Keywords: ACPA; anti-citrullinated protein antibody; AP; recombinant human placental alkaline phosphatase = hRESCAP® (human rescue alkaline phosphatase); DAS; disease activity score; DMARD; disease modifying anti-rheumatic drug; EULAR; European league against rheu
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Keywords: Plasmodium falciparum; Plasmodium berghei ANKA; Terpenes; Experimental cerebral malaria; Protein isoprenylation; Cytokines; [3H]-FPP; [1-(n)-3H]farnesyl pyrophosphate triammonium salt; [3H]-GGPP; [1-(n)-3H]geranylgeranyl pyrophosphate triammonium salt; CB
Keywords: 6-OHDA; 6-hydroxyl-dopamine; DA; dopamine; DBS; deep brain stimulation; DL; dorsolateral; FSIs; fast spiking interneurons; H2O2; hydrogen peroxide; i.p; intraperitoneal; LFP; local field potential; MSNs; medium spiny projecting neurons; PB; phosphate buff
Keywords: BLA; basolateral amygdala; CeA; central amygdala; i.p; intraperitoneal; IL; infralimbic cortex; LC; locus coeruleus; PL; prelimbic cortex; PND; postnatal day; pPVT; posterior paraventricular nucleus of the thalamus; SEM; standard error of the mean; SB3348
Keywords: A549; human lung adenocarcinoma; ANOVA; analysis of variance; b.wt; body weight; BEAS-2B; human bronchial epithelial cells; CAs; chromosomal aberrations; CAT; catalase; CNTs; carbon nanotubes; Cu; copper; DMSO; dimethylsulfoxide; DNA; deoxyribonucleic aci
Keywords: HPCs; hepatic progenitor cells; mtROS; mitochondrial reactive oxygen species; DEN; diethylnitrosamine; SPCs; stem/progenitor cells; HSCs; hematopoietic stem cells; NSCs; neural stem cells; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum;
Keywords: Biological toxins; Ricin; Botulinum neurotoxin; Staphylococcal enterotoxin; Saxitoxin; Standardization; Proficiency testing; AOAC; AOAC International; BoNT; Botulinum neurotoxin; CRM; Certified reference material; CWC; Chemical Weapons Convention; EFSA; E
Keywords: CH; chloral hydrate; CPP; conditioned place preference; 5-HT; 5-hydroxytryptamine; ANOVA; analysis of variance; LSD; least significant difference; NS; no significance; NMDA; N-methyl-D-aspartate; i.p; intraperitoneal; S.E.M.; standard error of the mean; M
Keywords: CMS; chronic mild stress; CNS; central nervous system; IL-6; interlukine-6; i.p; intraperitoneal; TNF-a; tumor necrosis factor-alpha; FST; forced-swim test; ELISA; enzyme-linked immunosorbent assay; FPN-1; ferroportin-1; PCR; polymerase chain reaction; Ch
Keywords: cRGD; brain-targeting drug delivery system; monocyte; depression; trefoil factor 3; cRGD; cyclic RGD; cRGDL; cRGD-modified liposomes; TFF3; trefoil factor 3; cRGDL-TFF3; cRGD liposomes loaded with TFF3; BBB; blood-brain barrier; i.p; intraperitoneal; HBME
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; NFTs; neurofibrillary tangles; p-tau; hyperphosphorylated tau; ROS; reactive oxygen species; [Zn2 +]i; intraneuronal Zn2 +; [Ca2 +]i; intraneuronal Ca2 +; m.o; month old; m.o.a; months of age; i.p; intraperito
Keywords: Antipsychotic; 1-(Biphenyl-4-yl)-2-[4-(substituted phenyl)-piperazin-1-yl]ethanones; Pharmacological evaluation; QSAR; Descriptor based similarity study; QSAR; quantitative structure activity relationship; EPS; extrapyramidal symptoms; GPCR; G-protein cou
Keywords: GBS; Guillain-Barre syndrome; CIDP; chronic inflammatory demyelinating polyneuropathy; AIDP; acute inflammatory demyelinating polyneuropathy; EAN; experimental autoimmune neuritis; EAE; experimental autoimmune encephalomyelitis; PNS; peripheral nervous
Keywords: AMD; age-related macular degeneration; CE; capillary electrophoreis; CPP; conditioned place preference; CK; creatine kinase; C. sativus L.; Crocus sativus L.; FAB-MS; fast atom bombardment-mass spectrometry; G. fructus; Gardenia fructus; G. jasminoides; G
Keywords: AVPRV1; arginine vasopressin receptor 1; BNST; bed nucleus of the stria terminalis; CNS; central nervous system; CPP; conditioned place preference; CRF; corticotropin releasing factor; CSF; cerebrospinal fluid; HPA; hypothalamic-pituitary-adrenal; ICV
Keywords: Azithromycin; Macrolide antibiotic; Mechanisms of action; Pharmacokinetics; Immunomodulation; Clinical efficacy; AECOPD; acute exacerbations of COPD; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; AUC; area under the plasma concentr
Gastroprotective activity of a pectic polysaccharide fraction obtained from infusion of Sedum dendroideum leaves
Keywords: Sedum dendroideum; Polysaccharide; Gastroprotective; Araf; Arabinofuranose; DEPT; Distortionless enhancement by polarization transfer; dn/dc; Specific refractive index increment; ESBAL; Eluted polysaccharide fraction obtained after dialysis procedure; Gal
Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model
Keywords: CNS; central nervous system; MS; multiple sclerosis; OPCs; oligodendrocyte precursor cells; OGD; oxygen/glucose deprivation; EAE; experimental autoimmune encephalomyelitis; VEP; visual evoked potential; LPC; lysolecithin; i.p; intraperitoneal; qRT-PCR; qa
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
Keywords: AEA; anandamide; ADT; acetone drop test; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CD11b; cluster of differentiation molecule; 11b; CD68, cluster of differentiation 68; CNS; central nervous system; COX-2; cyclooxygenase 2; EPM; elevated pl
Paternal Cocaine Disrupts Offspring Circadian Clock Function in a Sex-Dependent Manner in Mice
Keywords: 8-OH-DPAT; 8-hydroxy-n,n-dipropylaminotetralin; ANOVA; analysis of variance; BDNF; brain-derived neurotropic factor; CocSire; cocaine-sired offspring; CtlSire; control-sired offspring; DD; constant darkness; F1; first generation offspring; i.p; intraperit
Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism
Keywords: Flavonoids; Antidepressant; Forced swimming test; Serotonergic system; Molecular docking, Viola odorata; TST; Tail suspension test; FST; Forced swimming test; 5-HT; 5-Hydroxytryptamine; pCPA; para-chlorophenylalanine; DMSO; Dimethylsulfoxide; FLX; Fluoxet
Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice
Keywords: IR; iron ion 56Fe radiation; ROS; reactive oxygen species; cyto c; cytochrome c; Mfn2; mitofusin2; Drp1; dynamic-like protein; OPA1; andoptic atrophy gene1; ATP; adenosine triphosphate; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; ADP; adenosine 5â²-diph
Curcumin-loaded nanoparticles ameliorate glial activation and improve myelin repair in lyolecithin-induced focal demyelination model of rat corpus callosum
Keywords: MS; Multiple sclerosis; CNS; Central nervous system; AD; Alzheimer's disease; PD; Parkinson's disease; JAK-STAT; Janus kinase-signal transducer and activator of transcription; EAE; Experimental autoimmune encephalomyelitis; NPs; Nanoparticles; CS; Chi
Adenosine A2A receptor blockade attenuates spatial memory deficit and extent of demyelination areas in lyolecithin-induced demyelination model
Keywords: MS; multiple sclerosis; CNS; central nervous system; OPCs; oligodendrocyte precursor cells; EAE; experimental autoimmune encephalomyelitis; LPC; lysolecithin; DMSO; dimethylsulfoxide; i.p; intraperitoneal; i.c.v; intracerebroventricular; PBS; phosphate bu
Short and long term modulation of tissue minerals concentrations following oral administration of black cumin (Nigella sativa L.) seed oil to laboratory rats
Keywords: Nigella sativa; Black cumin; Seed oil; Laboratory rats; Natural herbs; Micro- and macrominerals; Tissue trace elements; Electrolytes; LD; lethal dose; b.w.; body weight; FAAS; flame atomic absorption spectrophotometry; GC-MS; gas chromatography-mass s
Methylglyoxal displays colorectal cancer-promoting properties in the murine models of azoxymethane and CT26 isografts
Keywords: ACs; aberrant crypts; ACFs; aberrant crypt foci; AGEs; advanced glycation end products; ALA; alagebrium chloride; AOM; azoxymethane; BW; body weight; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GLO; glyoxal
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors
Keywords: Sigma-2 receptors; Pancreatic cancer; Multifunctional compounds; Thiosemicarbazones; Mithocondrial superoxide; AST; aspartate aminotransferase; ALT; alanine aminotransferase; BUN; blood urea nitrogen; Cr; Creatinine; i.p; intraperitoneal; ROS; reactive ox
Activation of NPY-Y2 receptors ameliorates disease pathology in the R6/2 mouse and PC12 cell models of Huntington's disease
Keywords: Aβ; beta-amyloid; ABC; avidin-biotin complex; BBB; blood brain barrier; BDNF; brain derived neurotrophic factor; BSA; bovine serum albumin; CREB; cAMP response element binding protein; cDNA; complementary deoxyribonucleic acid; DAB, 3; 3-diaminobenzidine
Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats
Keywords: SCI; spinal cord injury; i.t; intrathecal; SNL; spinal nerve ligation; MW; molecular weight; BBB; Basso Beattie, and Bresnahan; PyrAP13; pyroglutamyl apelin-13; WK; week; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; PVDF; poly viny
Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction
Keywords: APAP; acetaminophen; bp; base pair; ChIP; chromatin immunoprecipitation; Cyp; cytochrome p450 enzyme; DEX; dexamethasone; Fgf21; fibroblast growth factor 21; GR; glucocorticoid receptor; GRE; glucocorticoid receptor response element; GSH; Glutathione; i.p
Overexpression of the 18Â kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects
Keywords: Dentate gyrus; 18Â kDa translocator protein; Allopregnanolone; Anxiety and depression; TSPO; 18 kDa translocator protein; CSF; plasma and cerebrospinal fluid; AP; anteroposterior; ML; mediolateral; DV; dorsoventral; i.p; intraperitoneally;
Docking, characterization and investigation of β-cyclodextrin complexed with farnesol, an acyclic sesquiterpene alcohol, produces orofacial antinociceptive profile in experimental protocols
Keywords: 5-HT3; 5-hydroxytryptamine; ANOVA; analysis of variance; Ca2+; calcium; CDs; cyclodextrins; DSC; differential scanning calorimetry; DTG; derivative thermogravimetry; DZP; diazepam; FAR; farnesol; FTIR; Fourier transform infrared spectroscopy; i.p; intrape
Enhancement of orofacial antinociceptive effect of carvacrol, a monoterpene present in oregano and thyme oils, by β-cyclodextrin inclusion complex in mice
Keywords: AAOP; According to American Academy of Orofacial Pain; CDs; cyclodextrins; CARV; carvacrol; CARV-βCD; β-cyclodextrin complex containing carvacrol; βCD; β-cyclodextrin; MOR; morphine; NAL; naloxone; i.p; intraperitoneal injection; p.o; oral administrat
Repeated dose studies with pure Epigallocatechin-3-gallate demonstrated dose and route dependant hepatotoxicity with associated dyslipidemia
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; GTE; green tea extract; i.v; intravenous; i.p; intraperitoneal; p.o; oral; EGCG; Green tea; Serum lipids; Dose dependant toxicity; Route dependant toxicity; Liver t
Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats
Keywords: AB; Applied Biosystems; AR; anaphylactic response; AU; arbitrary units; AUC; area under the curve; βLG; β-lactoglobulin; BN; Brown Norway; CC; conventional cocoa; FA; food allergy; FA-CC; food allergy group fed with a conventional cocoa diet; FA-NFC; fo
Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models
Keywords: ANOVA; analysis of variance; C4.4; flavonol kaempferol; Clonaz; clonazepam; GABA; gamma-Aminobutyric acid; GSH; reduced glutathione; HNC; Herbier National du Cameroun; i.p; intraperitoneally; MDA; malondialdehyde; NIH; National Institutes of Health; NMR;
Effect of Centaurium erythraea Rafn, Artemisia herba-alba Asso and Trigonella foenum-graecum L. on liver fat accumulation in C57BL/6J mice with high-fat diet-induced type 2 diabetes
Keywords: HFD; High fat diet; TFG; Trigonella foenum-graecum; AHA; Artemisia herba-alba Asso; CE; Centaurium erythraea Rafn; HDL-cholesterol; High-density lipoprotein; HOMA; Homeostasis model assessment; STD; Standard diet; NASH; Non alcoholic fatty liver disease;
A gold glyco-nanoparticle carrying a listeriolysin O peptide and formulated with Advax⢠delta inulin adjuvant induces robust T-cell protection against listeria infection
Keywords: APC; antigen-presenting cells; CFU; colony forming units; Ctsd; cathepsin-D; DC; dendritic cells; GNP; gold glyconanoparticles; i.p; intra-peritoneal; i.v; intra-venous; LLO; listeriolysin O; MHC; major histocompatibility complex; MIIC; MHC-class II antig
Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion
Keywords: Endocannabinoid system; CB1 knockout; Decidua; Embryotoxicity; 2-AG; 2-arachidonoylglycerol; 2-LG; 2-linoleoyl-sn-glycerol; 2-OG; 2-oleoyl-sn-glycerol; AEA; anandamide; AGly; N-arachidonoylglycine; CB1; cannabinoid receptor type 1; CB1-KO; CB1 receptor kn
Role of protein kinase CK2 in the dynamic interaction of platelets, leukocytes and endothelial cells during thrombus formation
Keywords: ADP; adenosin diphosphate; DAPI; 4â²,6-diamidine-2â²-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; DRB; 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole; ELISA; enzyme-linked immunosorbent assay; ER; endoplasmatic reticulum; FITC; fluorescein is
Cerebrosides from sea cucumber ameliorates cancer-associated cachexia in mice by attenuating adipose atrophy
Keywords: Cerebrosides; Inflammatory cytokines; White adipose tissue (WAT); Lipolysis; Lipogenesis; Long-chain base; AMC; sea cucumber Acaudina molpadioides cerebrosides; BAT; brown adipose tissue; BM; body mass; CAC; cancer-associated cachexia; C/EBP α (β); CCAA
Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway
Keywords: CYP; cytochrome P450; ROS; reactive oxygen species; O2â; superoxide anion; H2O2; hydrogen peroxide; HOâ; hydroxyl radicals; i.p; intraperitoneally; i.g; by gavage; AST; aspartate aminotransferase; ALT; alanine aminotransferase; MDA; malondialdehyde; S
The role of intrahepatic CD3Â +/CD4Â â/CD8Â â double negative T (DN T) cells in enhanced acetaminophen toxicity
Keywords: GrB; granzyme B; DN T; double negative T; APAP; acetaminophen; DILI; drug-induced liver injury; NAPQI; n-acetyl-benzoquinone imine; NK; natural killer; CTL; cytotoxic T lymphocytes; FasL; Fas ligand; Gr; granzyme; i.p; intraperitoneally; ALT; alanine tran
Additive antidepressant-like effects of fasting with imipramine via modulation of 5-HT2 receptors in the mice
Keywords: ANOVA; analysis of variance; 5-HT; serotonin; FST; forced swimming test; i.p; intraperitoneal; NMDA; N-methyl-d-aspartate; DOI; (±)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride; OFT; open field test; FST; forced swimming test; CREB; cAMP
Ghrelin inhibits BSCB disruption/hemorrhage by attenuating MMP-9 and SUR1/TrpM4 expression and activation after spinal cord injury
Keywords: BBB; blood-brain barrier; BSCB; blood spinal cord barrier; COX-2; cyclooxygenase-2; Ghrelin receptor; GHS-R1a; iNOS; inducible nitric oxide synthase; i.p; intraperitoneal; IL; interleukin; MMP; matrix metalloprotease; SCI; spinal cord injury; SUR1; sulfon
Histopathological features and distribution of EV71 antigens and SCARB2 in human fatal cases and a mouse model of enterovirus 71 infection
Keywords: EV71; enterovirus 71; HFMD; hand, foot, and mouth disease; SCARB2; scavenger receptor class B, member 2; CNS; central nervous system; i.p; intraperitoneal; RD; rhabdomyosarcoma; Enterovirus 71; Hand; foot; and mouth disease; Pathology; Human cases; Mouse
Adenosine A2A receptor antagonism reverses inflammation-induced impairment of microglial process extension in a model of Parkinson's disease
Keywords: aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; BSA; bovine serum albumin; CX3CR1; CX3C-type chemokine receptor 1; GFP; enhanced green fluorescent protein; IL; interleukin; i.p; intraperitoneal; s.c; subcutaneous; LPS; lipopolysaccharid
The cytogenetic effects of acrylamide on Carassius auratus periperial blood cells
Keywords: MN; micronucleus; IARC; International Agency for Research on Cancer; C. auratus; Carassius auratus; i.p; intraperitoneal; BN; binuclei; NPB; nucleoplasm bridged nuclei; NBUD; nuclear buds; PBS; Phosphate buffer saline; LMP; low melting point; EDTA; ethyle
FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1
Keywords: WAT; white adipose tissue; BAT; brown adipose tissue; UCP1; uncoupling protein 1; WA; white adipocyte; BA; brown adipocyte; FAO; fatty acid oxidation; FABP3; fatty acid binding protein3/heart-type fatty acid binding protein; Acyl-CoA; acyl-Coenzyme A; ACS
Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior
Keywords: CPP; conditioned place preference; DA; dopamine; Ext; extinction; i.p; intraperitoneal; l-THP; levo-tetrahydropalmatine; METH; methamphetamine; Rein; reinstatement; l-Tetrahydropalmatine; Methamphetamine; Conditioned place preference; Acquisition; Extinct