دانلود مقالات ISI درباره متابولیسم روده + ترجمه فارسی

کشف جذب روده اسید پارآمینو بنزوئیک، نشانگر مصرف غذا

Elucidation of the Intestinal Absorption of para-Aminobenzoic Acid, a Marker for Dietary Intake

Keywords: متابولیسم روده; intestinal absorption; intestinal metabolism; N-acetyltransferases (NAT); dose proportionality; enzyme kinetics; intestinal secretion/transport; GLYAT; glycine N-acyltransferase; NAT; arylamine N-acetyltransferase; PABA; para-aminobenzoic acid;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

توسعه یک فرمول رمان که بهبود زیست پذیری پیشکلامی از فسفورفین دیوپروکسیل فومارات

Development of a Novel Formulation That Improves Preclinical Bioavailability of Tenofovir Disoproxil Fumarate

Keywords: متابولیسم روده; bioavailability; Caco-2 cells; intestinal absorption; intestinal metabolism; membrane transporter; prodrugs;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Technical noteEvaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs

Keywords: متابولیسم روده; Intestinal metabolism; Intestinal absorption; Mini-Ussing chamber; Animal tissues; Transport index (TI);

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity

Keywords: متابولیسم روده; 1-OH-MDZ; 1-hydroxymidazolam; 4-OH-DCL; 4-hydroxydiclofenac; 5-OH-OME; 5-hydroxyomeprazole; CYP; cytochrome P450 enzymes; DXP; dextrorphan; ESI; electrospray ionization; EZE-Glc; ezetimibe glucuronide; LC-MS/MS; liquid chromatography tandem mass spectro

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates

Keywords: متابولیسم روده; CYP3A4; NADPH-cytochrome P450 reductase; Caco-2 cells; Human artificial chromosome vector; Intestinal metabolism; ABT; 1-aminobenzotriazole; CLint; intrinsic clearance; CPR; NADPH-cytochrome P450 reductase; Ct; threshold cycle; CYP; cytochrome P450; Eg;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Keywords: متابولیسم روده; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Interspecies Differences in the Metabolism of a Multiester Prodrug by Carboxylesterases

Keywords: متابولیسم روده; enzymes; hepatic metabolism; HPLC (high-performance/pressure liquid chromatography); intestinal metabolism; metabolism; prodrugs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions

Keywords: متابولیسم روده; active transport; drug interaction; efflux pumps; food effects; flavonoids; genistein; glyceollin; intestinal absorption; intestinal metabolism; phytoestrogen;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Explication of Definitional Description and Empirical Use of Fraction of Orally Administered Drugs Absorbed From the Intestine (Fa) and Intestinal Availability (Fg): Effect of P-glycoprotein and CYP3A on Fa and Fg

Keywords: متابولیسم روده; ABC transporters; intestinal absorption; intestinal metabolism; mathematical model; passive diffusion/transport;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers

Keywords: متابولیسم روده; Clinical pahrmacokinetics; Dose-response; Intestinal absorption; Intestinal metabolism; Mebabolite kinetics; Shakuyaku-kanzo-to; TJ-68; randomized crossover study; healthy adult volunteers;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug–Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 Substrates

Keywords: متابولیسم روده; clinical trial simulations; cytochrome P450; drug interactions; intestinal metabolism; pharmacokinetics; physiologically based pharmacokinetic modeling

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Presystemic Metabolism of AZ'0908, A Novel mPGES-1 Inhibitor: An In Vitro and In Vivo Cross-Species Comparison

Keywords: متابولیسم روده; ABC transporters; bioavailability; first-pass metabolism; intestinal metabolism; interspecies correlation; intestinal loss; CYP2J2; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of the Effect of the Uneven Distribution of CYP3A4 and P-Glycoprotein in the Intestine on the Barrier Function against Xenobiotics: A Simulation Study

Keywords: متابولیسم روده; intestinal absorption; intestinal metabolism; P-glycoprotein; CYP3A4; pharmacokinetics; bioavailability

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Absorption and Bioavailability of Glucosamine in the Rat

Keywords: متابولیسم روده; absorption; active transport; bioavailability; intestinal metabolism; transporters;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of Intestinal First-Pass Hydrolysis on the Oral Bioavailability of an Ester Prodrug of Fexofenadine

Keywords: متابولیسم روده; absorption; intestinal absorption; bioavailability; intestinal metabolism; pharmacokinetics; prodrugs; oral drug delivery; metabolic clearance; first-pass metabolism; intestinal secretion/transport

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Oral Coadministration of β-Glucuronidase to Increase Exposure of Extensively Glucuronidated Drugs that Undergo Enterohepatic Recirculation

Keywords: متابولیسم روده; β-glucuronidase; enterohepatic circulation; glucuronidation; site-specific delivery; intestinal metabolism; oral absorption; ADME; pharmacokinetics; intestinal absorption; bioavailability;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The effects of intralaboratory modifications to media composition and cell source on the expression of pharmaceutically relevant transporters and metabolizing genes in the Caco‐2 cell line

Keywords: متابولیسم روده; Caco‐2 cells; cell culture; variability; media composition; active transport; paracellular transport; transporters; gene expression; permeability; intestinal metabolism;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Use of Physiologically Based Pharmacokinetic Models to Evaluate the Impact of Intestinal Glucuronide Hydrolysis on the Pharmacokinetics of Aglycone

Keywords: متابولیسم روده; Intestinal metabolism; hepatic metabolism; UGTs; glucuronidation; intestinal bacteria; ABC transporters; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro

Keywords: متابولیسم روده; Non-ionic surfactants; Excipients; Inhibition effect; Cytochrome P450; Intestinal metabolism; Bioavailability

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Oral ileocolonic drug delivery by the colopulse-system: A bioavailability study in healthy volunteers

Keywords: متابولیسم روده; GIT, Gastro-intestinal tract; OCTT, Oro-cecal transit time; Ph.Eur., European PharmacopoeiaColon delivery; ColoPulse; Stable isotope; Intestinal metabolism; Bioavailability; Urea

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

Keywords: متابولیسم روده; intestinal absorption; permeation enhancers; cytochrome P450; excipients; intestinal metabolism; P-glycoprotein; passive diffusion/transport; permeability; jejunum; ileum;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

Absorption Barriers in the Rat Intestinal Mucosa: 2. Application of Physiologically Based Mathematical Models to Quantify Mechanisms of Drug Permeation and Metabolism

Keywords: متابولیسم روده; clearance; intestinal absorption; intestinal metabolism; mathematical model; membrane transport; paracellular transport; P-glycoprotein; pharmacokinetics; in silico modeling;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Keywords: متابولیسم روده; intestinal absorption; intestinal metabolism; active transport; mass spectrometry; inhibition; permeability; passive diffusion/transport; P-glycoprotein; transcellular transport; cytochrome P450;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2010 سفارش ترجمه

The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans

Keywords: متابولیسم روده; bioavailability; first-pass metabolism; intestinal absorption; pharamcokinetics; hepatic clearance; intestinal metabolism;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Assessment of Presystemic and Systemic Intestinal Availability of Orally Administered Drugs Using In Vitro and In Vivo Data in Humans: Intestinal Sulfation Metabolism Impacts Presystemic Availability Much More Than Systemic Availability of Salbutamol, SUL

Keywords: متابولیسم روده; intestinal metabolism; metabolic clearance; bioavailability; first‐pass metabolism; phase II metabolism;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Daidzein is absorbed by passive transport in isolated small intestine of rats

Keywords: متابولیسم روده; Daidzein; Intestinal absorption; Intestinal metabolism; Everted gut; Rats

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Investigation of the absorption mechanisms of baicalin and baicalein in rats

Keywords: متابولیسم روده; baicalin; Baicalein; absorption mechanism; intestinal absorption; intestinal excretion; intestinal metabolism; biliary excretion; in situ perfusion; oral drug delivery; HPLC (high-performance/pressure liquid chromatography);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

A simple and rapid ion-pair HPLC method for simultaneous quantitation of 4-nitrophenol and its glucuronide and sulfate conjugates

Keywords: متابولیسم روده; 4-nitrophenol; 4-nitrophenyl-glucuronide; 4-nitrophenyl-sulfate; HPLC assay; Ion-pair chromatography; Intestinal metabolism

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Prodrugs of scutellarin: Ethyl, benzyl and N,N-diethylglycolamide ester synthesis, physicochemical properties, intestinal metabolism and oral bioavailability in the rats

Keywords: متابولیسم روده; Scutellarin; Prodrugs; Glycolamide ester; Intestinal metabolism; Emulsion; Oral absorption; Bioavailability

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Factors influencing regional differences in intestinal absorption of UK-343,664 in rat: Possible role in dose-dependent pharmacokinetics

Keywords: متابولیسم روده; intestinal absorption; intestinal metabolism; nonlinear pharmacokinetics; P-glycoprotein; mucosal export; cytochrome P4503A;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Differentiation of organ availability by sequential and simultaneous analyses: Intestinal conjugative metabolism impacts on intestinal availability in humans*

Keywords: متابولیسم روده; intestinal metabolism; phase II enzymes; conjugation; bioavailability; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Role of the mucous/glycocalyx layers in insulin permeation across the rat ileal membrane

Keywords: متابولیسم روده; Insulin; Hyaluronidase; Mucous; Glycocalyx; Macromolecular drug delivery; Intestinal metabolism; Aprotinin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه