Keywords: HCY، هموسیستئین; CBS, cystathionine beta synthase; GSH, glutathione; Hcy, homocysteine; HHcy, hyperhomocysteinemia; HO-1, heme oxygenase I; PON1, paraoxonase 1; NQO1, NAD(P)H:quinone oxidoreductase; XME, xenobiotic-metabolizing enzymeHyperhomocysteinemia; Mice; Liver; Cad
مقالات ISI HCY، هموسیستئین (ترجمه نشده)
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Keywords: HCY، هموسیستئین; BHMT, betaine-homocysteine methyltransferase; CV, coefficient of variation; DMG, dimethylglycine; Hcy, homocysteine; IDL, instrumental detection limit; LOD, limit of detection; MRM, multiple reaction monitoring; RBC, red blood cell; tHcy, total homocystei
Keywords: HCY، هموسیستئین; Hcy, homocysteine; Cysta, cystathionine; Met, methionine; tHcy, total homocysteine; DBSs, dried blood spots; LC–MS/MS, liquid chromatography–tandem mass spectrometry; MRM, multiple reaction monitoring; RM, remethylation; CBS, cystathionine beta-synthase;
Keywords: HCY، هموسیستئین; DCFH, dichlorodihydrofluorescein diacetate; TBARS, thiobarbituric acid-reactive substances; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; GSH, reduced glutathione; Hcy, homocysteine; HCU, homocystinuria; CβS, cystathionine β-synth
Keywords: HCY، هموسیستئین; CAC, coronary artery calcification; GLU, fasting glucose; Hcy, homocysteine; IL, interleukin; VSMC, vascular smooth muscle cellIL-37; Arterial calcification; Inflammation
Keywords: HCY، هموسیستئین; SZ, schizophrenia; C1, one-carbon; Hcy, homocysteine; ROS, reactive oxygen species; SAM, S-adenosylmethionine; DNMT, DNA methyltransferase; FFQ, food frequency questionnaire; 24HDR, 24-hour dietary recall; RBC, red blood cell; SD, standard deviation; WMD,
Successful intrauterine treatment of a patient with cobalamin C defect
Keywords: HCY، هموسیستئین; cblC, cobalamin C; Hcy, homocysteine; OHCbl, hydroxycobalamin; tHcy, total homocysteine; MeCbl, methylcobalamin; AdoCbl, adenosylcobalamin; CNCbl, cyanocobalaminCobalamin C defect; Inborn error of metabolism; Hydroxycobalamin; Intrauterine treatment; Homo
Conversion from MCI to AD in patients with the APOE ε4 genotype: Prediction by plasma HCY and serum BDNF
Keywords: HCY، هموسیستئین; MCI, mild cognitive impairment; aMCI, amnestic mild cognitive impairment; AD, Alzheimer’s disease; APOE, apolipoprotein E; HCY, homocysteine; BDNF, brain-derived neurotrophic factor; CSF, cerebrospinal fluid; ELISA, enzyme-linked immunosorbent assay; PPV,
1,25-Dihydroxyvitamin D3 exerts neuroprotective effects in an ex vivo model of mild hyperhomocysteinemia
Keywords: HCY، هموسیستئین; Hcy, homocysteine; ROS, reactive oxygen species; RNS, reactive nitrogen species; DCFH-DA, 2′,7′-dihydrodichlorofluorescein diacetate; TBARS, thiobarbituric acid reactive species; TCA, trichloroacetic acid; SOD, superoxide dismutase; CAT, catalase; GPx, gl
Turkish propolis supresses MCF-7 cell death induced by homocysteine
Keywords: HCY، هموسیستئین; DCFH-DA, 2′7′-dichlorodihydrofluorescin diacetate; CAPE, Caffeic Acid Phenethyl Ester; GSH-Px, Glutathione Peroxidase; Hcy, Homocysteine; H2O2, Hydrogen Peroxide; MDA, Malondialdehyde; MCF-7 cells, Michigan Cancer Foundation-7 Cells; μg/ml, Microgram/mili
miR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine
Keywords: HCY، هموسیستئین; VSMCs, Vascular Smooth Muscle Cells; AS, atherosclerosis; Hcy, homocysteine; HHcy, Hyperhomocysteinemia; DNMT3b, DNA (cytosine-5)-methyltransferase 3b; nMS-PCR, nested methylation-specific-PCR; UTR, untranslated region; miRNAs, microRNAs; mfe, minimum fre
Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis
Keywords: HCY، هموسیستئین; CAD, coronary artery disease; PCAD, premature coronary artery disease; Hcy, homocysteine; MTHFR, 5, 10-methylenetetrahydrofolate reductase; OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg Equilibrium.Methylenetetrahydrofolate reductase (MTHFR
Hypercysteinemia promotes atherosclerosis by reducing protein S-nitrosylation
Keywords: HCY، هموسیستئین; Hcy, homocysteine; HDL-C, high-density lipoprotein cholesterol; HHcy, hypercysteinemia; HUVECs, human umbilical vein endothelial cells; Mϕ, macrophage; NF-κB, nuclear factor κB; NO, nitric oxide; ROS, reactive oxygen species; SMC, smooth muscle cell; SNO,
l-Arginine and vitamin C attenuate pro-atherogenic effects of high-fat diet on biomarkers of endothelial dysfunction in rats
Keywords: HCY، هموسیستئین; ADMA, dimethyl-l-arginine; BH4, (6R)-5,6,7,8-tetrahydro-l-biopterin; BMI, body mass index; CML, Nϵ-carboxymethyl lysine; CRP, C reactive protein; DNP, 2,4-dinitrophenyl; DNPH, 2,4-dinitrophenylhydrazine; DTT, dithiothreitol; Hcy, homocysteine; HDL, choles
Simultaneous determination of albumin and low-molecular-mass thiols in plasma by HPLC with UV detection
Keywords: HCY، هموسیستئین; CMQT, 2-chloro-l-methylquinolinium tetrafluoroborate; Cys, cysteine; Cys–Gly, cysteinylglycine; GSH, glutathione; Hcy, homocysteine; HSA, human serum albumin; TCEP, tris(2-carboxyethyl)phosphineAlbumin; Endogenic plasma thiols; High performance liquid chr
Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia
Keywords: HCY، هموسیستئین; ALT, alanine aminotransferase; APO, apolipoprotein; CBS, cystathionine beta synthase; DCPIP, 2,6-dichlorophenolindophenol; hcy, homocysteine; HDLs, high-density lipoproteins; hhcy, hyperhomocysteinemia; HPLC, high-performance liquid chromatography; KYNA,
Design of protein homocystamides with enhanced tumor uptake properties for 19F magnetic resonance imaging
Keywords: HCY، هموسیستئین; NTJKQVMEBUIIMX-UHFFFAOYSA-NSB RAS, Siberian Branch of the Russian Academy of Sciences; HSA, human serum albumin; PFT, perfluorotoluene; Hcy, homocysteine; Hcy-HSA, N-homocysteinylated human serum, albumin; HTL, homocysteine thiolactone; PFT-HTL, N-(2,3,5,
Homocysteine contribution to DNA damage in cystathionine β-synthase-deficient patients
Keywords: HCY، هموسیستئین; CAT, catalase; CBS, cystathionine β-synthase; DI, damage index; Hcy, homocysteine; LC–MS/MS, liquid chromatography electrospray tandem mass spectrometry; MTHFR, methylenetetrahydrofolate reductase; ROS, reactive oxygen species; SAH, S-adenosylhomocysteine
Maternal vitamin B12 deficiency detected in expanded newborn screening
Keywords: HCY، هموسیستئین; DBS, dried blood spot; Holo-TC, holo-transcobalamin; Hcy, homocysteine; MMA, methylmalonic acid; NBS, newborn screening; C3, propionyl carnitine; cbl, cobalamin; THF, tetrahydrofolate; MTHF, methyltetrahydrofolateVitamin B12 deficiency; Newborn screening;
B-vitamins intake, DNA-methylation of One Carbon Metabolism and homocysteine pathway genes and myocardial infarction risk: The EPICOR study
Keywords: HCY، هموسیستئین; DNA-methylation; B-vitamins; Myocardial infarction; One Carbon Metabolism; HomocysteineCVD, cardiovascular disease; Hcy, homocysteine; OCM, One Carbon Metabolism; DMR, differentially methylated region; RPMM, recursively partitioned mixture model; BMI, bod
One-carbon cycle alterations induced by Dyrk1a dosage
Keywords: HCY، هموسیستئین; CBS, cystathionine beta synthase; DS, Down syndrome; DYRK, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase; EGCG, epigallocatechin-gallate; GABA, gamma-amino-butyric-acid; GK, Goto-Kakizaki; hcy, homocysteine; NQO1, NAD(P)H:quinone oxidored
Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?
Keywords: HCY، هموسیستئین; APOE, apolipoprotein E; CV, cardiovascular; Hcy, homocysteine; HDL, high density lipoproteins; MTHFR, methylenetetrahydrofolate reductase; PXE, Pseudoxanthoma elasticumPseudoxanthoma elasticum; Skin-disease; Apolipoprotein E; Methylenetetrahydrofolate red
Homocysteine and DNA methylation: A review of animal and human literature
Keywords: HCY، هموسیستئین; Hcy, homocysteine; HHcy, hyperhomocysteinemia; HH, hyperhomocysteinemic; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; HM, high methionine; MD, methionine deficient; LF, low folate; LB6, low vitamin B6; LB12, low vitamin B12; FD, folate deficien
Vitamin B12 deficiency in Caenorhabditis elegans results in loss of fertility, extended life cycle, and reduced lifespan
Keywords: HCY، هموسیستئین; Caenorhabditis elegans; Cobalamin; Methionine synthase; Methylmalonic acid; Methylmalonyl-CoA mutase; Vitamin B12Ado-B12, 5′-deoxyadenosylcobalamin; B12, vitamin B12; C. elegans, Caenorhabditis elegans; CH3-B12, methylcobalamin; Hcy, homocysteine; MCM, me
Increased plasma homocysteine predicts arrhythmia recurrence after minimally invasive epicardial ablation for nonvalvular atrial fibrillation
Keywords: HCY، هموسیستئین; AF, atrial fibrillation; AUC, area under the curve; ECG, electrocardiogram; Hcy, homocysteine; RF, radiofrequency; ROC, receiver operating characteristic; TIA, transient ischemic attack24; 28
MTHFR C677T and A1298C gene polymorphisms and their relation to homocysteine level in Egyptian children with congenital heart diseases
Keywords: HCY، هموسیستئین; MTHFR, methylene tetrahydrofolate reductase; CHD, congenital heart diseases; SNP, single nucleotide polymorphism; ECHO, echocardiography; Hcy, homocysteine; DNA, deoxyribonucleic acid; PCR–RFLP, polymerase chain reaction–restriction fragment length polymo
Gene–environment and gene–gene interactions of specific MTHFR, MTR and CBS gene variants in relation to homocysteine in black South Africans
Keywords: HCY، هموسیستئین; CBS, cystathione-β-synthase; CVD, cardiovascular disease; CV, coefficient of variance; GGT, gamma (γ)-glutamyl transferase; Hcy, homocysteine; hs-CRP, high sensitivity C-reactive protein; HWE, Hardy–Weinberg equilibrium; MTHFR, methylenetetrahydrofolate r
Acute phase homocysteine related to severity and outcome of atherothrombotic stroke
Keywords: HCY، هموسیستئین; AA, aortic atheroma; AT, Atherothrombosis; BI, Barthel Index; CAOD, coronary artery occlusive disease; CE, Cardioembolism; CHD, coronary heart disease; CI, confidence interval; CT, cranial computed tomography; DM, diabetes mellitus; HCY, homocysteine; HT,
Homocysteine modifies extracellular ATP availability in macrophages
Keywords: HCY، هموسیستئین; Hcy, homocysteine; HHcy, hyperhomocysteinemia; CAD, coronary artery disease; FBS, fetal bovine serum; NTPDase, ectonucleoside triphosphate diphosphohydrolases; ADO, adenosineHomocysteine; Macrophages; Ecto-5′-nucleotidase; NTPDase
Stimulation of non-neuronal muscarinic receptors enhances chemerin/ChemR23 system in dysfunctional endothelial cells
Keywords: HCY، هموسیستئین; NNAs, non-neuronal acetylcholine systems; NNMR, non-neuronal muscarinic receptors; RAECs, rat aortic endothelial cells; Hcy, homocysteine; ox-LDL, oxidized low-density lipoprotein; Glu, glucose; Are, arecoline; Atr, atropine; RT-PCR, reverse transcriptase
Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis
Keywords: HCY، هموسیستئین; MTHFR, methylenetetrahydrofolate reductase; RPL, recurrent pregnancy loss; URPL, unexplained recurrent pregnancy loss; Hcy, homocysteine; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence intervalMethylenetetrahydrofolate reductase; Poly
Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice
Keywords: HCY، هموسیستئین; Apo A-I, apolipoprotein A-I; CBS, cystathionine-β-synthase; DS, Down syndrome; DYRK1A, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase-1A; HDL, high-density lipoprotein; Hcy, homocysteine; NFAT, nuclear factor of activated T cell; NQO1, NAD
No association between MTHFR C677T polymorphism and completed suicide
Keywords: HCY، هموسیستئین; Hcy, homocysteine; methyleneTHF, 5,10-methylenetetrahydrofolate; methylTHF, 5-methyltetrahydrofolate; MTHFR, methylenetetrahydrofolate reductasers1801133; Methylenetetrahydrofolate reductase (NADPH2); Molecular genetics; Single nucleotide polymorphism; Ri
Polymorphism of the methylenetetrahydrofolate reductase gene C677T and its influence on the antihypertensive and vascular protective effects of short-term lercanidipine treatment
Keywords: HCY، هموسیستئین; MTHFR, methylenetetrahydrofolate reductase; ABI, ankle-brachial index values; PWV, pulse wave velocity; SBP, systolic blood pressure; DBP, diastolic blood pressure; Hcy, homocysteine; ROS, reactive oxygen species; CCBs, calcium channel blockers; VGCCs, vo
Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism
Keywords: HCY، هموسیستئین; Ohe, overt hyperthyroidism; Oho, overt hypothyroidism; BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure; CRP, C-reactive protein; Hcy, homocysteine; IMA, ischemia-modified albumin; PG, plasma glucose; HDL-C, high-density l
Methylenetetrahydrofolate Reductase Gene 677CT Polymorphism and Isolated Congenital Heart Disease in a Mexican Population
Keywords: HCY، هموسیستئین; CCHD, complex congenital heart disease; CHD, congenital heart disease; Hcy, homocysteine; MTHFR, methylenetetrahydrofolate reductase; OR, odds ratio; SCHD, simple congenital heart diseaseCongenital heart disease; Mutation; Methylenetetrahydrofolate reduct
Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease/myocardial infarction in women: A case-control study
Keywords: HCY، هموسیستئین; Hcy, homocysteine; Lp(a), lipoprotein(a); CAD, coronary artery disease; CI, 95% confidence interval; MI, myocardial infarction; OR, odds ratio; MTHFR, methylene tetrahydrofolate reductase; LDL, low density lipoproteine; HDL, high density lipoproteine; MTH
Neurotoxic injury pathways in differentiated mouse motor neuron–neuroblastoma hybrid (NSC-34D) cells in vitro—Limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity
Keywords: HCY، هموسیستئین; ALS, amyotrophic lateral sclerosis; D-PBS, Dulbecco's Phosphate Buffered Saline; ER, endoplasmic reticulum; HCy, homocysteine; H2O2, hydrogen peroxide; IC50, concentration at which 50% of maximal response is inhibited; NCSS, Number Cruncher Statistical So
Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells
Keywords: HCY، هموسیستئین; Hcy, Homocysteine; HHcy, Hyperhomocysteinemia; HUVECs, Human umbilical vein endothelial cells; 5-aza-CdR, 5-aza-2′ deoxycytidine; 3-DZA, 3-deazadenosine; MSP, Methylation-specific PCR; ECs, Endothelial cells; PDGFs, Platelet-derived growth factors; VSMCs,
Effects of resveratrol on blood homocysteine level, on homocysteine induced oxidative stress, apoptosis and cognitive dysfunctions in rats
Keywords: HCY، هموسیستئین; Hcy, homocysteine; NO, nitric oxide; LPO, lipid peroxidation; MDA, malondialdehyde; 4-HDA, 4-hydroxyalkenals; PAR, proteinase activated receptor; MPP, 1-methyl-4-phenyl pyridinium; AMPK, AMP-activated kinase; ROS, reactive oxygen species; NF-κB, nuclear f
Homocysteine may accelerate skin aging: A new chapter in the biology of skin senescence?
Keywords: HCY، هموسیستئین; atherosclerosis; homocysteine; mechanism; prevention; skin agingCBS, cystathionine beta-synthase; Hcy, homocysteine; MMP, matrix metalloproteinase; UV, ultraviolet
Early reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetes
Keywords: HCY، هموسیستئین; CBS, cystathionine beta synthase; DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid); GK, Goto–Kakizaki; GSH, glutathione; Hcy, homocysteine; HFS, high-fat-sucrose; STZ, streptozotocin; tHcy, total Hcy; ZDF, Zucker diabetic fattyHomocysteine; Cystathionine beta s
Serum vitamin B12 concentrations within reference values do not exclude functional vitamin B12 deficiency in PKU patients of various ages
Keywords: HCY، هموسیستئین; Hcy, homocysteine; MMA, methylmalonic acid; Phe, phenylalanine; PKU, phenylketonuria; Vit B12, vitamin B12Phenylketonuria; Vitamin B12; Methylmalonic acid; Homocysteine; Metabolic control
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes
Keywords: HCY، هموسیستئین; BHMT, betaine homocysteine methyltransferase; BHMT-2, betaine homocysteine methyltransferase-2; BHMT, gene encoding betaine homocysteine methyltransferase; BHMT-2, gene encoding betaine homocysteine methyltransferase-2; Hcy, homocysteine; Met, methionine;
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist
Keywords: HCY، هموسیستئین; aCSF, artificial cerebrospinal fluid; CA, cysteic acid; CSA, cysteine sulfinic acid; CSF, cerebrospinal fluid; EAA, excitotoxic amino acids; HCA, homocysteic acid; HCSA, homocysteine sulfinic acid; Hcy, homocysteine; iGluR, ionotropic glutamate receptor;
Ginsenoside Rb1 prevents homocysteine-induced endothelial dysfunction via PI3K/Akt activation and PKC inhibition
Keywords: HCY، هموسیستئین; Akt, protein kinase B; ECGS, endothelial cell growth supplement; eNOS, endothelial nitric oxide synthase; FBS, fetal bovine serum; GS, ginsenosides; Hcy, homocysteine; HHcy, Hyperhomocysteinemia; HUVECs, human umbilical vein endothelial cells; l-NAME, N-n
Homocysteine and Reclassification of Cardiovascular Disease Risk
Keywords: HCY، هموسیستئین; cardiovascular risk; homocysteine; risk reclassificationCAC, coronary artery calcium; CHD, coronary heart disease; CRP, C-reactive protein; CVD, cardiovascular disease; FRS, Framingham risk score; Hcy, homocysteine; hs-CRP, high-sensitivity C-reactive pro
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity
Keywords: HCY، هموسیستئین; BHMT, betaine-homocysteine S-methyltransferase; BHMT-2, betaine-homocysteine S-methyltransferase 2; CBHcy, S-(Δ-carboxybutyl)-cyl-homocysteine; CBS, cystathionine β-synthase; Hcy, homocysteine; methyl-THF, methyltetrahydrofolate; MS, methionine synthase;
Interaction of Folate Intake and the Paraoxonase Q192R Polymorphism with Risk of Incident Coronary Heart Disease and Ischemic Stroke: The Atherosclerosis Risk in Communities Study
Keywords: HCY، هموسیستئین; Coronary Heart Disease; Folate; Genetic Polymorphism; Incidence; StrokeCHD, coronary heart disease; Hcy, homocysteine; CI, confidence interval; PON1, paraoxonase 1; HDL, high-density lipoprotein; OR, odds ratio; ARIC, Atherosclerosis Risk in Communities;
Aggregation and structural changes of αS1-, β- and κ-caseins induced by homocysteinylation
Keywords: HCY، هموسیستئین; ANS, 1-anilino-8-naphthalene sulfonate; beta-ME, beta-mercaptoethanol; BSA, bovine serum albumin; CD, circular dichroism; CN, casein; DLS, dynamic light scattering; DTNB, 5,5′-dithio-bis (2-nitrobenzoic acid); Hcy, homocysteine; DTT, dithiothreitol; IUP,