Keywords: LT، leukotriene; fMLP, N-formyl-methionyl-leucyl-phenylalanine; IL, interleukin; LT, leukotriene; PAF, platelet activating factor; C5a, complement 5a; CCD, charge-coupled device; HUVEC, human umbilical vein endothelial cells; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesu
مقالات ISI LT، leukotriene (ترجمه نشده)
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Cellular signalling of cysteinyl leukotriene type 1 receptor variants CysLT1-G300S and CysLT1-I206S
Keywords: LT، leukotriene; cysLTs, cysteinyl-leukotrienes; CysLT1, cysteinyl-leukotriene type 1 receptor; WT, wild-type; LT, leukotriene; GPCR, G-protein-coupled receptorCysteinyl-leukotriene; CysLT1; Variant; Signalling; Atopy
Clostridium difficile-induced colitis in mice is independent of leukotrienes
Keywords: LT، leukotriene; Clostridium difficile; Leukotriene; Eicosanoid; Nosocomial infectionCDI, Clostridium difficile infection; TcdA, Clostridium difficile toxin A; TcdB, Clostridium difficile toxin B; LT, leukotriene; LTB4, leukotriene B4; CysLTs, cysteinyl leukotrienes; 5-LO
Quantitation of leukotriene B4 in human sputum as a biomarker using UPLC–MS/MS
Keywords: LT، leukotriene; BQL, below quantitation limit; COPD, chronic obstructive pulmonary disease; DTT, dithiothreitol; HQC, high QC; HSA, human serum albumin; LLE, liquid-liquid extraction; LLOQ, low limit of quantitation; LQC, low QC; LT, leukotriene; LTA4, leukotriene A4; LT
Effect of verapamil on bronchial goblet cells of asthma: An experimental study on sensitized animals
Keywords: LT، leukotriene; Asthma; Calcium channel; Experimental model; Goblet cell; VerapamilELISA, enzyme linked immunosorbent assay; LT, leukotriene; PBS, phosphate-buffered saline; OVA, ovalbumin; Alum, aluminum hydroxide; BALF, bronchoalveolar lavage fluid; COPD, chronic obstr
Increased cysteinyl leukotriene concentration and receptor expression in tonsillar tissues of Chinese children with sleep-disordered breathing
Keywords: LT، leukotriene; AHI, apnea–hypopnea index; BMI, body mass index; CysLT, cysteinyl leukotriene; CysLTR, cysteinyl leukotriene receptor; CysLT1-R, CysLT subtype 1 receptor; CysLT2-R, CysLT subtype 2 receptor; IQR, interquartile range; LT, leukotriene; LTE4, leukotriene E4;
Role of leukotriene B4 receptor signaling in human preadipocyte differentiation
Keywords: LT، leukotriene; LT, leukotriene; LOX, lipoxygenase; TGFBI, transforming growth factor beta-induced 68 kDa; INS, insulin; DEX, dexamethasone; IBMX, 3-isobutyl-methylxanthine; ROSI, rosiglitazone; NDGA, nordehydroguaiaretic acid; TNFα, tumor necrosis factor alpha; IL-6, in
Interaction between eicosanoids and the complement system in salmonid fish
Keywords: LT، leukotriene; COX, cyclooxygenase; EIA, enzyme immunoassay; HEPE, hydroxy eicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; RP-HPLC, reverse phase high performance liquid chromatography; LO, lipoxygenase; LT, leukotriene; LX, lipoxin; PL, phospholipase; PG, pr
Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway
Keywords: LT، leukotriene; ERK, extracellular signal-regulated kinase; FBS, fetal bovine serum; JNK, c-Jun N-terminal kinase; LTB4, leukotriene B4; LT, leukotriene; MMP-9, matrix metalloproteinase-9; p38 MAPK, p38 mitogen-activated protein kinase; RT-PCR, Reverse Transcription-Poly
Marine natural products targeting phospholipases A2
Keywords: LT، leukotriene; 5-HPTETE, 5-hydroperoxyeicosatetraenoic acid; COX, cyclooxygenase; cPLA2, cytosolic PLA2; IP3, inositol 1,4,5-triphosphate; iPLA2, calcium independent PLA2; LOX, lipoxygenase; (Lp)PLA2, lipoprotein-associated PLA2; LT, leukotriene; NO, nitric oxide; PAF,
Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1
Keywords: LT، leukotriene; Lipid mediator; Knockout mouse; Inflammation; Hypersensitivity; Arachidonic cascadeBLT, leukotriene B4 receptor; DTH, delayed-type hypersensitivity; GPCR, G-protein coupled receptor; LT, leukotriene; LTB4, leukotriene B4; 5-LO, 5-lipoxygenase; rmIL-12, re
Specialized pro-resolving lipid mediators in the inflammatory response: An update
Keywords: LT، leukotriene; AA, arachidonic acid; ATL, aspirin-triggered lipoxin; AT-RvD, aspirin-triggered D-series resolvin; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; FA, fatty acid; I/R, ischemia/reperfusion; LT, leukotriene; LTB4, leukotriene B4 (5S,12R-dihydroxy-ei
Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale
Keywords: LT، leukotriene; Cytokine; Eicosanoid; Fatty acid; Fish oil; InflammationAA, arachidonic acid (20:4n-6); DHA, docosahexaenoic acid (22:6n-3); EPA, eicosapentaenoic acid (20:5n-3); IκB, inhibitory subunit of NF-κB; IL, interleukin; LT, leukotriene; NF-κB, nuclear factor κB
Maternal dietary n-3 fatty acids alter cardiac ventricle fatty acid composition, prostaglandin and thromboxane production in growing chicks
Keywords: LT، leukotriene; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; PUFA, polyunsaturated fatty acids; PG, prostaglandin; PGE2, prostaglandin E2; PGE3, prostaglandin E3; LT, leukotriene; LTB4, leukotriene B4; LTB5, leukotriene B5; TX, thromboxane; TXA2, thromboxane A2
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma
Keywords: LT، leukotriene; Asthma; Pharmacogenetics; Leukotrienes; Response rate; 5-Lipoxygenase5-LO, 5-lipoxygenase; ALOX5, 5-lipoxygenase gene; CysLT, cysteinyl leukotriene; FEV1, forced expiratory volume in the 1 s; LT, leukotriene; LTRAs, leukotriene receptor antagonists
Opposite effects of PU.1 on mast cell stimulation
Keywords: LT، leukotriene; BM, bone marrow-derived; DC, dendritic cells; LC, langerhans cells; LT, leukotriene; LPS, lipopolysaccharoide; MC, mast cells; PG, prostagrandineDendritic cells; FcεRI; Mast cells; PU.1; TLR4
Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
Keywords: LT، leukotriene; Cysteinyl leukotrienes; corticosteroids; IL-4CCS, Corticosteroid; CysLT, Cysteinyl leukotriene; CysLT1R, Cysteinyl leukotriene receptor 1; CysLT2R, Cysteinyl leukotriene receptor 2; 5-LO, 5-Lipoxygenase; LT, Leukotriene; LTC4S, Leukotriene C4 synthase
Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease
Keywords: LT، leukotriene; AA, arachidonic acid; BMI, body mass index; CD, Crohn disease; EFA, essential fatty acids; EMP, erythrocyte membrane phospholipids; EPA, eicosapentaenoic acid; IBD, inflammatory bowel disease; LA, linoleic acid; LT, leukotriene; MUFA, monounsaturated fatt
Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst
Keywords: LT، leukotriene; BME, methanolic extract of Bacopa monniera; BuOH, butanol; COX, cyclooxygenase; DPPH, 1,1-diphenyl-2-picrylhydrazyl; EtOAc, ethyl acetate fraction; INDO, indomethacin; LOX, lipoxygenase; LPS, lipopolysaccharide; LT, leukotriene; NSAIDs, non-steroidal anti
Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes
Keywords: LT، leukotriene; AA, arachidonic acid; CA, carnosic acid; CS, carnosol; DCF-DA, 2′,7′-dichlorofluorescein diacetate; fMLP, N-formyl-methionyl-leucyl-phenylalanine; HLE, human leukocyte elastase; LO, lipoxygenase; LT, leukotriene; PG buffer, PBS plus 1 mg/ml glucose; PLA2,
Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosanoids in rat neutrophils and human platelets
Keywords: LT، leukotriene; AA, arachidonic acid; COX, cyclooxygenase; PLA2, phospholipase A2; 5-,12-HETE, hydroxyeicosatetraenoic acid; 12-HHT, 12-hydroxyheptadecatrienoic acid; 5-LOX, 5-lipoxygenase; LT, leukotriene; NDGA, nordihydroguaiaretic acid; NSAIDs, non-steroidal anti-infl
Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators
Keywords: LT، leukotriene; COX-2, cyclooxygenase 2; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; HETE, hydroxyeicosatetraenoic acid; LT, leukotriene; LX, lipoxin; LXA4, 5S, 6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid; 15-epi-LXA4, 5S,6R,15R-trihydroxy-7,9,
The relationship between the fatty acid composition of immune cells and their function
Keywords: LT، leukotriene; Arachidonic acid; Eicosapentaenoic acid; Docosahexaenoic acid; Fish oil; Inflammation; Eicosanoid; Cytokine; Macrophage; LymphocyteDHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; IL, interleukin; LAT, linker of activated T cells; LT, leukotriene; M
Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses
Keywords: LT، leukotriene; cPLA2α, Cytosolic phospholipase A2α; PAF, Platelet activating factor; MOG, Myelin oligodendrocyte glycoprotein; PLP, Phospholipid protein; PG, Prostaglandin; LT, Leukotriene; LX, Lipoxin; AA, Arachidonic acid; LO, Lipoxygenase; AUC, Area under the curve;
Host immune responses to rhinovirus: Mechanisms in asthma
Keywords: LT، leukotriene; Asthma; exacerbation; rhinovirus; immune response to virus; pathogenesisEC, Epithelial cell; ICAM-1, Intercellular adhesion molecule 1; ICS, Inhaled corticosteroid; IP, Inducible protein; LT, Leukotriene; MIP, Macrophage inflammatory protein; RANTES, Regu
Advances in pediatric asthma 2006
Keywords: LT، leukotriene; Asthma; severe asthma; early intervention in asthma; biomarkers; therapeuticsBDR, Bronchodilator response; eNO, Exhaled nitric oxide; FVC, Forced vital capacity; ICS, Inhaled corticosteroid; LABA, Long-acting β2-adrenergic agonist; LT, Leukotriene; LTRA,
Increased leukotriene concentrations in gingival crevicular fluid from subjects with periodontal disease and atherosclerosis
Keywords: LT، leukotriene; BOP, bleeding on probe; CCA, common carotid artery; cIMA, cross-sectional intima-media area; GCF, gingival crevicular fluid; LT, leukotriene; PD, pocket depth; PLI, dental plaque indexLeukotriene B4; Cysteinyl-leukotrienes; Lipoxygenase; Inflammation; Car
Omega 3 – Omega 6: What is right for the liver?
Keywords: LT، leukotriene; DNA, deoxyribonucleic acid; LT, leukotriene; PG, prostaglandin; PUFA, polyunsaturated fatty acid; TNF, tumor necrosis factor; TX, thromboxaneOmega-3 fatty acids; Fatty liver; Macro- and microvesicular steatosis; Ischemia/reperfusion; Eicosanoids
G protein-coupled receptors and the modification of FcɛRI-mediated mast cell activation
Keywords: LT، leukotriene; BMMCs, bone marrow-derived mast cells; cAMP, cyclic adenosine monophosphate; EP, E prostanoid receptor; FcɛRI, high affinity IgE-receptor; GPCR, G protein-coupled receptor; IgE, immunoglobulin E; LPA, lysophosphatidic acid; LT, leukotriene; MIP-1α, macrop
Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats
Keywords: LT، leukotriene; SNP, sodium nitroprusside; NO, nitric oxide; eNOS, constitutively expressed endothelial NO synthase; iNOS, inducible NO synthase; I/R, ischemia and reperfusion; LT, leukotriene; 5-LO, 5-lipoxygenase; LTC4S, leukotriene C4 synthase; mGST, microsomal glutat
Increased Leukotriene E4 in the Exhaled Breath Condensate of Children With Mild Asthma
Keywords: LT، leukotriene; childhood asthma; exhaled breath condensate; leukotriene E4; mild asthmacys-LT, cysteinyl leukotriene; EBC, exhaled breath concentrate; eNO, exhaled nitric oxide; LT, leukotriene; PC15, provocative concentration of methacholine causing a 15% fall in FEV1
The role of allergic rhinitis in nasal responses to sudden temperature changes
Keywords: LT، leukotriene; Indoor air quality; environmental illness; air conditioning; inflammatory mediatorsECP, Eosinophil cationic protein; IAQ, Indoor air quality; LT, Leukotriene; PAR, Persistent allergic rhinitis; sICAM-1, Soluble intercellular adhesion molecule 1
Fungal zymosan induces leukotriene production by human mast cells through a dectin-1–dependent mechanism
Keywords: LT، leukotriene; Fungal infection; mast cells; lipid mediators; GM-CSF; IL-1β; allergy; bronchoconstrictionCBMC, Cord blood–derived mast cell; LT, Leukotriene; ITAM, Immunoreceptor tyrosine activation motif; NF-κB, Nuclear factor-κB; PG, Prostaglandin; SCF, Stem cell fact
5. IgE, mast cells, basophils, and eosinophils
Keywords: LT، leukotriene; IgE; IgE receptor; mast cell; basophil; eosinophilAPC, Antigen-presenting cell; ITAM, Immunoreceptor tyrosine-based activation motif; LT, Leukotriene; MBP, Major basic protein; PG, Prostaglandin; SCF, Stem cell factor; STAT, Signal transducer and activato
Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes
Keywords: LT، leukotriene; B cells; lipid mediators; antibodies; cell surface molecules; receptor; IL-4CysLT, Cysteinyl leukotriene; L4.5, CD154-transfected murine L929 fibroblasts; LT, Leukotriene; NF-κB, Nuclear factor-κB; PAF, Platelet-activating factor; PBL, Peripheral blood ly
The role of the mast cell in the pathophysiology of asthma
Keywords: LT، leukotriene; Mast cells; asthma; airway smooth muscle; bronchial mucous glands; chemokines; TNF-αASM, Airway smooth muscle; BHR, Bronchial hyperresponsiveness; EB, Eosinophilic bronchitis; HLMC, Human lung mast cell; LT, Leukotriene; PAR, Protease-activated receptor;
Group V secretory phospholipase A2 amplifies the induction of cyclooxygenase 2 and delayed prostaglandin D2 generation in mouse bone marrow culture-derived mast cells in a strain-dependent manner
Keywords: LT، leukotriene; BMMC, bone marrow-derived mast cells; cPLA2, cytosolic phospholipase A2; COX, cyclooxygenase; HBA, Hanks' balanced salt solution without Mg2+ or CA2+ containing 0.1% BSA; LT, leukotriene; PG, prostaglandin; SCF, stem cell factor; sPLA2, secretory phosphol
Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation
Keywords: LT، leukotriene; AA, arachidonic acid; LOX, lipoxygenase; NDGA, nordihydroguaiaretic acid; LT, leukotriene; MAPK, mitogen-activated protein kinase; PI3K, phosphatydilinositol 3-kinase; PG, prostaglandin; COX, cyclooxygenase; HETE, hydroxyeicosatetraenoic acid; CysLT, cyst
Sensory system-predominant distribution of leukotriene A4 hydrolase and its colocalization with calretinin in the mouse nervous system
Keywords: LT، leukotriene; leukotriene B4; sensory nervous system; immunohistochemistryDAB, diaminobenzidine; EDTA, ethylenediaminetetraacetic acid; IHC, inner hair cell; INL, inner nuclear layer of the retina; LT, leukotriene; OHC, outer hair cell; PBS, phosphate-buffered saline;
Mexican migrant ethnopharmacology: Pharmacopoeia, classification of medicines and explanations of efficacy
Keywords: LT، leukotriene; AIDS, acquired immune deficiency syndrome; GI, gastrointestinal; LT, leukotriene; MDS, multi-dimensional scaling; NSAID, non-steroidal anti-inflammatory drug; PG, prostaglandin; PGE2, prostaglandin E2; USA, United States of AmericaUrban ethnopharmacology;
At what stage in metazoan evolution did leukotriene generation first appear?-key insights from cartilaginous fish
Keywords: LT، leukotriene; Ray; Leukotriene A hydrolase; Lipid mediators; Inflammation; HETE, hydroxyeicosatetraenoic acid; LO, lipoxygenase; LT, leukotriene; PG, prostaglandin; RP-HPLC, reverse phase high performance liquid chromatography;