2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4
Keywords: 2-Hydroxyisoquinoline-1,3(2H,4H)-dione; Integrase; Ribonuclease H; Magnesium complexation; AntiretroviralHAART, highly active antiretroviral therapies; HIV-1, human immunodeficiency virus type 1; IN, integrase; LDA, lithium diisopropylamide; LEDGF, lens e