Keywords: LBs، بدن Lewy; AD, Alzheimer’s disease; Aβ, β amyloid; PD, Parkinson disease; l-DOPA, l-dihydroxyphenylalanine; LBs, Lewy bodies; DA, dopamine; APP, amyloid precursor protein; CVD, cardiovascular diseaseNeurological disorders; Alzheimer’s disease; Parkinson disease; Car
مقالات ISI LBs، بدن Lewy (ترجمه نشده)
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Keywords: LBs، بدن Lewy; α-Syn, alpha-synuclein; Aβ, amyloid-beta protein; BBB, blood–brain barrier; CNS, central nervous system; CSF, cerebrospinal fluid; DA, dopaminergic; ICV, intracerebroventricular; LBs, Lewy bodies; LPS, lipopolysaccharide; LRP-1, low-density lipoprotein re
Lysines, Achilles’ heel in alpha-synuclein conversion to a deadly neuronal endotoxin
Keywords: LBs، بدن Lewy; AGEs, advanced glycation end-products; ALDH, aldehyde dehydrogenases; aS, alpha-synuclein; ALP, autophagic lysosomal pathway; DHA, docosahexaenoic acid; DOPAL, 3,4dihydroxyphenylacetaldehyde; 4-HNE, 4-hydroxynonenal; LBs, Lewy Bodies; MDA, malondialdehyde
Fasudil, a Rho kinase inhibitor, promotes the autophagic degradation of A53T α-synuclein by activating the JNK 1/Bcl-2/beclin 1 pathway
Keywords: LBs، بدن Lewy; α-syn, α-synuclein; PD, Parkinson׳s disease; ROCK, Rho kinase; WT, wild-type; LBs, Lewy bodies; UPS, ubiquitin proteasome system; BSA, bovine serum albumin; CMA, chaperone-mediated autophagy; 3-MA, 3-methyladenine; Co-IP, Co-Immunoprecipitation; TEM, Tran
Cellular response of human neuroblastoma cells to α-synuclein fibrils, the main constituent of Lewy bodies
Keywords: LBs، بدن Lewy; α-Syn, α-Synuclein; 2D-DIGE, two dimensional differential in-gel electrophoresis; MS, mass spectrometry; PD, Parkinson's disease; PTMs, post-translational modifications; LBs, Lewy bodies; PD, Parkinson's disease; DLBs, Dementia with Lewy Bodies; emPAI, Ex
S-nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells
Keywords: LBs، بدن Lewy; METH, methamphetamine; PD, Parkinson's disease; NOS, nitric oxide synthase; NO, nitric oxide; α-syn, α-synuclein; PDI, protein disulphideisomerase; L-NNA, N-nitro-L-arginine; LBs, Lewy bodies; ER, endoplasmic reticulum; SNO-PDI, S-nitrosylated PDIMethamph
Membrane-bound α-synuclein interacts with glucocerebrosidase and inhibits enzyme activity
Keywords: LBs، بدن Lewy; α-syn, α-synuclein; PD, Parkinson disease; LBs, Lewy bodies; GD, Gaucher disease; GCase, glucocerebrosidase; WT, wild-type; α-glu A, acid α-glucosidase; N15, α-syn peptide residues 1–15; C23, α-syn peptide residues 118–140; MES, 2-(N-morpholino)ethanesulf
Synthesis and in vitro evaluation of α-synuclein ligands
Keywords: LBs، بدن Lewy; PD, Parkinson’s disease; AD, Alzheimer’s disease; LBs, Lewy bodies; LNs, Lewy neuritis; CNS, central nervous system; DMF, dimethylformamide; DMSO, dimethyl sulfoxide; SDS–PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; ThT, thioflavin T;
Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease
Keywords: LBs، بدن Lewy; PD, Parkinson's disease; L-Dopa, levo-dopa; SN, substantia nigra; REM, Rapid eye movement; RBD, rapid eye movement sleep disorder; LBs, Lewy bodies; α-syn, alpha-synuclein; TNFα, tumor necrosis factor-alpha; IL, interleukin; I-MIBG, I-meta-iodobenzylguani
G protein-coupled receptor kinase 5, overexpressed in the α-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression
Keywords: LBs، بدن Lewy; GRKs, G protein-coupled receptor kinases; LBs, Lewy bodies; pS129-α-synuclein, α-synuclein phosphorylated at Ser-129; shRNA, short hairpin ribonucleic acid; HDAC, histone deacetylase; GPCRs, G protein-coupled receptors; NLS, DNA-binding nuclear localizati
Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
Keywords: LBs، بدن Lewy; PD, Parkinson's disease; PDD, Parkinson's disease with dementia; AD, Alzheimer's disease; α-Syn, α-synuclein; LBs, Lewy bodies; p-Tau, hyperphosphorylated Tau; GSK-3β, glycogen synthase kinase 3β; p-GSK-3β, GSK-3β phosphorylated at Tyr216; IFG, inferior f
Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease
Keywords: LBs، بدن Lewy; DAergic, dopaminergic; DCFH2DA, 2,7′-dichlorofluorescein diacetate; ETC, electron transport chain; LBs, Lewy bodies; MPP+, 1-methyl-4-phenylpyridinium; MPTP, 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine; mtDNA, mitochondrial DNA; NT2, human teratocarcinom
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy
Keywords: LBs، بدن Lewy; BCIP/NBT, 5-bromo-4-chloro-3-indolyl-phosphate/nitroblue tetrazolium; GCIs, glial cytoplasmic inclusions; GNIs, glial intranuclear inclusions; HSPs, heat shock proteins; LBs, Lewy bodies; MSA, multiple system atrophy; MSA-C, MSA of the cerebellar type; MS
α-Synuclein facilitates the toxicity of oxidized catechol metabolites: Implications for selective neurodegeneration in Parkinson’s disease
Keywords: LBs، بدن Lewy; DA, dopamine; PD, Parkinson’s disease; SN, substantia nigra; LBs, Lewy bodies; α-S, α-synuclein; WT, wild type; AS, antisense; DAQ, dopamine quinone; dopaquinone, DOQ; β-S, β-synuclein; CAT, chloramphenicol acetyltransferase; MTT, 3-(4,5-dimethylthiazo-2-
Dopamine D1 receptor-mediated toxicity in human SK-N-MC neuroblastoma cells
Keywords: LBs، بدن Lewy; Ala, alanine; ATP, adenosine trisphosphate; Cit, citrate; DA, dopamine; Glu, glutamate; ISOPROT, isoproterenol; Lac, lactate; LBs, lewy bodies; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide; NMR, nuclear magnetic resonance; PD, Parkin