Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Obesity; Adipokine; Adipocyte; Beta-cell; Insulin secretion; FABP4T2D, type 2 diabetes; NEFA, non-esterified fatty acid; GSIS, glucose-stimulated insulin secretion; SILAC, stable-isotope labelling by amino acids in cell culture; ELISA, enzyme-linked immun
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Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Stimulus-coupled secretion; Insulin; β-Cell; Diabetes; Pyruvate; Mitochondria; DrosophilaIMM, inner mitochondrial membrane; MPC1 and MPC2, Mitochondrial Pyruvate Carrier 1 and 2; GSIS, glucose-stimulated insulin secretion; IPCs, Insulin-producing Cells; O
Mitochondrial uncoupling protein-2 is not involved in palmitate-induced impairment of glucose-stimulated insulin secretion in INS-1E insulinoma cells and is not needed for the amplification of insulin release
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; BSA, bovine serum albumin; DAPI, 4′,6-diamidino-2-phenyl-indole; GSIS, glucose-stimulated insulin secretion; UCP, uncoupling protein; NEFA, non-esterified fatty acidPancreatic beta cells; Glucolipotoxicity; Uncoupling protein-2 (UCP2); Glucose-stimulated
Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Munc18c; Exocytosis; Newcomer insulin granules; Human isletsSyn, syntaxin; SG, secretory insulin-containing granule; GSIS, glucose-stimulated insulin secretion; PM, plasma membrane; KD, knock down; CmPatch, clamp capacitance measurements; TIRFM, total int
Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Thiazolidine derivative; DPP-4 inhibitor; Pancreatic β-cells; Cellular kineticsPio, pioglitazone; Alo, alogliptin; GSIS, glucose-stimulated insulin secretion; IPITT, intraperitoneal glucose tolerance test; PPARγ, peroxisome proliferator-activated receptor
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Beta-cell; Insulin secretion; Insulin sensitivity; Genetic background; Mouse strainDI, disposition index; FSIVGTT, frequently sampled intravenous glucose tolerance test; GIR, glucose infusion rate; GSIS, glucose-stimulated insulin secretion; IDE, insulin
Methylated trivalent arsenicals are potent inhibitors of glucose stimulated insulin secretion by murine pancreatic islets
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; As3mt, arsenic (+ 3 oxidation state) methyltransferase; ATP, adenosine tri-phosphate; DMAs, dimethyl-arsenic; DMAsIII, dimethylarsinite; ELISA, enzyme-linked immuno-sorbent assay; GLUT, glucose transporter; GSIS, glucose-stimulated insulin secretion; HG-C
Embryo-transfer of the F2 postnatal calorie restricted female rat offspring into a control intra-uterine environment normalizes the metabolic phenotype
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; ET, Embryo Transfer; CON, Control group with ad lib access to calories; PNGR, Postnatal growth restriction; GSIS, Glucose-stimulated insulin secretion; HGP, Hepatic glucose production; AUC, Area under the curve; IVGTT, Intravenous glucose tolerance test;
Marrubiin, a constituent of Leonotis leonurus, alleviates diabetic symptoms
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; AI, atherogenic index; ASP, aspirin; AUC, area under the curve; C, control; CVD, cardiovascular diseases; DM, diabetes mellitus; FFAs, free fatty acids; Glut, glucose transporter; GSIS, glucose-stimulated insulin secretion; IL, interleukin; IPGTT, intrape
PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; G6pase, glucose-6-phosphatase; GSIS, glucose-stimulated insulin secretion; GTT, glucose tolerance tests; HFD, high-fat diet; HGP, hepatic glucose production; ITT, insulin tolerance tests; PANDER, pancreatic-derived factor; PEPCK, phosphoenolpyruvate carbo
CNTF protects MIN6 cells against apoptosis induced by Alloxan and IL-1β through downregulation of the AMPK pathway
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; CNTF, ciliary neurotrophic factor; NO, nitric oxide; ROS, reactive oxygen species; GSIS, glucose-stimulated insulin secretion; AMPK, AMP-activated protein kinase; LKB1, liver kinase B1; CaMKII, Ca2+/calmodulin complex activated kinase II; ACC, acetyl-CoA
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; EAATs, excitatory amino acid transporters; GSIS, glucose-stimulated insulin secretion; αKIC, alpha-ketoisocaproate; trans-PDC, l-trans-pyrrolidine-2,4-dicarboxylateAlpha-cells; Beta-cells; α-Ketoglutarate; Excitatory amino acid transporter; Glutamine; GAB
Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; DPP4, dipeptidyl peptidase inhibitor 4; GLP-1, glucagon-like peptide-1; GPCR, G-protein-coupled receptor; GPR119, G-protein-coupled receptor 119; GSIS, glucose-stimulated insulin secretion; RFU, relative fluorescence unit; T2DM, type 2 diabetes mellitusGP
Ghrelin inhibits insulin secretion through the AMPK–UCP2 pathway in β cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; AICAR, 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK, AMP-activated protein kinase; GHSR, growth-hormone secretagogue receptor; GSIS, glucose-stimulated insulin secretion; KRBH, Krebs–Ringer bicarbonate–Hepes buffer; PPAR, peroxisome prolifera
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; CAT, catalase; GCLC, γ-glutamate-cysteine ligase catalytic subunit; GPx, glutathione peroxidase; GSIS, glucose-stimulated insulin secretion; O2−, superoxide; GSH, reduced glutathione; GS, glutathione synthetase; GR, glutathione reductase; GSSG, oxidized g
Insulin and glucose sensitivity, insulin secretion and β-cell distribution in endocrine pancreas of the fruit bat Artibeus lituratus
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Akt, protein kinase B; ANOVA, analysis of variance; AOU, arbitrary optical arbitrary units; AUC, are under the glucose curve; GSIS, glucose-stimulated insulin secretion; ipGTT, intraperitoneal glucose tolerance test; ipITT, intraperitoneal insulin toleran
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; DPP4, dipeptidyl peptidase inhibitor 4; GLP-1, glucagon-like peptide-1; GPR119, G-protein-coupled receptor 119; GSIS, glucose-stimulated insulin secretion; HbA1c, hemoglobin A1c; HEK, human embryonic kidney; LPC, lysophosphatidylcholine; OEA, oleoylethano
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the α2-adrenergic receptors in beta cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; α2-AR, α2-adrenergic receptors; AMPK, AMP-activated protein kinase; Ca2+, calcium; CREB, cAMP response element binding; DRD2, dopamine receptor D2; ERK1/2, extracellular signal-regulated kinases 1/2; GSIS, glucose-stimulated insulin secretion; HG clamp, h
SNAP-251–180 enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet β-cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; Kv, voltage-gated K+ channel; GSIS, glucose-stimulated insulin secretion; VDCC, voltage-dependent calcium channel; SNARE protein, soluble N-ethylmaleimide sensitive factor (NSF) attachment protein or SNAP receptor; SNAP-25, synaptosome-associated protein-
Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic β-cells
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; ARF-6, ADP-ribosylation factor-6; G-proteins, guanosine triphosphate-binding proteins; GDI, GDP-dissociation inhibitor; GEF, guanine nucleotide exchange factor; GRFs, G-protein regulatory factors; GSIS, glucose-stimulated insulin secretion; Tiam1, T-lymph
Bridging the gap between protein carboxyl methylation and phospholipid methylation to understand glucose-stimulated insulin secretion from the pancreatic β cell
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; CML, carboxylmethylation; GSIS, glucose-stimulated insulin secretion; MTA, methylthiodeoxyadenosine; PP2A, protein phosphatase 2A; PP2Ac, catalytic subunit of PP2A; SAM, S-adenosylmethioninePancreatic β cells; Protein phosphatase 2A; Glucose-stimulated in
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; BSA, bovine serum albumin; AICAR, 5-aminoimidazole-4-carboxamide riboside; AMPK, AMP-activated protein kinase; DMEM, Dulbecco's modified Eagle's medium; FCS, fetal calf serum; GSIS, glucose-stimulated insulin secretion; H2-DCFDA, dihydrodichlorofluorescei
Mitochondrial uncoupling proteins—What is their physiological role?
Keywords: GSIS، ترشح انسولین تحریک شده توسط گلوکز; AAPH, 2,2-azobis(2-methylpropionamidine) dihydrochloride; ANT, adenine nucleotide translocase; BAT, brown adipose tissue; CNS, central nervous system; ETC, electron transfer chain; GSIS, glucose-stimulated insulin secretion; HNE, 4-hydroxy-trans-2-nonenal