degradation-enhancing α-like protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; GCN2; general control non-derepre

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2016 سفارش ترجمه

سازگاری متابولیک عضله اسکلتی به هیپرامنمیایی، اثرات مفید ل-لوسین را در سیروز ایجاد می کند

Metabolic adaptation of skeletal muscle to hyperammonemia drives the beneficial effects of l-leucine in cirrhosis

Keywords: αKG; alpha ketoglutarate; BCAA/LEU; branched chain amino acids enriched with l-leucine; CHOP; C/EBP homology protein; eIF2α; eukaryotic initiation factor 2 alpha; GADD34; growth arrest and DNA damage inducible protein 34; GCN2; general control non-depre

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

انتقال گلوتامین. از منبع انرژی تا حسگر و فراتر از آن

Glutamine transport. From energy supply to sensing and beyond

Keywords: GLS; glutaminase; GDH; glutamate dehydrogenase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; TCA; tricarboxylic acid cycle; SS; succinylCoA synthetase; ME; malic enzyme; IDH1; isocytrate dehydrogenase; AARE; aminoacid responsive element

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

تنظیم وابسته به پروتئین تغذیه و متابولیسم

Protein-dependent regulation of feeding and metabolism

Keywords: amino acids; dietary protein; FGF21; GCN2; leucine; macronutrient

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

تنظیم مقررات اکسیدانی سنتز پروتئین در کاندیدا آلبیکنس

Oxidant-specific regulation of protein synthesis in Candida albicans

Keywords: Candida albicans; Oxidative stress; Gcn2; Gcn4; Translational regulation

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

تنظیم سنتز پروتئین عضلانی و اثرات حالت های کاتابولیک

Regulation of muscle protein synthesis and the effects of catabolic states

Keywords: 4E-BP1; eIF4E binding protein 1; 5′-UTR; 5′-untranslated region; AMPK; AMP-activated protein kinase; eIF; eukaryotic initiation factor; GCN2; general-control nonderepressible; GEF; guanine nucleotide exchange factor; GSK-3; glycogen synthase kinase-3;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells

Keywords: BCR-ABL; Integrated stress response; PERK; GCN2; ATF4;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells

Keywords: AA; amino acid; AAR; AA response; ATF; activating transcription factor; C/EBP; CAAT/enhancer binding protein; CARE; C/EBP-ATF response element; CRE; cyclic AMP response element; IF2; eukaryotic initiation factor 2; GAPDH; glyceraldehyde 3-phosphate dehydr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Arabidopsis ILITHYIA protein is necessary for proper chloroplast biogenesis and root development independent of eIF2α phosphorylation

Keywords: GCN; General Control Non-derepresible; GCN1; GCN2; Arabidopsis; Transcriptomic; eIF2α;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Arginine inhibits the malignant transformation induced by interferon-gamma through the NF-κB-GCN2/eIF2α signaling pathway in mammary epithelial cells in vitro and in vivo

Keywords: IFN-γ; Interferon gamma; Arg; Arginine; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B cells; GCN2; general control nonderepressible 2; eIF2α; eukaryotic initiation factor 2; BMECs; bovine mammary epithelial cells; BC; breast cancer; R

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2

Keywords: Protein synthesis; Translation; Translational control; eIF2; eIF2B; Gcn2; Control engineering; Robustness;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice

Keywords: ALT; alanine transaminase; AST; aspartate transaminase; Atgl; adipose triglyceride lipase; AU; arbitrary unit; AUC; area under the curve; BSA; bovine serum albumin; CHOP; C/EBP homologous protein; Cpt2; carnitine palmitoyltransferase 2; DHE; dihydroethidi

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance

Keywords: Endoplasmic reticulum; Epigenetics; Obesity; Triglycerides; Insulin resistance; BMI; body mass index; CASP12; caspase 12; CpG; cytosine-phosphate-guanine site; DBP; diastolic blood pressure; DiOGenes; diet obesity and genes dietary trial; DNAJC1; dnaJ hea

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Comparative transcriptome analysis reveals multiple functions for Mhy1p in lipid biosynthesis in the oleaginous yeast Yarrowia lipolytica

Keywords: ACL; ATP-citrate lyase; cAMP; cyclic AMP; CS; citrate synthase; GABA; gamma-aminobutyric acid; GC; gas chromatograph; Gcn2; general control nonderepressible 2; GO; Gene Ontology; IPM; isopropylmalate; KEGG; Kyoto Encyclopedia of Genes and Genomes; LP; lip

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules

Keywords: SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

A new role of GCN2 in the nucleolus

Keywords: GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Human Keratinocyte Differentiation Requires Translational Control by the eIF2α Kinase GCN2

Keywords: ATF4; activating transcription factor 4; CHOP; C/EBP homologous protein; eIF2α; eukaryotic initiation factor 2 alpha; eIF2α-P; phosphorylated eukaryotic initiation factor 2; ER; endoplasmic reticulum; GADD34; growth arrest and DNA damage protein 34; GCN

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells

Keywords: LGALS3; Galectin 3; LGALS1; Galectin 1; AML; Acute myeloid leukemia; qRT-PCR; Real-time PCR; AKT; Protein kinase B; ERK; Extracellular receptor kinase; BCL2; B cell lymphoma 2; BCL-XL; B cell lymphoma 2 Like 1; MCL-1; Myeloid cell leukemia 1; Ph +;  Phi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2α phosphorylation in prostate cancer

Keywords: CHO; Chinese hamster ovary; CHX; cycloheximide; DIG; digoxigenin; FACS; fluorescence-activated cell sorting; GCN2; general control non-derepressible-2; HRI; heme regulated inhibitor of translation; IRES; internal ribosome entry sites; ITAFs; IRES trans-ac

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells

Keywords: AA; amino acid; AAR; AA response; ActD; actinomycin D; ASNS; asparagine synthetase; ATF4; activating transcription factor 4; cFOS; FBJ murine osteosarcoma viral oncogene homolog; DOX; doxycycline; eIF2; eukaryotic initiation factor 2; ERK; extracellular-s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Keywords: Translational regulation; GCN2; eIF2; GCN1; IMPACT; YIH1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1

Keywords: Apoptosis; Mcl-1; Degradation motif; PEST domain; β-TrCP; β-transducin repeat-containing protein; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma-2; BH domain; Bcl-2 homology domain; Bim; Bcl-2-interacting mediator; BSA; bovine serum albumin; Ca

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

GCN2 kinase plays an important role triggering the remission phase of experimental autoimmune encephalomyelitis (EAE) in mice

Keywords: EAE; GCN2; Foxp3; IDO; pDCs;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans

Keywords: C. elegans; Caenorhabditis elegans; WT; wild-type; EF4; elongation factor 4; mtEF4; mitochondrial EF4; mtDNA; mitochondrial DNA; BP; base pairs; ETC; electron transport chain; mtEFTu, mtEFG1 and mtEFTs; mitochondrial elongation factor Tu, G1 and Ts; MMP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation

Keywords: AAR; amino acid response; Apaf-1; apoptotic protease-activating factor-1; ATF; activating transcription factor; Bcl-2; B cell lymphoma-2; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CHOP; CCAAT/enhancer-binding protein

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels

Keywords: Heat shock factor 1; Amino acid deprivation; Methionine; DNAJB1; NRF2; GCN2; general non-derepressible 2; ATF; activating transcription factor; ASNS; asparagine synthetase; SAM; S-adenosylmethionine; HMOX1; heme oxygenase 1; GSTP; glutathione S-transferas

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory

Keywords: Translation initiation; Synaptic plasticity; long-term memory; Knockout eIF2; GCN2; PERK; PKR; HRI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ATF4; activating transcription factor 4; ca; constitutively active; dn; dominant negative; ERK; extracellular signal-related protein kinase; FBS; fetal bovine serum; GCN2; general control non-dere

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis

Keywords: PKZ; a protein kinase containing Z-DNA binding domains; PKR; protein kinase R; eIF2α; eukaryotic initiation factor 2α; HRI; heme-regulated eIF2α kinase; PERK; RNA-regulated protein kinase (PKR)-like endoplasmic reticulum kinase; GCN2; general control n

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Identity crisis of Th17 cells: Many forms, many functions, many questions

Keywords: JAK; janus kinase; STAT; signal transducer activator of transcription; mTOR; mammalian target of rapamycin; GCN2; general controlled non-derepressible 2; Th17 cells; Plasticity; IL-17; RORC; RORγt; CCR6; CD161;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Pkh1 interacts with and phosphorylates components of the yeast Gcn2/eIF2α system

Keywords: GAAC; general amino acid control; HM; hydrophobic motif; PIF; PDK1-interacting fragment; Yeast; Gcn2; PDK1; Pkh1-3; PKA; Sch9; PKB;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation

Keywords: Leucine; Myoblast; Differentiation; myf5; myoD; mTOR; GCN2

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Endoplasmic reticulum stress enhances γ-secretase activity

Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; PS; presenilin; ATF4; activating transcription factor 4; GCN2; general control non-derepressible 2; PKR; protein kinase RNA; PERK; PKR-like ER kinase; HRI; heme-regulated inhibitor; eIF2α; eukary

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of GCN2 as new redox regulator for oxidative stress prevention in vivo

Keywords: GCN2; Leucine-imbalanced diet; Oxidative stress; GPX1; Hepatic protein carbonylation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway

Keywords: GCN2; ATF4; p8; AARE; Amino acid

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

RNA granules: The good, the bad and the ugly

Keywords: ATXN2; Ataxin-2; BicD; Bicaudal D; CBP; CREB Binding Protein; CPEB; Cytoplasmic Polyadenylation Element Binding protein; DHC; Dynein Heavy Chain; DIC; Dynein Intermediate Chain; FAK; Focal Adhesion Kinase; FUS/TLS/hnRNP P2; Fused in Sarcoma; G3BP; Ras-GAP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

CD11c+CD8+ T cells: Two-faced adaptive immune regulators

Keywords: 1-MT, 1-methyl d,l-tryptophan; GCN2, general control non-derepressible-2; IDO, indoleamine 2,3-dioxygenaseCD11c+CD8+ T cells; 4-1BB; IFN-γ; IDO; GCN2

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular mechanisms involved in the adaptation to amino acid limitation in mammals

Keywords: Amino acid; Gene expression; GCN2; ATF4; ATF2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Stress Signaling in the Methionine-Choline-Deficient Model of Murine Fatty Liver Disease

Keywords: Steatosis; Steatohepatitis; Endoplasmic Reticulum Stress; Integrated Stress; apoB100; apolipoprotein B100; ATF6; activating transcription factor-6; Bcl-xL; B-cell lymphoma extra-large; BiP; immunoglobulin-binding protein; CHOP; C/EBP homologous protein; e

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

GCN2 activation and eIF2α phosphorylation in the maturation of mouse oocytes

Keywords: Oocyte; GCN2; eIF2; Protein synthesis; Translational control

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2α

Keywords: ATF-4; Activating transcription factor-4; CHOP; C/EBP [CCAAT/enhancer binding protein] homologous protein (also known as GADD153); eIF2α; α-subunit of the eukaryotic translation initiation factor-2; eIF4; Eukaryotic translation initiation factor-4; GAAD

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Amino-acid limitation induces the GCN2 signaling pathway in myoblasts but not in myotubes

Keywords: Amino acid; Gene expression; GCN2; Myotube; Myoblast

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Altered protein synthesis is a trigger for long-term memory formation

Keywords: Translation; Protein kinase; Learning; PKM-ζ; Positive feedback; Knockout mouse; mTOR; GCN2; eIF2; 4E-BP; S6K

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Eukaryotic initiation factor 2α kinase is a nitric oxide-responsive mercury sensor enzyme: Potent inhibition of catalysis by the mercury cation and reversal by nitric oxide

Keywords: HRI; heme-regulated eIF2α kinase or heme-regulated inhibitor; eIF2α; α-subunit of eukaryotic initiation factor 2; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; Fe3+-hemin; Fe3+-protoporphyrin IX complex; Fe2+-heme; Fe2+-proto

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Role of amino acids in the translational control of protein synthesis in mammals

Keywords: eEF; eukaryotic elongation factor; eIF; eukaryotic initiation factor; GCN2; general control nonderepressible; His-RS; histidyl-tRNA synthetase; MES; mouse embryonic stem; met-tRNAi; initiator methionyl-tRNA; mTOR; mammalian target of rapamycin; PI 3-kinas

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه