Keywords: گیرنده کاپا اپیوئید; BNST; Bed nucleus of the stria terminalis; DYN; Dynorphin; KOR; Kappa-opioid receptor; MOR; mu-opioid receptor; nor-BNI; nor-binaltorphimine; Oprk1; KOR gene; Pdyn; Prodynorphin - DYN gene; USV; Ultrasonic vocalization; SA; Self administration; Alcohol de
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Keywords: گیرنده کاپا اپیوئید; Kappa opioid receptor; Serotonin; Clearance; Serotonin transporter; Phosphorylation; Trafficking; 5-HT; 5-hydroxytryptamine (serotonin); Akt X; Akt inhibitor X (10-(4â²-(N-diethylamino)butyl)-2-chlorophenoxazine); Akt; protein kinase B/Akt; BNI; nor-bina
Keywords: گیرنده کاپا اپیوئید; ANS; autonomic nervous system; BP; blood pressure; CFA; Complete Freund's adjuvant; DRG; dorsal root ganglion; fMRI; functional magnetic resonance imaging; FSH; Follicle-stimulating hormone; GABA; gamma-Aminobutyric acid; KOR; kappa-opioid receptor; LH; L
Keywords: گیرنده کاپا اپیوئید; Pentazocine; Morphine; Antinociception; Kappa-opioid receptor; Mu-opioid receptor;
Keywords: گیرنده کاپا اپیوئید; Alcohol dependence and withdrawal; GTPyS coupling; Kappa-opioid receptor; Alcohol self-administration; Zyklophin
Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake
Keywords: گیرنده کاپا اپیوئید; Hypothalamus; Melanin-Concentrating Hormone; Kappa-opioid receptor; Food intake; Melanin-Concentrating Hormone (MCH) (PubChem CID: 24868207); Naloxone hydrochloride (PubChem CID: 5464092); Norbinaltorphimine dyhydrochloride (norBNI) (PubChem CID: 5480230)
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace
Keywords: گیرنده کاپا اپیوئید; Analgesia; Butyrylfentanyl; Mu-opioid receptor; MT-45; U-47700; DAMGO; [D-Ala2,N-MePhe4,Gly-ol]-enkephalin; DPDPE; [D-Pen2, D-Pen5]-enkephalin; DOR-1; delta-opioid receptor; GTPγS; guanosine 5â²-O-[gamma-thio]triphosphate; KOR-1; kappa-opioid receptor;
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics
Keywords: گیرنده کاپا اپیوئید; Salvia divinorum; Lamiaceae family; Salvinorin A; Kappa-opioid receptor; Hallucinogen; Therapeutics;
Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC
Keywords: گیرنده کاپا اپیوئید; Heterodimerization; Apelin receptor; Kappa-opioid receptor; Myocardial contractility; Phosphorylated ERK1/2; Protein kinase C;
Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H
Keywords: گیرنده کاپا اپیوئید; Cav2 channel; κ-opioid receptor agonist U50488H; Inactivation; Use-dependent block; ATP; adenosine 5â²-triphosphate; Cav2.1, Cav2.2, and Cav2.3; neuronal voltage-gated P/Q-, N-, and R-type calcium channels, respectively; Cav1.3; neuronal voltage-gated L
Fibroblast heterogeneity and its implications for engineering organotypic skin models in vitro
Keywords: گیرنده کاپا اپیوئید; Organotypic skin; Fibroblast heterogeneity; Wound healing; Skin models; Skin substitutes; Tissue engineering; 3D; three-dimensional; AdSCs; adipose-derived stem cells; AP-1; activated protein-1; Blimp1; B lymphocyte-induced maturation protein-1; BP; bullo
Original ReportSpinal Endomorphin 2 Antinociception and the Mechanisms That Produce It Are Both Sex- and Stage of Estrus Cycle-Dependent in Rats
Keywords: گیرنده کاپا اپیوئید; Endomorphin; estrus cycle; kappa-opioid receptor; dynorphin; antinociception;
The Effects of Kappa-Opioid Receptor on Stretch-Induced Electrophysiological Changes in Infarcted Rat Hearts
Keywords: گیرنده کاپا اپیوئید; Kappa-opioid receptor; Arrhythmia; Monophasic action potential duration; Mechanoelectric feedback; Acute myocardial infarction
Ligand/kappa-opioid receptor interactions: Insights from the X-ray crystal structure
Keywords: گیرنده کاپا اپیوئید; Kappa-opioid receptor; Tetrapeptide; Molecular modeling; Combinatorial chemistry
Kappa Opioid Receptor-Mediated Dysregulation of Gamma-Aminobutyric Acidergic Transmission in the Central Amygdala in Cocaine Addiction
Keywords: گیرنده کاپا اپیوئید; Addiction; anxiety; central amygdala; cocaine; GABA; kappa-opioid receptor
Conceptualizing withdrawal-induced escalation of alcohol self-administration as a learned, plasticity-dependent process
Keywords: گیرنده کاپا اپیوئید; Anxiety; Dependence; Dynorphin; Extended Amygdala; Extracellular matrix; Kappa-opioid receptor; Matrix metalloproteinase; Negative reinforcement; Nucleus accumbens; Stress
Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors
Keywords: گیرنده کاپا اپیوئید; Estrogens; Estrogen receptors; Antinociception; Nociception; Opioid; Opioid receptors; Sexual dimorphism; Mu-opioid receptor; Kappa-opioid receptor; Rapid membrane estrogen receptor signaling
Inhibitory effects of processed Aconiti tuber on morphine-induced conditioned place preference in rats
Keywords: گیرنده کاپا اپیوئید; Processed Aconiti tuber; Morphine; Conditioned place preference; Kappa-opioid receptor; Dynorphin;
GABAergic transmission modulates ethanol excitation of ventral tegmental area dopamine neurons
Keywords: گیرنده کاپا اپیوئید; reward; mesolimbic; alcohol dependence; electrophysiology; inhibitory synaptic transmission; aCSF; artificial cerebral spinal fluid; ANOVA; analysis of variance; CeA; central amygdale; DA; dopaminergic; DOR; delta-opioid receptor; KOR; kappa-opioid recept
The kappa-opioid receptor is upregulated in the spinal cord and locus ceruleus but downregulated in the dorsal root ganglia of morphine tolerant rats
Keywords: گیرنده کاپا اپیوئید; Morphine tolerance; Kappa-opioid receptor; Spinal cord; Locus ceruleus; Dorsal root gangliaACTB, β-actin; Ct, cycles of threshold; DAMGO, [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DOR, delta-opioid receptor; DPMP, descending pain modulation pathway; DRG, dor
MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: A novel dual-acting μ- and κ-opioid agonist with potent a
Keywords: گیرنده کاپا اپیوئید; Antinociception; Mu-opioid receptor; Kappa-opioid receptor; Morphine; Rewarding effect; Gastrointestinal transit
Endogenous kappa-opioid receptor systems inhibit hyperalgesia associated with localized peripheral inflammation
Keywords: گیرنده کاپا اپیوئید; Inflammation; Kappa-opioid receptor; Rostral ventromedial medulla; Knockout; Spinal cord; CFA; Norbinaltorphimine; Gene deletion; Rat; Mouse;
Inhibitory effect of processed Aconiti tuber on the development of antinociceptive tolerance to morphine: Evaluation with a thermal assay
Keywords: گیرنده کاپا اپیوئید; Processed Aconiti tuber; Morphine tolerance; Kappa-opioid receptor
Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice
Keywords: گیرنده کاپا اپیوئید; Fear conditioning; Water maze; Spatial memory; CA3 hippocampus; Kappa-opioid receptor; Mouse
Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats
Keywords: گیرنده کاپا اپیوئید; Chronic constriction injury (CCI); Dynorhin; Neuropathic pain; Processed aconiti tuber; Herbal medicine; Kappa-opioid receptor
Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine
Keywords: گیرنده کاپا اپیوئید; Processed Aconiti tuber; Mesaconitine; Aconitine; Hypaconitine; Morphine tolerance; Kappa-opioid receptor;
Inhibition of morphine tolerance by processed Aconiti tuber is mediated by kappa-opioid receptors
Keywords: گیرنده کاپا اپیوئید; Processed Aconiti tuber; Aconitum carmichaeli; Ranunculaceae; Morphine tolerance; Nor-binaltorphimine; Kappa-opioid receptor; Mu-opioid receptor
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)
Keywords: گیرنده کاپا اپیوئید; Salvinorin; Kappa-opioid receptor; Structure–activity relationship; Agonist; Partial agonist
Alteration of kappa-opioid receptor system expression in distinct brain regions of a genetic model of enhanced ethanol withdrawal severity
Keywords: گیرنده کاپا اپیوئید; Neural basis of behavior; Drugs of abuse: alcohol, barbiturates, and benzodiazepines; EtOH; ethanol; WSP; Withdrawal Seizure-Prone; WSR; Withdrawal Seizure-Resistant; HIC(s); handling induced convulsion(s); AR; autoradiography; Pyr; pyrazole; D2; DBA/2J;