Keywords: CaMKII; calcium/calmodulin dependent protein kinase type II; NMDAR; N-methyl-d-aspartate receptor; GluN2B; full length GluN2B subunit of NMDAR; MLS-NR2B; GluN2B residues 1271-1311 with a mitochondrial localizing sequence; MK-801; (5S,10R-(+)-5-Methyl-10
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Keywords: Ketamine; Depression; NMDAR; GluN2B; AMPAR; Ambient glutamate; Cortex; Inhibition; Disinhibition; NMDA receptor; AMPA receptor; Homeostatic synaptic plasticity; Protein synthesis; Folimycin (PubChem CID: 6438151); Glutamate (PubChem CID: 33032); Ketamine
Keywords: d-cycloserine; Stress; Reconsolidation; Zif-268; GluN2B; Amygdala; Midazolam;
Keywords: AMPA; alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; AMPAR; alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor; CA1; cornu ammonis 1 hippocampal region; cDNA; complementary deoxyribonucleic acid; COX-2; cyclooxygenase 2; EAAT; ex
Keywords: Amphetamine; Endocannabinoids; Glutamate; Monoamines; Endogenous opioids; Pharmacology; 5-HT; serotonin; ACh; acetylcholine; ADHD; attention-deficit/hyperactivity disorder; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived n
Ghrelin upregulates the phosphorylation of the GluN2B subunit of the NMDA receptor by activating GHSR1a and Fyn in the rat hippocampus
Keywords: Hippocampal CA1; GHSR1a knockout mice; Slice culture; GluN2B;
Modulation of CaMKIIa-GluN2B interaction in levodopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's rats
Keywords: CaMKIIa; GluN2B; Interactions; L-dopa-induced dyskinesia; Coimmunoprecipitation;
The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)
Keywords: Abeta; Alzheimer; LTP; NMDA; Radiprodil; GLUN2B; Spine density;
Striatal GluN2B involved in motor skill learning and stimulus-response learning
Keywords: GluN2B; Dorsal striatum; Motor skill learning; S-R learning; LTP; NMDAR;
CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content
Keywords: Excitotoxicity; CYP46A1; Huntington's disease; Lipid rafts; GluN2B; Cholesterol;
The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons
Keywords: Human induced pluripotent stem cell-derived neurons; iCell Neurons; iCell GlutaNeurons; NMDA receptors; GluN2B; Positive allosteric modulators;
Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task
Keywords: NR2B NMDA receptor; GluN2B; Rat; Gambling task; Impulsive action; Impulsive choice;
GluN2B/CaMKII mediates CFA-induced hyperalgesia via HDAC4-modified spinal COX2 transcription
Keywords: Inflammatory pain; GluN2B; NMDA; CaMKII; HDAC4; COX2;
Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons
Keywords: Chotosan; Neuroprotective effects; GluN2B;
Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists
Keywords: MK-801; Puberty; Dentate gyrus; Cortex; Gender; GluN2B;
Research articleCXCL13 regulates the trafficking of GluN2B-containing NMDA receptor via IL-17 in the development of remifentanil-induced hyperalgesia in rats
Keywords: CXCL13; CXCR5; IL-17; GluN2B; Remifentanil-induced hyperalgesia;
Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus
Keywords: Nicotine; GluN2A; GluN2B; Src; Fyn; Neuregulin 1; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; AMPAR; α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor; AP5; 2-amino-5-phosphonovaleric acid; DNQX; 6,7-dinitroquinoxaline-2,3-dion
Prefrontal cortical GABAergic and NMDA glutamatergic regulation of delayed responding
Keywords: Gamma-aminobutyric acid; NMDA receptor; Prefrontal cortex; Working memory; GluN2B; Schizophrenia;
CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility
Keywords: CDKL5; Developmental disorders; Epilepsy; Hippocampus; Excitatory synapses; NMDA receptors; GluN2B; SAP102; Ifenprodil;
Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD)
Keywords: Alzheimer; Amyloid beta; VSDI; LTP; In vitro; Hippocampus; GluN2B;
Acute stress regulates phosphorylation of N-methyl-d-aspartate receptor GluN2B at S1284 in hippocampus
Keywords: AMPAR; a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Cdk5; Cyclin-dependent kinase 5; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; NMDAR; N-methyl-D-aspartate receptor; PSD; postsynapti
The levels of the GluN2A NMDA receptor subunit are modified in both the neonatal and adult rat brain by an early experience involving denial of maternal contact
Keywords: ANOVA; analysis of variance; CaMKII; calcium/calmodulin-dependent protein kinase II; CTR; control; DER; denied the expected reward; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; LG-ABN; licking, grooming and nursing in arched back position; LSD; least
Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits
Keywords: Development; GluN2A; GluN2B; Parvalbumin; Rett syndrome; Visual cortex
A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain
Keywords: Chronic pain; NMDA; GluN2B; Nav1.8; Nav1.7; Substituted aminoquinoline
Blocking GluN2B subunits reverses the enhanced seizure susceptibility after prolonged febrile seizures with a wide therapeutic time-window
Keywords: FSs; febrile seizures; IL-1β; interleukin-1β; IL-1Ra; interleukin-1 receptor antagonist; TLE; temporal lobe epilepsy; MES; maximal electrical shock; KA; kainic acid; CB1R; cannabinoid type 1 receptor; Febrile seizures; GluN2B; IL-1β; Seizure susceptibi
Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment
Keywords: NMDA; N-methyl d-aspartate; 5-CSRTT; 5-choice serial reaction time task; SD; stimulus duration; ITI; inter trial interval; LH; limited hold; PCP; phencyclidine; DRL; differential reinforcement of lower rates of responding; PAL; paired associate learning;
Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors
Keywords: Parkinson's disease; NMDA receptor; GluN2B; GluN2D; Striatum; 6-Hydroxydopamine lesion;
A novel phosphorylation site of N-methyl-d-aspartate receptor GluN2B at S1284 is regulated by Cdk5 in neuronal ischemia
Keywords: NMDA receptor; GluN2B; S1284; Cdk5; Ischemia; LTP;
Inhibition of in vivo [3H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice
Keywords: NMDA; GluN2B; Channel blocker; Antagonist; Radioligand binding; Occupancy
Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease
Keywords: NMDA receptor; GluN2B; NR2B; PS2APP; Alzheimer's disease; Synaptic plasticity; LTP; LTD; Perisynaptic; Ro25-6981;
Research ReportMetabotropic glutamate receptor 5 upregulates surface NMDA receptor expression in striatal neurons via CaMKII
Keywords: mGluR; Striatum; GluN1; GluN2B; NR2B; G protein-coupled receptor; Phosphorylation; DHPG;
Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity
Keywords: Glutamate; Dendritic spine; GRID1; GluD1; GluN2B;
Research ReportNMDA receptor binding is reduced within mesocorticolimbic regions following chronic inhalation of toluene in adolescent rats
Keywords: Inhalant abuse; Animal model; Autoradiography; qPCR; NMDA; GluN2B;
The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
Keywords: AgRP; NMDAR; GluN2B; Metabolism; Glycemia; LeptinAgRP, agouti-related peptide; POMC, pro-opiomelanocortin; NMDARs, N-methyl-d-aspartate receptors; Lepob/ob mice, obese leptin-deficient mice; GABA, gamma-aminobutyric acid; EPSCs, excitatory post-synaptic s
Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons
Keywords: Rhynchophylline; NMDA receptor subunit GluN1; GluN2B; Hippocampal neurons; Toxicity; Neonatal rats
Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner
Keywords: Interleukin receptor type I; NMDA glutamate receptors; GluN2B; Maternal deprivation; Immune priming; Sex differences;
Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors
Keywords: Glutamate; GluN2B; Indoles; Ifenprodil; Molecular docking;
Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice
Keywords: Huntington disease; NMDA receptor; GluN2B; Extrasynaptic; p38; pCREB; Calpain; Calcium signaling; Striatum; Memantine;
Estradiol replacement extends the window of opportunity for hippocampal function
Keywords: NR2B; Long term potentiation; 17Ã-estradiol; E2; GluN2B; Plasticity; NMDA; Learning and memory;
Research ReportMultiple effects of copper on NMDA receptor currents
Keywords: NMDA; N-methyl-d-aspartate; NR; NMDA receptor; GluN1; NMDA receptor subunit 1; GluN2A; NMDA receptor subunit 2A; GluN2B; NMDA receptor subunit 2B; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; DTT; Dithiothreitol; DTNB; 5,5â²-dithiobis-(2-ni
Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease
Keywords: Alzheimer's disease; Amyloid beta; Iron; NMDA; GluN2B; Transgenic mouse;
Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain
Keywords: Hsp70; heat shock protein 70; NMDAR; n-methyl-d-aspartate receptors; P7; Postnatal Day 7; i.p; intraperitoneal; DG; dentate gyrus; Antidepressant; GluN2B; MK-801; Neurotoxicity; Retrosplenial cortex;
Nuclear respiratory factor 2 regulates the expression of the same NMDA receptor subunit genes as NRF-1: Both factors act by a concurrent and parallel mechanism to couple energy metabolism and synaptic transmission
Keywords: NRF-2/GABP; Nuclear respiratory factor 2/GA binding protein; Grin; Gene name for NMDA receptor; Gene regulation; NRF-2; GABP; GluN1; GluN2B; NMDA;
Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B
Keywords: Sp; Specificity protein transcription factor; Grin; Gene name for NMDA receptor; Sp4; GluN1; GluN2A; GluN2B; NMDA; Gene regulation;
Blockade of ventral midbrain NMDA receptors enhances brain stimulation reward: A preferential role for GluN2A subunits
Keywords: Glutamate; GluN2A; GluN2B; NMDA; Reward; Ventral midbrain;
Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus
Keywords: Ketamine; GluN2B; NMDA; Autoradiography; Receptor occupancy
NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test
Keywords: NMDA, N-methyl-D-aspartate; (DCS), D-cycloserine; LTP, Long-term potentiation; LTD, long-term depression; ANOVA, analysis of varianceAntidepressant; Curcumin; Forced swim test; GluN2B; NMDA receptor
Dephosphorylation of GluN2B C-terminal tyrosine residues does not contribute to acute ethanol inhibition of recombinant NMDA receptors
Keywords: Ethanol; Phosphorylation; GluN2B; Electrophysiology;
Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects
Keywords: Nonsynaptic ionotropic receptors; GluN2B; GluN2A; Excitotoxicity; Neuroprotection; Extrasynaptic receptors
Developmental changes in the acute ethanol sensitivity of glutamatergic and GABAergic transmission in the BNST
Keywords: Adolescent; NMDA receptor; Bed nucleus of the stria terminalis (BNST); GABA; GluN2B