دانلود مقالات ISI درباره پاکسازی ذاتی + ترجمه فارسی

بحث بر روی مدل کبد به خوبی همزاد: مجدد مجدد از مدل پراکندگی و دوباره تجزیه و تحلیل داده های لیدوکائین

Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data

Keywords: پاکسازی ذاتی; AAG; α1-acid glycoprotein; IPRL; isolated perfused rat liver; IVIVE; in vitro-in vivo extrapolation; PBPK; physiologically based pharmacokinetic(s); PK; pharmacokinetic(s); Pharmacokinetics; Well-stirred model; Parallel-tube model; Dispersion model; Hepa

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

مطالعات متابولیسم آفت کش های شیمیایی: بررسی انتقادی

Metabolism studies of chiral pesticides: A critical review

Keywords: پاکسازی ذاتی; AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

مدلسازی فیزیولوژیکی مبتنی بر فارماکوکینتیک از نظر قرارگیری و تعاملات دارویی و داروئی برای والپروئیک اسید و دیوالپروکس

Physiologically based pharmacokinetic modeling of disposition and drug-drug interactions for valproic acid and divalproex

Keywords: پاکسازی ذاتی; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

آیا آلما ماتسین برای استفاده در مطالعات زیستی قابل دسترس است؟ - بررسی مجدد اثر آن

Alamethicin for using in bioavailability studies? - Re-evaluation of its effect

Keywords: پاکسازی ذاتی; Clint; intrinsic clearance; Clint app.; apparent intrinsic clearance; DAD; diod array detector; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; fu; unbound fraction of a drug in the microsomal incubation mixture; HPLC; high performance liquid chromat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

محدودیت ها، ساخت و تایید یک مدل موش مبتنی بر فیزیولوژیک مبتنی بر فاکتوریل

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model

Keywords: پاکسازی ذاتی; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

متفورمین و سایمتیدین: مدلسازی فارماکوکینتیک مبتنی بر فیزیولوژیک برای بررسی اثرات متقابل دارو

Metformin and cimetidine: Physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions

Keywords: پاکسازی ذاتی; AUC; area under the plasma concentration-time curve; B/P; blood-to-plasma ratio; CYP; cytochrome P450; CLint; intrinsic clearance; Cmax; maximum plasma concentration; CLPD; passive permeability-surface area product; DDI; drug-drug interaction; fa; fract

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

ارزیابی تأثیرات اختلالات کودک / بزرگسالان در اثر مصرف کبد اول بر فاکتور تعدیل سینتکس انسانی برای سموم مصرف شده

Assessing the impact of child/adult differences in hepatic first-pass effect on the human kinetic adjustment factor for ingested toxicants

Keywords: پاکسازی ذاتی; ADH; alcohol dehydrogenase; BSA; body surface area; BH; body height; BW; body weight; Clint; intrinsic clearance; Clintad; intrinsic clearance in average adult; Clintind; intrinsic clearance in any individual; CAss; arterial blood concentration at steady-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Kinetic characterization of bile salt transport by human NTCP (SLC10A1)

Keywords: پاکسازی ذاتی; NTCP; SLC10A1; Glycochenodeoxycholate; 3-Sulfo-glycolithocholate; Kinetics; Intrinsic clearance;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Development of human biotransformation QSARs and application for PBT assessment refinement

Keywords: پاکسازی ذاتی; In vivo biotransformation; Biotransformation half-life; QSAR; Hazard assessment; Refined PBT assessment; 1-CoPK; one-compartment pharmacokinetic model; AD; Applicability Domain; ADME; Absorption, Distribution, Metabolism and Elimination; B; Bioaccumulati

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria

Keywords: پاکسازی ذاتی; AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin

Keywords: پاکسازی ذاتی; CLint; intrinsic clearance; CYP; cytochrome P450; HPLC; high performance liquid chromatography; Km; Michaelis-Menten constant; MS; mass spectroscopy; PAPS; 3′-Phosphoadenosine-5′-phosphosulfate; QTOF; Quadrupole time-of-flight; shRNA; short hairpin RN

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis

Keywords: پاکسازی ذاتی; CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes

Keywords: پاکسازی ذاتی; Bile canaliculi; Collagen; Hepatic drug disposition; Methods; Sandwich-cultured rat hepatocytes; AUC; Area Under the Curve; BEI; biliary excretion index; CDF; 5-(6)-carboxy-2-dichlorofluorescein; CDFDA; 5-(6)-carboxy-2-dichlorofluorescein diacetate; Clint

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of genetic polymorphism on the inhibition of dopamine formation from p-tyramine catalyzed by brain cytochrome P450 2D6

Keywords: پاکسازی ذاتی; CYP2D6; Dopamine formation; Genetic polymorphism; Drug interaction; CLint; intrinsic clearance; CYP or P450; cytochrome P450; DHEA; dehydroepiandrosterone; IC50; 50% inhibitory concentration; Iu; unbound concentration of the inhibitor; Ki; inhibitory cons

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro

Keywords: پاکسازی ذاتی; Ketamine; CYP2C9; Gene polymorphism; Metabolism; Intrinsic clearance;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

Keywords: پاکسازی ذاتی; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates

Keywords: پاکسازی ذاتی; CYP3A4; NADPH-cytochrome P450 reductase; Caco-2 cells; Human artificial chromosome vector; Intestinal metabolism; ABT; 1-aminobenzotriazole; CLint; intrinsic clearance; CPR; NADPH-cytochrome P450 reductase; Ct; threshold cycle; CYP; cytochrome P450; Eg;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clea

Keywords: پاکسازی ذاتی; Fatty acids; CYP450 enzymes; Enzyme inhibition; Michaelis-Menten kinetics; Bovine serum albumin (BSA); Intrinsic clearance; Well-stirred model; Hepatic clearance; In vitro - In vivo extrapolation (IVIVE);

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids

Keywords: پاکسازی ذاتی; AUDA; 212-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid; 4-HBP; 4-hydroxybenzophenone; ACN; acetonitrile; CLother(AA); aggregate clearance of other pathways of AA; CLother(EET); aggregate clearance of other pathways of EET; AA; arac

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

Keywords: پاکسازی ذاتی; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of ursolic acid

Keywords: پاکسازی ذاتی; Ursolic acid; UDP-glucuronosyltransferases; Metabolism pathway; Metabolism characterization; UA; ursolic acid; HLMs; human liver microsomes; HIMs; human intestinal microsomes; UGTs; UDP-glucuronosyltransferases; DDI; drug-drug interactions; RILD; Resear

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases

Keywords: پاکسازی ذاتی; GA; glabridin; UGT; UDP-glucuronosyltransferases; HLM and HIM; liver and intestinal microsomes from humans, respectively; RLM and RIM; liver and intestinal microsomes from rats, respectively; CyLM and DLM; liver microsomes from cynomolgus monkeys and beag

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes

Keywords: پاکسازی ذاتی; Benzo[a]pyrene; Dibenzo[def,p]chrysene; Michaelis–Menten; VMAX; KM; Intrinsic clearance

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

Keywords: پاکسازی ذاتی; AUC; area under the plasma concentration-time curve; DDI; drug-drug interaction; CLint; intrinsic clearance; BCRP; Breast Cancer Resistance Protein; HEK293; Human Embryonic Kidney 293 (cell-line); MRP; Multidrug resistance-associated protein; NTCP; Sodi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat

Keywords: پاکسازی ذاتی; DEHP; In vitro hepatic metabolism; In vitro intestinal metabolism; Human; Rat; Intrinsic clearance;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Prediction of Total Hepatic Clearance by Combining Metabolism, Transport, and Permeability Data in the In Vitro-In Vivo Extrapolation Methods: Emphasis on an Apparent Fraction Unbound in Liver for Drugs

Keywords: پاکسازی ذاتی; hepatocytes; intrinsic clearance; unbound fraction; metabolism; transport; permeability; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

Keywords: پاکسازی ذاتی; hepatocytes; intrinsic clearance; unbound fraction; computational ADME; in vitro–in vivo extrapolation; in vitro–in vivo correlation; IVIVE; pharmacokinetics; physiologically based pharmacokinetics; PBPK modeling

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Stereoselectivity in Pharmacokinetics of Rivoglitazone, A Novel Peroxisome Proliferator-Activated Receptor γ Agonist, in Rats and Monkeys: Model-Based Pharmacokinetic Analysis and In Vitro-In Vivo Extrapolation Approach

Keywords: پاکسازی ذاتی; pharmacokinetics; protein binding; metabolic clearance; metabolism; distribution; chiral inversion; stereoselectivity; in vitro–in vivo extrapolation (IVIVE); unbound fraction; intrinsic clearance

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Keywords: پاکسازی ذاتی; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Evaluation of Hepatic Clearance Prediction Using In Vitro Data: Emphasis on Fraction Unbound in Plasma and Drug Ionisation Using a Database of 107 Drugs

Keywords: پاکسازی ذاتی; in vitro-in vivo correlations (IVIVC); hepatocytes; microsomes; clearance; intrinsic clearance; protein binding; prediction; precision; bias;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin

Keywords: پاکسازی ذاتی; AIC; Akaike's information criterion; UGT; UDP-glucuronosyltransferase; UDPGA; uridine diphosphoglucuronic acid; LTC4; leukotriene C4; NTP; National Toxicology Program; SD; Sprague-Dawley; DMEM; Dulbecco's modified Eagle's medium; AP; apical; BL; basolat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Analogue tracers and lumped constant in capillary beds

Keywords: پاکسازی ذاتی; Microvascular tracer kinetics in vivo; Intrinsic clearance; 2-[18F]Fluoro-2-deoxy-d-glucose PET; Positron emission tomography; Bi-substrate enzyme kinetics

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase

Keywords: پاکسازی ذاتی; SDR; short-chain dehydrogenyse/reductase; AKR; aldo-keto reductase; 11β-HSD1; 11β-hydroxysteroid dehydrogenase 1; ANT; anthracycline; DAUN; daunorubicin; DAUNOL; daunorubicinol; ADAUN; aglycone of daunorubicin; ADAUNOL; aglycone of daunorubicinol; DOX;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Keywords: پاکسازی ذاتی; Hepatocyte characterization methods; Cytochrome P450; HepaRG; Intrinsic clearance; P450 enzyme induction; Primary human hepatocytes

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

On the prediction of hepatic clearance using the diluted plasma in metabolic stability assay

Keywords: پاکسازی ذاتی; hepatic clearance; intrinsic clearance; metabolic stability; protein binding; microsomal binding; well-stirred model; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance

Keywords: پاکسازی ذاتی; Hepatocytes; In vivo; In vitro; Intrinsic clearance; Microsomes

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Pharmacokinetics of Chlorzoxazone in Rats with Diabetes: Induction of CYP2E1 on 6-Hydroxychlorzoxazone Formation

Keywords: پاکسازی ذاتی; CZX and OH-CZX; rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS); pharmacokinetics; CYP2E1; rats; disease state; CYP enzymes; metabolism; intrinsic clearance; protein binding;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

In vitro–in vivo extrapolation of quantitative hepatic biotransformation data for fish : I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models

Keywords: پاکسازی ذاتی; Fish; Biotransformation; Intrinsic clearance; Kinetic models

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2006 سفارش ترجمه

Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases

Keywords: پاکسازی ذاتی; UDP-glucuronosyltransferases; LC/ESI/MS/MS; n-in-one cocktails; Intrinsic clearance;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه