Keywords: Mass movement; Landslide inventory; Google Earth; Topography; Seismicity; Climate; Air temperature; Sediment yield; AUC; area under the ROC curve; LSD1; landslide dataset based on digitized landslide inventories; LSD2; landslide dataset based on mapped la
مقالات ISI (ترجمه نشده)
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Keywords: Epigenetics; LSD1; KDM1A; Reversible inhibitor; Stem cell differentiation; Cancer therapy; Epigenetic therapy; Acute myeloid leukaemia;
Keywords: Dictyostelium discoideum; Mycobacteria; Dormancy; Lipid droplet; Intracytosolic lipid inclusion; Perilipin; Tb; Tuberculosis; Mtb; Mycobacterium tuberculosis; FAs; fatty acids; TAG; striacylglycerols; LDs; lipid droplets; HCV; hepatitis C virus; ILIs; int
Keywords: 5-aza-CdR; 5-aza-2â²-deoxycytidine; AML; acute myeloid leukemia; ANRIL; antisense non-coding RNA in the INK4 locus; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A; CoREST; co-repressor for element-1-silencing transcription factor
Keywords: Lsd1; lipid storage droplet protein 1; PAT family; perilipin, ADRP, TIP 47 family; MD; molecular dynamics; DMPG; 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol; MAS; magic-angle spinning; CP; cross polarization; DARR; dipolar-assisted rotational resonance;
Keywords: Hox gene; Olfactory receptor gene; LOCK; Histone lysine methylation; LSD1; Polycomb;
Keywords: lncRNA; long/large noncoding RNA; Xist; X-inactive specific transcript; mESC; mouse embryonic stem cell; Evf2; embryonic ventral forebrain 2; Six3os; sine oculis-related homeobox 3 homolog, opposite strand; Dlx1as; distal-less homeobox 1, antisense; EGO;
Keywords: LSD1; Esophageal squamous cell carcinoma; Invasion;
Investigating the binding mechanism of (4-Cyanophenyl)glycine derivatives as reversible LSD1 by 3D-QSAR, molecular docking and molecular dynamics simulations
Keywords: LSD1; (4-Cyanophenyl)glycine derivatives; 3D-QSAR; Molecular docking; Molecular dynamics simulations; MM-PBSA;
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer
Keywords: lncRNA; HOXA-AS2; Diagnosis; Therapeutic target; Prognosis; APL; Acute promyelocytic leukemia; ATRA; All trans retinoic acid; Bax; BCL2-Associated X; BC; Breast cancer; Bcl-2; B-cell lymphoma-2; c-Myc; MYC proto-oncogene; CRC; Colorectal cancer; DDIT3; DN
In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators
Keywords: ARC; Arcuate nucleus; AgRP; Agouti-related peptide; bHLH; Basic-helix-loop-helix; BPA; Bisphenol A; LSD1; Demethylase enzyme; Ngn; Neurogenin; NPY; Neuropeptide Y; NPCs; Neuroprogenitor cells; POMC; Pro-opiomelanocortin; Neuroprogenitor cells; Proliferati
FOXP4-AS1 participates in the development and progression of osteosarcoma by downregulating LATS1 via binding to LSD1 and EZH2
Keywords: Osteosarcoma; FOXP4-AS1; LSD1; EZH2; LATS1;
The physiopathologic interplay between stem cells and tissue niche in muscle regeneration and the role of IL-6 on muscle homeostasis and diseases
Keywords: IL-; interleukin; SC; satellite cell; ECM; extracellular matrix; MuSCs; muscle stem cells; ROS; reactive oxygen species; Treg; regulatory T cells; Pax7; Paired box protein 7; Myf5; myogenic factor 5; MyoD; myoblast determination protein; MRF; muscle regul
Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop
Keywords: SNAIL; Snail family transcriptional repressor; ZEB; Zinc finger E-box binding homeobox; BMP1; Bone Morphogenetic protein1; TWIST; twist family bHLH transcription factor 1; GSC; goosecoid hemeobox; TGF-β; transforming growth factor beta; NPC; nasopharynge
Redox and the circadian clock in plant immunity: A balancing act
Keywords: ROS; reactive oxygen species; H2O2; hydrogen peroxide; RNS; reactive nitrogen species; NO; nitric oxide; GSH1; γ-glutamylcysteine synthetase; SA; salicylic acid; JA; jasmonic acid; PAMP; pathogen-associated molecular pattern; PTI; pattern-triggered immun
Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo
Keywords: LSD1; EZH2; Acute myeloid leukemia; Synergistic effect; Drug combination;
Dynamic regulation of six histone H3 lysine (K) methyltransferases in response to prolonged anoxia exposure in a freshwater turtle
Keywords: K; lysine; R; arginine; H3K4me1; monomethylated histone H3 lysine 4; H3K27me1; monomethylated histone H3 lysine 27; H3K9me3; trimethylated histone H3 lysine 9; HP1; heterochromatin protein 1; HKMT; histone lysine methyltransferases; SAM; S-adenosyl-L-meth
Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy
Keywords: ROS; reactive oxygen species; 8-oxoGua; 8-Oxo-7,8-dihydroguanine; UNG; uracil-DNA glycosylase; TET; ten-eleven translocation protein; 5-mCyt; 5-Methylcytosine; 5-hmCyt; 5-Hydroxymethylcytosine; 5-fCyt; 5-formylcytosine; 5-caCyt; 5-Carboxycytosine; BER; ba
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
STAT3: The art of multi-tasking of metabolic and immune functions in obesity
Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti
Riboflavin attenuates myocardial injury via LSD1-mediated crosstalk between phospholipid metabolism and histone methylation in mice with experimental myocardial infarction
Keywords: Riboflavin; LSD1; Cardiac protection; Metabolism; Histone methylation;
Discovery of tranylcypromine analogs with an acylhydrazone substituent as LSD1 inactivators: Design, synthesis and their biological evaluation
Keywords: LSD1; Inhibitor; Phenylalanyl hydrazones; Tranylcypromine;
Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1
Keywords: Epigenetics; LSD1; KDM1A; Reversible inhibitor; Stem cell differentiation; Cancer therapy; Epigenetic therapy; Acute myeloid leukaemia;
MicroRNA-137 and its downstream target LSD1 inversely regulate anesthetics-induced neurotoxicity in dorsal root ganglion neurons
Keywords: DRGN; Mouse; Anesthesia; Neurotoxicity; miR-137; LSD1; KDM1A;
Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark?
Keywords: Oxidatively generated DNA damage; Base excision repair; OGG1; LSD1; Regulation of transcription;
3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors
Keywords: LSD1; 6-Aryl-5-cyano-pyrimidine; 3D-QSAR; Molecular docking; Molecular dynamics simulations;
Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors
Keywords: LSD1; Inhibitors; Selective; Reversible; Docking; DCM; dichloromethane; TBSCl; tert-butyldimethylsilyl chloride; TBAF; tetrabutylammonium fluoride; rt; room temperature; DMF; N,N-dimethylformamide; THF; tetrahydrofuran; DIEA; N,N-diisopropylethylamine;
Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1
Keywords: Estrogen; TFPI-2; MCF7 cells; Demethylation; ERα; LSD1;
LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer
Keywords: LSD1; lysine specific demethylase 1; KDM; lysine demethylase; SCLC; small cell lung cancer; NSCLC; non-small cell lung cancer; LSD1; LSD1+8a; KDM; SCLC; Neuroendocrine marker; Resistance to chemotherapy;
LSD1 collaborates with EZH2 to regulate expression of interferon-stimulated genes
Keywords: LSD1; EZH2; Histone modification; Interferon pathway; IRF9;
Epigenetic regulation of epithelial to mesenchymal transition by the Lysine-specific demethylase LSD1/KDM1A
Keywords: EMT; LSD1; Chromatin; Cell migration and invasion; Cancer;
Oncogene LSD1 is epigenetically suppressed by miR-137 overexpression in human non-small cell lung cancer
Keywords: Lung cancer; NSCLC; LSD1; MiR-137; Biochemistry; Western blot;
LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1
Keywords: LSD1; histone lysine specific demethylase 1; ESCC; esophageal squamous cell carcinoma; E2F1; E2F transcription factor; FAD; flavin adenine dinucleotide; ERBB2; epidermal growth factor receptor 2; CCNA2; cyclin-A2; NSCLC; non-small cell lung cancer; PHLDB2
CACUL1 functions as a negative regulator of androgen receptor in prostate cancer cells
Keywords: CACUL1; AR; LSD1; Prostate cancer; Transcriptional activityCACUL1, CDK2-associated cullin; AR, androgen receptor; LSD1, lysine specific demethylase 1; GST, glutathione S-transferase; β-gal, β-galactosidase; GFP, green fluorescent protein; ARE, AR-responsi
Update on rational targeted therapy in AML
Keywords: High-risk AML; IDH; BET; HDAC inhibitors; LSD1; DOT1L; Flavopiridol; Palbociclib; Volasertib; Wee1; Idasanutlin; Aurora kinase; Rigosertib; Hedgehog; BH3-mimetic; Venetoclax; Pevonedistat; Tosedostat
The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer
Keywords: LSD1; Histone demethylase; Epigenetic modification; Oral cancer
The effects of LSD1 inhibition on self-renewal and differentiation of human induced pluripotent stem cells
Keywords: LSD1; hiPSCs; Self-renewal; Differentiation; Mechanism;
Functional biotechnologyβ-carbonic anhydrases and carbonic ions uptake positively influence Arabidopsis photosynthesis, oxidative stress tolerance and growth in light dependent manner
Keywords: CAs; carbonic anhydrases; CO2; carbon dioxide; Fv/Fm; maximum quantum efficiency of photosystem II (PSII); LHCs; light harvesting complexes; lsd1; lesion simulating disease 1; ME; malic enzyme; NaHCO3; sodium bicarbonate; NPQ; non-photochemical quenching;
Interference of lysine-specific demethylase 1 inhibits cellular invasion and proliferation in vivo in gastric cancer MKN-28 cells
Keywords: Lentivirus; shRNA; LSD1; Cisplatin; Gastric cancer
Dynamic epigenetic mechanisms regulate age-dependent SOX9 expression in mouse articular cartilage
Keywords: ACs; articular chondrocytes; H3K4me2; histone 3 lysine 4 dimethylation; OA; osteoarthritis; WT; wild-type; IHC; immunohistochemistry; HE; haematoxylin and eosin; qPCR; quantitative real-time RT-PCR; P1; first passage of cultured cells; MeDIP; methylated D
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr
Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies
Keywords: Herpes simplex virus; Chromatin; Demethylase; LSD1; JMJD2; HCF-1; Latency;
Gold nanorod delivery of LSD1 siRNA induces human mesenchymal stem cell differentiation
Keywords: Nanocarriers; Human mesenchymal stem cells; AuNRs; LSD1; Hepatocyte growth factor
SALL4: An emerging cancer biomarker and target
Keywords: ESCs; embryonic stem cells; AML; acute myeloid leukemia; CSCs; cancer stem cells; iPS; induced pluripotent stem cell; HSCs/HPCs; hematopoietic stem/progenitor cells; MDS; myelodysplastic syndrome; LSCs; leukemic stem cells; CML; chronic myeloid leukemia;
The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a
Keywords: AAV-Cre; adeno-associated virus with Cre recombinase; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; BIX-01924; G9a inhibitor; CA1; cornu ammonis 1; DNA; deoxyribonucleic acid; Drd1; dopamine recep
miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSMC proliferation
Keywords: ATRA; all-trans retinoic acid; cdk2; cyclin-dependent kinase 2; HASMC; human aortic smooth muscle cell; HDAC2; histone deacetylase 2; KLF; Krüppel-like factor; LSD1; lysine-specific demethylase 1; miR; microRNA; NCoR; nuclear receptor corepressor; p21; p
Spatiotemporal expression analysis of Prdm1 and Prdm1 binding partners in early chick embryo
Keywords: Neural crest; Prdm1; Lsd1; Hdac1&2; G9a; Prmt5;
Inhibition of LSD1 by Pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo
Keywords: LSD1; Pargyline; Epithelial-mesenchymal transition; Androgen deprivation therapy; Castration resistant prostate cancer;
LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process
Keywords: LSD1; Pancreatic cancer; Glycolysis; HIF1α
A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events
Keywords: Ethnomedicine; Ophiorrhiza nicobarica; HSV; Immediate-early transcription; LSD1;