Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Treatment; Juniperus oxycedrus; Lavandula luisieri; Cymbopogon citratus; Plant extracts; α-pinene; Citral;
مقالات ISI تریپانوسومیوز انسان آفریقایی (ترجمه نشده)
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Keywords: تریپانوسومیوز انسان آفریقایی; Chagas disease; Human african trypanosomiasis; Cruzain; Rhodesain; Inhibitors; Synthesis;
Keywords: تریپانوسومیوز انسان آفریقایی; TM; traditional medicine; SSA; sub-Saharan Africa; NTD; neglected tropical diseases; HAT; Human African Trypanosomiasis; DALYs; disability adjusted life years; DOAJ; Directory of open access journals; IC50; 50% inhibitory concentration; AAT; African anima
Keywords: تریپانوسومیوز انسان آفریقایی; BBB; blood-brain barrier; CNS; central nervous system; HAT; human African trypanosomiasis; NTDs; neglected tropical diseases; PDB; Protein Data Bank; PPPs; public-private partnerships; R&D; research and development; RNAi; RNA interference; SBDD; structure
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Sero-diagnosis; Multiplex assay; Recombinant antigens; Sero-surveillance;
Keywords: تریپانوسومیوز انسان آفریقایی; 5-Nitro-2-aminothiazoles; Type I nitroreductase; Antitrypanosomal agents; Chagas disease; Leishmania; MZSRZQZBRGCXDO-UHFFFAOYSA-N; NTD; Neglected tropical diseases; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; T. cruzi; Trypanosoma
Keywords: تریپانوسومیوز انسان آفریقایی; Nitrotriazoles; Type I nitroreductase; Chagas disease; HAT disease; Leishmania; NTD; Neglected tropical diseases; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; T. cruzi; Trypanosoma cruzi; Bnz; benznidazole (N-benzyl-2-(2-nitro-1H-i
Keywords: تریپانوسومیوز انسان آفریقایی; ATG; autophagy; BSF; bloodstream-form; CAA; citrate and/or cis-aconitate; FP; fluorescent protein; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFP; green-fluorescent protein; HAT; human African trypanosomiasis; HXK; hexokinase; LS; long-slender; PAD;
Keywords: تریپانوسومیوز انسان آفریقایی; AOI; area of interest; CSF; cerebrospinal fluid; Dpi; day post-infection; HAT; Human African trypanosomiasis; iNOS; inducible nitric oxide synthase; LD; light/dark; LH; lateral hypothalamus; LPS; lipopolysaccharide; MCH; melanin-concentrating hormone; OX;
Keywords: تریپانوسومیوز انسان آفریقایی; Anthrax; bovine TB; brucellosis; burden of disease; cysticercosis; DALY; echinococcosis; human African trypanosomiasis; neglected zoonotic diseases; One Health; poverty; rabies; under-reporting;
Keywords: تریپانوسومیوز انسان آفریقایی; South Sudan; Human African trypanosomiasis; Sleeping sickness; Case detection; Equity; Ethnicity; Displacement; Medical humanitarianism;
Keywords: تریپانوسومیوز انسان آفریقایی; Nitrotriazoles; Nitroimidazoles; Heteroarylamides; Heteroarylsulfonamides; Chagas disease; Antitrypanosomal agents; NTD; neglected tropical diseases; T. cruzi; Trypanosoma cruzi; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; Nfx; ni
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Sleeping sickness; Naphthoquinone derivatives; Micellar media;
Multiple quantitative structure-activity relationships (QSARs) analysis for orally active trypanocidal N-myristoyltransferase inhibitors
Keywords: تریپانوسومیوز انسان آفریقایی; QSAR; TbNMT; Pyrazole sulphonamides; Human African trypanosomiasis; TbNMT; Trypanosoma brucei N-myristoyltransferase; HAT; Human African Trypanosomiasis; GA; Genetic algorithm; MLR; Multiple linear Regression; QSAR; Quantitative structure-activity analysi
A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo
Keywords: تریپانوسومیوز انسان آفریقایی; Diagnostic accuracy; Sensitivity& specificity; Rapid diagnostic test; Human African trypanosomiasis; Trypanosoma brucei gambiense;
Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation
Keywords: تریپانوسومیوز انسان آفریقایی; 1D and 2D NMR; One and two-dimensional nuclear magnetic resonance; BALB//3T3; Mouse fibroblasts; CH2Cl2/MeOH; Methylene chloride/Methanol; DMSO; Dimethylsulfoxide; HAT; Human African Trypanosomiasis; NTDs; Neglected tropical diseases; SAR; Structure-activ
Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family
Keywords: تریپانوسومیوز انسان آفریقایی; Apiaceae; Essential oils; Human African trypanosomiasis; Trypanosoma brucei; BALB/3T3;
The conserved hypothetical protein Tb427.10.13790 is required for cytokinesis in Trypanosoma brucei
Keywords: تریپانوسومیوز انسان آفریقایی; DAPI; 4´, 6-diamidino-2-phenylindole; DIC; differential interference contrast; dsRNA; double-stranded RNA; eGFP; enhanced green fluorescent protein; FAZ; flagellum attachment zone; HAT; human African trypanosomiasis; ORF; open reading frame; qRT-PCR; qua
Inhibitory effects of (+)-spectaline and iso-6-spectaline from Senna spectabilis on the growth and ultrastructure of human-infective species Trypanosoma brucei rhodesiense bloodstream form
Keywords: تریپانوسومیوز انسان آفریقایی; Senna spectabilis; Piperidine alkaloids; (+)-spectaline; Iso-6-spectaline; Tyrpanosoma brucei rhodesiense; Autophagy; HAT; human African trypanosomiasis; DNDi; Drugs for Neglected Diseases initiative; IC50; half maximal inhibitory concentration; PCD; prog
Differences in pathogenicity and virulence of Trypanosoma brucei gambiense field isolates in experimentally infected Balb/C mice
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Trypanosoma brucei gambiense; Clinical diversity; Phenotypic diversity; Mouse model; Pathogenicity; Virulence; Host-parasite interaction; Multivariate analysis;
IgM, lgG and IL-6 profiles in the Trypanosoma brucei brucei monkey model of human African trypanosomiasis
Keywords: تریپانوسومیوز انسان آفریقایی; IgM; IgG; IL-6; T. b. brucei; Human African trypanosomiasis; Monkey model;
Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Methionyl-tRNA synthetase; Structure-based design; Trypanosoma brucei;
QSAR modeling for anti-human African trypanosomiasis activity of substituted 2-Phenylimidazopyridines
Keywords: تریپانوسومیوز انسان آفریقایی; Anti-HAT activity; QSAR; Substituted 2-Phenylimidazopyridines; HAT; Human African Trypanosomiasis; GA; Genetic algorithm; MLR; Multiple linear Regression; QSAR; Quantitative structure-activity analysis; WHO; World health organization; ADMET; Absorption, D
Synthesis and evaluation of analogs of 5â²-(((Z)-4-amino-2-butenyl)methylamino)-5â²-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity
Keywords: تریپانوسومیوز انسان آفریقایی; AdoMet; S-adenosyl-l-methionine; AdoMetDC; S-adenosylmethionine decarboxylase; BBB; bloodbrain barrier; Boc; tert-butoxycarbonyl; BSA; N,O-bis(trimethylsilyl)acetamide; CNS; central nervous system; DEAD; diethyl azodicarboxylate; DIAD; diisopropyl azodica
Factors influencing passive surveillance for T. b. rhodesiense human african trypanosomiasis in Uganda
Keywords: تریپانوسومیوز انسان آفریقایی; Human african trypanosomiasis; HAT; Sleeping sickness; Tyrpanosoma brucei rhodesiense; Trypanosoma brucei gambiense; Health systems; Diagnostic capacity; Surveillance; Uganda; Under-reporting;
Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors
Keywords: تریپانوسومیوز انسان آفریقایی; Human African Trypanosomiasis; “Sleeping Sickness”; Trypanosoma brucei inhibitor; Hit-to-lead optimization;
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation
Keywords: تریپانوسومیوز انسان آفریقایی; Neglected tropical disease; Human African trypanosomiasis; Target class repurposing; Trypanosoma brucei; Leishmania major; Trypanosoma cruzi; Plasmodium falciparum;
Trypanosome-induced Interferon-γ production in whole blood stimulation assays is associated with latent Trypanosoma brucei gambiense infections
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Trypanotolerance; Cytokines; IFN-γ; Whole blood stimulation
Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes
Keywords: تریپانوسومیوز انسان آفریقایی; Benzothiophenes; Fluorinated drugs; Antitrypanosomal activity; Sleeping sickness; Human African Trypanosomiasis; Trypanosoma brucei rhodesiense
Synthesis of large Stokes shift and narrow emission indole-triazole-carboxamide peptidomimetics via MCR-click strategy
Keywords: تریپانوسومیوز انسان آفریقایی; Indole; Carboxamide; Stokes shift; Human African Trypanosomiasis; Click chemistry;
Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Methionyl-tRNA synthetase; Structure-guided design; AP; auxiliary pocket; CNS; central nervous system; EMP; enlarged methionine pocket; HAT; human African trypanosomiasis; MetRS; methionyl-tRNA synthetase; SAR; structure-act
Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Sleeping sickness; Trypanosoma brucei gambiense; Drug resistance; Melarsoprol; Pentamidine; Aquaporin; Reverse genetics
ReviewLiaisons dangereuses: sexual recombination among pathogenic trypanosomes
Keywords: تریپانوسومیوز انسان آفریقایی; Trypanosoma brucei; Genetic exchange; Meiosis; Human African trypanosomiasis; Life cycle; Haploid gamete;
Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis
Keywords: تریپانوسومیوز انسان آفریقایی; Polymeric nanoparticles; PLGA; Nanobody nanoparticles conjugation; PEGylation; Specific cell targeting; Human African trypanosomiasis;
Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro
Keywords: تریپانوسومیوز انسان آفریقایی; pKa; Dibasic compound; T. brucei; Imidazoline; Halogen scan; BBB; blood-brain barrier; CNS; central nervous system; DIPEA; N,N-diisopropylethylamine; HAT; human African trypanosomiasis; HEK cells; human endothelial kidney cells; TFA; trifluoroacetic aci
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents
Keywords: تریپانوسومیوز انسان آفریقایی; Nitrotriazoles; Piperazides; Trypanocidal; Leishmanicidal; Chagas disease; NTD; neglected tropical diseases; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; T. cruzi; Trypanosoma cruzi; Bnz; benznidazole (N-benzyl-2-(2-nitro-1H-imidaz
Human African trypanosomiasis with 7-year incubation period: Clinical, laboratory and neuroimaging findings
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Trypanosomiasis; Trypanosoma brucei gambiense; Sleeping sickness; Chronic encephalitis; Magnetic resonance imaging; Cerebrospinal fluid;
Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model
Keywords: تریپانوسومیوز انسان آفریقایی; Brain; Coenzyme-Q10; Encephalopathy; Human African trypanosomiasis; Melarsoprol; Purple tea anthocyanins;
N1,N1-Dimethyl-N3-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis
Keywords: تریپانوسومیوز انسان آفریقایی; Alkaloids; Anti-parasite; Anti-protozoa; Human African trypanosomiasis;
CYP1A1 and CYP1B1-Mediated Biotransformation of the Antitrypanosomal Methamidoxime Prodrug DB844 Forms Novel Metabolites Through Intramolecular Rearrangement
Keywords: تریپانوسومیوز انسان آفریقایی; CYP1A1; CYP1B1; cytochrome P450; intramolecular rearrangement; drug metabolism; prodrugs; human African trypanosomiasis; nitric oxide; CID, collision-induced dissociation; CNS, central nervous system; CYP, cytochrome P450; HAT, human African trypanosomias
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines
Keywords: تریپانوسومیوز انسان آفریقایی; Trypanosoma brucei; Plasmodium falciparum; Parasite chemotherapy; Guanidine; Minor groove binder; surface plasmon resonance (SPR) biosensor; BBB; blood-brain barrier; CNS; central nervous system; DIPEA; diisopropylethylamine; EDAC; 1-ethyl-3-(3-dimethyl
HLA-G 3â² UTR-2 haplotype is associated with Human African trypanosomiasis susceptibility
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Sleeping sickness; HLA-G; Genetic susceptibility; UTR; Haplotype;
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents
Keywords: تریپانوسومیوز انسان آفریقایی; T. cruzi; Trypanosoma cruzi; T. brucei; Trypanosoma brucei; HAT; human African trypanosomiasis; Nfx; nifurtimox (4-(5-nitrofurfurylindenamino)-3-methylthio-morpholine-1,1-dioxide); Bnz; benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide); NTR; t
Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda
Keywords: تریپانوسومیوز انسان آفریقایی; Glossina fuscipes; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; human African trypanosomiasis; sleeping sickness; population genetics; vector control; Uganda
Translation of human African trypanosomiasis biomarkers towards field application
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Biomarkers; Diagnosis; Stage determination; Diagnostic tools
3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis
Keywords: تریپانوسومیوز انسان آفریقایی; 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides; Human African trypanosomiasis; Sleeping sickness; Trypanosomacidal agent; Trypanosoma bruceiBBB, blood–brain barrier; cPPB, chromatographic plasma protein binding; cytotox., cytotoxicity; DCM, dichloromethane; DMAP,
Synthesis and antikinetoplastid activity of a series of N,N′-substituted diamines
Keywords: تریپانوسومیوز انسان آفریقایی; Leishmaniasis; Chagas’ disease; Human African trypanosomiasis; Diamines; Reductive amination
Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Thiopyrano[2,3-d][1,3]thiazoles; Trypanosoma brucei; Antitrypanosomal activity;
Iotrochamides A and B, antitrypanosomal compounds from the Australian marine sponge Iotrochota sp.
Keywords: تریپانوسومیوز انسان آفریقایی; Iotrochamides A and B; Cinnamoyl-amino acids; Human African trypanosomiasis; Trypanocidal
Short communicationAPOL1 expression is induced by Trypanosoma brucei gambiense infection but is not associated with differential susceptibility to sleeping sickness
Keywords: تریپانوسومیوز انسان آفریقایی; Human African trypanosomiasis; Apolipoprotein L-I; Expression; Resistance/susceptibility;