Keywords: HNE، 4-hydroxynonenal; DBI, double bond index; DHN-MA, 1,4-dihydroxynonane–mercapturic acid; EIA, enzyme immunoassay; FAME, fatty acid methyl ester; HNE, 4-hydroxynonenal; HNE-His, HNE-histidine protein adduct; MDA, malondialdehyde; MPO, myeloperoxidase; PUFA, polyunsaturated f
مقالات ISI HNE، 4-hydroxynonenal (ترجمه نشده)
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Keywords: HNE، 4-hydroxynonenal; Aβ, amyloid beta; DTDP, 4,4′-dithiodipyridine; HNE, 4-hydroxynonenal; EFRET, Fluorescence Resonance Energy Transfer efficiency; FLIM, Fluorescence Lifetime Imaging Microscopy; NACA, N-acetylcysteine amide; PS1, presenilin 1Oxidative stress; Lipid peroxida
Keywords: HNE، 4-hydroxynonenal; AD, Alzheimer’s disease; AGEs, advanced glycation end products; C-L, caspase-like activity; CT-L, chymotrypsin-like activity; FNK, fructosamine-3-kinase; HNE, 4-hydroxynonenal; HD, Huntington’s disease; Ins/IGF-1, Insulin/Insulin Growth Factor; IIS, Insul
Keywords: HNE، 4-hydroxynonenal; DMNQ, 2,3-dimethoxy-1,4-naphthoquinone; 2-DG, 2-deoxy-d-glucose; ECAR, extracellular acidification rate; FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; HNE, 4-hydroxynonenal; OCR, oxygen consumption rate; RA, retinoic acid; ROS, reactive oxyg
Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways
Keywords: HNE، 4-hydroxynonenal; VSMC, vascular smooth muscle cell; OPN, osteopontin; HNE, 4-hydroxynonenal; WT, wild type; EGFR, epidermal growth factor receptor; PDGFR, platelet-derived growth factor receptor; ChIP, chromatin immunoprecipitation; RTK, receptor tyrosine kinases; PCNA, p
Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
Keywords: HNE، 4-hydroxynonenal; HNE, 4-hydroxynonenal; ROS, reactive oxygen species; PMA, 3-phorbol myristate acetate; XF assay, extracellular flux assay; PBMC, peripheral blood mononuclear cells; PMN, polymorphonuclear granulocytes; S. aureus, Staphylococcus aureus; NADPH, nicotinamide
4-Hydroxynonenal induces persistent insolubilization of TDP-43 and alters its intracellular localization
Keywords: HNE، 4-hydroxynonenal; Oxidative stress; ALS; HNE; TDP-43ALS, amyotrophic lateral sclerosis; HNE, 4-hydroxynonenal
Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels
Keywords: HNE، 4-hydroxynonenal; 8OG, 8-oxoguanine (8-oxo-7,8-dihydroguanine); CTT, carnitine transporter; ET, ergothioneine; ETT, ergothioneine transporter; HNE, 4-hydroxynonenal; LC, liquid chromatography; MDA, malondialdehyde; MS, mass spectrometryErgothioneine; Singlet oxygen; 8-Oxog
Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies
Keywords: HNE، 4-hydroxynonenal; 3NT, 3-Nitrotyrosine; HNE, 4-Hydroxynonenal; AD, Alzheimer disease; aMCI, amnestic mild cognitive impairment; APP, amyloid precursor protein; AICD, amyloid precursor protein intracellular domain; Aβ, amyloid-β; BACE1, beta-secretase 1; CTF, C-terminal fra
A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes
Keywords: HNE، 4-hydroxynonenal; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; EPR, electron paramagnetic resonance; GM1, monosialotetrahexosyl ganglioside; GPI, glycosylphosphatidylinositol; H2FDA, dihydrofluorescein diacetate; HNE, 4-hydroxynonenal; LMW iron, low-molecular-wei
Physicochemical and immunological studies on 4-hydroxynonenal modified HSA: Implications of protein damage by lipid peroxidation products in the etiopathogenesis of SLE
Keywords: HNE، 4-hydroxynonenal; HNE, 4-hydroxynonenal; LPDA, lipid peroxidation derived aldehydes; SLE, systemic lupus erythematosus; HSA, human serum albumin; ROS, reactive oxygen species; DNPH, 2,4-dinitrophenyl hydrazine
Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in rat liver
Keywords: HNE، 4-hydroxynonenal; HNE, 4-hydroxynonenal; ONE, 4-oxononenal; DHN, 1,4-dihydroxynonene; ω-6 PUFA, ω-6 polyunsaturated fatty acid; GSH, reduced glutathione; BHB-CoA, 3-hydroxybutyryl-CoA; AcAc-CoA, acetoacetyl-CoA; MID, mass isotope distributions; TMS, trimethylsilyl; KG, ket
Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin
Keywords: HNE، 4-hydroxynonenal; AMD, age-related macular degeneration; CSB, cytoskeleton stabilization buffer; ERG, electroretinography; HNE, 4-hydroxynonenal; PFA, paraformaldehyde; POS, shed photoreceptor outer segment tips; RPE, retinal pigment epithelium; TLC, thin-layer chromatogra
Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation
Keywords: HNE، 4-hydroxynonenal; PE, Phosphatidylethanolamine; IsoLG, Isolevuglandin; NAPE, N-acyl-PE; CAPE, N-carboxyacyl-PE; al-PE, Aldehyde-modified PE; MDA, Malondialdehyde; HNE, 4-hydroxynonenal; ONE, 4-oxynonenal; am-PE, Amadori-modified PE; pHA-PE, p-hydroxyphenylacetaldehyde-modi
Bioenergetic function in cardiovascular cells: The importance of the reserve capacity and its biological regulation
Keywords: HNE، 4-hydroxynonenal; AMCMs, adult mouse cardiomyocytes; BDM, 2,3-butanedione monoxime; DMEM, Dulbecco's modified Eagle's medium; ECAR, extracellular acidification rate; FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone; HNE, 4-hydroxynonenal; NRCM, neonatal rat cardiom
Effect of aging and oxidative stress on elongation factor-2 in hypothalamus and hypophysis
Keywords: HNE، 4-hydroxynonenal; CH, cumene hydroperoxide; CO, carbonyl groups; 2,4-DNPH, 2,4-dinitrophenylhydrazine; eEF-2, elongation factor-2; GH, growth hormone; GHRH, growth-hormone-releasing hormone; HHS, hypothalamus–hypophysis system; HNE, 4-hydroxynonenal; HS, hypophysis; HT, hy
Proteomic studies on protein modification by cyclopentenone prostaglandins: Expanding our view on electrophile actions
Keywords: HNE، 4-hydroxynonenal; cyPG, cyclopentenone prostaglandins; COX, cyclooxygenase; AA, arachidonic acid; HNE, 4-hydroxynonenal; PPAR, peroxisome proliferator activated receptor; HO-1, heme oxygenase-1; hPGD2s, hematopoietic prostaglandin D2 synthase; 15d-PGJ2, 15-deoxy-Δ12,14-pro
4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK
Keywords: HNE، 4-hydroxynonenal; BSA, bovine serum albumin; cysLT, cysteinyl leukotrienes; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; FLAP, five lipoxygenase activating protein; HNE, 4-Hydroxynonenal; JNK, c-Jun N-terminal kinase; LTB4, leukotriene B4; LT-R, leu
Aldo–keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels
Keywords: HNE، 4-hydroxynonenal; AKR1B10, aldo–keto reductase family 1 B10; DHN, 1,4-dihydroxynonene; EGFP, enhanced green fluorescent protein; ESI, electrospray ionization; HNE, 4-hydroxynonenal; HPLC–MS, high-performance liquid chromatography–mass spectroscopy; HPLC–UV, high-performanc
Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides
Keywords: HNE، 4-hydroxynonenal; ARSA, arylsulfatase A; CGT, ceramide galactosyltransferase; COX2, cyclooxygenase-2; CST, cerebroside sulfotransferase; GALC, galactosylceramidase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HNE, 4-hydroxynonenal; LS, lysosulfatides; d18:2, sphingadi
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase
Keywords: HNE، 4-hydroxynonenal; HNE, 4-hydroxynonenal; 5-LO, 5-lipoxygenase; oxLDL, oxidized low-density lipoprotein; LTB4, leukotriene B4; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; DiI, 1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perc
Adduct formation of 4-hydroxynonenal and malondialdehyde with elongation factor-2 in vitro and in vivo
Keywords: HNE، 4-hydroxynonenal; CH, cumene hydroperoxide; eEF-2, elongation factor-2; HNE, 4-hydroxynonenal; LP, lipid peroxides; MDA, malondialdehyde.Adduct; Carbonyl groups; Cumene hydroperoxide; 4-Hydroxynonenal; Elongation factor 2; Lipid peroxides; Malondialdehyde; Free radicals
Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
Keywords: HNE، 4-hydroxynonenal; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CsA, cyclosporin A; CYP2E1, cytochrome P450 2E1; GSH, glutathione; HNE, 4-hydroxynonenal; iNOS, inducible nitric oxide synthase; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAPK, m
Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma
Keywords: HNE، 4-hydroxynonenal; MRP, multidrug-resistant protein; NSCLC, non-small-cell lung carcinoma; HNE, 4-hydroxynonenal; EpRE, electrophile response elementElectrophile response element; Lung cancer; 4-Hydroxynonenal; Keap1; H460 cell line; H358 cell line; A549 cell line; HBE1 cel
4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-κB signaling pathways
Keywords: HNE، 4-hydroxynonenal; MMP, matrix metalloproteinase; HNE, 4-hydroxynonenal; ROS, reactive oxygen species; PI3K, phosphatidylinositol 3-kinase; NF-κB, nuclear factor-κB; VSMC, vascular smooth muscle cells; SOD, superoxide dismutase.4-Hydroxynonenal; MMP-2; Mitochondrial ROS; Ak
4-hydroxynonenal contributes to macrophage foam cell formation through increased expression of class A scavenger receptor at the level of translation
Keywords: HNE، 4-hydroxynonenal; HNE, 4-Hydroxynonenal; SR, scavenger receptors; SR-A, class A SR; oxLDL, oxidized low density lipoprotein; ROS, reactive oxygen species; DiI, 1,1′-Dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate; Act D, actinomycin D; CHX, cycloheximide; 35S-
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain
Keywords: HNE، 4-hydroxynonenal; AD, Alzheimer's disease; BER, base-excision repair; CER, cerebellum; DTT, dithiothreitol; FL, frontal lobe; HNE, 4-hydroxynonenal; LAD, late-stage Alzheimer's disease; MCI, mild cognitive impairment; NC, normal control; NFT, neurofibrillary tangle; PL, pa
Lipid peroxidation: control of cell proliferation, cell differentiation and cell death
Keywords: HNE، 4-hydroxynonenal; Lipid peroxidation; Proliferation; Differentiation; ApoptosisADP, adenosin-diphosphate; ALDH, aldehyde deydrogenase; CDK, cyclin-dependent kinases; HNE, 4-hydroxynonenal; MDA, malonildialdehyde; MEL, murine erythroleukemic cells; PPAR, peroxisome prolifer
Evaluation of the 1-methyl-2-phenylindole colorimetric assay for aldehydic lipid peroxidation products in plants: Malondialdehyde and 4-hydroxynonenal
Keywords: HNE، 4-hydroxynonenal; Free radical; Lipid peroxidation; Oxidative stressBHT, butylated hydroxytoluene; EDTA, ethylene diamine tetra-acetic acid; HCl, hydrochloric acid; HNE, 4-hydroxynonenal; MDA, malondialdehyde; MSA, methanesulphonic acid; PVPP, water-insoluble polyvinylpoly
Ferric iron is genotoxic in non-transformed and preneoplastic human colon cells
Keywords: HNE، 4-hydroxynonenal; DNA, desoxy ribonucleic acid; APC, adenomatous polyposis coli; ddH2O, double distilled water; FCS, fetal calf serum; Fe-NTA, ferric nitrilotriacetate; FISH, fluorescence in situ hybridization; K-RAS, Kirsten rat sarcoma; HNE, 4-hydroxynonenal; H2O2, hydro
Age-dependent inhibition of proteasome chymotrypsin-like activity in the retina
Keywords: HNE، 4-hydroxynonenal; proteasome; retina; retinal pigment epithelium; aging; chymotrypsin-like activityANOVA, analysis of variance; BCA, bicinchoninic acid; CHAPS, 3-[(3-cholamidopropyl)dimethylamino]-1-propanesulfonate; DTT, dithiotreitol; HNE, 4-hydroxynonenal; NEM, N-ethylm
Oxidative stress and dopamine depletion in an intrastriatal 6-hydroxydopamine model of Parkinson’s disease
Keywords: HNE، 4-hydroxynonenal; reactive oxygen species; protein carbonyls; 4-hydroxynonenal; striatum; substantia nigra; agingANOVA, analysis of variance; DA, dopamine; DNP, 2,4-dinitrophenylhydrazine; HNE, 4-hydroxynonenal; HPLC, high pressure liquid chromatography; I:C ratio, ratio o
4-Hydroxynonenal and PPARγ ligands affect proliferation, differentiation, and apoptosis in colon cancer cells
Keywords: HNE، 4-hydroxynonenal; PPARγ, peroxisome proliferator-activated receptor-γ; HNE, 4-hydroxynonenal; 15d-PGJ2, 15-deoxy-prostaglandin J2; TUNEL, terminal deoxynucleotidyl transferase biotin-dUTP nick-end labeling; DMEM, Dulbecco's modified Eagle's medium4-Hydroxynonenal; PPARγ; 1
Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs
Keywords: HNE، 4-hydroxynonenal; PUFAs, polyunsaturated fatty acids; MDA, malondialdehyde; NEFA, non-esterified fatty acid; BHT, butylhydroxytoluene; HNE, 4-hydroxynonenal; FLAP, 5-lipoxygenase activating protein; COX, cyclooxygenase; LOX, lipoxygenasePUFAs; Human lung cancer; Lipid pero
Trapping of 4-hydroxynonenal by glutathione efficiently prevents formation of DNA adducts in human cells
Keywords: HNE، 4-hydroxynonenal; GST, glutathione S-transferase; HNE, 4-hydroxynonenal; HNE–GSH, 3-glutathionyl-4-hydroxy-2-nonanal; HNE–dGuo, (1-hydroxyhexyl)-8-hydroxy-1,N2-propano-2′-deoxyguanosine; HPLC–MS/MS, high-performance liquid chromatography associated with tandem mass spectro
Acrolein is a mitochondrial toxin: Effects on respiratory function and enzyme activities in isolated rat liver mitochondria
Keywords: HNE، 4-hydroxynonenal; Acrolein; Mitochondrial respiration; Mitochondrial complex; Mitochondrial swelling; Dehydrogenase; Protein carbonylDCPIP, 2,6-dichloroindophenol indophenol; DNPH, 2,4-dinitrophenylhydrazone; HNE, 4-hydroxynonenal; INT, p-iodonitrotetrazolium violet; alpha
Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells
Keywords: HNE، 4-hydroxynonenal; BCA, bicinchonic acid; DCFH-DA, 2′,7′-dichlorofluorescein-diacetate; H2O2, hydrogen peroxide; HNE, 4-hydroxynonenal; HSF-1, heat shock factor 1; Iron–ascorbate, ferrous sulfate plus l-ascorbic acid; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliu
Circulating 4-hydroxynonenal–protein thioether adducts assessed by gas chromatography–mass spectrometry are increased with disease progression and aging in spontaneously hypertensive rats
Keywords: HNE، 4-hydroxynonenal; CVD, cardiovascular disease; DHN, 1,4-dihydroxynonene; GCMS, gas chromatography–mass spectrometry; HNE, 4-hydroxynonenal; LPO, lipid peroxidation; SHR, spontaneous hypertensive rat; RSD, relative standard deviation; LOQ, limit of quantification; LOD, limi
Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos
Keywords: HNE، 4-hydroxynonenal; Cu, copper; CuSO4, copper sulfate; eNOS, endothelial nitric oxide synthase; Fe, iron; GD, gestation day; GPx, glutathione peroxidase; HNE, 4-hydroxynonenal; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; iNOS, inducible nitric oxide synthase; ICP-AES, inductively c
Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
Keywords: HNE، 4-hydroxynonenal; MCAO, middle cerebral artery occlusion; ROS, reactive oxygen species; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; RNS, reactive nitrogen species; NO, nitric oxide; MDA, malondialdehyde; HNE, 4-hydroxynonenal; PLA2, phospholipase A2; cPLA2,
24-norUrsodeoxycholic Acid Is Superior to Ursodeoxycholic Acid in the Treatment of Sclerosing Cholangitis in Mdr2 (Abcb4) Knockout Mice
Keywords: HNE، 4-hydroxynonenal; AEC, β-amino-9-ethyl-carbazole; AP, alkaline phosphatase; CK, cytokeratin; GSH, glutathione; HNE, 4-hydroxynonenal; Mdr, multidrug resistance gene; Mdr2−/−, Mdr2 (Abcb4) knockout mice; PSC, primary sclerosing cholangitis; α-SMA, α-smooth muscle actin; VCA