Keywords: GPCR، G-پروتئین گیرنده; Tm, melting temperature; GPCR, G-protein-coupled receptor; ET-1, endothelin-1; ETBR, endothelin type B receptor; β1AR, β1 adrenergic receptor; A2AR, adenosine A2A receptor; NTSR1, neurotensin receptor 1; CRF1R, corticotropin-releasing factor type 1 recept
مقالات ISI GPCR، G-پروتئین گیرنده (ترجمه نشده)
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Keywords: GPCR، G-پروتئین گیرنده; 20E, 20-hydroxyecdysone; JH, juvenile hormone; HaEpi, Helicoverpa armigera epidermal cell line; GPCR, G-protein-coupled receptor; RTK, receptor tyrosine kinase; STIM1, stromal interaction molecule 1; Orai1, calcium release-activated calcium modulator 1; T
Keywords: GPCR، G-پروتئین گیرنده; AcMNPV, autographa californica multicapsid nucleopolyhedrovirus; BEVS, Baculovirus expression vector system; CHO, Chinese hamster ovary; EGFP, enhanced green fluorescent protein; ELISA, enzyme-linked immunosorbet assay; GPCR, G-protein-coupled receptor; h
Keywords: GPCR، G-پروتئین گیرنده; PD, Parkinson’s disease; MM, malignant melanoma; MC1R, the melanocortin 1 receptor gene; GPCR, G-protein-coupled receptor; MCRs, melanocortin receptors; α-MSH, α-melanocyte stimulating hormone; cAMP, the cyclic AMP; VPS35, the vacuolar protein sorting 35
Label-free detection of small-molecule binding to a GPCR in the membrane environment
Keywords: GPCR، G-پروتئین گیرنده; BLI, biolayer interferometry; BSA, bovine serum albumin; CXCR4, chemokine (C-X-C motif) receptor 4; CXCR3, chemokine (C-X-C motif) receptor 3; Da, Dalton; EDC, N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride; GPCR, G-protein-coupled receptor;
Elastic deformation and area per lipid of membranes: Atomistic view from solid-state deuterium NMR spectroscopy
Keywords: GPCR، G-پروتئین گیرنده; DMPC-d54, 1,2-diperdeuteriomyristoyl-sn-glycero-3-phosphocholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; GPCR, G-protein-coupled receptor; MD, molecular dynamics; NMR, nuclear magnetic resonance; PEG, polyethylene glycol; RQC, residual quadrup
The evolutionary analysis reveals domain fusion of proteins with Frizzled-like CRD domain
Keywords: GPCR، G-پروتئین گیرنده; FZD, Frizzled; CRD, Cysteine-rich domain; Fz-CRD, Frizzled-like Cysteine-rich domain; TM, transmembrane domain; 7TM, seven-transmembrane domain; GPCR, G-protein-coupled receptor; SFRP, secreted Frizzled-related protein; Smo, Smoothened; MuSK, muscle skele
Phospholipase C-β in immune cells
Keywords: GPCR، G-پروتئین گیرنده; BCR, B cell receptor; CT, C-terminal; DAG, diacylglycerol; dko, double knockout; GAP, GTPase-activating protein; GPCR, G-protein-coupled receptor; HSC, hematopoietic stem cell; IL, interleukin; IP3, inositol 1,4,5-trisphosphate; ITAM, immunoreceptor tyros
Interactions of the α-subunits of heterotrimeric G-proteins with GPCRs, effectors and RGS proteins: A critical review and analysis of interacting surfaces, conformational shifts, structural diversity and electrostatic potentials
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; Gα, α subunit of heterotrimeric G-proteins; Gβ, β subunit of heterotrimeric G-proteins; Gγ, γ subunit of heterotrimeric G-proteins; β2AR, β2 adrenergic receptor; RGS, regulator of G-protein signaling; GAP, GTPase accelera
Activation of TRPC4β by Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron
Keywords: GPCR، G-پروتئین گیرنده; TRPC, transient receptor potential canonical; GPCR, G-protein-coupled receptor; EGFP, enhanced GFP; GTPγS, guanosine5′-3-O-(thio)triphosphate; PTX, pertussis toxin; PIP2, phosphatidylinositol 4,5-bisphosphate; CaMK, Ca2+/calmodulin-dependent protein kinas
Ischemic stroke and traumatic brain injury: The role of the kallikrein–kinin system
Keywords: GPCR، G-پروتئین گیرنده; B1R, kinin receptor B1; B2R, kinin receptor B2; BBB, blood–brain barrier; eNOS, endothelial isoform of NOS; ERK, extracellular signal-regulated kinase; FXII, coagulation factor XII; FXIIa, coagulation factor XIIa; GPCR, G-protein-coupled receptor; IL, int
Glycosylphosphatidylinositol (GPI)-anchoring of mamba toxins enables cell-restricted receptor silencing
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; GPI, glycosylphosphatidylinositol; eGFP, enhanced green fluorescent protein; MT, muscarinic toxin; NA, noradrenaline; CCh, carbachol, carbamoylcholine chloride; NMS, N-methylscopolamine; Δ[Ca2+]i, change in intracellular
GRK5 ablation contributes to insulin resistance
Keywords: GPCR، G-پروتئین گیرنده; ANOVA, analysis of variance; GPCR, G-protein-coupled receptor; GRK, GPCR kinase; KO, knockout; SD, standard diet; HFD, high-fat diet; WAT, white adipose tissue; PBS, phosphate buffered saline; EDTA, ethylene diamine tetraacetic acid; TC, total cholesterol
Autoantibodies in primary Sjögren's syndrome patients induce internalization of muscarinic type 3 receptors
Keywords: GPCR، G-پروتئین گیرنده; Ca2+]i, cytoplasmic free Ca2+ concentration; CCh, carbachol; CDE, clathrin-dependent endocytosis; CICT, CCh-induced [Ca2+]i transient; CQ, chloroquine; GPCR, G-protein-coupled receptor; hSMG, human submandibular gland; M3R, muscarinic type 3 receptor; pSS
Role of HCA2 (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin
Keywords: GPCR، G-پروتئین گیرنده; NA, nicotinic acid; FAE, fumaric acid ester; GPCR, G-protein-coupled receptor; HCA2, hydroxy-carboxylic acid receptor 2; PG, prostaglandin; COX, cyclooxygenase; MMF, monomethyl fumarate; DMF, dimethyl fumarate; cPLA2, cytosolic phospholipase A2; GRK, GPCR
Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; PH, pleckstrin homology; PI, phosphatidylinositoll; TGN, trans-Golgi networkPhosphatidylinositol; PI4P; 4-Kinase; Phospholipid
Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system
Keywords: GPCR، G-پروتئین گیرنده; CSF, cerebrospinal fluid; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FFA, free fatty acid; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GPCR, G-protein-coupled receptor; GPR, G-protein receptor; β-FNA, β-funaltrexamine; i.c.v., intracerebr
Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration
Keywords: GPCR، G-پروتئین گیرنده; DC, dendritic cell; LPS, lipopolysaccharide; PK, pharmacokinetics; GPCR, G-protein-coupled receptor; hERG, human ether-à-go-go related gene; FEV1, forced expiratory volume 1; KO, knock-out; wt, wild-type; CYP, cytochrome P450; MEC, minimal effective conce
Incomplete activation of human eosinophils via the histamine H4-receptor: Evidence for ligand-specific receptor conformations
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; EPO, eosinophil peroxidase; fMLP, N-formyl-l-methionyl-l-leucyl-l-phenylalanine; UR-PI376, 2-cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[(2-phenylthio)ethyl]guanidine; PMA, phorbol 12-myristate 13-acetate; JNJ7777120, 1-[(5-ch
Agonist ligand discrimination by the two orexin receptors depends on the expression system
Keywords: GPCR، G-پروتئین گیرنده; A11,dL15-orexin-B, Ala11,d-Leu15-orexin-B; CHO, Chinese hamster ovary; GPCR, G-protein-coupled receptor; GFP, green fluorescent protein; HBM, Hepes-buffered medium; HEK, human embryonic kidney; probenecid, p-(dipropylsulfamoyl) benzoic acidOrexin; Hypocre
5-Hydroxy-eicosapentaenoic acid is an endogenous GPR119 agonist and enhances glucose-dependent insulin secretion
Keywords: GPCR، G-پروتئین گیرنده; AA, arachidonic acid; CHO, Chinese hamster ovary; ELISA, enzyme-linked immunosorbent assay; EPA, eicosapentaenoic acid; GLP-1, glucagon-like peptide-1; GPCR, G-protein-coupled receptor; HTB, Hepes Tyrode’s bovine albumin buffer; PCR, polymerase chain reac
Distinct pharmacological properties of morphine metabolites at Gi-protein and β-arrestin signaling pathways activated by the human μ-opioid receptor
Keywords: GPCR، G-پروتئین گیرنده; DAMGO, [d-Ala2, N-MePhe4, Gly-ol]-enkephalin; FRET, fluorescence (or: Förster) resonance energy transfer; GPCR, G-protein-coupled receptor; GRK, G-protein-coupled-receptor kinaseMorphine; Metabolite; FRET; G-protein; β-Arrestin
Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor
Keywords: GPCR، G-پروتئین گیرنده; AVP, [arginine8]vasopressin; ELISA, enzyme-linked immunosorbent assay; GPCR, G-protein-coupled receptor; InsP, inositol phosphate; InsP3, inositol trisphosphate; OT, oxytocin; OTA, d(CH2)5Tyr(Me)2Thr4Orn8Tyr(NH2)9vasotocin; OTR, oxytocin receptor; TM, tra
Lysophosphatidylcholine induces Ca2+ mobilization in Jurkat human T lymphocytes and CTLL-2 mouse T lymphocytes by different pathways
Keywords: GPCR، G-پروتئین گیرنده; 2-APB, 2-aminoethoxydiphenyl borate; CRAC, calcium release-activated calcium current; FBS, fetal bovine serum; GPCR, G-protein-coupled receptor; IP3, inositol trisphosphate; LPC, lysophosphatidylcholine; PLA2, phospholipase A2; SCID, severe combined immun
Parathyroid hormone (PTH) regulates the sodium chloride cotransporter via Ras guanyl releasing protein 1 (Ras-GRP1) and extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein kinase (MAPK) pathway
Keywords: GPCR، G-پروتئین گیرنده; DAG, diacylglycerol; DCT, distal convoluted tubule; DMEM, Dulbecco’s modified eagle’s medium; FBS, fetal bovine serum; GPCR, G-protein-coupled receptor; IgG, immunoglobulin G; mDCT, mouse distal convoluted tubule; NCC, sodium chloride cotransporter; PAGE,
Novel antigen design for the generation of antibodies to G-protein-coupled receptors
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; B2AR, beta 2-adrenergic receptor; GLP1R, glucagon-like peptide 1 receptor; NPY5R, neuropeptide Y receptor 5; ABP, albumin binding protein; HPA, Human Protein Atlas.GPCR; Antibody; Antigen design
Interactions of Interleukin-8 with the Human Chemokine Receptor CXCR1 in Phospholipid Bilayers by NMR Spectroscopy
Keywords: GPCR، G-پروتئین گیرنده; 1TM1–72, the first transmembrane helix domain corresponding to residues 1–72 of CXCR1; DHPC, 1,2-dihexanoyl-sn-glycero-3-phosphocholine; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; GPCR, G-protein-coupled receptor; IL-8, interleukin-8; ND1–38, the
Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor
Keywords: GPCR، G-پروتئین گیرنده; Melanocortin peptides; MC4 receptor; NMR spectroscopy; DPC micelle solution; Docking studiesh-MCR, human Melanocortin Receptor; cAMP, cyclic adenosine monophosphate; GPCR, G-protein-coupled receptor; MSH, melanocyte stimulating hormones; ACTH, adreno-cort
Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion
Keywords: GPCR، G-پروتئین گیرنده; DPP4, dipeptidyl peptidase inhibitor 4; GLP-1, glucagon-like peptide-1; GPCR, G-protein-coupled receptor; GPR119, G-protein-coupled receptor 119; GSIS, glucose-stimulated insulin secretion; RFU, relative fluorescence unit; T2DM, type 2 diabetes mellitusGP
Evidence for constitutive dimerization of niacin receptor subtypes
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; BRET2, improved bioluminescence resonance energy transfer; GFP2, modified green fluorescent protein; Rluc, Renilla luciferase; NIACR1, niacin receptor 1; NIACR2, niacin receptor 2.Niacin receptors; Dimerization; Agonist;
A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation
Keywords: GPCR، G-پروتئین گیرنده; Ox-A, orexin-A; GPCR, G-protein-coupled receptor; Ox1R, orexin receptor 1; [Ca2+]i, intracellular calcium concentration; PKC, protein kinase C; PKD, protein kinase D; HEKOx1R, HEK293 cells stably transfected with Ox1R; GF-X, GF109203X; fura-2 AM, fura-2-a
LPA3, a unique G protein-coupled receptor for lysophosphatidic acid
Keywords: GPCR، G-پروتئین گیرنده; LPA, lysophosphatidic acid; ATX, autotaxin; GPCR, G-protein-coupled receptor; LPP, lipid phosphate phosphatase; lysoPLD, lysophospholipase D; PAP, prostatic acid phosphatase; PLA, phospholipase A; PA, phosphatidic acidLPA3; Lysophosphatidic acid
Modulation of HDL metabolism by the niacin receptor GPR109A in mouse hepatocytes
Keywords: GPCR، G-پروتئین گیرنده; ABCA1, ATP binding cassette transporter A1; ApoA-I, apolipoprotein A-I; cAMP, cyclic adenosine monophosphate; CETP, cholesteryl ester transfer protein; GPCR, G-protein-coupled receptor; HDL-C, high density lipoprotein cholesterol; IBMX, 3-isobutyl-1-methy
Two insulin-like peptide family members from the mosquito Aedes aegypti exhibit differential biological and receptor binding activities
Keywords: GPCR، G-پروتئین گیرنده; BSA, bovine serum albumin; ILP, insulin-like peptides; DIR, Drosophila insulin receptor; GPCR, G-protein-coupled receptor; IGFs, insulin-like growth factors; IGFR, insulin growth factor-like receptor; IR, insulin receptor; MAPK, mitogen-activated protein
Propranolol suppresses angiogenesis in vitro: Inhibition of proliferation, migration, and differentiation of endothelial cells
Keywords: GPCR، G-پروتئین گیرنده; β-AR, beta-adrenergic receptor; bFGF, basic fibroblast growth factor; CDK, cyclin-dependent kinase; CKI, cyclin kinase inhibitor; EC, endothelial cell; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; GPCR, G-protein-coupled receptor;
Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; GRK, G-protein-coupled receptor kinase; ER, endoplasmic reticulum; HEK293, human embryonic kidney cell line; CHO, Chinese hamster ovary cell lineGPCR; Dopamine; D4 receptor; β-arrestin; Internalization; Phosphorylation
Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1
Keywords: GPCR، G-پروتئین گیرنده; FFA, free fatty acid; GPCR, G-protein-coupled receptor; LPA, lysophosphatidic acid; LPI, lysophosphatidylinositol; MAFP, methyl arachidonoyl fluorophosphate; PA, phosphatidic acid; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylino
Structure–activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: Synthesis, biological evaluation, and α1d computational study
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; AR, adrenoreceptor; TM, transmembrane; LUTS, lower urinary tract symptoms; BPH, benign prostatic hyperplasia; TM, transmembrane; SDM, site-directed mutagenesis; PDB, protein data bank; CHO, chinese hamster ovary; QSARs, q
KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; BTB, broad-complex, tramtrack, and Bric à Brac; HEK293, Human Embryonic Kidney 293; CHO, Chinese hamster ovary; IP, immunoprecipitation; IB, immunoblotting; E3, ubiquitin-conjugating enzyme; HA, hemagglutinin; siRNA, smal
Parenteral medium-chain triglyceride-induced neutrophil activation is not mediated by a Pertussis Toxin sensitive receptor
Keywords: GPCR، G-پروتئین گیرنده; Parenteral; Medium-chain triglycerides; Neutrophil; Human; Immune modulation; G-protein-coupled receptorSTZ, serum-treated zymosan; PT, pertussis toxin; GPCR, G-protein-coupled receptor; ROS, reactive oxygen species; MCFFAs, medium-chain free fatty acids;
Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes
Keywords: GPCR، G-پروتئین گیرنده; hCB1, human CB1 cannabinoid receptor; GPCR, G-protein-coupled receptor; HEPES, N-[2-hydroxyethylpiperazine-N′-2-ethane]sulfonic acid; TFE, trifluoroethanol; MD, molecular dynamics; SUV, small unilamellar vesicle; SPC, simple point charge; POPC, 1-palmitoy
Estrogen Rapidly Modulates 5-Hydroxytrytophan-Induced Visceral Hypersensitivity via GPR30 in Rats
Keywords: GPCR، G-پروتئین گیرنده; 5HT, serotonin; 5HTP, 5-hydroxytryptophan CGRP, calcitonin gene related peptide; CRD, colorectal distension; DPN, diarylpropionitrile; DRG, dorsal root ganglion; EMG, electromyogram; ER, estrogen receptor; GPCR, G-protein-coupled receptor; IR, immunoreact
C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation
Keywords: GPCR، G-پروتئین گیرنده; ASP, acylation stimulating protein; FITC, fluorescein isothiocyanate; GFP, green fluorescent protein; GPCR, G-protein-coupled receptor; HA, hemaglutinin; HSF, human skin fibroblast; KO, knockout; LPS, lipopolysaccharide; OVA, ovalbumin; PFA, paraformaldeh
Structure of the Third Intracellular Loop of the Vasopressin V2 Receptor and Conformational Changes upon Binding to gC1qR
Keywords: GPCR، G-پروتئین گیرنده; DMSO, dimethyl sulfoxide; DPC, dodecyl phosphocholine; Gd(DTPA-BMA), Gd-diethylenetriamine pentaacetic acid–bismethylamide; GPCR, G-protein-coupled receptor; gC1qR, receptor for the globular domains of the C1q complement; HSQC, heteronuclear single quantu
Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8
Keywords: GPCR، G-پروتئین گیرنده; RGS, regulators of G-protein signaling; G-protein, heterotrimeric guanine nucleotide-binding proteins; GPCR, G-protein-coupled receptor; MACHR, muscarinic acetylcholine receptor; i3L, third intracellular loop; BRET, bioluminescence energy transfer; GST, g
Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; Gα, G-protein α-subunit; Gβ1γ2, G-protein β1γ2 subunit dimer; BV, budded virus; AC, adenylyl cyclase; ACVI, adenylyl cyclase type VI; PBS, phosphate-buffered saline; TBS, Tris-buffered saline; SDS, sodium dodecyl sulfate;
Receptor activation involving positive allosteric modulation, unlike full agonism, does not result in GABAB receptor desensitization
Keywords: GPCR، G-پروتئین گیرنده; GABAB receptor; Allosteric modulators; Desensitization; GS39783GABA, γ-aminobutyric acid; GPCR, G-protein-coupled receptor; CHO, Chinese hamster ovary; CPA, N6-cyclopentyladenosine; GTPγS, guanosine 5′-O-(3-thiotriphosphate); DIV, day in vitro; HBSS, Hank
[Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes
Keywords: GPCR، G-پروتئین گیرنده; [Ca2+]c, cytosolic calcium concentration; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; GPCR, G-protein-coupled receptor; PBS, phosphate-buffered saline; UII, urotensin II; URP, urotensin II-related peptide; UT, UII receptorUrotensin
Novel pharmacological targets based on receptor heteromers
Keywords: GPCR، G-پروتئین گیرنده; GPCR, G-protein-coupled receptor; KD, Dissociation constant; DC, dimer cooperativity indexAdenosine; Cannabinoid; Dopamine; Opioid; Fitting data; Receptor dimer; Receptor oligomer; Allosteric regulation; Cooperativity; Drug target
Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors
Keywords: GPCR، G-پروتئین گیرنده; FTIR, Fourier transform infrared; GPCR, G-protein-coupled receptor; H, transmembrane helix; β2AR, β2-adrenergic receptor; PC, phosphatidyl choline; DDM, n-dodecyl-β-d-maltoside; OG, n-octyl β-d-glucoside; H, transmembrane helix; MES, 2-(N-morpholino)ethan