Keywords: Retinal pigment epithelium; Extracellular vesicles; Exosomes; Tight junctions; HDAC6; Age-related macular degeneration;
مقالات ISI (ترجمه نشده)
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Keywords: FK228 (PubChem CID: 5352062); PXD101 (PubChem CID: 6918638); SAHA (PubChem CID: 5311); LBH-589 (PubChem CID: 6918837); tubacin (PubChem CID: 6675804); tubastatin A (PubChem CID: 49850262); ACY-1215 (PubChem CID: 53340666); ACY-241 (PubChem CID: 53340426);
Keywords: Phthalates; Breast cancer; Diet; Endocrine disruptor; Estrogenic receptor; EDCs; endocrine disrupting chemicals; DEHP; di(2-ethylhexyl) phthalate; BBzP; butylbenzyl phthalate; DnBP; di-n-butyl phthalate; DMP; dimethyl phthalate; DEP; diethyl phthalate; ME
Keywords: PC1/2; Pkd1/2, polycystin 1/2; TRPV4; transient receptor potential vanilloid 4; AC6; adenylyl cyclase 6; cAMP; cyclic adenosine monophosphate; IFT88; intraflagellar transport 88; Kif3a; kinesin family member 3A; HDAC6; histone deacetylase 6; BBS; Bardet-B
Keywords: Histone deacetylase inhibitor; Benzohydroxamic acid; HDAC6; HDAC8;
Keywords: AD; Alzheimer disease; ATP; adenosine triphosphate; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; BDNF; brain derived neurotrophic factor; CMA; chaperone-mediated autophagy; CR; caloric restriction; Ex; exercise; GABA; gamma-aminobutyr
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: Hemorrhagic shock; Two-hit; Tubastatin A; HDAC6; Mouse
Keywords: HIBM; hereditary inclusion-body myopathy; s-IBM; sporadic inclusion-body myositis; GNE; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; GNE/MNK; UDP-GlcNAc 2-epimerase/ManNAc kinase; DMRV; distal myopathy with rimmed vacuoles; CK; creatine
Keywords: Histone deacetylases; HDAC6; Melanoma; Nexturastat; Tubastatin A;
Keywords: ACEi; angiotensin-converting enzyme inhibitor; AF; atrial fibrillation; A-II; angiotensin-II; ANP; atrial natriuretic peptide; ARB; angiotensin receptor blocker; BP; blood pressure; BMI; body mass index; BNP; brain natriuretic peptide; CaMKII; calmodulin-
Keywords: ASFV; African swine fever virus; VF; viral factory; EEA1; early endosomal antigen 1; EE; early endosomes; LE; Late endosomes; MVB; multivesicular bodies; PtdIns; phosphoinositides or inositol phosphates; PI3K; phosphoinositide 3-kinase; PtdIns3P; phosphat
Keywords: Ataxin-3; HDAC6; Tubulin dimer; Small angle X-ray scattering; Surface plasmon resonance;
Inhibition of histone deacetylase reduces lipopolysaccharide-induced-inflammation in primary mammary epithelial cells by regulating ROS-NF-кB signaling pathways
Keywords: HDAC6; Tubastatin; ROS; Inflammation; Cytokines; NF-κB;
Type I collagen promotes primary cilia growth through down-regulating HDAC6-mediated autophagy in confluent mouse embryo fibroblast 3T3-L1 cells
Keywords: Collagen I; Primary cilium; Autophagy; HDAC6; 3T3-L1 cells;
Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin
Keywords: DLBCL; CHOP resistance; MiR-148b; Ezrin; HDAC6;
4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway
Keywords: Breast cancer; Adriamycin; 4-Hydroxybenzoic acid; HIPK2/p53; HDAC6;
Restoration of mutant hERG stability by inhibition of HDAC6
Keywords: hERG; HDAC6; Acetylation; Ubiquitination; LQT2;
Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Keywords: Abl; ableson kinase; ABR; actin binding repeat; Arg; ableson related gene kinase; Arp2/3; actin related protein 2/3; ATAT1; alpha-tubulin N-acetyltransferase 1; DMEM; Dulbecco's modified Eagle's medium; DOX; doxycycline; Erk; extracellular signal-re
Effect of Tubastatin A on the Functional Recovery of Cauda Equina Injury in Rats
Keywords: Cauda equina injury; Deacetylation; Dorsal root ganglion; HDAC6; Tubulin post-translational modification; CEC; Cauda equine compression; DRG; Dorsal root ganglion; FGF-21; Fibroblast growth factor; HDAC6; Histone deacetylase 6; HE; Hematoxylin-eosin; SD;
HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway
Keywords: Gloima stem cells; Radioresistance; HDAC6; Hedgehog pathway; Gli1;
Recent advances in the discovery of potent and selective HDAC6 inhibitors
Keywords: HDAC6; HDAC6 inhibitors; Zinc binding groups; Hydroxamic acids; Sulfur containing ZBGs;
HDAC6 interacts with PTPN1 to enhance melanoma cells progression
Keywords: Melanoma; HDAC6; PTPN1; ERK1/2; MMP9;
A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer
Keywords: TC24; HDAC6; Apoptosis; Cell cycle; Gastric cancer;
Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease
Keywords: ATF4; activating transcription factor 4; BSA; bovine serum albumin; CHX; cycloheximide; CQ; hydroxychloroquine; HD; Huntington's disease; HDAC6; histone deacetylase 6; Htt; huntingtin; mHtt; mutant huntingtin; Lamp1; lysosomal associated membrane protein
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome
Keywords: iPSCâderived neurons; RNA-seq; GABA; HDAC6; acetylated α-tubulin; HDAC6 inhibitors;
Genetic disruption of tubulin acetyltransferase, αTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/β-catenin signaling
Keywords: Microtubule acetylation; Colon cancer; Invasion; Wnt1; αTAT1; HDAC6;
MiR-206 inhibits Head and neck squamous cell carcinoma cell progression by targeting HDAC6 via PTEN/AKT/mTOR pathway
Keywords: HNSCC; MiR-206; Progression; HDAC6; PTEN/AKT/mTOR pathway;
Original ArticleHDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis
Keywords: Histone deacetylase 6; HDAC6-selective inhibitor; p53; Hsp90; Apoptosis; CHX; cycloheximide; CRC; colorectal cancer cells; DBD; DNA-binding domain; HDAC6; histone deacetylase 6; HDACi; histone deacetylase inhibitors; Hsp90; heat shock protein 90; KO; Knoc
Original ArticleHDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells
Keywords: HDAC4; HDAC6; Glioblastoma; Radiotherapy; Radioresistance; GBM; glioblastoma; TMZ; temozolomide; RT; radiotherapy; HDACs; Histone deacetylases; HATs; Histone acetyltransferases; DSBs; DNA double-strand breaks; OS; Overall survival; shRNA; short hairpin RN
Discovery of a fluorescent probe with HDAC6 selective inhibition
Keywords: HDAC6; Fluorescent probe; Aggresome; Neurodegenerative disease;
Synthesis of a selective HDAC6 inhibitor active in neuroblasts
Keywords: Histone deacetylases; Isoform selectivity; HDAC6; PAMPA; Neuroblastoma cells;
Ciliopathies: Does HDAC6 Represent a New Therapeutic Target?
Keywords: cilium; ciliopathy; ciliary disassembly; HDAC6; HDAC6 inhibitor
Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy
Keywords: HDAC6; Viral infection; Viral pathogenesis; Antiviral therapy; CBP; cAMP response element-binding protein (CREB) binding protein; HCV; hepatitis C virus; HDAC6; histone deacetylase 6; HIV; human immunodeficiency virus; IAV; influenza A virus; IFN; interfe
HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma
Keywords: HDAC6; Glioblastoma; EGFR; TemozolomideERK, extracellular signal-regulated kinase; Hsp90, heat shock protein 90; LC3, microtubule-associated protein 1A/1B-light chain 3; PARP, poly ADP-ribose polymerase; SIRT, silent mating type information regulation 2 h
HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway
Keywords: HDAC6; PrP106-126; Neuronal death; Autophagy; PI3K-Akt-mTOR;
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6
Keywords: RIG-I; HDAC6; Deacetylation; HCV; West Nile virus; Interferon; Innate immunity
The size of the primary cilium and acetylated tubulin are modulated during adipocyte differentiation: Analysis of HDAC6 functions in these processes
Keywords: Adipocyte; Primary cilium; Acetylated α-tubulin; HDAC6
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis
Keywords: Breast transformation; Cancer; GRK2; HDAC6; Pin1; Acetylation;
Essential role of HDAC6 in the regulation of PD-L1 in melanoma
Keywords: Histone deacetylases; HDAC6; PD-L1; STAT3; PP2A; Melanoma; Nexturastat; Tubastatin A;
4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer
Keywords: HDAC6; HDAC inhibitor; Prostate cancer; Microtubular organization; HSP90α
Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages
Keywords: HDAC6; histone deacetylase 6; ROS; reactive oxygen species; Nox2; NADPH oxidase enzyme 2; MAPK; mitogen-activated protein kinase; NF-κB; nuclear factor kappa B; AP-1; activator protein-1; ROS; HDAC6; Inflammation; Cytokines; MAPK; NF-κB; AP-1; Macrophag
HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway
Keywords: HDAC6; HPOB; Glucocorticoid receptor; Mitochondrial translocation; Hsp90; Cort; corticosterone; DRP1; dynamin-related protein 1; Fis1; mitochondrial fission molecule 1; GCs; glucocorticoids; GR; glucocorticoid receptor; HDACs; histone deacetylases; Hsps;
The store-operated Ca2Â + entry-mediated signaling is important for cancer spread
Keywords: bFGF; basic fibroblast growth factor; CRAC; calcium release-activated channels; CAD; CRAC activation domain;; CaM kinase II; Ca2Â +/calmodulin-dependent protein kinase II; ER; endoplasmic reticulum; EGF; epidermal growth factor; ECM; extracellular matrix;
TDP-43/FUS in motor neuron disease: Complexity and challenges
Keywords: AD; Alzheimer's disease; Ago2; Argonaute 2; ALS; Amyotrophic lateral sclerosis; ALS/PD; amyotrophic lateral sclerosis and Parkinsonism-dementia complex; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ATF3; activating transcription factor 3
Autophagy machinery in the context of mammalian mitophagy
Keywords: PINK1; PTEN-induced putative kinase 1; CCCP; carbonyl cyanide m-chlorophenylhydrazone; OMM; outer mitochondrial membrane; ATG; autophagy-related; ULK1; unc-51 like kinase 1; FIP200; focal adhesion kinase family interacting protein of 200Â kDa; mTor; mecha
miR-433 inhibits oral squamous cell carcinoma (OSCC) cell growth and metastasis by targeting HDAC6
Keywords: Oral squamous cell carcinoma (OSCC); miR-433; HDAC6; SAS; HSC2
HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons
Keywords: HDAC6; Mitochondria; Autophagy; Huntingtin; Huntington's disease; Neurodegeneration;
Enhancement of Stress Resilience Through Histone Deacetylase 6–Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics
Keywords: Acetylation; ACY-738; Hsp90; HDAC6; Raphe; Resilience; Serotonin; Social defeat; Stress
Pharmocologic treatment with histone deacetylase 6 inhibitor (ACY-738) recovers Alzheimer's disease phenotype in amyloid precursor protein/presenilin 1 (APP/PS1) mice
Keywords: HDAC6; Alzheimer's disease; Axonal transport; Acetylated tubulin; Microtubule; Therapeutic; Preclinical; ACY-738