Keywords: HNE، 4-Hydroxy-2-nonenal; Toxicant mixture; Acrylamide; Additive; Synergistic; Concentration addition; Environmental toxicologyMVK, methylvinyl ketone; EA, 2-ethylacrolein; MA, methyl acrylate; ACR, acrylamide; HNE, 4-Hydroxy-2-nonenal; NAC, N-acetylcysteine; GSH, glutathione; HSA
مقالات ISI HNE، 4-Hydroxy-2-nonenal (ترجمه نشده)
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Keywords: HNE، 4-Hydroxy-2-nonenal; LC, l-Carnitine; ALC, acetyl-l-carnitine; ATP, adenosine triphosphate; ROS, reactive oxygen species; H2O2, hydrogen peroxide; GPx, glutathione peroxidase; CAT, catalase; SOD, superoxide dismutase; HNE, 4-hydroxy-2-nonenal; GSH, reduced glutathione; HSP, h
Comprehensive analysis of the lipophilic reactive carbonyls present in biological specimens by LC/ESI-MS/MS
Keywords: HNE، 4-Hydroxy-2-nonenal; AA, arachidonic acid; DH, dansyl hydrazine; DHA, docosahexaenoic acid; 2,4-DDE, 2,4-decadienal; EDE, 4,5-epoxy-2-decenal; 2,4-HxDE, 2,4-hexadienal; 2,4-HpDE, 2,4-heptadienal; HNE, 4-hydroxy-2-nonenal; IS, internal standard; LA, linoleic acid; LC/ESI-MS/MS
Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile
Keywords: HNE، 4-Hydroxy-2-nonenal; Cox, cyclooxygenase; EMSAs, electrophoretic movility shift assays; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HNE, 4-hydroxy-2-nonenal; MAPK, mitogen-activated protein kinase; RIPA, radioimmunoprecipitation assay; RT-PCR, reverse transcription-polym
Sensitivity of the aldehyde-induced and free fatty acid-induced activities of plant uncoupling protein to GTP is regulated by the ubiquinone reduction level
Keywords: HNE، 4-Hydroxy-2-nonenal; Aldehydes (all trans-retinal and 4-hydroxy-2-nonenal); Linoleic acid; Purine nucleotides; Solanum tuberosum; Ubiquinone reduction level; Uncoupling proteinBSA, bovine serum albumin; FFA, free fatty acid(s); HNE, 4-hydroxy-2-nonenal; LA, linoleic acid; PN,
The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis
Keywords: HNE، 4-Hydroxy-2-nonenal; DHN-MA, 1,4-Dihydroxynonane-mercapturic acid; DNPH, 2,4-Dinitrophenylhydrazine; ESI, Electrospray ionization; FT-ICR, Fourier transform ion cyclotron resonance; HNE, 4-Hydroxy-2-nonenal; HODA, 9-Hydroxy-12-oxo-10(E)-dodecenoic acid; HPETE, Hydroperoxyeico
Pathophysiological roles of aldo–keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers
Keywords: HNE، 4-Hydroxy-2-nonenal; AKR, aldo–keto reductase; BPS, 3-bromo-5-phenylsalicylic acid; CDDP, cis-diamminedichloroplatinum; CDDP-R, CDDP-resistant variant of colon cancer HCT15 cells; DPBS, Dulbecco’s phosphate-buffered saline; HNE, 4-hydroxy-2-nonenal; keap1, Kelch-like ECH-asso
The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4
Keywords: HNE، 4-Hydroxy-2-nonenal; HNE, 4-hydroxy-2-nonenal; GST, glutathione S-transferase; LPO, lipid peroxidation; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; HUVEC, human umbilical vascular endothelial cells; RPE, retinal pigment epithe
Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment
Keywords: HNE، 4-Hydroxy-2-nonenal; 3-NT, 3-nitrotyrosine; AD, Alzheimer disease; HNE, 4-hydroxy-2-nonenal; HO, heme oxygenase; MCI, mild cognitive impairment; PC, protein carbonyls; pSer, phosphoserine; pThr, phosphothreonine; pTyr, phosphotyrosineAlzheimer disease; Heme oxygenase; Mild co
Functional muscle impairment in facioscapulohumeral muscular dystrophy is correlated with oxidative stress and mitochondrial dysfunction
Keywords: HNE، 4-Hydroxy-2-nonenal; FSHD, facioscapulohumeral dystrophy; DUX4, double homebox 4 gene; ROS, reactive oxygen species; HNE, 4-hydroxy-2-nonenal; TBARS, thiobarbituric acid-reactive substances; MnSOD, manganese-dependent superoxide dismutase; Cu-SOD, copper–zinc-dependent supero
Redox regulation in health and disease — Therapeutic potential of berberine
Keywords: HNE، 4-Hydroxy-2-nonenal; 8-OH-dG, 8-hydroxy-2′-deoxyguanosine; AP-1, activator protein-1; DM, diabetes mellitus; GSH, reduced glutathione; GSSG, oxidized glutathione; H2O2, hydrogen peroxide; HNE, 4-hydroxy-2-nonenal; HIF-1, hypoxia inducible factor-1; iNOS, inducible nitric oxid
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action
Keywords: HNE، 4-Hydroxy-2-nonenal; PC, protein carbonyls; HNE, 4-hydroxy-2-nonenal; 3-NT, 3-nitrotyrosine; Aβ, amyloid beta peptide; 7-K, 7-ketocholesterol; 25-OH, 25-hydroxy cholesterolAlzheimer disease; Atorvastatin; Cholesterol oxidation products; Oxidative stress; Cognitive function
Mitochondrial oxidative stress and respiratory chain dysfunction account for liver toxicity during amiodarone but not dronedarone administration
Keywords: HNE، 4-Hydroxy-2-nonenal; NAC, N-acetylcysteine; GSH, reduced glutathione; GSSG, oxidized glutathione; HPLC, high-precision liquid chromatography; ROS, reactive oxygen species; FRL, free radical leak; UV, ultraviolet; HNE, 4-hydroxy-2-nonenal; Δψmt, mitochondrial membrane potentia
Inhibition by 4-hydroxynonenal (HNE) of Ca2+ transport by SERCA1a: Low concentrations of HNE open protein-mediated leaks in the membrane
Keywords: HNE، 4-Hydroxy-2-nonenal; HNE, 4-hydroxy-2-nonenal; SR, sarcoplasmic reticulum; SERCA1a, sarcoplasmic reticulum Ca2+-ATPase isoform 1a; Ca2+-ATPase, calcium-dependent adenosine triphosphatase (EC 3.6.1.38); ROS, reactive oxygen species; GSH, reduced glutathione; DTNB, 5,5′-dithiob
A synopsis of the process of lipid peroxidation since the discovery of the essential fatty acids
Keywords: HNE، 4-Hydroxy-2-nonenal; C18:2n-6, linoleic acid; C18:3n-3, α-linolenic acid; C20:4n-6, arachidonic acid; C20:5n-3, eicosapentanoic acid; C22:5n-3, docosapentaenoic acid; C22:6n-3, docosahexaenoic acid; HHE, 4-hydroxy-2-hexenal; HNE, 4-hydroxy-2-nonenal; L, lipid radical; LH, lip
Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death
Keywords: HNE، 4-Hydroxy-2-nonenal; Calpain; Hsp70.1; Hydroxynonenal; Lysosomal rupture; Neuronal deathHsp, Heat shock protein; HNE, 4-hydroxy-2-nonenal; CA1, cornu Ammonis 1; Lamp-2, lysosome-associated membrane protein-2; PUFA, polyunsaturated fatty acid; ALLN, N-acetyl-Leu-Leu-Nle-CHO
Multiple roles of microsomal glutathione transferase 1 in cellular protection: A mechanistic study
Keywords: HNE، 4-Hydroxy-2-nonenal; BuOOH, tert-butylhydroperoxide; CuOOH, cumene hydroperoxide; GST, glutathione transferase; G418, Geneticin; HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; MGST1, microsomal glutathione transferase 1; MPT, mitochondrial permeability transition; ROS, react
Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes
Keywords: HNE، 4-Hydroxy-2-nonenal; CL, chemiluminescence; CYP, cytochrome P450; DHA, docosahexaenoic acid; Gpx, glutathione peroxidase; GSH and GSSG, reduced and oxidized forms of glutathione respectively; GST, glutathione S-transferase; HNE, 4-hydroxy-2-nonenal; IFNgamma, interferon gamma
Quantitation of mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites in a smoking cessation study
Keywords: HNE، 4-Hydroxy-2-nonenal; BMI, body mass index; DHN, 1,4-dihydroxy-2-nonene; EPI, enhanced product ion; GSH, glutathione; GST, glutathione S-transferase; HNA, 4-hydroxy-2-nonenoic acid; HNAL, 4-hydroxy-2-nonenoic acid lactone; HNE, 4-hydroxy-2-nonenal; HPLC, high performance liqui
Inhibition of hepatic mitochondrial aldehyde dehydrogenase by carbon tetrachloride through JNK-mediated phosphorylation
Keywords: HNE، 4-Hydroxy-2-nonenal; ALDH2, mitochondrial class 2 aldehyde dehydrogenase; Asc, sodium ascorbate; DTT, dithiothreitol; JNK, c-Jun N-terminal protein kinase; HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; 2-DE, two-dimensional electrophoresis; MAPK, mitogen-activated protein k
Uncoupling protein-2 knockdown mediates the cytotoxic effects of cisplatin
Keywords: HNE، 4-Hydroxy-2-nonenal; BSO, L-buthionine sulfoximine; CDDP, cisplatin; FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone; 5-FU, 5-fluorouracil; GPx, glutathione peroxidase; GRd, glutathione reductase; GSSG, glutathione disulfide; HNE, 4-hydroxy-2-nonenal; mtDNA, mitochon
Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model
Keywords: HNE، 4-Hydroxy-2-nonenal; hydrogen; hyperglycemia; MCAO; neuroprotectionAQP4, aquaporin4; BBB, blood–brain barrier; FITC, fluorescein isothiocyanate; HNE, 4-Hydroxy-2-Nonenal; MCAO, middle cerebral artery occlusion; MMPs, matrix metalloproteinases; PBS, phosphate buffered solution
The role of c-Jun phosphorylation in EpRE activation of phase II genes
Keywords: HNE، 4-Hydroxy-2-nonenal; HNE, 4-hydroxy-2-nonenal; EpRE, electrophile-responsive element; AP-1, activator protein-1; GCLC, catalytic subunit of GCL; GCLM, modulator subunit of GCL; NQO2, NAD(P)H:quinone oxidoreductase 2; NQO1, NAD(P)H:quinone oxidoreductase-1; HepG2, human hepato
Differential distribution of 4-hydroxynonenal adducts to sulfur and nitrogen residues in blood proteins as revealed using Raney nickel and gas chromatography–mass spectrometry
Keywords: HNE، 4-Hydroxy-2-nonenal; DHN, 1,4-dihydroxynonane; DNPH, 2,4-dinitrophenylhydrazine; GCMS, gas chromatography–mass spectrometry; HNE, 4-hydroxy-2-nonenal; HNE-P, protein-bound HNE; DHN-P, protein-bound DHN; PAA, polyamino acid; TBDMS, t-butyldimethylsilylAldehydes; Lipoperoxidati
The role of lysosomal rupture in neuronal death
Keywords: HNE، 4-Hydroxy-2-nonenal; CA1, cornu Ammonis 1; ER, endoplasmic reticulum; Hsp, heat-shock protein; Hsc, heat-shock constitutive protein; HNE, 4-hydroxy-2-nonenal; Lamp, lysosome-associated membrane protein; MALDI-TOF/TOF, matrix-assisted laser desorption ionization-time of flight
Characterization of Two Novel Aldo–Keto Reductases from Arabidopsis: Expression Patterns, Broad Substrate Specificity, and an Open Active-Site Structure Suggest a Role in Toxicant Metabolism Following Stress
Keywords: HNE، 4-Hydroxy-2-nonenal; AKR, aldo–keto reductase; HNE, 4-hydroxy-2-nonenal; ABA, abscisic acid; RT, reverse transcription; BR, brassinosteroid; EDTA, ethylenediaminetetraacetic acid; ESRF, European Synchrotron Radiation Facility; PDB, Protein Data Bankstress response; aldo–keto
Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease
Keywords: HNE، 4-Hydroxy-2-nonenal; AD, Alzheimer's disease; HNE, 4-hydroxy-2-nonenal; IPL, inferior parietal lobule; MCI, mild cognitive impairment; NO, nitric oxide; 3-NT, 3-Nitrotyrosine; PCO, protein carbonyls; SOD, superoxide dismutaseMild cognitive impairment (MCI); Alzheimer's diseas
Malondialdehyde generated from peroxidized linolenic acid causes protein modification in heat-stressed plants
Keywords: HNE، 4-Hydroxy-2-nonenal; Heat stress; Malondialdehyde; Protein modification; Linolenic acid; Polyunsaturated fatty acid peroxidation; ArabidopsisHHE, 4-hydroxy-2-hexenal; HNE, 4-hydroxy-2-nonenal; LHCP, light-harvesting complex protein; MDA, malondialdehyde; OEC33, oxygen-evolvin
Oxidative and nitrative protein modifications in Parkinson's disease
Keywords: HNE، 4-Hydroxy-2-nonenal; α-syn, α-synuclein; PD, Parkinson's disease; SN, substantia nigra; PTM, posttranslational modification; GSH, glutathione (reduced); GSSG, glutathione (oxidized); MDA, malondialdehyde; HNE, 4-hydroxy-2-nonenal; 8OHG, 8-hydroxyguanosine; 3NT, 3-nitrotyrosin
Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models
Keywords: HNE، 4-Hydroxy-2-nonenal; HNE, 4-hydroxy-2-nonenal; FapyAdenine, 4,6-diamino-5-formamidopyrimidine; 5-OHC, 5-hydroxycytosine; 8-OHA, 8-hydroxyadenine; 5-OHU, 5-hydroxyuracil; ADLs, activities of daily living; AD, Alzheimer's disease; APP, amyloid (A) β, amyloid precursor protein;
Cytotoxic effects of various stressors on PC12 cells: Involvement of oxidative stress and effect of antioxidants
Keywords: HNE، 4-Hydroxy-2-nonenal; AAPH, 2,2′-azobis(amidinopropane) dihydrochloride; As2O3, arsenic trioxide; BO653, 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran; DCFH-DA, 2′,7′-dichlorofluorescin diacetate; HNE, 4-hydroxy-2-nonenal; KC, 7-ketocholesterol; MTT, 3-(4,5-di
Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: Role of NADPH oxidase-derived ROS
Keywords: HNE، 4-Hydroxy-2-nonenal; EtOH-PC, ethanol preconditioning; ROS, reactive oxygen species; HNE, 4-hydroxy-2-nonenal; NADPH oxidase, nicotinamide adenine dinucleotide phosphate oxidase; CCA, common carotid arteries; rCBF, regional cerebral blood flow; I/R, ischemia/reperfusion; DND,
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and α-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease
Keywords: HNE، 4-Hydroxy-2-nonenal; AD, Alzheimer's disease; ALCAR, acetyl-L-carnitine; BSA, bovine serum albumin; DHLA, dihydrolipoic acid; ERK, extracellular signal-regulated kinase; HNE, 4-hydroxy-2-nonenal; HO, heme oxygenase; Hsps, heat shock proteins; iNOS, inducible nitric oxide synt
Novel electrochemical approach to enhanced toxicity of 4-oxo-2-nonenal vs. 4-hydroxy-2-nonenal (role of imine): Oxidative stress and therapeutic modalities
Keywords: HNE، 4-Hydroxy-2-nonenal; ROS, reactive oxygen species; OS, oxidative stress; HNE, 4-hydroxy-2-nonenal; ONE, 4-oxo 2 nonenal; ET, electron transfer; His, hislidine; Cys, cysteine; Lys, lysine; RCS, reactive carbonyl species; ARE, antioxidant response element
Up-regulation of γ-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity: implications for Parkinson's disease
Keywords: HNE، 4-Hydroxy-2-nonenal; PD, Parkinson's disease; GGT, γ-glutamyl transpeptidase; GSH, glutathione; ROS, reactive oxygen species; GCL, γ-glutamylcysteine ligase; HNE, 4-hydroxy-2-nonenal; SN, substantia nigra; CI, complex I; GS, glutathione synthetase; tet, tetracycline; dox, dox
Oxidatively modified autoantigens in autoimmune diseases
Keywords: HNE، 4-Hydroxy-2-nonenal; AGE, advanced glycation end product; AI, autoimmune; BD, Behcet’s disease; EAE, experimental autoimmune encephalomyelitis; GAD, glutamic acid decarboxylase; HNE, 4-hydroxy-2-nonenal; LDL, low-density lipoproteins; MDA, malondialdehyde; oxLDL, oxidized LDL
Vitamin E deficiency accelerates nitrate tolerance via a decrease in cardiac P450 expression and increased oxidative stress
Keywords: HNE، 4-Hydroxy-2-nonenal; P450, cytochrome P450; NTG, nitroglycerin; NO, nitric oxide; cAK, cAMP-activated protein kinase; cGK-I, cGMP-activated protein kinase I; NOx, nitrite and nitrate; HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; ROS, reactive oxygen species; RNS, reactive
Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart
Keywords: HNE، 4-Hydroxy-2-nonenal; DCPIP, dichlorophenol indophenol; DNPH, dinitrophenylhydrazine; FAD, flavin adenine dinucleotide; HNE, 4-hydroxy-2-nonenal; ROS, reactive oxygen species; SDH, succinate dehydrogenaseType I diabetes; Streptozotocin; Mitochondria; Succinate dehydrogenase; H
Hepatic Iron Overload Induces Hepatocellular Carcinoma in Transgenic Mice Expressing the Hepatitis C Virus Polyprotein
Keywords: HNE، 4-Hydroxy-2-nonenal; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; HHE, 4-hydroxy-2-hexenal; HNE, 4-hydroxy-2-nonenal; IL, interleukin; PCNA, proliferating cell nuclear antigen; PCR, polymerase chain reaction; ROS, reactive oxygen species; RT-PCR, reverse-transcription polymerase chai
Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation
Keywords: HNE، 4-Hydroxy-2-nonenal; ALDH2, mitochondrial aldehyde dehydrogenase; BSO, l-buthionine-sulphoximine; DTT, dithiothreitol; GSH-EE, glutathione-ethylester; GSNO, S-nitrosoglutathione; HNE, 4-hydroxy-2-nonenal; MDA, malondialdehyde; NO, nitric oxide; S-NO-Cys, S-nitroso-cysteine; R