Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect
Keywords: گیوتانک; Top, DNA topoisomerases; TopIB, DNA topoisomerase IB; LdTopIB, L. donovani TopIB; LiTopIB, L. infantum TopIB; IFP1.4, infrared fluorescent protein 1.4; SI48h, selectivity index at 48 h; MDR-1, multidrug resistant protein 1DNA topoisomerase IB; Gimatecan;